Elevated serum levels of sFas in acute viral hepatitis

2001 ◽  
Vol 13 (12) ◽  
pp. 1507-1508
Author(s):  
Maximilian Schöniger-Hekele ◽  
Christian Müller
Keyword(s):  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Elevated Serum ◽  
Serum Levels

scholarly journals Evaluation of Serum Levels of Hepatic Enzymes and Plasma Proteins between Different Types of Acute Viral Hepatitis

2013 ◽  
Vol 3 (1) ◽  
pp. 19-22
Author(s):  
MA Zaman ◽  
HB Asad ◽  
MN Roy ◽  
N Hoque ◽  
M Nasiruddin ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Plasma Proteins ◽  
Acute Viral Hepatitis ◽  
Geometric Mean ◽  
Serum Levels ◽  
Hepatitis E ◽  
Cross Sectional Study ◽  
Hepatic Enzymes ◽  
Cross Sectional ◽  
Different Types

This cross-sectional study was carried out in 80 serologically diagnosed cases of acute viral hepatitis to assess and compare the serum hepatic enzymes & plasma proteins between four different types (A,B,C,E), 20 in each group. Hepatitis E, hepatitis B and hepatitis C were more prevalent in males than that in females. The study showed that geometric mean of S.AST of all the four types differed significantly (F= 274.94, p<0.001). Geometric mean of S.ALT, S.AST and S.ALP in cases of HCV were significantly lower than others (p<0.001). Geometric mean of S.ALT & S.AST in cases of HEV were significantly increased than others (p<0.001). But the geometric mean of S.ALP of HBV was significantly higher than others (p<0.001). On the other hand though S.ALP of HAV and HEV was lower than HBV but significantly higher than HCV (p<0.001). The mean±SD of serum albumin of HCV was decreased significantly in contrast to those of HAV and HBV (p<0.001). A:G ratio of HCV was also significantly lower than other three (p<0.001). It was revealed through the study that hepatic enzymes were most affected in cases of HEV but least affected in cases of HCV. DOI: http://dx.doi.org/10.3329/bjmb.v3i1.13803 Bangladesh J Med Biochem 2010; 3(1): 19-22

scholarly journals Evaluation of Liver Enzymes and calculation of AST to ALT ratio in patients with acute viral hepatitis

2021 ◽  
Vol 3 (2) ◽  
pp. 83-86
Author(s):  
Arun Pandeya ◽  
Naveen Kumar Shreevastva ◽  
Arun Dhungana ◽  
Anup Pandeya ◽  
Binita Pradhan
Keyword(s):  
Viral Hepatitis ◽  
Healthy Subjects ◽  
Biochemical Parameters ◽  
Liver Enzymes ◽  
Acute Viral Hepatitis ◽  
Early Stage ◽  
Calculated Data ◽  
Serum Levels ◽  
Appropriate Care ◽  
Control Serum

Background: Acute viral hepatitis is a common liver-associated abnormality encountered in clinical practice. The number of biochemical parameters is estimated to detect a hepatic abnormality, which can measure the severity and types of damage to hepatocytes, among which liver enzymes and bilirubin levels are assessed routinely which are raised in acute viral hepatitis.Objective: This study aims to assess the liver enzymes, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, and calculation of AST to ALT ratio in acute viral hepatitis and to compare these parameters with the control group.Methodology: This study included a total of 81 subjects diagnosed with acute viral hepatitis as cases and age and sex-matched, the same number of healthy subjects as control. Serum levels of AST and ALT, alkaline phosphatase (ALP), and bilirubin were analyzed using standard methods. Serum AST to ALT ratio was calculated. Data analysis was done using SPSS Version 17.0 and the results were expressed as mean ±standard deviation (SD).Results: A mean serum activities of aminotransferases were statistically significantly raised in viral hepatitis compared to that in control.AST (514.85±350.66 VS 25.65±5.29; p<0.001) and ALT (781.65±525.69 VS 27.94±6.50; p<0.001). Similarly, serum levels of(ALP)were significantly increased in acute viral hepatitis compared to that in control (202.17±75.46 VS 98.83±27.99; p<0.001. However, a ratio of AST to ALT was decreased significantly (0.66±0.15 VS 0.94±0.21; p= 0.001) in acute viral hepatitis compared to that in control.Conclusion: Both the aminotransferases and bilirubin levels are raised significantly, where, a rise in ALT is greater than a rise in AST, hence, the ratio of AST to ALT is decreased significantly in acute viral hepatitis than that in control. Thus, this decreased pattern of AST to ALT can diagnose acute viral hepatitis at an early stage and can help appropriate care and treatment to the patients.

scholarly journals Cholestatic hepatitis due to Salmonella typhi

2011 ◽  
Vol 1 (1) ◽  
pp. 13 ◽  
Author(s):  
Ayse Albayrak ◽  
Sibel Seda Gunbey ◽  
Ferda Aktas
Keyword(s):  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Rare Complication ◽  
Elevated Serum ◽  
Clinical Importance ◽  
Public Health Problem ◽  
Clinical Feature ◽  
Gamma Glutamyl Transferase ◽  
Important Public Health Problem ◽  
Glutamyl Transferase

Salmonella infection occurs worldwide and is still an important public health problem in many developing countries. The infection can affect almost all major organs including the liver. Severe hepatic involvement with a clinical feature of acute hepatitis is a rare complication. In this paper, a 39-year-old male with acute cholestatic typhoid hepatitis is presented. The case had a tender hepatomegaly and elevated serum alanine and aspartate transaminase, alkaline phosphatase, and gamma glutamyl transferase levels; these features cannot been distinguished from those of acute viral hepatitis. Serological and viral markers of acute viral hepatitis were negative. No pathology could be determined in abdomen Ultrasonography (USG) or Magnetic Reso - nance (MR) Cholangiography. As enteric fever is a common infection, the recognition of salmonella hepatitis is of clinical importance. When patients from an endemic or outbreak area present acute febrile hepatitis, typhoid fever should be a consideration.

Elevated serum thymidine kinase activity in patients with acute viral hepatitis

1993 ◽  
Vol 28 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Katsuaki Tanaka ◽  
Toshihiro Sishido ◽  
Manabu Morimoto ◽  
Shuji Inoue ◽  
Yutaro Takamura ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Thymidine Kinase ◽  
Kinase Activity ◽  
Acute Viral Hepatitis ◽  
Elevated Serum ◽  
Thymidine Kinase Activity

Acute viral hepatitis C

2008 ◽  
Vol 12 (2) ◽  
pp. 89-94
Author(s):  
İsmail Hamdi Kara
Keyword(s):  
Hepatitis C ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Viral Hepatitis C

Acute viral hepatitis

2008 ◽  
Vol 12 (1) ◽  
pp. 39-43
Author(s):  
İsmail Hamdi Kara
Keyword(s):  
Viral Hepatitis ◽  
Acute Viral Hepatitis

Acute Viral Hepatitis in Men Having Sex with Men

Aids Reviews ◽  
2020 ◽  
Vol 22 (3) ◽  
Author(s):  
José Vicente Fernández-Montero ◽  
Vicente Soriano
Keyword(s):  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Sex With Men

scholarly journals The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients

2021 ◽  
Author(s):  
Bianca Mages ◽  
Thomas Fuhs ◽  
Susanne Aleithe ◽  
Alexandra Blietz ◽  
Constance Hobusch ◽  
...  
Keyword(s):  
Animal Models ◽  
Neuronal Damage ◽  
Degradation Products ◽  
Focal Cerebral Ischemia ◽  
Elevated Serum ◽  
Serum Levels ◽  
Ultrastructural Level ◽  
Stroke Patients ◽  
Protein Levels ◽  
Cytoskeletal Elements

AbstractIn the setting of ischemic stroke, the neurofilament subunit NF-L and the microtubule-associated protein MAP2 have proven to be exceptionally ischemia-sensitive elements of the neuronal cytoskeleton. Since alterations of the cytoskeleton have been linked to the transition from reversible to irreversible tissue damage, the present study investigates underlying time- and region-specific alterations of NF-L and MAP2 in different animal models of focal cerebral ischemia. Although NF-L is increasingly established as a clinical stroke biomarker, MAP2 serum measurements after stroke are still lacking. Therefore, the present study further compares serum levels of MAP2 with NF-L in stroke patients. In the applied animal models, MAP2-related immunofluorescence intensities were decreased in ischemic areas, whereas the abundance of NF-L degradation products accounted for an increase of NF-L-related immunofluorescence intensity. Accordingly, Western blot analyses of ischemic areas revealed decreased protein levels of both MAP2 and NF-L. The cytoskeletal alterations are further reflected at an ultrastructural level as indicated by a significant reduction of detectable neurofilaments in cortical axons of ischemia-affected areas. Moreover, atomic force microscopy measurements confirmed altered mechanical properties as indicated by a decreased elastic strength in ischemia-affected tissue. In addition to the results from the animal models, stroke patients exhibited significantly elevated serum levels of MAP2, which increased with infarct size, whereas serum levels of NF-L did not differ significantly. Thus, MAP2 appears to be a more sensitive stroke biomarker than NF-L, especially for early neuronal damage. This perspective is strengthened by the results from the animal models, showing MAP2-related alterations at earlier time points compared to NF-L. The profound ischemia-induced alterations further qualify both cytoskeletal elements as promising targets for neuroprotective therapies.

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