scholarly journals Cholestatic hepatitis due to Salmonella typhi

2011 ◽  
Vol 1 (1) ◽  
pp. 13 ◽  
Author(s):  
Ayse Albayrak ◽  
Sibel Seda Gunbey ◽  
Ferda Aktas
Keyword(s):  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Rare Complication ◽  
Elevated Serum ◽  
Clinical Importance ◽  
Public Health Problem ◽  
Clinical Feature ◽  
Gamma Glutamyl Transferase ◽  
Important Public Health Problem ◽  
Glutamyl Transferase

Salmonella infection occurs worldwide and is still an important public health problem in many developing countries. The infection can affect almost all major organs including the liver. Severe hepatic involvement with a clinical feature of acute hepatitis is a rare complication. In this paper, a 39-year-old male with acute cholestatic typhoid hepatitis is presented. The case had a tender hepatomegaly and elevated serum alanine and aspartate transaminase, alkaline phosphatase, and gamma glutamyl transferase levels; these features cannot been distinguished from those of acute viral hepatitis. Serological and viral markers of acute viral hepatitis were negative. No pathology could be determined in abdomen Ultrasonography (USG) or Magnetic Reso - nance (MR) Cholangiography. As enteric fever is a common infection, the recognition of salmonella hepatitis is of clinical importance. When patients from an endemic or outbreak area present acute febrile hepatitis, typhoid fever should be a consideration.

Elevated serum levels of sFas in acute viral hepatitis

2001 ◽  
Vol 13 (12) ◽  
pp. 1507-1508
Author(s):  
Maximilian Schöniger-Hekele ◽  
Christian Müller
Keyword(s):  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Elevated Serum ◽  
Serum Levels

scholarly journals Myocarditis Caused by Brucella melitensis in the Absence of Endocarditis: Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Maria Lagadinou ◽  
Virginia Mplani ◽  
Dimitrios Velissaris ◽  
Periklis Davlouros ◽  
Markos Marangos
Keyword(s):  
Brucella Melitensis ◽  
Rare Complication ◽  
Public Health Problem ◽  
University Hospital ◽  
Cardiac Complications ◽  
Important Public Health Problem ◽  
Life Saving ◽  
Retrosternal Pain ◽  
Almost All ◽  
The University

Brucellosis remains an important public health problem with endemic characteristics in many countries. Brucellosis can affect almost all organs and systems of human body. Cardiac complications are unusual, occurring in less than 2% of patients and usually manifest as endocarditis. We present the case of a 21-year-old Caucasian man, who was admitted to the University Hospital of Patras, Western Greece, with fatigue, fever up to 39°C, and retrosternal pain. Musculoskeletal, genitourinary, gastrointestinal, hematologic, nervous, skin, and mucous membranes and respiratory complications have been reported in several cases of brucellosis. Development of myocarditis is a highly rare complication of brucellosis, particularly in the absence of concomitant endocarditis. Clinicians should be aware of this clinical entity especially in endemic areas as appropriate antibiotic treatment is life-saving and may prevent serious cardiologic disorders.

scholarly journals Narthecium ossifragum (L.) Huds. Causes Kidney Damage in Goats: Morphologic and Functional Effects

2003 ◽  
Vol 40 (3) ◽  
pp. 317-327 ◽  
Author(s):  
H. Wisløff ◽  
A. Flåøyen ◽  
N. Ottesen ◽  
T. Hovig
Keyword(s):  
Elevated Serum ◽  
Basement Membranes ◽  
Gamma Glutamyl Transferase ◽  
Narthecium Ossifragum ◽  
Urine Protein ◽  
Functional Changes ◽  
Ultrastructural Studies ◽  
Cytoplasmic Vacuolization ◽  
Peritubular Capillaries ◽  
Glutamyl Transferase

We studied the effects of Narthecium ossifragum on goat kidneys. Twenty-five Norwegian dairy goats, 5 weeks to 4 months of age, were orally dosed with an aqueous extract from N. ossifragum. In experiment 1, we studied microscopic and functional changes in 12 animals that were euthanatized 2, 3, 4, 5, and 6 days after treatment. In experiment 2, we included ultrastructural studies on serial renal biopsies and urine analysis from five extract-treated animals and two controls. In addition, urine samples were collected from four dosed and two control goats. Ultrasonography revealed perirenal and retroperitoneal fluids. Microscopic changes were observed after 6 hours. The findings, most obvious in the inner cortex and the outer medulla, consisted of cytoplasmic vacuolization, interstitial edema, and focal necrosis of tubular epithelial cells. Ultrastructurally, the tubules had loss of microvilli, irregular cytoplasmic vacuolization, mitochondrial swelling with loss of cristae, and irregular but continuous basement membranes even with necrosis. In the glomeruli, there were occasional endothelial damage and shortening and swelling of the foot processes. Peritubular capillaries had breaks in the vessel walls and irregular endothelial cell edema, and the interstitium had marked edema. The functional lesions included elevated serum urea, creatinine, and magnesium concentrations, a slight decrease in serum calcium concentration, elevated urine protein and urine protein-creatinine ratio, and increased activities of urine alkaline phosphatase and gamma glutamyl transferase. Our findings indicate a fast-acting toxic principle inducing damage by both direct toxic and secondary ischemic effects.

scholarly journals A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Naveen T. Krishnareddy ◽  
Jestin V. Thomas ◽  
Saritha S. Nair ◽  
Johannah N. Mulakal ◽  
Balu P. Maliakel ◽  
...  
Keyword(s):  
Placebo Group ◽  
Delivery System ◽  
Elevated Serum ◽  
Hepatic Function ◽  
Controlled Study ◽  
Gamma Glutamyl Transferase ◽  
Medical Council ◽  
Clinical Trial Registry ◽  
Glutamyl Transferase ◽  
Double Blinded

Considering the recent interest in free (unconjugated) curcuminoids delivery, the present study investigated the efficacy of a novel food-grade free-curcuminoids delivery system (curcumin-galactomannoside complex; CGM) in improving the hepatic function markers (inflammation and oxidative stress) in chronic alcoholics. The double-blinded, placebo-controlled study randomized 48 subjects with elevated serum transaminases and gamma-glutamyl transferase (GGT) levels, who were allocated to two groups (n=24) and to receive either placebo or CGM at (250 mg × 2)/day for 8 weeks. While liver function markers (transaminases and GGT) in the placebo group showed an increase (~ 9.5%), CGM group indicated a significant decrease in transaminases (31%) and GGT (29%) from the baseline levels. The beneficial effect of CGM was also clear from the significant increase (p <0.001) in endogenous antioxidants (GSH, SOD, and GPx) and decrease in inflammatory markers (IL-6 and CRP) levels (p <0.001) as compared to both the baseline and placebo group. To summarize, the nutritional intervention of CGM-curcumin was found to offer a significant hepatoprotective effect to attenuate the alcohol induced alterations to hepatic function markers. The Indian Medical Council and Drug Controller General of India approved Clinical Trial Registry No. CTRI/2018/03/012385.

scholarly journals Acute Acalculous Cholecystitis due to Viral Hepatitis A

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Safak Kaya ◽  
Ahmet Emre Eskazan ◽  
Nurettin Ay ◽  
Birol Baysal ◽  
Mehmet Veysi Bahadir ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Rare Complication ◽  
Acalculous Cholecystitis ◽  
Acute Acalculous Cholecystitis ◽  
Surgical Trauma ◽  
High Morbidity ◽  
Viral Hepatitis A ◽  
Acute Viral Hepatitis A

Inflammation of the gallbladder without evidence of calculi is known as acute acalculous cholecystitis (AAC). AAC is frequently associated with gangrene, perforation, and empyema. Due to these associated complications, AAC can be associated with high morbidity and mortality. Medical or surgical treatments can be chosen according to the general condition of the patient, underlying disease and agent. Particularly in acute acalculous cholecystitis cases, early diagnosis and early medical treatment have a positive effect on the patient and protect them from surgical trauma. ACC is a rare complication of acute viral hepatitis A. Herein, we present an adult patient of acalculous cholecystitis due to acute viral hepatitis A. She responded to the conservative management.

scholarly journals SANATIVE EFFECT OF MULTIHERBAL FORMULATION – AKSS16-LIV01 ON CCL4-INDUCED HEPATIC DYSFUNCTION IN MICE

2021 ◽  
pp. 101-106
Author(s):  
SOUMENDRA DARBAR ◽  
SRIMOYEE SAHA ◽  
KAUSIKISANKAR PRAMANIK ◽  
ATISKUMAR CHATTOPADHYAY
Keyword(s):  
Biochemical Parameters ◽  
Hepatic Dysfunction ◽  
Public Health Problem ◽  
Hepatoprotective Effect ◽  
Gamma Glutamyl Transferase ◽  
Standard Drug ◽  
Group I ◽  
Total Plasma Protein ◽  
Extracellular Matrix Components ◽  
Glutamyl Transferase

Objectives: Hepatic dysfunction is a critical public health problem affecting the global population, characterized by excessive deposition of extracellular matrix components due to increased matrix production and decreased matrix degradation. The present work was aimed to evaluate hepatoprotective effect of AKSS16-LIV01 a newly developed multiherbal formulation against carbon tetrachloride (CCl4)-induced liver dysfunction in Swiss albino mice to establish it as a bench to bedside formulation catering to the various facets of hepatic malfunction. Methods: Thirty-six Swiss adult albino Wister mice divided into six groups. Group-I control untreated animals, Group-II received AKSS16-LIV01 (400 mg/kg), Group-III received CCl4 (1 ml/kg-bw), Group-IV received AKSS16-LIV01 (200 mg/kg) after 2 weeks CCl4 induction, Group-V received AKSS16-LIV01 (400 mg/kg) after 2 weeks CCl4 induction, and Group-VI received standard drug silymarin (100 mg/kg). At the end of the experimental period, all the animals were fasted overnight and blood was collected through retro-orbital plexus for preparation of serum and was analyzed for biochemical parameters, lipid profile, and total plasma protein. Liver tissue was collected for histological study. Results: The combined plant extract including six Indian medicinal herbs and three medicinal spices (AKSS16-LIV01) showed significant hepatoprotective effect by controlling the various essential biochemical parameters in serum. Moreover, treatment with AKSS16-LIV01 raised the level of serum total protein, normalizes the serum biochemical and lipid profiles parameters. Pre-treatment with AKSS16-LIV01 in mice also restored the alteration of various liver parameters such as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, blood urea nitrogen, total bilirubin, and direct bilirubin on CCl4-induced liver damage. Gross liver morphology and normal histological examination of the liver also supported hepatic protection by AKSS16-LIV01. Conclusion: Taken together, these results suggest that AKSS16-LIV01 may induce remarkable protective effects against hepatic injury induced by CCl4 treatment.

scholarly journals Gamma-glutamyl-transferase may predict COVID-19 outcomes in hospitalized patients

2021 ◽  
Author(s):  
Ahmet Yozgat ◽  
benan kasapoglu ◽  
Alpaslan Tanoğlu ◽  
Güray Can ◽  
Yusuf Serdar Sakin ◽  
...  
Keyword(s):  
Intensive Care ◽  
Laboratory Data ◽  
Elevated Serum ◽  
Hospitalized Patients ◽  
Gamma Glutamyl Transferase ◽  
Laboratory Findings ◽  
Gamma Glutamyl ◽  
Predictive Role ◽  
Glutamyl Transferase ◽  
D Dimer

Aim: In this study, we aimed to define the predictive role of liver function tests at admission to the hospital in outcomes of hospitalized patients with COVID-19. Material and Method: In this multicentric retrospective study, a total of 269 adult patients (≥18 years of age) with confirmed COVID-19 who were hospitalized for the treatment were enrolled. Demographic features, complete medical history, and laboratory findings of the study participants at admission were obtained from the medical records. Patients were grouped regarding their ICU requirements during their hospitalization periods. Results: Among all 269 participants, 106 were hospitalized in the intensive care unit (ICU) and 66 died. The patients hospitalized in ICU were older than patients hospitalized in wards (p=0.001) and expired patients were older than alive patients (p=0.001). Age, elevated serum D-dimer, creatinine, and gamma-glutamyl transferase (GGT) levels at admission were independent factors predicting ICU hospitalization and mortality in COVID-19 patients. Conclusion: In conclusion, in hospitalized patients with COVID-19, laboratory data on admission, including serum, creatinine, GGT and d-dimer levels have an important predictive role for the ICU requirement and mortality. Since these tests are readily available in all hospitals and inexpensive, some predictive formulas may be calculated with these parameters at admission, to define the patients requiring intensive care.

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