Evaluation of Liver Enzymes and calculation of AST to ALT ratio in patients with acute viral hepatitis

Background: Acute viral hepatitis is a common liver-associated abnormality encountered in clinical practice. The number of biochemical parameters is estimated to detect a hepatic abnormality, which can measure the severity and types of damage to hepatocytes, among which liver enzymes and bilirubin levels are assessed routinely which are raised in acute viral hepatitis.Objective: This study aims to assess the liver enzymes, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, and calculation of AST to ALT ratio in acute viral hepatitis and to compare these parameters with the control group.Methodology: This study included a total of 81 subjects diagnosed with acute viral hepatitis as cases and age and sex-matched, the same number of healthy subjects as control. Serum levels of AST and ALT, alkaline phosphatase (ALP), and bilirubin were analyzed using standard methods. Serum AST to ALT ratio was calculated. Data analysis was done using SPSS Version 17.0 and the results were expressed as mean ±standard deviation (SD).Results: A mean serum activities of aminotransferases were statistically significantly raised in viral hepatitis compared to that in control.AST (514.85±350.66 VS 25.65±5.29; p<0.001) and ALT (781.65±525.69 VS 27.94±6.50; p<0.001). Similarly, serum levels of(ALP)were significantly increased in acute viral hepatitis compared to that in control (202.17±75.46 VS 98.83±27.99; p<0.001. However, a ratio of AST to ALT was decreased significantly (0.66±0.15 VS 0.94±0.21; p= 0.001) in acute viral hepatitis compared to that in control.Conclusion: Both the aminotransferases and bilirubin levels are raised significantly, where, a rise in ALT is greater than a rise in AST, hence, the ratio of AST to ALT is decreased significantly in acute viral hepatitis than that in control. Thus, this decreased pattern of AST to ALT can diagnose acute viral hepatitis at an early stage and can help appropriate care and treatment to the patients.

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Features of biochemical indices and content of enzymes in the serum of syphilis patients with viral hepatites B and C in the course of treatment

Medicni perspektivi (Medical perspectives) ◽

10.26641/2307-0404.2021.3.241971 ◽

2021 ◽

Vol 26 (3) ◽

pp. 107-113

Author(s):

S.V. Zakharov ◽

V.K. Zakharov ◽

V.V. Gorbuntsov

Keyword(s):

Functional State ◽

Biochemical Parameters ◽

Early Stage ◽

Serum Levels ◽

Test Methods ◽

Comprehensive Examination ◽

Before And After ◽

Biochemical Indices ◽

Increased Activity ◽

Latent Syphilis

Objective – before and after the treatment to determine the functional state of the liver, serum levels of enzymes and biochemical indices in syphilis patients with viral hepatites B and C. The results of the study are based on the data from a comprehensive examination of 35 patients with syphilis alone and 127 patients with syphilis co-infected with viral hepatites B and C before and after treatment. Test methods: hepatology, rheogeopathography, enzyme content and biochemical parameters determined in the serum. According to the results of radionuclide hepatology it has been established that disorders of the functional capacity of the liver already occur in the early stages of the disease. The most significant disorders have been in the patients with the prescription of infection for more than 12 months and in the patients co-infected with viral hepatites B and C. A disorder of pigment metabolism and increased activity of transaminases have been revealed in early latent syphilis. In co-infection with viral hepatites B and C an increase in total bilirubin, Lactate dehydrogenase, Alanine transaminase, Aspartate aminotransferase and albumin has been revealed. Dysproteinemia has been revealed in patients with early latent syphilis co-infected with hepatitis C. Patients with early latent syphilis treated with immunomodulators tend to normalize these indices. In patients with syphilis a disorder of the functional state of the liver have been revealed already at an early stage of the disease. The most pronounced disorder of biochemical parameters and activity of liver enzymes are observed in syphilis patients with viral hepatites B and C, as well as in patients with early latent syphilis only with the prescription of the infection for more than 12 months; in such a case it is advisable to use drugs affecting the immune system.

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Evaluation of Serum Levels of Hepatic Enzymes and Plasma Proteins between Different Types of Acute Viral Hepatitis

Bangladesh Journal of Medical Biochemistry ◽

10.3329/bjmb.v3i1.13803 ◽

2013 ◽

Vol 3 (1) ◽

pp. 19-22

Author(s):

MA Zaman ◽

HB Asad ◽

MN Roy ◽

N Hoque ◽

M Nasiruddin ◽

...

Keyword(s):

Viral Hepatitis ◽

Plasma Proteins ◽

Acute Viral Hepatitis ◽

Geometric Mean ◽

Serum Levels ◽

Hepatitis E ◽

Cross Sectional Study ◽

Hepatic Enzymes ◽

Cross Sectional ◽

Different Types

This cross-sectional study was carried out in 80 serologically diagnosed cases of acute viral hepatitis to assess and compare the serum hepatic enzymes & plasma proteins between four different types (A,B,C,E), 20 in each group. Hepatitis E, hepatitis B and hepatitis C were more prevalent in males than that in females. The study showed that geometric mean of S.AST of all the four types differed significantly (F= 274.94, p<0.001). Geometric mean of S.ALT, S.AST and S.ALP in cases of HCV were significantly lower than others (p<0.001). Geometric mean of S.ALT & S.AST in cases of HEV were significantly increased than others (p<0.001). But the geometric mean of S.ALP of HBV was significantly higher than others (p<0.001). On the other hand though S.ALP of HAV and HEV was lower than HBV but significantly higher than HCV (p<0.001). The mean±SD of serum albumin of HCV was decreased significantly in contrast to those of HAV and HBV (p<0.001). A:G ratio of HCV was also significantly lower than other three (p<0.001). It was revealed through the study that hepatic enzymes were most affected in cases of HEV but least affected in cases of HCV. DOI: http://dx.doi.org/10.3329/bjmb.v3i1.13803 Bangladesh J Med Biochem 2010; 3(1): 19-22

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Elevated serum levels of sFas in acute viral hepatitis

European Journal of Gastroenterology & Hepatology ◽

10.1097/00042737-200112000-00017 ◽

2001 ◽

Vol 13 (12) ◽

pp. 1507-1508

Author(s):

Maximilian Schöniger-Hekele ◽

Christian Müller

Keyword(s):

Viral Hepatitis ◽

Acute Viral Hepatitis ◽

Elevated Serum ◽

Serum Levels

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Detection of Circulating CEA-IgM Complexes in Early Stage Colorectal Cancer

The International Journal of Biological Markers ◽

10.1177/172460080502000402 ◽

2005 ◽

Vol 20 (4) ◽

pp. 204-208 ◽

Cited By ~ 29

Author(s):

F. Castaldi ◽

M. Marino ◽

L. Beneduce ◽

C. Belluco ◽

F. De Marchi ◽

...

Keyword(s):

Colorectal Cancer ◽

Early Detection ◽

Immune Complexes ◽

Healthy Subjects ◽

Early Stage ◽

Serum Levels ◽

Free Form ◽

Squamous Cell Carcinoma Antigen ◽

Stage 1 ◽

Detection Specificity

We have recently shown that alpha fetoprotein (AFP) and squamous cell carcinoma antigen (SCCA), biomarkers associated with hepatocellular carcinoma, may be detected in patient sera as circulating immune complexes with IgM, and that assessment of serum levels of AFP-IgM and SCCA-IgM may be used for the detection of liver cancer. In this study we measured the levels of carcinoembryonic antigen (CEA) as free form (FCEA) and complexed to IgMs (CEA-IgM) in sera of patients affected by colorectal carcinoma (CRC) at different stages as well as in healthy subjects. FCEA levels were above the 5 ng/mL cutoff in 43% of CRC patients (31/72) and CEA-IgM levels were above the 200 AU/mL cutoff in 38% of CRC patients (27/72). Serum levels of CEA-IgM immune complexes (IC) and FCEA did not overlap and 64% of patients (46/72) were positive for at least one marker without compromising the detection specificity (94%). Early detection of CRC was significantly improved by CEA-IgM IC assay. CRC patients at an early stage (stage 1) had elevated CEA-IgM levels in 29% of cases (7/24), while FCEA levels were elevated in only 8% of cases (2/24). These results indicate that CEA-IgM is a complementary serological marker to FCEA which is much more sensitive for early stage CRC, and that the combination of these biomarkers may be useful in the early detection of colorectal cancer.

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Effect of dietary aflatoxins (AFB1) on hematological and biochemical indices of male buffaloes

Indian Journal of Animal Research ◽

10.18805/ijar.v0iof.9166 ◽

2017 ◽

Author(s):

Omer Naseer ◽

Jawaria Ali Khan ◽

Muhammad Sarwar Khan ◽

Muhammad Ovais Omer ◽

Junaid Naseer ◽

...

Keyword(s):

Aflatoxin B1 ◽

Feed Intake ◽

Biochemical Parameters ◽

Hematological Parameters ◽

Serum Levels ◽

Serum Biochemical Parameters ◽

Control Serum ◽

Serum Biochemical ◽

Biochemical Indices ◽

To Receive

The objective of the study was to determine the effect of dietary aflatoxin B1 (AFB1) in growing male buffaloes in terms of feed intake, hematological and serum biochemical parameters. Thirty six bovine growing male buffaloes between 6 months to 12 months of age were divided into four groups to receive diet having no AFB1, 0.6mg/kg, 0.8mg/kg and 1.0mg/kg AFB1 of feed per animal per day for 28 days. The results indicate that the average daily feed intake of AFB1-treated growing male buffaloes significantly declined (P > 0.05) compared with the control. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatinine were significantly increased (P > 0.05) in response to AFB1, However change in blood urea nitrogen (BUN) levels was non-significant values of all hematological parameters decreased significantly (P > 0.05) in1.0mg/kg AFB1 group as compared to other groups after day 14 onward.

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