High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction

2004 ◽  
Vol 11 (5) ◽  
pp. 408-411 ◽  
Author(s):  
Pirkko J. Pussinen ◽  
Georg Alfthan ◽  
Jaakko Tuomilehto ◽  
Sirkka Asikainen ◽  
Pekka Jousilahti
Keyword(s):  
Myocardial Infarction ◽  
Porphyromonas Gingivalis ◽  
Serum Antibody ◽  
High Serum ◽  
Antibody Levels

High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction

2004 ◽  
Vol 11 (5) ◽  
pp. 408-411 ◽  
Author(s):  
P. J. Pussinen ◽  
G. Alfthan ◽  
J. Tuomilehto ◽  
S. Asikainen ◽  
P. Jousilahti
Keyword(s):  
Myocardial Infarction ◽  
Porphyromonas Gingivalis ◽  
Serum Antibody ◽  
High Serum ◽  
Antibody Levels

scholarly journals HUMORAL IMMUNE RESPONSE TO PORPHYROMONAS GINGIVALIS IN POSTPARTUM WOMEN AND NEWBORNS

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Soraya Castro Trindade ◽  
Isaac Suzart Gomes-Filho ◽  
Simone Seixas da Cruz ◽  
Edson José Carpintero Rezende ◽  
Thiago Carôso Fróes ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Serum Antibody ◽  
Serum Levels ◽  
Maternity Hospital ◽  
Cross Sectional Study ◽  
High Serum ◽  
Postpartum Women ◽  
Cross Sectional ◽  
Humoral Immune ◽  
Antibody Levels

Aims: The aim of this study was to evaluate the presence of Porphyromonas gingivalis (Pg) the in subgingival biofilm, as well as to compare the immune responses of postpartum women and their newborns to Porphyromonas gingivalis using antibody serum levels.Methods: A total of 43 postpartum women and 24 newborns were selected in the municipal maternity hospital of Alagoinhas, Bahia, Brazil between February and December 2003, for this cross-sectional study. The presence of Pg was verified using polymerase chain reaction. The immunoglobulin serum levels: IgG1, IgG2, IgG3, IgG4 and IgA, reactive to Pg ATCC33277, were tested using ELISA. Results: 39,3% of the postpartum women biofilm samples were positive for Pg. The incidence of the pathogen in the women with periodontitis (70%) was higher than in the group of women without periodontitis (30,30%). Among the newborns, high serum levels of IgG4 anti-Pg were observed (p<0.001).Conclusion: Our findings confirm that postpartum women with periodontitis present remarkable incidence of Porphyromonas gingivalis which may influence systemic response, as represented by high levels of serum antibody levels against this pathogen in women and newborns. Furthermore, evidence suggests that some antibodies crossed the placental barrier in newborns. 

Study of Antibody Levels in Children with Purulent Otitis Media

1980 ◽  
Vol 89 (3_suppl) ◽  
pp. 117-120 ◽  
Author(s):  
P. Branefors ◽  
T. Dahlberg ◽  
O. Nylén
Keyword(s):  
Otitis Media ◽  
Serum Antibody ◽  
Acute Otitis Media ◽  
High Serum ◽  
Haemophilus Influenzae Type ◽  
Enzyme Linked Immunosorbent Assay ◽  
Polysaccharide Antigens ◽  
Antibody Titers ◽  
Iga Antibody ◽  
Antibody Levels

A series of episodes of acute otitis media were studied with reference to the bacterial findings in the nasopharynx and the specific antibody response in a group of children nine months to ten years of age, with previous frequent episodes of acute otitis media, Serum IgG, IgM and IgA antibody levels against five polysaccharide antigens, namely Haemophilus influenzae type b and Streptococcus pneumoniae types 3, 6, 19 and 23, were studied by means of an enzyme-linked immunosorbent assay. The selection of polysaccharide antigens was based on isolation frequency. The sera to be tested were tenfold serially diluted. An extinction of 0.2 over the base was taken as the end-point titer and expressed as in-log10. The results showed that most children including those under three years of age showed increasing homologous antibody titers at an infection, or had already initially very high antibody titers, especially of the IgG class. The titers reached levels of 104 to 105. In some cases, however, it could be shown that high serum antibody titers did not give protection against a new infection with the same serological type of bacteria. It was also demonstrated that most children, regardless of age, had IgG and IgM titers against the heterologous antigens. In some cases the levels were quite high (103 to 104). However, the IgA antibody levels were lower and in a considerable number of samples antibodies were not even detectable.

W13-P-015 High serum antibody levels toperiodontal pathogens are associated with subclinical, prevalent, and future CHD

2005 ◽  
Vol 6 (1) ◽  
pp. 89
Author(s):  
P. Pussinen ◽  
K. Nyyssönen ◽  
G. Alfthan ◽  
R. Salonen ◽  
J.A. Laukkanen ◽  
...  
Keyword(s):  
Serum Antibody ◽  
High Serum ◽  
Antibody Levels

scholarly journals Antibody response and persistence in volunteers following immunization with varying dosages of a trivalent surface antigen influenza virus vaccine

1985 ◽  
Vol 94 (1) ◽  
pp. 87-95 ◽  
Author(s):  
R. Jennings ◽  
T. L. Smith ◽  
A. R. Mellersh ◽  
A. Clark ◽  
R. C. Spencer ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Surface Antigen ◽  
Virus Vaccine ◽  
Serum Antibody ◽  
Influenza Virus Vaccine ◽  
High Serum ◽  
Antibody Responses ◽  
High Incidence ◽  
Student Volunteers ◽  
Antibody Levels

SUMMARYThe serum antibody responses and 50% protective levels (PL50) of antibody were determined, using the SRH test, at one and twelve months post-vaccination in a group of student volunteers immunized with one of three dosages of a trivalent surface-antigen influenza virus vaccine, or with placebo.It was found that, for the H3, H1 and B haemagglutinin components present in the vaccine, a dose of 6 μg HA elicited high serum antibody responses at one month post-immunization. High mean antibody levels and a high incidence of volunteers with PL50 values of antibody against each of the HA components of the vaccine remained in the volunteer group twelve months later. The results are discussed in relation to the vaccine dosage used and the nature of the population immunized.

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