scholarly journals HUMORAL IMMUNE RESPONSE TO PORPHYROMONAS GINGIVALIS IN POSTPARTUM WOMEN AND NEWBORNS

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Soraya Castro Trindade ◽  
Isaac Suzart Gomes-Filho ◽  
Simone Seixas da Cruz ◽  
Edson José Carpintero Rezende ◽  
Thiago Carôso Fróes ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Serum Antibody ◽  
Serum Levels ◽  
Maternity Hospital ◽  
Cross Sectional Study ◽  
High Serum ◽  
Postpartum Women ◽  
Cross Sectional ◽  
Humoral Immune ◽  
Antibody Levels

Aims: The aim of this study was to evaluate the presence of Porphyromonas gingivalis (Pg) the in subgingival biofilm, as well as to compare the immune responses of postpartum women and their newborns to Porphyromonas gingivalis using antibody serum levels.Methods: A total of 43 postpartum women and 24 newborns were selected in the municipal maternity hospital of Alagoinhas, Bahia, Brazil between February and December 2003, for this cross-sectional study. The presence of Pg was verified using polymerase chain reaction. The immunoglobulin serum levels: IgG1, IgG2, IgG3, IgG4 and IgA, reactive to Pg ATCC33277, were tested using ELISA. Results: 39,3% of the postpartum women biofilm samples were positive for Pg. The incidence of the pathogen in the women with periodontitis (70%) was higher than in the group of women without periodontitis (30,30%). Among the newborns, high serum levels of IgG4 anti-Pg were observed (p<0.001).Conclusion: Our findings confirm that postpartum women with periodontitis present remarkable incidence of Porphyromonas gingivalis which may influence systemic response, as represented by high levels of serum antibody levels against this pathogen in women and newborns. Furthermore, evidence suggests that some antibodies crossed the placental barrier in newborns. 

High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction

2004 ◽  
Vol 11 (5) ◽  
pp. 408-411 ◽  
Author(s):  
Pirkko J. Pussinen ◽  
Georg Alfthan ◽  
Jaakko Tuomilehto ◽  
Sirkka Asikainen ◽  
Pekka Jousilahti
Keyword(s):  
Myocardial Infarction ◽  
Porphyromonas Gingivalis ◽  
Serum Antibody ◽  
High Serum ◽  
Antibody Levels

scholarly journals Seroprevalence of antibodies for pertussis and diphtheria among people leaving or entering China: a cross-sectional study

2019 ◽  
Vol 13 (05) ◽  
pp. 394-399
Author(s):  
Hui Han ◽  
Zhiqiang Fang ◽  
Xiangguang Ye ◽  
Hailei Wu ◽  
Feng Zuo ◽  
...  
Keyword(s):  
Serum Antibody ◽  
Cross Sectional Study ◽  
Igg Antibodies ◽  
Male Population ◽  
Cross Sectional ◽  
Adult Men ◽  
Population Immunity ◽  
Chinese Adult ◽  
Almost All ◽  
Antibody Levels

Introduction: Despite high population immunity, pertussis remains one of the leading causes of vaccine-preventable deaths worldwide. The aim of this study was to determine the seroprevalence of IgG antibodies to pertussis toxin (PT) and diphtheria among the adult male population leaving or entering China. Methodology: Blood samples were obtained from 240 Chinese and 207 African healthy adults that were leaving and entering China, respectively. Serum IgG antibodies against PT (anti-PT IgG) and diphtheria were determined. Results: The mean concentration of anti-PT IgG antibodies was 13.82 IU/mL and 18.11 IU/mL for the leaving and entering populations, respectively. None of the studied Chinese leaving China were seropositive for pertussis. Of the 240 subjects leaving China, 209 (87.1%) had anti-diphtheria antibody concentrations of ≥ 0.1 IU/mL and 31 (12.9%) had antibody concentrations between 0.01 and 0.099 IU/mL. Eleven (5.31%) of the studied Africans entering China had anti-PT IgG antibodies higher than 30 IU/mL and thus were considered seropositive for pertussis. Of the 207 Africans entering China, antibody concentrations of ≥ 0.1 IU/mL were found in 164 subjects (79.2%) while 43 (20.8%) had antibody concentrations between 0.01 and 0.099 IU/mL. Conclusions: Almost all Chinese adult men leaving China and most African men entering China have very low serum antibody levels of pertussis. Furthermore, the antibody level of diphtheria among these two populations was low among adults. A larger population study is needed to determine whether booster vaccinations against pertussis and diphtheria should be considered for adults in China and also for Africans entering China.

scholarly journals Determinants of gestational night blindness in pregnant women from Rio de Janeiro, Brazil

2015 ◽  
Vol 19 (5) ◽  
pp. 851-860 ◽  
Author(s):  
Cláudia Saunders ◽  
Maria do Carmo Leal ◽  
Paulo Augusto Ribeiro Neves ◽  
Patricia de Carvalho Padilha ◽  
Letícia Barbosa Gabriel da Silva ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Rio De Janeiro ◽  
Night Blindness ◽  
Maternity Hospital ◽  
Cross Sectional Study ◽  
Postpartum Women ◽  
Cross Sectional ◽  
Group I ◽  
History Of ◽  
Nutritional Monitoring

AbstractObjectiveTo describe the prevalence and determinants of gestational night blindness in pregnant women receiving care in a hospital in Rio de Janeiro, Brazil.DesignCross-sectional study of pregnant and postpartum women receiving care in a public hospital in Rio de Janeiro from 1999 to 2001 (group I; n 225) or from 2005 to 2008 (group II; n 381). Night blindness was identified through a standardized and validated interview (WHO, 1996). The determinants of gestational night blindness were identified through a hierarchical logistic regression model.SettingPublic maternity hospital in Rio de Janeiro, RJ, Brazil.SubjectsAdult pregnant and postpartum women (n 606), aged ≥20 years.ResultsThe prevalence of gestational night blindness was 9·9 %. The final model revealed that not living in the South Zone of Rio de Janeiro (distal level: adjusted OR=1·846; 95 % CI 1·002, 3·401), belonging to group I (intermediate level: adjusted OR=2·183; 95 % CI 1·066, 4·471) and for the proximal level, having a history of abortion (adjusted OR=2·840; 95 % CI 1·134, 7·115) and having anaemia during the first and second trimesters of pregnancy (adjusted OR=3·776; 95 % CI 1·579, 9·029) were determinants of gestational night blindness.ConclusionGestational night blindness should be assessed for during the prenatal care of all pregnant women, especially those living in deprived areas of the city and/or who have a history of abortion or anaemia. Nutritional monitoring is recommended during pregnancy to control gestational night blindness.

High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction

2004 ◽  
Vol 11 (5) ◽  
pp. 408-411 ◽  
Author(s):  
P. J. Pussinen ◽  
G. Alfthan ◽  
J. Tuomilehto ◽  
S. Asikainen ◽  
P. Jousilahti
Keyword(s):  
Myocardial Infarction ◽  
Porphyromonas Gingivalis ◽  
Serum Antibody ◽  
High Serum ◽  
Antibody Levels

scholarly journals Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 143
Author(s):  
Florentia Kanakoudi-Tsakalidou ◽  
Evangelia Farmaki ◽  
Eleni Papadimitriou ◽  
Anna Taparkou ◽  
Eleni Agakidou ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Humoral Immune ◽  
Measles Antibodies ◽  
Measles Outbreaks ◽  
First Year Of Life ◽  
Antibody Levels

Measles outbreaks have surfaced in Europe during the last decades. Infants <12 months of age were the most severely affected pediatric population. The aim of this study was to investigate the duration of maternally derived measles antibodies in infants aged 1 to 12 months in relation to maternal humoral immune status and other parameters. In a prospective, cross-sectional cohort study, 124 mother/infant pairs and 63 additional infants were recruited from October 2015 through December 2019. Infants were hospitalized in a university pediatric department of a general hospital. Demographic and epidemiological data were recorded and blood samples were collected from mothers and their infants. Commercially available enzyme-linked immunosorbent assay (ELISA) was used for measuring measles antibodies. Fifty nine percent of mothers had vaccine-induced and 15% infection-acquired measles immunity. Eighty-eight percent and 94% of infants were unprotected by 5 and 10 months of age, respectively. Maternal antibody levels and infant age were significant independent predictors of infants’ antibody levels whereas the method of maternal immunity acquisition, age, and origin [Greek/non-Greek] were not. Our findings suggest that about 90% of infants are susceptible to measles beyond the age of 4 months. To our knowledge, these are the first data from Greece reported under the current community composition and epidemiological conditions.

scholarly journals Levels of Thyroid Peroxidase Antibodies is Higher in Threatened Abortion

2016 ◽  
pp. 134-138
Author(s):  
I Nyoman A. Sanjaya ◽  
Syarif T Hidayat
Keyword(s):  
Serum Levels ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Thyroid Peroxidase ◽  
Cross Sectional ◽  
Thyroid Peroxidase Antibody ◽  
Significant Difference ◽  
Threatened Abortion ◽  
The Mean ◽  
Antibody Levels

Objective: To assess the relationship between the incidence of threatened abortion with serum levels of TPO antibodies. Methods: This was cross-sectional study involving subjects 40 cases and 40 controls. The study was conducted September 2012 to November 2012. The difference in the levels of thyroid peroxidase antibody was tested by Mann-Whitney test. Result: In this study, hypothyroidism was found only in the abortion group, as many as 6 subjects (15%) and subclinical hypothyroidism was more prevalent in threatened abortion group, found in 2 people (5%), compared to normal pregnant group, found in only 1 person (2.5%). This study revealed a significant difference in the mean levels of TPO antibodies in the threatened abortion and normal pregnancy group. The mean levels of TPO antibodies in threatened abortion group was 91.76 ± 133.18 IU/ml with the lowest level of 14.41 IU/ml and the highest levels of 534.47 IU/ml while in the normal pregnancy group found an average 12.97 ± 3.91 IU/ml with the lowest value 2.02 IU/ml and the highest value of 20.78 IU/ml. In this study, subjects with TPO antibody levels ≥ 125 IU/ml, all of them experienced threatened abortion (n = 7) and found the risk of miscarriage by 2.212-fold compared with subjects with TPO levels < 125 IU/ml. Conclusion: There are differences in the levels of TPO antibodies in patients with threatened abortion and in normal pregnancies, with average levels of TPO antibodies in imminent abortion group is higher than normal pregnancy group. There is a relationship between TPO antibody levels ≥ 125 IU/ml with the incidence of threatened abortion, with the risk of threatened abortion increasing 2.212 times. [Indones J Obstet Gynecol 2013; 1-3: 134-8] Keywords: threatened abortion, thyroid peroxidase antibody (TPO)

scholarly journals 2310. No Recurrence in Recovered People with CCHF: A Cross-Sectional Study From Turkey, Preliminary Report

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S792-S792
Author(s):  
Iftihar Koksal ◽  
Firdevs Aksoy ◽  
Selcuk Kaya ◽  
Mustafa Tas ◽  
Gurdal Yilmaz
Keyword(s):  
Disease Transmission ◽  
Serum Antibody ◽  
Hemorrhagic Fever ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Limited Data ◽  
Cross Sectional ◽  
Long Time ◽  
Tick Borne Disease ◽  
Antibody Levels

Abstract Background Crimean-Congo hemorrhagic fever (CCHF) is a widespread, tick-borne disease of humans. CCHF is an endemic in Turkey, and since 2004 many cases have been reported from different regions in the country. CCHF infection in humans can lead to antibody responses that can be protective but there is limited data about the immunity of CCHF. The aim of this study was to investigate the possibility of recurrence of CCHF in people who previously had this disease. Methods The patients who were diagnosed with CCHF between 2005 and 2018 were followed up and contacted via phone in order to answer several survey questions about CCHF. Patients who still live in the same places, who have high risks of disease transmission because of husbandry or farming and high potential of contact with ticks were included in this study. Those who changed their living place and stopped husbandry or farming were excluded from this study. The questions in the survey are the following: Have you had CCHF after your discharge from the hospital?; Has there been any tick contact?; Did you ever get a tick removed from your body? Did you or your family members have CCHF at the same time or at different periods of time? Has anyone had CCHF in the area you live? Do your animals have ticks? Do you live in the same place? Have you changed your job? Results Ninety-nine out of 351 patients who were contacted via phone had data eligible to be included in the criteria. The amount of time elapsed after the discharge of the patients was between 1 and 14 years in average. None of the patients had experienced CCHF disease again. Also, 6 of these patients were bitten by ticks repeatedly (2–5 times). An average of 7–10 years had passed since the transmission of the disease by the patients. Conclusion The results show that the CCHF disease creates an immune response and this response continues for a long time. The findings will be more enlightening with the measurement of the serum antibody levels of patients. Disclosures All authors: No reported disclosures.

scholarly journals Evaluation of the Blood Level of Adiponectin in Pregnant Adolescents

2021 ◽  
Vol 43 (06) ◽  
pp. 429-435
Author(s):  
Elaine Cristina Rocha Pádua ◽  
Silvia Daher ◽  
Isa de Pádua Cintra Sampaio ◽  
Edward Araujo Júnior ◽  
Cristina Falbo Guazzelli
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Adiponectin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sectional Study ◽  
Pregnant Adolescents ◽  
Cross Sectional ◽  
Adolescent Group ◽  
Gestational Weight ◽  
Intergroup Comparison

Abstract Objective To evaluate serum levels of adiponectin in pregnant adolescents between 30 and 36 weeks of gestation. Method: A prospective cross-sectional study enrolled 67 normal pregnant women between 30 and 36 weeks of gestation and eutrophic (body mass index [BMI]: 18.5–25 kg/m2), of which 36 were adolescents (< 20 years old) and 31 adults (≥ 20 years old). Serum adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). The t-student or Mann-Whitney tests were used for intergroup comparison. Results Pregnant adolescents showed significantly higher serum adiponectin concentrations compared with pregnant adults (p = 0.04). No differences were observed in adiponectin levels in younger pregnant adolescents (< 16 years old) compared with older pregnant adolescents (≥ 16 years old). Adiponectin values were divided into 3 subgroups: < 3,000 ng/mL, between 3,000 and 5,000 ng/mL, and > 5,000 ng/mL. Birthweight was significantly higher in women > 5,000 ng/mL when compared with < 3,000 ng/mL in the adolescent group. No association between pregestational adiponectin levels and BMI, gestational weight gain, and gestational age was observed; however, there was a positive relation with birthweight (p = 0.0239). Conclusion Serum adiponectin values in pregnant adolescents between 30 and 36 weeks of gestation were higher compared with pregnant adults; however, no differences between younger and older pregnant adolescents were observed.

scholarly journals Effect of disease duration on the association between serum albumin and mucosal healing in patients with ulcerative colitis

2021 ◽  
Vol 8 (1) ◽  
pp. e000662
Author(s):  
Sen Yagi ◽  
Shinya Furukawa ◽  
Kana Shiraishi ◽  
Yu Hashimoto ◽  
Kazuhiro Tange ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Serum Albumin ◽  
Clinical Outcomes ◽  
Clinical Remission ◽  
Acute Inflammation ◽  
Japanese Patients ◽  
Cross Sectional Study ◽  
Mucosal Healing ◽  
High Serum ◽  
Cross Sectional

ObjectiveSerum albumin is used as a marker of acute inflammation. Several studies have addressed the association between serum albumin and clinical outcome in patients with ulcerative colitis (UC). While mucosal healing (MH) has been indicated as the therapeutic goal for UC, the association between serum albumin and MH remains unclear. We evaluated this issue in patients with UC overall and explored whether duration of UC affected this association.DesignThis cross-sectional study recruited consecutive patients with UC. Study subjects consisted of 273 Japanese patients with UC. Serum albumin was divided into tertiles based on its distribution in all study subjects. One endoscopy specialist was responsible for measuring partial MH and MH, which were defined as a Mayo endoscopic subscore of 0–1 and 0, respectively. The association between serum albumin and clinical outcomes was assessed by multivariate logistic regression.ResultsRates of clinical remission, partial MH and MH were 57.9%, 63% and 26%, respectively. Only high serum albumin (>4.4 mg/dL) was significantly positively associated with MH (OR 2.29 (95% CI: 1.03 to 5.29), p for trend=0.043). In patients with short UC duration (<7 years) only, high serum albumin was significantly positively associated with MH and clinical remission. In patients with long UC duration (≥7 years), in contrast, no association between serum albumin and clinical outcomes was found.ConclusionIn Japanese patients with UC, serum albumin was significantly positively associated with MH. In patients with short UC duration, serum albumin might be a useful complementary marker for MH.

scholarly journals Factors associated with early resumption of sexual intercourse among women during extended postpartum period in Northwest Ethiopia: a cross sectional study

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Birye Dessalegn Mekonnen
Keyword(s):  
Sexual Health ◽  
Sexual Activity ◽  
Sexual Intercourse ◽  
Postnatal Care ◽  
Cross Sectional Study ◽  
Northwest Ethiopia ◽  
Postpartum Women ◽  
Care Providers ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background Postpartum sexual health and practice need to be integrated in the current maternal healthcare services to address sexual health problems. However, postpartum sexual practice has received little attention, and was not often discussed by healthcare providers during prenatal and postnatal care. Thus, this study was aimed to assess early resumption of sexual intercourse and associated factors among postpartum women in Gondar city, Northwest Ethiopia. Methods A community based cross-sectional study was conducted from January 20 to February 20, 2020. A systematic random sampling technique was used to select 634 postpartum women. A pretested, structured and interviewer-administered questionnaire was used to collect data. Data were entered into Epi Info 7.2.2 and exported to SPSS version 20 for analysis. Bivariable and multivariable logistic regressions analysis were done. Variables with p- value of < 0.05 were considered as statistically significant. Results The magnitude of early resumption of sexual intercourse after childbirth was found to be 26.9% (95% CI: 23.2, 30.8). Urban resident (AOR = 6.12, 95% CI: 2.41, 15.66), parity of one (AOR = 2.26, 95% CI: 1.66, 7.78), husband demand (AOR = 2.66, 95% CI: 1.72, 4.11), postnatal care (AOR = 1.45, 95% CI: 1.06, 2.18) and use of family planning (AOR = 2.72, 95% CI: 1.51, 3.43) were factors significantly associated with early resumption of sexual intercourse. Conclusion The study found that more than one fourth of women had resumed sexual intercourse within six weeks of following childbirth. The finding of this study suggests the need of integrating discussions of postpartum sexual activity into routine prenatal, intrapartum and postnatal care with collaborative effort of policy makers, program planners, health care providers and other stakeholders. Moreover, spousal communication on postpartum sexual activity should be encouraged.

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