A Prospective Surveillance Study of Methicillin Resistance Levels of Staphylococcus aureus Strains Isolated in Selected High-Risk Wards of a Large Tertiary Care Hospital

2002 ◽  
Vol 11 (8) ◽  
pp. 427-436 ◽  
Author(s):  
Roberto Manfredi ◽  
Anna Nanetti ◽  
Roberta Valentini ◽  
Leonardo Calza ◽  
Francesco Chiodo
Keyword(s):  
Staphylococcus Aureus ◽  
High Risk ◽  
Tertiary Care Hospital ◽  
Methicillin Resistance ◽  
Tertiary Care ◽  
Surveillance Study ◽  
Care Hospital ◽  
Prospective Surveillance ◽  
Large Tertiary Care

scholarly journals Susceptibility of Clinical Isolates of Staphylococcus aureus to Ceftaroline

2021 ◽  
Author(s):  
Harsha Sreedharan ◽  
KB Asha Pai
Keyword(s):  
Staphylococcus Aureus ◽  
Tertiary Care Hospital ◽  
Methicillin Resistance ◽  
Descriptive Analysis ◽  
Tertiary Care ◽  
The United States ◽  
Clinical Isolates ◽  
Diffusion Method ◽  
Clinical Samples ◽  
Care Hospital

Introduction: Methicillin-Resistant Staphylococcus aureus(MRSA) infection is a major global healthcare problem, the prevalence of which varies from 25-50% in India. It is known to cause Skin and Soft tissue Infections (SSI), endovascular infections, endocarditis, pneumonia, septic arthritis, osteomyelitis, and sepsis. Vancomycin is the drug of choice for treating severe MRSA infections. Ceftaroline, a fifth-generation cephalosporin has been approved by the United States Food and Drug Administration (US FDA) for treating acute bacterial SSI caused by susceptible micro-organisms including MRSA, Community acquired respiratory tract infection, MRSA bacteremia and endocarditis. Aim: To assess the susceptibility of clinical isolates of S. aureusto ceftaroline, in a Tertiary Care Hospital. Materials and Methods: This prospective study was conducted in the Department of Microbiology of a Tertiary Care Hospital over a period of two months from June 2019 to July 2019. S.aureus isolates from various clinical samples were screened for methicillin resistance by disc diffusion method using cefoxitin disc and ceftaroline susceptibility of these isolates was assessed by E-strip method. The isolates were classified as ceftaroline susceptible, Susceptibility Dose Dependent (SDD) and ceftaroline resistant respectively as per CLSI guidelines. A descriptive analysis of the data was done and the results were presented as frequencies and percentages. Results: All the S.aureus isolates were found to be susceptible to ceftaroline. Methicillin Sensitive Staphylococcus aureus(MSSA) isolates had lower Minimum Inhibitory Concentration (MIC) when compared to MRSA. The highest MIC among MRSA was 0.5 μg/mL. Conclusion: Ceftaroline can be considered as an effective alternative for treatment of infections caused by MRSA.

scholarly journals Detection of Oxacillin (Methicillin)-resistant Staphylococcus aureus Isolated from a Tertiary-care Hospital, Georgetown, Guyana

2020 ◽  
pp. 1-7
Author(s):  
Paul Cheddie ◽  
Drovashti Seepersaud ◽  
Tereasia Ramlochan
Keyword(s):  
Staphylococcus Aureus ◽  
Tertiary Care Hospital ◽  
Methicillin Resistance ◽  
Tertiary Care ◽  
Hospital Setting ◽  
Tertiary Hospital ◽  
Care Hospital ◽  
Prevalence Survey ◽  
Methicillin Resistant ◽  
Broth Microdilution Method

Background and Aim: Methicillin-resistant Staphylocccus aureus (MRSA) continues to be a major problem globally. Previous data had suggested that the prevalence of MRSA infections in the tertiary hospital setting was 51%. The aim of this study was to conduct a point prevalence survey of MRSA infections occurring at a tertiary-care hospital in Georgetown, Guyana, and to determine to what extent methicillin-resistance was occurring among Staphylococcus aureus isolates utilising the minimum inhibitory concentration (MIC) data. Study Design: This study was based on a prospective, analytical design. Place and Duration of Study: Microbiology department, Georgetown Public Hospital Corporation (GPHC), and Department of Medical Technology, University of Guyana, between May 2019 and July 2019. Methodology: A total of 101 consecutive, non-repetitive, laboratory-identified MRSA and methicillin-susceptible Staphylococcus aureus (MSSA) isolates were tested using an oxacillin broth microdilution method. Results: We found that 65.4% of Staphylococcus aureus were oxacillin (methicillin) resistant with a majority of the isolates being high level oxacillin resistant strains (i.e., MICs > 256 μg/ml) (84.85%). Most of the resistant isolates were collected from patients admitted to medical and surgical wards. Conclusion: Methicillin-resistance continues to be a major problem in the hospital setting and conventional techniques are unlikely to identify all of the potentially resistant isolates.

scholarly journals PROFILE OF STAPHYLOCOCCUS AUREUS ISOLATED FROM PATIENTS ADMITTED IN A TERTIARY CARE HOSPITAL WITH ESPECIAL REFERENCE TO METHICILLIN RESISTANCE

2020 ◽  
pp. 1-2
Author(s):  
Asmita Singh ◽  
Anita Pandey ◽  
Amit Singh ◽  
Priyanka Chaturvedi
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Agents ◽  
Tertiary Care Hospital ◽  
Methicillin Resistance ◽  
Tertiary Care ◽  
Hospital Setting ◽  
Clinical Isolates ◽  
Care Hospital ◽  
Wide Range ◽  
High Level

BACKGROUND: Staphylococcus aureus is a major human pathogen that causes wide range of clinical infections. Methicillin-resistant Staphylococcus aureus(MRSA) is endemic in India and is a dangerous pathogen causing hospital acquired infection leadings to signicant morbidity and mortality. OBJECTIVE:To study the prole of Staphylococcus aureusisolated from patients admitted in a tertiary care hospital. RESULT: Majority of clinical isolates of S.aurueswas obtained from patients of skin and soft tissue infection(54.66%) followed by those suffering from respiratory infection (13.33%), blood stream infection (13.33%) and UTI(8%). S.aureus was predominantly isolated from IPD samples, maximum cases were in the age group of 31-40 years and males outnumbered females. There was predominance of MRSA 112 (74.66%)which showed high level of resistance to penicillin (100%), ciprooxacin (82.14 %), co-trimoxazole (79.46%) and moxioxacin(85.71%). All the clinical isolates of S.aureuswere sensitive to linezolid andvancomycin (MIC <1ugm/ml). CONCLUSIONS: The clinical isolates of S.aureusshowed high level of resistance to various antimicrobial agents which is a signicant nosocomial threat. Surveillance and infection control practices should be carried out to prevent cross transmission of such resistant pathogen within the hospital setting

scholarly journals Assessment of Bacteremia in a Large Tertiary Care Hospital in Northern Vietnam: a Single-Center Retrospective Surveillance Study

2019 ◽  
Vol 72 (2) ◽  
pp. 118-120
Author(s):  
Nozomi Takeshita ◽  
Nguyen Quoc Anh ◽  
Doan Mai Phuong ◽  
Do Van Thanh ◽  
Pham Phuong Thuy ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Surveillance Study ◽  
Care Hospital ◽  
Single Center ◽  
Northern Vietnam ◽  
Large Tertiary Care

scholarly journals Risk of burnout among radiographers in a large tertiary care hospital in Saudi Arabia

2019 ◽  
Vol 8 (4) ◽  
pp. 38
Author(s):  
Khalid Alyousef ◽  
Hatim Alharbi ◽  
Rashed Alkharfi ◽  
Winnie Philip
Keyword(s):  
Saudi Arabia ◽  
High Risk ◽  
Emotional Exhaustion ◽  
Human Services ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Maslach Burnout Inventory ◽  
Personal Accomplishment ◽  
Care Hospital ◽  
Large Tertiary Care

Objective: Radiographers are known to be at increased risk of burnout due to the emotionally taxing interactions that they have with their patients on a daily basis. The aim of this study was to assess the risk of burnout among radiographers in a large tertiary care hospital in Saudi Arabia.Methods: This was an observational, cross-sectional study using the Maslach Burnout Inventory-Human Services Survey (MBI-HSS). This tool has been extensively tested and validated. 150 full-time radiographers at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia were invited. Trainees, interns and on job trainees (OJT) were excluded to ensure sample homogeneity. Results: 150 participants were invited to participate in the questionnaire with response rate 142 (95%). 70 participants (49%) were male and 72 (51%) female. Maslach Burnout Inventory-Human Services Survey subscale results: The mean (± SD) score for emotional exhaustion, depersonalization and personal accomplishment were 21.44 (± 13.0), 8.12 (± 6.99) and 35.63 (± 8.59) respectively. Moderate to high risk of burnout for emotional exhaustion, depersonalization and personal accomplishment were reported in 67%, 52% and 58% of participants respectively. Conclusions: 67% of radiographers were at moderate to high risk of burnout for emotional exhaustion, 52% for depersonalization and 58% for personal accomplishment. Policymakers should take necessary steps to recognize factors contributing to staff burnout and take appropriate steps to improve the work environment.

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