scholarly journals P0435 / #2037: ELEVATED DIAPHRAGMATIC TONIC ACTIVITY IN CHILDREN: AN AGE-SPECIFIC DEFINITION PROPOSITION

2021 ◽  
Vol 22 (Supplement 1 3S) ◽  
pp. 223-224
Author(s):  
V. Plante ◽  
C. Poirier ◽  
M. Sauthier ◽  
S. Al Omar ◽  
G. Emeriaud
Keyword(s):  
Tonic Activity ◽  
Specific Definition

TONIC ACTIVITY AND GRAVITATIONAL CONTROL OF THE POSTURAL MUSCLE

2020 ◽  
Vol 54 (6) ◽  
pp. 58-72
Author(s):  
B.S. Shenkman ◽  
◽  
T.M. Mirzoev ◽  
I.B. Kozlovskaya ◽  
◽  
...  
Keyword(s):  
Nervous System ◽  
Signal Pathways ◽  
Tonic Activity ◽  
Postural Muscle ◽  
Continuous Work ◽  
Tonic System ◽  
The Brain ◽  
Almost Continuous ◽  
Fundamental Conclusion ◽  
Sensory Mechanisms

The review is an attempt to describe and give a meaning to the accumulated data about the mechanisms controlling the structure and functionality of the postural muscle the almost continuous work of which makes it possible for the humans and animals to exist actively on Earth's surface. A great bulk of these data was obtained, described and systematized by professor I.B. Kozlovskaya and her pupils. A body of the most interesting facts and regularities was documented in other laboratories and research centers, quite often under the influence of ideas suggested by I.B. Kozlovskaya. The concept of the tonic system, that is, an integral physiological apparatus comprising not only slow and fast muscular fibers and small controlling motoneurons but also a complex of the brain (up to and including the striatum and motor cortex) and sensory mechanisms, constitutes the most important parts of her theoretical legacy. The fundamental conclusion of this review is that the gravity-dependent tonic contracting activity of the postural muscle controlled by the nervous system and afferent mechanisms is key to maintaining its structure, signal pathways and mechanic properties crucial for its constant anti-gravity activity.

Immediate diaphragmatic electromyogram responses to imperceptible mechanical loads in conscious humans

1992 ◽  
Vol 73 (1) ◽  
pp. 248-259 ◽  
Author(s):  
E. J. Kobylarz ◽  
J. A. Daubenspeck
Keyword(s):  
Electrical Activity ◽  
Lung Volume ◽  
Muscle Activity ◽  
Normal Subjects ◽  
Tonic Activity ◽  
Phasic Activity ◽  
Mechanical Loads ◽  
Oral Airway ◽  
Pattern Regulation ◽  
Adaptive Pattern

We used an esophageal electrode to measure the amplitude and neural inspiratory and expiratory (N TE) timing responses of crural diaphragmatic electrical activity in response to flow-resistive (R) and elastic (E) loads at or below the threshold for conscious detection, applied pseudorandomly to the oral airway of eight normal subjects. We observed a rapid first-breath neural reflex that modified respiratory timing such that N TE lengthened significantly in response to R loads in six of eight subjects and shortened in response to E loading in six of seven subjects. The prolongation of N TE with R loading resulted primarily from lengthening the portion of N TE during which phasic activity in the diaphragm is absent (TE NDIA), whereas E loading shortened N TE mainly by reducing TE NDIA. Most subjects responded to both types of loading by decreasing mean tonic diaphragmatic activity, the average level of muscle activity that exists when no phasic changes are occurring, as well as its variability. The observed timing responses are consistent in direction with optimally adaptive pattern regulation, whereas the modulation of tonic activity may be useful in neural regulation of end-expiratory lung volume.

scholarly journals Similar Vertices and Isomorphism Detection for Planar Kinematic Chains Based on Ameliorated Multi-Order Adjacent Vertex Assignment Sequence

2021 ◽  
Vol 34 (1) ◽  
Author(s):  
Liang Sun ◽  
Zhizheng Ye ◽  
Fuwei Lu ◽  
Rongjiang Cui ◽  
Chuanyu Wu
Keyword(s):  
Degree Of Freedom ◽  
Adjacent Vertex ◽  
Topological Graph ◽  
Innovative Design ◽  
Kinematic Chains ◽  
Effectiveness And Efficiency ◽  
Definition Of ◽  
Specific Definition

AbstractIsomorphism detection is fundamental to the synthesis and innovative design of kinematic chains (KCs). The detection can be performed accurately by using the similarity of KCs. However, there are very few works on isomorphism detection based on the properties of similar vertices. In this paper, an ameliorated multi-order adjacent vertex assignment sequence (AMAVS) method is proposed to seek out similar vertices and identify the isomorphism of the planar KCs. First, the specific definition of AMAVS is described. Through the calculation of the AMAVS, the adjacent vertex value sequence reflecting the uniqueness of the topology features is established. Based on the value sequence, all possible similar vertices, corresponding relations, and isomorphism discrimination can be realized. By checking the topological graph of KCs with a different number of links, the effectiveness and efficiency of the proposed method are verified. Finally, the method is employed to implement the similar vertices and isomorphism detection of all the 9-link 2-DOF(degree of freedom) planar KCs.

scholarly journals No relationship between bone mineral density and syndesmophyte formation at the same level in the lumbar spine of patients with radiographic axial Spondyloarthritis

RMD Open ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. e001391
Author(s):  
Mary Lucy Marques ◽  
Sofia Ramiro ◽  
Pedro M Machado ◽  
Desirée van der Heijde ◽  
Floris A van Gaalen
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Axial Spondyloarthritis ◽  
Mineral Density ◽  
Multivariable Analyses ◽  
Low Incidence ◽  
Post Hoc ◽  
Generalised Estimating Equations ◽  
Specific Definition

ObjectiveTo investigate if in radiographic axial Spondyloarthritis (r-axSpA) low vertebral bone mineral density (BMD) is associated with development of new syndesmophytes at the same vertebral level.MethodsIn a post-hoc analysis from the ASSERT trial (infliximab vs placebo), dual-energy X-ray absorptiometry was used to measure baseline BMD (g/cm2) of the lumbar spine L1 to L4. Syndesmophyte formation was assessed in the same vertebrae on conventional radiographs defined as an increase in modified Stoke Ankylosing Spondylitis Spine Score from 0 or 1 to 2 or 3 after 2 years. Radiographs were scored by two readers. Generalised estimating equations (GEE) adjusted for within-patient correlation across multiple vertebrae, taking potential confounders into account.ResultsWe analysed 599 vertebrae in 165 r-axSpA patients (78% male, mean (SD) age 38 (10) years, 67% with at least one syndesmophyte anywhere in the spine). In total, 24 to 74 new syndesmophytes developed in 9 (5%) to 30 (18%) patients and 13 (2%) to 39 (7%) vertebrae, if either a syndesmophyte was seen by both or only one of the readers (ie, specific and sensitive definitions) respectively. In multivariable analyses, no association was found between baseline local vertebral BMD and new syndesmophyte formation after 2 years: adjOR (95% CI): 0.56 (0.01, 44.45) (specific definition) and 0.26 (0.03, 2.63) (sensitive definition).ConclusionIn patients with active and established r-axSpA, with an observed low incidence of lumbar spine syndesmophyte formation over 2 years, no relationship was found between baseline BMD and new radiographic syndesmophyte formation at the same vertebra.

Consent after the House of Lords: Taking and leading astray the Law of Theft

Legal Studies ◽  
1993 ◽  
Vol 13 (3) ◽  
pp. 308-322
Author(s):  
Mitchell C. Davies
Keyword(s):  
Criminal Law ◽  
House Of Lords ◽  
The Law ◽  
Definition Of ◽  
Specific Definition

The objectives of the Criminal Law Revision Committee when drafting the radical reforms proposed by the 1966 Theft Bill were described by a contemporary commentator2 as being: ‘. . . to do away with the more embarrassing and restrictive technicalities of the existing law . . .’In the same place it was observed that the Committee faced a choice between creating a specific definition of the various theft offences and their elements, or one whose generality would allow it to evolve to meet the challenges presented by ever more complex and sophisticated dishonest dealing.

“What’s in a name?”

Target ◽  
2007 ◽  
Vol 19 (2) ◽  
pp. 313-325 ◽  
Author(s):  
Mary Snell-Hornby
Keyword(s):  
Translation Studies ◽  
Technical Term ◽  
Central Concept ◽  
Lingua Franca ◽  
Scholarly Discourse ◽  
Functionalist Approach ◽  
Specific Definition

Terminology has often proved to be a problem in scholarly discourse, and Translation Studies is a case in point. Even the name of the discipline has been an issue since James Holmes brought it up in 1972, and the central concept of the time, equivalence, despite incessant debate and revaluation in some schools of thought, has in others long since been discarded as an illusion. Basically there are three possibilities open to the scholar wanting to introduce a new technical term: – As in the case of norm (Toury), a word from general language can be used in a specified sense and defined as such. The danger arises that it can be misinterpreted and used differently in other languages (as with Vermeer’s Norm). – the invention of completely new terms, as with Justa Holz-Mänttäri’s Botschaftsträger. – A word is taken over from a classical dead language, such as Latin or Greek, and given a specific definition for the theory concerned, as was the case with skopos in the functionalist approach. Referring to experience in editing the Handbuch Translation, the essay discusses this issue in detail. It also deals with the use of English as a lingua franca in the metadiscourse of Translation Studies.

Effects of reversible blockade of basal ganglia on a voluntary arm movement

1992 ◽  
Vol 68 (5) ◽  
pp. 1516-1534 ◽  
Author(s):  
M. Kato ◽  
M. Kimura
Keyword(s):  
Basal Ganglia ◽  
Elbow Joint ◽  
Dynamic Control ◽  
Arm Movement ◽  
Gamma Aminobutyric Acid ◽  
Tonic Activity ◽  
Visually Guided ◽  
Holding Period ◽  
Antagonist Muscles ◽  
Agonist And Antagonist

1. The effects of a reversible blockade of basal ganglia were examined in two monkeys trained to perform a visually guided, step-tracking arm movement around the elbow joint. To block glutamatergic excitation, kynurenate (a glutamate antagonist) was locally injected into the putamen and the external segment (GPe) and the internal segment (GPi) of the globus pallidus contralateral to the arm tested. Muscimol [a gamma-aminobutyric acid (GABA) agonist] was also used to suppress neuronal activity in these structures. The drugs were injected in the arm area of the putamen, which was identified by microstimulation or by recording neural activity. For the GPe and GPi, injections were made into the area medioventral to the arm area of the putamen. 2. The blockade of the putamen caused abnormal braking of the arm movements. The first step of the movement became hypometric, and multiple steps were necessary to reach the target. The electromyographic (EMG) analysis revealed an increase of burst activity in the antagonist muscles and a decrease of that in the agonist muscles at the fast movements. The tonic activity increased in the extensor muscles during a holding period. 3. The blockade of the GPi caused dysmetric movements. Amplitude and peak velocity of the first step of movement largely fluctuated among trials. It became difficult for the animal to brake and adjust its arm onto the target. 4. The blockade of the GPe caused a flexion posture at the elbow joint of the contralateral arm. The tonic activity of the flexor muscles increased. Cocontraction of the agonist and antagonist muscles was also observed. 5. These results suggest that the putaminopallidal system of the basal ganglia contributes to both of two motor functions: 1) static control to maintain the posture with tonic muscle activity, and 2) dynamic control to enable fast movements.

Home Videorecording of "Spells" in Children

PEDIATRICS ◽  
1985 ◽  
Vol 76 (4) ◽  
pp. 612-613
Author(s):  
ROBERT C. WOODY
Keyword(s):  
Hospital Admission ◽  
Seizure Activity ◽  
Tonic Activity ◽  
Partial Seizures ◽  
High Quality ◽  
Complex Partial Seizures ◽  
Permanent Record ◽  
First Case ◽  
The Family ◽  
At Home

The increasing availability of videorecording cameras and cassette recorders now permits the visual documentation of medical events in children at home by parents. On two occasions recently, we asked families to videorecord their children's presumed seizure activity at home. In the first case, a 10-month-old white boy had frequent "spells" which by history appeared to be complex partial seizures. Routine awake and asleep EEG tracings were normal, and the family resisted hospital admission for financial reasons. Anticonvulsant medications were prescribed, and the family suggested that they borrow their parent's videocassette recorder to document their son's spells at home. Their videorecordings produced a high quality, permanent record of definite complex partial symptom activity clearly revealing eye deviation, nystagmus, and associated head and arm tonic activity.

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