A 47-Year-Old Patient With Multiple Desquamative Patches and Subsequent Onset of Papular Lesions: Answer

2020 ◽  
Vol 42 (10) ◽  
pp. 791-792
Author(s):  
Giuseppe Broggi ◽  
Lorenzo Cerroni ◽  
Sebastiano Scavo ◽  
Gaetano Magro ◽  
Rosario Caltabiano
Keyword(s):  
Subsequent Onset

scholarly journals Lifetime co-morbidities between social phobia and mood disorders in the US National Comorbidity Survey

1999 ◽  
Vol 29 (3) ◽  
pp. 555-567 ◽  
Author(s):  
R. C. KESSLER ◽  
P. STANG ◽  
H.-U. WITTCHEN ◽  
M. STEIN ◽  
E. E. WALTERS
Keyword(s):  
Social Phobia ◽  
Mood Disorders ◽  
Age Of Onset ◽  
Population Attributable Risk ◽  
Population Data ◽  
Major Depressive ◽  
National Comorbidity Survey ◽  
Increased Risk ◽  
The Us ◽  
Subsequent Onset

Background. General population data were used to study co-morbidities between lifetime social phobia and mood disorders.Methods. Data come from the US National Comorbidity Survey (NCS).Results. Strong associations exist between lifetime social phobia and major depressive disorder (odds ratio 2·9), dysthymia (2·7) and bipolar disorder (5·9). Odds ratios increase in magnitude with number of social fears. Reported age of onset is earlier for social phobia than mood disorders in the vast majority of co-morbid cases. Temporally-primary social phobia predicts subsequent onset of mood disorders, with population attributable risk proportions of 10–15%. Social phobia is also associated with severity and persistence of co-morbid mood disorders.Conclusions. Social phobia is a commonly occurring, chronic and seriously impairing disorder that is seldom treated unless it occurs in conjunction with another co-morbid condition. The adverse consequences of social phobia include increased risk of onset, severity and course of subsequent mood disorders. Early outreach and treatment of primary social phobia might not only reduce the prevalence of this disorder itself, but also the subsequent onset of mood disorders.

scholarly journals Psychotic experiences and general medical conditions: a cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys

2018 ◽  
Vol 48 (16) ◽  
pp. 2730-2739 ◽  
Author(s):  
Kate M. Scott ◽  
Sukanta Saha ◽  
Carmen C.W. Lim ◽  
Sergio Aguilar-Gaxiola ◽  
Ali Al-Hamzawi ◽  
...  
Keyword(s):  
Mental Health ◽  
Chronic Pain ◽  
Mental Disorders ◽  
Severe Headache ◽  
Medical Conditions ◽  
Psychotic Experiences ◽  
World Mental Health ◽  
Wide Range ◽  
Comorbid Mental Disorders ◽  
Subsequent Onset

AbstractBackgroundPrevious work has identified associations between psychotic experiences (PEs) and general medical conditions (GMCs), but their temporal direction remains unclear as does the extent to which they are independent of comorbid mental disorders.MethodsIn total, 28 002 adults in 16 countries from the WHO World Mental Health (WMH) Surveys were assessed for PEs, GMCs and 21 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) mental disorders. Discrete-time survival analyses were used to estimate the associations between PEs and GMCs with various adjustments.ResultsAfter adjustment for comorbid mental disorders, temporally prior PEs were significantly associated with subsequent onset of 8/12 GMCs (arthritis, back or neck pain, frequent or severe headache, other chronic pain, heart disease, high blood pressure, diabetes and peptic ulcer) with odds ratios (ORs) ranging from 1.3 [95% confidence interval (CI) 1.1–1.5] to 1.9 (95% CI 1.4–2.4). In contrast, only three GMCs (frequent or severe headache, other chronic pain and asthma) were significantly associated with subsequent onset of PEs after adjustment for comorbid GMCs and mental disorders, with ORs ranging from 1.5 (95% CI 1.2–1.9) to 1.7 (95% CI 1.2–2.4).ConclusionsPEs were associated with the subsequent onset of a wide range of GMCs, independent of comorbid mental disorders. There were also associations between some medical conditions (particularly those involving chronic pain) and subsequent PEs. Although these findings will need to be confirmed in prospective studies, clinicians should be aware that psychotic symptoms may be risk markers for a wide range of adverse health outcomes. Whether PEs are causal risk factors will require further research.

scholarly journals Measuring ACPA in the general population or primary care: is it useful?

RMD Open ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. e001085
Author(s):  
Axel Finckh ◽  
Delphine Courvoisier ◽  
Celine Lamacchia
Keyword(s):  
Rheumatoid Arthritis ◽  
Primary Care ◽  
General Population ◽  
Disease Burden ◽  
Screening Strategy ◽  
Screening And Prevention ◽  
Significant Disease ◽  
Diagnostic Properties ◽  
Peptide Antibodies ◽  
Subsequent Onset

Rheumatoid arthritis (RA) is associated with a significant disease burden and high costs for society. Because the disease has identifiable preclinical stages, screening and prevention have become a possibility in RA. Anticitrullinated peptide antibodies (ACPAs) are arguably the most likely candidate biomarker to screen for RA. This paper reviews the evidence for the use of ACPAs as a screening test in the broader general population, to identify individuals at high risk of subsequent onset of RA. We will review the diagnostic properties of the test and its positive and negative predictive value in different settings. We will discuss how ACPA testing could effectively be integrated in a broader screening strategy for RA.

Effect of Deprivation Level and Overtraining on Differential Conditioning and Reversal

1969 ◽  
Vol 24 (1) ◽  
pp. 51-57
Author(s):  
James R. Ison ◽  
Harvey Black
Keyword(s):  
Water Deprivation ◽  
Instrumental Conditioning ◽  
Deprivation Level ◽  
Positive Stimulus ◽  
Prior Training ◽  
Reversal Performance ◽  
Response Measurement ◽  
Early Acquisition ◽  
Subsequent Onset

60 rats received 60 or 204 differential instrumental conditioning trials under 3-, 19- or 43-hr. water deprivation, followed by 60 reversal trials. In early acquisition speeds to both S+ and S—were greater with increased deprivation, but the subsequent onset of differentiation was most rapid in groups run at 43-hr. deprivation, this produced by their slower running to S—. Reversal performance was but little affected by deprivation, not was there any interaction between deprivation level and amount of prior training in the determination of reversal performance. Reversal performance was related to amount of prior training in a complicated fashion depending on the stimulus, the point of response measurement and the stage of training: First, number of prior reinforcements increased both start and run speeds to the old positive stimulus in early reversal but had no effect on start speeds and decreased run speeds in later reversal; second, number of prior non-reinforcements did not affect speed acquisition to the new positive stimulus.

Effects of bromocriptine at parturition in the tammar wallaby, Macropus eugenii

1990 ◽  
Vol 2 (1) ◽  
pp. 79 ◽  
Author(s):  
TP Fletcher ◽  
G Shaw ◽  
MB Renfree
Keyword(s):  
Post Partum ◽  
Tammar Wallaby ◽  
Plasma Prolactin ◽  
Plasma Progesterone ◽  
Macropus Eugenii ◽  
Sequence Of Events ◽  
Prostaglandin Release ◽  
Peripartum Period ◽  
And Control ◽  
Subsequent Onset

Female tammar wallabies were treated with the dopamine agonist bromocriptine at the end of pregnancy to suppress the peripartum pulse of plasma prolactin. The animals were subsequently observed, and a series of blood samples taken to define the hormonal profiles before and immediately after parturition. Birth was observed in 4/5 control animals and occurred in 8/9 bromocriptine-treated animals. The peripartum peak in plasma PGFM concentrations was not affected by bromocriptine although the pulse of prolactin normally seen at parturition was completely abolished. The timing of luteolysis was apparently unaffected, as plasma progesterone concentrations fell similarly in both treated and control animals immediately after parturition. However, all of the neonates of the bromocriptine-treated animals died within 24 h, possibly because of a failure to establish lactation. Subsequent onset of post-partum oestrus was delayed or absent both in control and in bromocriptine-treated animals, suggesting that the frequent blood sampling and disturbances in the peripartum period interfered with these endocrine processes. It is concluded that both prolactin and prostaglandin can induce luteolysis in the pregnant wallaby, but that the normal sequence of events results from a signal of fetal origin inducing a prostaglandin release from the uterus, which in turn releases a pulse of prolactin that induces a progesterone decline.

scholarly journals Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents

2009 ◽  
Vol 195 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Ian M. Goodyer ◽  
Alison Bacon ◽  
Maria Ban ◽  
Tim Croudace ◽  
Joe Herbert
Keyword(s):  
High Risk ◽  
Serotonin Transporter ◽  
Depressive Episode ◽  
Gene Promoter ◽  
Depressive Illness ◽  
Short Allele ◽  
Morning Cortisol ◽  
Serotonin Transporter Genotype ◽  
S Allele ◽  
Subsequent Onset

BackgroundThe short (s) allele of the serotonin transporter gene promoter (5-HTTLPR) may be associated with exposure to social adversities and the subsequent onset of depressive illness in adulthood.AimsTo test in adolescents at high risk for depression whether the short ‘s’ allele is associated with levels of morning cortisol and the subsequent onset of a depressive episode.MethodHigh-risk adolescents (n = 403) were genotyped for 5-HTTLPR. Salivary samples were obtained on four consecutive school days within 1 h of waking from 393 (97.5%) individuals and 367 (91%) underwent a mental state reassessment at 12 months.ResultsMultilevel analysis revealed higher levels of salivary cortisol in short allele carriers (s/s>s/l>l/l). A subsequent episode of depression was increased in those with higher cortisol and the ‘s’ allele, and independently by depressive symptoms at entry, in both genders.ConclusionsThe short allele of 5-HTTLPR may moderate the association between morning cortisol and the subsequent onset of a depressive episode.

Influence of lambing date on subsequent ovarian cyclicity and ovulation rate in ewes

1997 ◽  
Vol 65 (1) ◽  
pp. 75-81 ◽  
Author(s):  
L. M. Mitchell ◽  
M. E. King ◽  
R. P. Aitken ◽  
J. M. Wallace
Keyword(s):  
Breeding Season ◽  
Ovulation Rate ◽  
Breeding Period ◽  
Ovarian Activity ◽  
Blood Samples ◽  
Natural Breeding ◽  
Seasonal Decline ◽  
Ovarian Cyclicity ◽  
Ovarian Cycles ◽  
Subsequent Onset

AbstractThe effect of lambing date on the subsequent onset and duration of ovarian cyclicity in Mule (Bluefaced Leicester × Scottish Blackface) ewes was investigated. Nineteen ewes which had lambed in January (16 January 1993 (s.e. 3 days)) and been weaned in February-March and 22 comparable ewes which had lambed in May (14 May 1993 (s.e. 2 days)) and been weaned on 23 August were maintained at pasture as two isolated groups. A raddled vasectomized ram was continually present with each group from 14 July 1993 to 26 May 1994 and marked (oestrous) ewes were recorded twice weekly. Ovarian activity was assessed by measuring peripheral progesterone concentrations in blood samples collected twice weekly and by laparoscopic viewing of the ovaries of all ewes during October, January and March. The onset and duration of ovarian activity were significantly affected by the previous lambing date. For January and May lambing ewes, mean dates of onset were 5 September 1993 (s.e. 2 days) v. 25 September 1993 (s.e. 4 days) (P < 0·001) and of cessation were 5 April 1994 (s.e. 5 days) v. 10 April 1994 (s.e. 3 days). Mean durations of ovarian activity were 212 (s.e. 6) and 195 (s.e. 5) days (P < 0·05) during which 12·4 (s.e. 0·29) and 11·5 (s.e. 0·38) ovarian cycles respectively were recorded. Ovulation rate was not affected by previous lambing date but was significantly lower in March compared with October (January lambing ewes 1·7 (s.e. 0·1) v. 2·3 (s.e. 0·1) (P < 0·001); May lambing ewes 1·6 (s.e. 0·1) v. 2·1 (s.e. 0·1) (P < 0·01)). Results demonstrate that (i) Mule ewes have a potential breeding season of up to 8 months duration; (ii) the onset and duration of ovarian activity can be influenced by previous lambing date; and (Hi) a seasonal decline in ovulation rate may, in practical terms, result in a lower lambing percentage for animals bred towards the end of their natural breeding period.

Daily smoking and the subsequent onset of psychiatric disorders

2004 ◽  
Vol 34 (2) ◽  
pp. 323-333 ◽  
Author(s):  
N. BRESLAU ◽  
S. P. NOVAK ◽  
R. C. KESSLER
Keyword(s):  
Smoking Cessation ◽  
Panic Disorder ◽  
Psychiatric Disorders ◽  
Composite International Diagnostic Interview ◽  
Diagnostic Interview ◽  
World Health ◽  
Daily Smoking ◽  
Smoking Intensity ◽  
Health Organization ◽  
Subsequent Onset

Background. Recent research has demonstrated that smokers are at an elevated risk for psychiatric disorders. This study extends the enquiry by examining: (1) the specificity of the psychiatric sequelae of smoking; and (2) the variability in the likelihood of these sequelae by proximity and intensity of smoking.Method. Data come from the National Comorbidity Survey (NCS), a representative sample of the US population 15–54 years of age. The Smoking Supplement was administered to a representative subset of 4414 respondents. A modified World Health Organization – Composite International Diagnostic Interview was used to measure DSM-III-R disorders. Survival analysis with smoking variables as time-dependent covariates was used to predict the subsequent onset of specific psychiatric disorders.Results. The estimated effects of daily smoking varied across disorders. In the case of mood disorders, daily smoking predicted subsequent onset, with no variation between current versus past smokers or by smoking intensity. In the case of panic disorder and agoraphobia, current but not past smoking predicted subsequent onset; furthermore, the risk of these disorders in past smokers decreased with increasing time since quitting. In the case of substance use disorders, current but not past smoking predicted subsequent onset, with no variation by time since quitting or smoking intensity.Conclusions. The data suggest that smoking cessation programmes would not prevent the onset of mood disorder, as ex-smokers do not differ from current smokers in their risk for these disorders. In comparison, daily smoking might be a causal factor in panic disorder and agoraphobia, conditions that might be preventable by smoking cessation. Additionally, current smoking might serve as a marker for targeting interventions to prevent alcohol and drug disorders.

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