Parvimonas micra Necrotizing Panophthalmitis Involving the Sclera, Cornea, Uvea, Retina, and Orbit

Abstract Background Parvimonas micra (P. micra) is a gram-positive anaerobic coccus that is detected widely on the skin, in the oral mucosa and in the gastrointestinal tract. In certain circumstances, P. micra can cause abdominal abscesses, bacteraemia and other infections. To the best of our knowledge, there have been no case reports describing the biological characteristics of P. micra-related pneumonia. These bacteria do not always multiply in an aerobic organ, such as the lung, and they could be easily overlooked because of the clinical mindset. Case presentation A 35-year-old pregnant woman was admitted to the emergency department 4 weeks prior to her due date who was exhibiting 5 points on the Glasgow coma scale. A computed tomography (CT) scan showed a massive haemorrhage in her left basal ganglia. She underwent a caesarean section and brain surgery before being admitted to the ICU. She soon developed severe pneumonia and hypoxemia. Given that multiple sputum cultures were negative, the patient’s bronchoalveolar lavage fluid was submitted for next-generation sequencing (NGS) to determine the pathogen responsible for the pneumonia; as a result, P. micra was determined to be the causative pathogen. Accordingly the antibiotic therapy was altered and the pneumonia improved. Conclusion In this case, we demonstrated severe pneumonia caused by the anaerobic organism P. micra, and the patient benefited from receiving the correct antibiotic. NGS was used as a method of quick diagnosis when sputum culture failed to distinguish the pathogen.

Download Full-text

Late onset prosthetic joint infection caused by Parvimonas micra

Anaerobe ◽

10.1016/j.anaerobe.2021.102414 ◽

2021 ◽

pp. 102414

Author(s):

Fernando Maroto Piñeiro ◽

Judith Álvarez Otero ◽

Jose Luis Lamas Ferreiro ◽

Ana B. Sanjurjo Rivo ◽

Antonio Pintado García ◽

...

Keyword(s):

Prosthetic Joint Infection ◽

Late Onset ◽

Joint Infection ◽

Prosthetic Joint ◽

Parvimonas Micra

Download Full-text

Atypical Presentation of Periprosthetic Joint Infection After Total Knee Arthroplasty due to Parvimonas micra

Arthroplasty Today ◽

10.1016/j.artd.2020.09.021 ◽

2020 ◽

Vol 6 (4) ◽

pp. 901-905

Author(s):

Dustin Randall ◽

Young Jee ◽

Aimen Vanood ◽

David Mayo

Keyword(s):

Total Knee Arthroplasty ◽

Knee Arthroplasty ◽

Periprosthetic Joint Infection ◽

Joint Infection ◽

Atypical Presentation ◽

Parvimonas Micra ◽

Total Knee

Download Full-text

Qat Chewing and Periodontal Pathogens in Health and Disease: Further Evidence for a Prebiotic-Like Effect

BioMed Research International ◽

10.1155/2015/291305 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Abdulrahman Al-Alimi ◽

Tara Taiyeb-Ali ◽

Nasruddin Jaafar ◽

Nezar Noor Al-hebshi

Keyword(s):

Multiple Comparisons ◽

Study Groups ◽

Periodontal Pathogens ◽

Periodontal Health ◽

Significance Level ◽

Parvimonas Micra ◽

Nominal Significance ◽

Health And Disease ◽

Filifactor Alocis ◽

Total Bacteria

Aim. Qat chewing has been reported to induce subgingival microbial shifts suggestive of prebiotic-like properties. The objective here was to assess the effect of qat chewing on a panel of classical and new putative periopathogens in health and periodontitis.Materials and Methods. 40 qat chewers and 40 nonchewers, equally stratified by periodontal health status, were recruited. Taqman, real-time PCR was used to quantify total bacteria,Porphyromonas gingivalis,Tannerella forsythia,Treponema denticola,Parvimonas micra,Filifactor alocis, Synergistetes, and TM7s in pooled subgingival biofilm samples. Differences in microbial parameters between the study groups were analysed using ordinal regression.Results. In health, the qat chewers harboured significantly lower relative counts ofP. gingivalis,T. forsythia, Synergistetes, and TM7s after adjustment for multiple comparisons (P≤0.007). At nominal significance level, they also carried lower counts of TM7s andP. micra(P≤0.05). In periodontitis, the chewers had lower counts of all taxa; however, onlyT. denticolawithstood correction for multiple comparisons (P≤0.0063).Conclusions. Qat chewing is associated with lower proportions of periopathogens, particularly in subjects with healthy periodontium, which supports previous reports of its prebiotic-like properties. This potentially beneficial biological effect can be exploited by attempting to isolate the active fraction.

Download Full-text

Characterization of the Subgingival Cultivable Microbiota in Patients with Different Stages of Periodontitis in Spain and Colombia. A Cross-Sectional Study

Microorganisms ◽

10.3390/microorganisms9091940 ◽

2021 ◽

Vol 9 (9) ◽

pp. 1940

Author(s):

Roquelina Pianeta ◽

Margarita Iniesta ◽

Diana Marcela Castillo ◽

Gloria I. Lafaurie ◽

Mariano Sanz ◽

...

Keyword(s):

Bacterial Species ◽

Fusobacterium Nucleatum ◽

Cross Sectional Study ◽

Sectional Study ◽

Chi Square ◽

Cross Sectional ◽

Campylobacter Rectus ◽

Parvimonas Micra ◽

Final Sample

The objective was to characterize and compare the subgingival microbiota in patients diagnosed according to the World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions 2018. For this cross-sectional study, Spanish and Colombian subjects (characterized as health/gingivitis, periodontitis in stages I-II or stages III-IV) were clinically assessed, and subgingival samples were taken and processed by culture. The comparisons among patients with periodontal status (and between countries) was made using Mann–Whitney, Kruskal–Wallis, ANOVA and chi-square tests. The final sample consisted of 167 subjects. Eikenella corrodens and Parvimonas micra were more frequently detected in health/gingivitis and Porphyromonas gingivalis in periodontitis (p < 0.05). Higher total counts were observed in Colombia (p = 0.036). In Spain, significantly higher levels of P. gingivalis and Campylobacter rectus were observed, and of Tannerella forsythia, P. micra, Prevotella intermedia, Fusobacterium nucleatum, Actinomyces odontolyticus and Capnocytophaga spp. in Colombia (p < 0.001). P. micra was more prevalent in health/gingivitis and stage I-II periodontitis in Colombia, and P. gingivalis in all periodontitis groups in Spain (p < 0.05). As conclusions, significant differences were detected in the microbiota between health/gingivitis and periodontitis, with minor differences between stages of periodontitis. Differences were also relevant between countries, with Colombia showing larger counts and variability of bacterial species.

Download Full-text

Lung abscess by Actinomyces odontolyticus and Parvimonas micra co-infection presenting as acute respiratory failure

Medicine ◽

10.1097/md.0000000000016911 ◽

2019 ◽

Vol 98 (35) ◽

pp. e16911 ◽

Cited By ~ 3

Author(s):

Sang Suk Yun ◽

Hyun Seop Cho ◽

Manbong Heo ◽

Jong Hwan Jeong ◽

Hyang Rae Lee ◽

...

Keyword(s):

Respiratory Failure ◽

Acute Respiratory Failure ◽

Lung Abscess ◽

Parvimonas Micra

Download Full-text

Diagnostic Models for Screening of Periodontitis with Inflammatory Mediators and Microbial Profiles in Saliva

Diagnostics ◽

10.3390/diagnostics10100820 ◽

2020 ◽

Vol 10 (10) ◽

pp. 820

Author(s):

Jungwon Lee ◽

Jun-Beom Lee ◽

Hyun-Young Song ◽

Min Jung Son ◽

Ling Li ◽

...

Keyword(s):

Immunoglobulin A ◽

Stage Iv ◽

Fusobacterium Nucleatum ◽

Operating Characteristics ◽

Active Matrix ◽

Campylobacter Rectus ◽

Reactive Protein ◽

Salivary Biomarkers ◽

Parvimonas Micra ◽

Diagnostic Models

This study aims to investigate and assess salivary biomarkers and microbial profiles as a means of diagnosing periodontitis. A total of 121 subjects were included: 28 periodontally healthy subjects, 24 with Stage I periodontitis, 24 with Stage II, 23 with Stage III, and 22 with Stage IV. Salivary proteins (including active matrix metalloproteinase-8 (MMP-8), pro-MMP-8, total MMP-8, C-reactive protein, secretory immunoglobulin A) and planktonic bacteria (including Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, Prevotella intermedia, Porphyromonas nigrescens, Parvimonas micra, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Actinomyces viscosus) were measured from salivary samples. The performance of the diagnostic models was assessed by receiver operating characteristics (ROCs) and area under the ROC curve (AUC) analysis. The diagnostic models were constructed based on the subjects’ proteins and/or microbial profiles, resulting in two potential diagnosis models that achieved better diagnostic powers, with an AUC value > 0.750 for the diagnosis of Stages II, III, and IV periodontitis (Model PA-I; AUC: 0.796, sensitivity: 0.754, specificity: 0.712) and for the diagnosis of Stages III and IV periodontitis (Model PA-II; AUC: 0.796, sensitivity: 0.756, specificity: 0.868). This study can contribute to screening for periodontitis based on salivary biomarkers.

Download Full-text

A rare case of polymicrobial chronic maxillary sinusitis due to concurrent isolation of Parvimonas micra and Fusobacterium nucleatum

Anaerobe ◽

10.1016/j.anaerobe.2020.102284 ◽

2020 ◽

Vol 66 ◽

pp. 102284

Author(s):

Theodoros Karampatakis ◽

Anastasia Papavasiliou ◽

Dimitris Tatsis ◽

Konstantinos Paraskevopoulos ◽

Helen Katsifa

Keyword(s):

Rare Case ◽

Maxillary Sinusitis ◽

Fusobacterium Nucleatum ◽

Parvimonas Micra ◽

Chronic Maxillary Sinusitis

Download Full-text

Comparative In Vitro Resistance of Human Periodontal Bacterial Pathogens to Tinidazole and Four Other Antibiotics

Antibiotics ◽

10.3390/antibiotics9020068 ◽

2020 ◽

Vol 9 (2) ◽

pp. 68 ◽

Cited By ~ 3

Author(s):

Thomas E. Rams ◽

Jacqueline D. Sautter ◽

Arie J. van Winkelhoff

Keyword(s):

Fusobacterium Nucleatum ◽

Periodontal Pathogens ◽

Test Species ◽

Campylobacter Rectus ◽

Resistant Species ◽

Streptococcus Constellatus ◽

Parvimonas Micra ◽

Severe Periodontitis ◽

Resistant Strains

The in vitro resistance of selected red/orange complex periodontal pathogens to tinidazole was compared with four other antibiotics. Subgingival biofilm samples from 88 adults with severe periodontitis were anaerobically incubated on enriched Brucella blood agar with and without supplementation with tinidazole (16 mg/L), metronidazole (16 mg/L), amoxicillin (8 mg/L), doxycycline (4 mg/L), or clindamycin (4 mg/L). Growth of Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia/nigrescens, Parvimonas micra, Fusobacterium nucleatum, Streptococcus constellatus, or Campylobacter rectus on antibiotic-supplemented plates indicated their in vitro antibiotic resistance. Tinidazole inhibited all test species, except P. intermedia/nigrescens, P. micra, and S. constellatus in 3.8%, 10.2%, and 88.9% of species-positive patients, respectively. Significantly fewer patients yielded tinidazole-resistant test species, and had significantly lower subgingival proportions of tinidazole-resistant organisms, than patients with amoxicillin, doxycycline, or clindamycin-resistant species, but not those with metronidazole-resistant strains. Joint in vitro species resistance to tinidazole and amoxicillin, or metronidazole and amoxicillin, was rare. Tinidazole performed in vitro similar to metronidazole, and markedly better than amoxicillin, doxycycline, or clindamycin, against fresh clinical isolates of red/orange complex periodontal pathogens. As a result of its similar antimicrobial spectrum, and more convenient once-a-day oral dosing, tinidazole should be considered in place of metronidazole for systemic periodontitis drug therapy.

Download Full-text