The Microbiome of Catheter Collected Urine in Males with Bladder Cancer According to Disease Stage

2021 ◽  
Vol 205 (1) ◽  
pp. 86-93 ◽  
Author(s):  
Bianca Oresta ◽  
Daniele Braga ◽  
Massimo Lazzeri ◽  
Nicola Frego ◽  
Alberto Saita ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Disease Stage

Impact of equal access healthcare on race disparities in bladder cancer.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 399-399
Author(s):  
Nikhil V. Kotha ◽  
Abhishek Kumar ◽  
Edmund M. Qiao ◽  
Daniel R. Cherry ◽  
Vinit Nalawade ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Healthcare System ◽  
Equal Access ◽  
Disease Stage ◽  
Seer Database ◽  
Cancer Specific Survival ◽  
Black Patients ◽  
Black Veterans ◽  
Multivariable Models ◽  
White Patients

399 Background: Outcomes in bladder cancer are disproportionately worse for black patients compared to white patients. We hypothesize these disparities arise in part due to differences in access to healthcare and therefore may be mitigated in an equal access healthcare system, such as the Veterans Affairs’ (VA) system. Here, we examine outcomes by race for patients with bladder cancer within the VA system and then compare these outcomes to those in the Surveillance, Epidemiology, and End Results (SEER) database. Methods: We performed a retrospective cohort study using VA Informatics and Computing Infrastructure (VINCI) and SEER. We included all patients diagnosed with bladder cancer, American Joint Committee on Cancer (AJCC) stage 0-4 diagnosed between 2000 and 2018. Endpoints of overall survival (OS), bladder cancer-specific survival (BCS), and non-bladder cancer-specific survival (NCS) were evaluated in multivariable Cox and Fine-Gray models. Results: Using the VA dataset, we identified 36322 veterans (9.0% black, 91.0% white) with bladder cancer. Black veterans were more likely to have more comorbidities, reside in zip codes with lower median income and education levels, and present with higher stage disease (AJCC stages 2-4) than white veterans (23.3% vs 19%). In multivariable models accounting for disease stage among other covariables, there were no statistically significant differences in any survival endpoint (Table). Using the SEER dataset, we identified 130998 patients (5.9% black, 94.1% white) with bladder cancer. In similar multivariable models, SEER’s black patients had statistically significant inferior outcomes in all survival endpoints compared to SEER’s white patients (Table). Conclusions: While racial disparities for patients with bladder cancer in the SEER database were observed, no differences in survival outcomes between black and white patients were observed in the VA healthcare system. Of note, black veterans presented with more advanced stage, suggesting a delay in diagnosis or a more aggressive cancer phenotype compared to white patients. Our findings underscore the need to bridge healthcare disparities across diverse racial groups. Our study highlights the beneficial impact of an equal access healthcare system in reducing financial and social barriers to healthcare to counteract racial health disparities. Further research is required to delineate these disparities and guide appropriate screening strategies. [Table: see text]

Cancer stage and quality of life in bladder cancer.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 466-466
Author(s):  
Hannah McCloskey ◽  
Sean McCabe ◽  
Kathryn Gessner ◽  
Pauline Filippou ◽  
Judy Hamad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bladder Cancer ◽  
Cancer Patients ◽  
Multivariable Analysis ◽  
Multiple Linear Regression Model ◽  
Disease Stage ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Lower Stage

466 Background: Bladder cancer requires treatment and surveillance which varies in intensity by disease stage. Our objective was to evaluate stage-specific differences in generic and bladder cancer-specific quality of life (QOL) among a large bladder cancer cohort. Methods: We performed a cross-sectional survey of bladder cancer patients using the Bladder Cancer Advocacy Network Patient Survey Network and Inspire platforms to determine generic and bladder cancer-specific QOL using the EORTC QLQ-C30 and Bladder Cancer Index. Patients were also queried regarding demographic, socioeconomic and clinical characteristics. We present descriptive statistics and a multiple linear regression model to identify factors independently associated with QOL domain score. Results: 972 respondents self-identified as patients with bladder cancer. Among respondents, 41% were female and 97% were white. The mean age was 67.6 years (range 29 to 93 years). Patients identified as having non-muscle-invasive bladder cancer (NMIBC, n=578 [63%]), MIBC (n=270, 30%), and metastatic bladder cancer (n=63, 7%). On bivariable analysis ( Table), lower stage was significantly associated with better generic (p<0.01) and bladder-cancer specific QOL (p<0.01). This associated persisted on multivariable analysis adjusted for age, sex, race, years since diagnosis, and comorbidity (p<0.01 for generic, urinary, sexual, and bowel QOL). Conclusions: Disease stage significantly impacts generic and bladder cancer-specific QOL among bladder cancer survivors. Differential impact by stage may be important for the development of tailored interventions to improve QOL for bladder cancer patients. [Table: see text]

Microscopic haematuria at time of diagnosis is associated with lower disease stage in patients with newly diagnosed bladder cancer

2015 ◽  
Vol 117 (5) ◽  
pp. 783-786 ◽  
Author(s):  
Daniel Ramirez ◽  
Amit Gupta ◽  
Daniel Canter ◽  
Brian Harrow ◽  
Ryan W. Dobbs ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Disease Stage ◽  
Microscopic Haematuria ◽  
Newly Diagnosed

Full analysis of the prostatic urethra at the time of radical cystoprostatectomy for bladder cancer: impact on final disease stage

2009 ◽  
Vol 455 (5) ◽  
pp. 449-453 ◽  
Author(s):  
Justine Varinot ◽  
Philippe Camparo ◽  
Morgan Roupret ◽  
Marc Olivier Bitker ◽  
Fréderique Capron ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prostatic Urethra ◽  
Disease Stage ◽  
Radical Cystoprostatectomy ◽  
Full Analysis

SOME GENERAL CHARACTERISTICS OF PATIENTS WITH THE BLADDER CANCER, HISTOPATHOLOGY AND THE RELATION WITH THE STAGE

2017 ◽  
pp. 22-28
Author(s):  
Van Mao Nguyen
Keyword(s):  
Bladder Cancer ◽  
Male Patient ◽  
Tumour Size ◽  
Cell Cancer ◽  
University Hospital ◽  
Disease Stage ◽  
Low Grade ◽  
Key Words Bladder Cancer ◽  
Histopathological Grade ◽  
The Times

Background: The tumourlike lesions of the bladder highly oriented as malignant tumours in which the urothelial type was predominant. Many factors were related to this disease, especially the age, gender and smoking have been indicated. The diagnosis, staging and the determination of the factor related to the disease stage were important for the treatment. Objectives: To describe some general characteristics of patients with the bladder cancer. To determine the relation between some general characteristics of patients with the bladder cancer, histopathological grade and the stage. Materials, method: cross - sectional study on 59 cases in Hue University Hospital and Hue Central Hospital from April, 2016 to March, 2017. Results: the male patients were dominant with M/F ratio: 3.2/1; the average age was 66,5, most of them were peasants and the smoking male patient was accounting for 61.0%; the tumours appeared for the first time were 64.4%, for the second time or more were 35.6%. Histopathology and the relation with the disease stage showed that: the most frequent type of cancer was urothelial (98.3%), the squamous cell cancer was only 1.7%; histopathologically, the high grade was frequent (83.1%) including the grade 2 (50.9%), grade 3 (32.2%) and the low grade (grade 1) of only 16.9%; the majority of the tumours were in muscular invave stage (79.7%) and the superficial ones were lower of only 20.3%; there was the relation between histopathological grade and the invasive stage; otherwise it didn’t find any relation between the times of history that patients affected or the tumour size with the stage of bladder cancer in this research. Conclusion: majority of the patients came at the late stage (muscular invasive tumour) and the number of bladder cancer in male was higher than in female, about 61% of male patient have been smoking. There was the relation between histopathological grade and the invasive stage; otherwise it didn’t find any relation between the times of history that patients affected or the tumour size with the stage of bladder cancer in this research. Key words: bladder cancer, histopathology, urothelial carcinoma, differentiation grade, stage, muscular invasion

Bladder cancer caregiver quality of life and patient cancer severity.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 456-456
Author(s):  
Kathryn Gessner ◽  
Sean McCabe ◽  
Pauline Filippou ◽  
Hannah McCloskey ◽  
Judy Hamad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Bladder Cancer ◽  
Cancer Patients ◽  
Well Being ◽  
Private Life ◽  
Disease Stage ◽  
Cancer Caregivers ◽  
The Impact

456 Background: Bladder cancer patients’ care is often managed by caregivers, yet caregiving can create a physiologic and emotional burden that compromises the caregivers’ own quality of life (QOL). Our objective was to determine the impact of disease stage on caregiver QOL among a large national cohort of bladder cancer patients. Methods: We performed a cross-sectional survey of bladder cancer caregivers using the Bladder Cancer Advocacy Network Patient Survey Network and Inspire platforms to determine caregiver QOL using the CareGiver QOL questionnaire (CarGOQoL). Caregivers were also queried regarding demographic, socioeconomic and clinical characteristics of their loved one. We present descriptive statistics and a multiple linear regression model to identify factors independently associated with QOL domain score. Results: 132 respondents self-identified as caregivers of patients with bladder cancer. Among respondents, 85% were a spouse, 86% were female, and 97% were white. The mean age was 63 years (range 34 to 72 years) and 73% of respondents completed college. The highest cancer stage for patients was non-invasive in 42%, muscle-invasive in 33%, and metastatic in 24%. On bivariable analysis, stage was associated with leisure and social support but was not associated with global QOL, psychologic or physical well-being, burden, relationship with healthcare, administration and finances, coping, self-esteem or private life. However, on multivariable analysis controlling for age, race, years since diagnosis, and comorbidity, stage was significantly associated with Caregiver QOL (p=0.04). Conclusions: Disease stage significantly impacts QOL among bladder cancer caregivers. As the caregiver is increasingly considered as a stakeholder in survivorship efforts, future interventions should consider targeting social support among caregivers of patients with advanced bladder cancer.

scholarly journals Survival rate of patients with bladder cancer and its related factors in Kurdistan Province (2013–2018): a population-based study

BMC Urology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Mozhdeh Amiri ◽  
Sofimajidpour Heshmatollah ◽  
Nader Esmaeilnasab ◽  
Jamshid Khoubi ◽  
Ebrahim Ghaderi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Survival Rate ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Disease Stage ◽  
Related Factors ◽  
Hazards Model

Abstract Background Bladder cancer is one of the most common urinary tract cancers. This study aims to estimate the survival rate of patients with bladder cancer according to the Cox proportional hazards model based on some key relevant variables. Methods In this retrospective population-based cohort study that explores the survival of patients with bladder cancer and its related factors, we first collected demographic information and medical records of 321 patients with bladder cancer through in-person and telephone interviews. Then, in the analysis phase, Kaplan–Meier method and log-rank test were used to draw the survival curve, compare the groups, and explore the effect of risk factors on the patient survival rate using Cox proportional hazards model. Results The median survival rate of patients was 63.2 (54.7–72) months and one, three and five-year survival rates were 87%, 68% and 54%, respectively. The results of multiple analyses using Cox's proportional hazards model revealed that variables of sex (male gender) (HR = 11.8, 95% CI: 0.4–100.7), more than 65 year of age (HR = 4.1, 95% CI: 0.4–11), occupation, income level, (HR = 0.4, 95% CI: 0.2–0.8), well differentiated tumor grade (HR = 3.2, 95% CI: 1.7–6) and disease stage influenced the survival rate of patients (p < 0.05). Conclusion The survival rate of patients with bladder cancer in Kurdistan province is relatively low. Given the impact of the disease stage on the survival rate, adequate access to appropriate diagnostic and treatment services as well as planning for screening and early diagnosis, especially in men, can increase the survival rate of patients.

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