Sex and Race (Black-White) Differences in the Relationship of Childhood Risk Factors to Adulthood Arterial Stiffness: The Bogalusa Heart Study

Background.—The ability to predict mortality is useful to clinicians, policy makers and insurers. At the current time, prediction of future mortality is still an inexact process with some proposing that epigenetic assessments could play a role in improving prognostics. In past work, we and others have shown that DNA methylation status at cg05575921, a well-studied measure of smoking intensity, is also a predictor of mortality. However, the exact extent of that predictive capacity and its independence of other commonly measured mortality risk factors are unknown. Objective.—To determine the capacity of methylation to predict mortality. Method.—We analyzed the relationship of methylation at cg05575921 and cg04987734, a recently described quantitative marker of heavy alcohol consumption, to mortality in the Offspring Cohort of the Framingham Heart Study using proportional hazards survival analysis. Results.—In this group of participants (n = 2278) whose average age was 66 ± 9 years, we found that the inclusion of both cg05575921 and cg04987734 methylation to a base model consisting of age and sex only, or to a model containing 11 commonly used mortality risk factors, improved risk prediction. What is more, prediction accuracy for the base model plus methylation data was increased compared to the base model plus known predictors of mortality (CHD, COPD, or stroke). Conclusion.—Cg05575921, and to a smaller extent cg04987734, are strong predictors of mortality risk in older Americans and that incorporation of DNA methylation assessments to these and other loci may be useful to population scientists, actuaries and policymakers to better understand the relationship of environmental risk factors, such as smoking and drinking, to mortality.

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Relation of Childhood Risk Factors to Left Ventricular Hypertrophy (Eccentric or Concentric) in Relatively Young Adulthood (from the Bogalusa Heart Study)

The American Journal of Cardiology ◽

10.1016/j.amjcard.2008.01.045 ◽

2008 ◽

Vol 101 (11) ◽

pp. 1621-1625 ◽

Cited By ~ 59

Author(s):

Ahmet Toprak ◽

Hongwei Wang ◽

Wei Chen ◽

Timir Paul ◽

Sathanur Srinivasan ◽

...

Keyword(s):

Risk Factors ◽

Left Ventricular Hypertrophy ◽

Young Adulthood ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

Bogalusa Heart Study ◽

Heart Study ◽

Childhood Risk Factors

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Racial (black-white) comparisons of the relationship of levels of endogenous sex hormones to serum lipoproteins during male adolescence: the Bogalusa Heart Study.

Circulation ◽

10.1161/01.cir.74.6.1226 ◽

1986 ◽

Vol 74 (6) ◽

pp. 1226-1234 ◽

Cited By ~ 26

Author(s):

S R Srinivasan ◽

D S Freedman ◽

G S Sundaram ◽

L S Webber ◽

G S Berenson

Keyword(s):

Sex Hormones ◽

Serum Lipoproteins ◽

Bogalusa Heart Study ◽

Heart Study ◽

Relationship Of ◽

The Relationship ◽

Endogenous Sex Hormones

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Dietary studies and the relationship of diet to cardiovascular disease risk factor variables in 10-year-old children — The Bogalusa Heart Study

American Journal of Clinical Nutrition ◽

10.1093/ajcn/31.2.328 ◽

1978 ◽

Vol 31 (2) ◽

pp. 328-340 ◽

Cited By ~ 109

Author(s):

G C Frank ◽

G S Berenson ◽

L S Webber

Keyword(s):

Cardiovascular Disease ◽

Risk Factor ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Cardiovascular Disease Risk Factor ◽

Bogalusa Heart Study ◽

Disease Risk Factor ◽

Heart Study ◽

Relationship Of ◽

The Relationship

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OS 04-08 THE RELATIONSHIP BETWEEN CHILDHOOD RISK FACTORS AND LONG-TERM ARTERIAL STIFFNESS — A 26-YEAR FOLLOW-UP STUDY

Journal of Hypertension ◽

10.1097/01.hjh.0000499999.95692.bd ◽

2016 ◽

Vol 34 (Supplement 1) ◽

pp. e57

Author(s):

Jianjun Mu ◽

Chao Chu ◽

Dan Wang ◽

Tongshuai Guo ◽

Yang Wang ◽

...

Keyword(s):

Risk Factors ◽

Arterial Stiffness ◽

Follow Up Study ◽

Childhood Risk Factors ◽

The Relationship

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The Relationship of the Atlantic Diet with Cardiovascular Risk Factors and Markers of Arterial Stiffness in Adults without Cardiovascular Disease

Nutrients ◽

10.3390/nu11040742 ◽

2019 ◽

Vol 11 (4) ◽

pp. 742 ◽

Cited By ~ 7

Author(s):

Carmela Rodríguez-Martín ◽

Luis Garcia-Ortiz ◽

Emiliano Rodriguez-Sanchez ◽

Carlos Maderuelo-Fernandez ◽

Alba Lugones-Sanchez ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Pulse Wave ◽

Diet And Physical Activity ◽

Relationship Of ◽

The Relationship

Background: Studying the adherence of the population to the Atlantic Diet (AD) could be simplified by an easy and quickly applied dietary index. The aim of this study is to analyse the relationship of an index measuring compliance with recommendations regarding the Atlantic diet and physical activity with cardiovascular disease risk factors, cardiovascular risk factors, obesity indexes and arterial stiffness markers. Methods: We included 791 individuals from the EVIDENT study (lifestyles and arterial ageing), (52.3 ± 12 years, 61.7% women) without cardiovascular disease. Compliance with recommendations on AD was collected through the responses to a food frequency questionnaire, while physical activity was measured by accelerometer. The number of recommendations being met was estimated using a global scale between 0 and 14 points (a higher score representing greater adherence). Blood pressure, plasma lipid and glucose values and obesity rates were measured. Cardiovascular risk was estimated with the Framingham equation. Results: In the overall sample, 184 individuals (23.3%) scored between 0–3 on the 14-point index we created, 308 (38.9%) between 4 and 5 points, and 299 (37.8%) 6 or more points. The results of multivariate analysis yield a common tendency in which the group with an adherence score of at least 6 points shows lower figures for total cholesterol (p = 0.007) and triglycerides (p = 0.002). Similarly, overall cardiovascular risk in this group is the lowest (p < 0.001), as is pulse wave velocity (p = 0.050) and the mean values of the obesity indexes studied (p < 0.05 in all cases). Conclusion: The rate of compliance with the Atlantic diet and physical activity shows that greater adherence to these recommendations is linked to lower cardiovascular risk, lower total cholesterol and triglycerides, lower rates of obesity and lower pulse wave velocity values.

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The Relationship of Modifiable Risk Factors with Indicators of Arterial Stiffness and Vascular Age in Patients with Arterial Hypertension

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2021-02-12 ◽

2021 ◽

Vol 17 (1) ◽

pp. 42-48

Author(s):

A. M. Tuktarov ◽

T. S. Kazanceva ◽

A. E. Filippov ◽

A. G. Obrezan

Keyword(s):

Risk Factors ◽

Arterial Stiffness ◽

Arterial Hypertension ◽

Pulse Wave ◽

Modifiable Risk Factors ◽

Hypertensive Patients ◽

Vascular Age ◽

The Mean ◽

Relationship Of ◽

The Relationship

Aim. To study the relationship of modifiable risk factors (RF) with indicators of arterial stiffness and vascular age based on the contour analysis of the pulse wave velocity in hypertensive patients.Material and methods. The material of the study was the data from a survey of patients undergoing clinical observation at the polyclinic of MMC SOGAZ. A total of 107 patients were examined, in which 70 were men and 37 were women. The average age was 52.3±18.29. Photoplethysmography was used as a special research method, performed using the AngioScan-01 diagnostic complex. The main indicators used to evaluate the stiffness of large vessels were: stiffness index (SI), reflection index (RI), augmentation index (Alp75), age index (AGI), pulse wave types (PV) and vascular age (VA).Results. The mean values of arterial stiffness indices in patients with essential arterial hypertension (AH) and healthy individuals (control) had significant differences. The mean SI, Alp75, and VA values in the group of patients with AH were 7.8±1.03, 7.0±14.44 and 50.8±15.93 versus 7.2±1.73, 0.5±18.02 and 43.8±16.94, respectively (p< 0.05). In both groups, a strong inverse correlation of passport age with C-type PV was revealed (r=0.74, p< 0.01), which reflected the dynamics of a gradual age-dependent decrease in vascular compliance. The average VA value in the control group was 63.1±16.99 years with an average passport age of 59.5±8.79 years, which significantly differed from VA in hypertensive patients (p< 0,05). Overweight, hypercholesterolemia, elevated low-density lipoprotein levels, lack of adequate antihypertensive control, and left ventricular diastolic dysfunction were significantly associated with early vascular (arterial) aging.Conclusion. Patients with hypertension, in addition to high blood pressure, significantly differ from normotensive control in terms of arterial stiffness. The lack of control over modifiable RF of patients with hypertension is associated with early vascular aging.

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