Role of Xingnaojing Injection in treating acute cerebral hemorrhage

Objective: Hypertensive intracerebral hemorrhage (HICH) is one of the common multiple diseases in neurology. Patients with severe HICH have high risk of disability and poor prognosis. Methods: In order to explore the clinical effect of mild hypothermia combined with micro-traumatic evacuation of cerebral hemorrhage in the treatment of severe HICH, 136 patients with severe HICH were selected and divided into control group and study group using random number table method, 68 each group. The control group was treated with micro-traumatic evacuation of cerebral hemorrhage on the basis of conventional symptomatic treatment, while the study group was treated with mild hypothermia combined with micro-traumatic evacuation of cerebral hemorrhage on the basis of conventional symptomatic treatment. After treatment, the two groups were followed up for eight weeks. Results: The overall effective rate, residual hematoma volume, rebleeding rate, National Institute of Health stroke scale (NIHSS) score, Barthel index score and incidence of adverse reactions after treatment were observed and compared. The overall effective rate of the study group was 89.7%, which was significantly higher than that of the control group (67.6%). The mortality rate of the study group was 3.0%, which was significantly lower than that of the control group (14.7%, P<0.05). The residual hematoma volume and rebleeding rate of the study group were significantly lower than those of the control group (P<0.05). Before treatment, the NIHSS score and Barthel index score of the two groups had no significant differences (P>0.05). After treatment, they were improved, and the improvement of the study group was more significant (P<0.05). The incidence of adverse reactions in the study group was 10.0%, which was significantly lower than that in the control group (36.0%, P<0.05). Conclusion: Mild hypothermia in combination with micro-traumatic evacuation of cerebral hemorrhage has significant clinical effect in the treatment of severe HICH. It can significantly improve neurological function and quality of life, causing few adverse reactions. Its clinical application value is high. doi: https://doi.org/10.12669/pjms.35.5.593 How to cite this:Zhang Y, Song L, Zhao J. Role of scalp hypothermia in patients undergoing minimally invasive evacuation of hypertensive cerebral hemorrhage. Pak J Med Sci. 2019;35(5):1451-1455. doi: https://doi.org/10.12669/pjms.35.5.593 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hereditary Cerebral Hemorrhage with Amyloidosis -Dutch Type: A Study of Fibrinolysis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648372 ◽

1992 ◽

Vol 67 (01) ◽

pp. 016-018 ◽

Cited By ~ 1

Author(s):

J Haan ◽

C Kluft ◽

F W G Leebeek ◽

A C W de Bart ◽

O J S Buruma ◽

...

Keyword(s):

Factor Viii ◽

Acute Phase ◽

Cerebral Hemorrhage ◽

Blood Levels ◽

Bleeding Tendency ◽

C Reactive Protein ◽

Reactive Protein ◽

Quiescent Phase ◽

Hemostasis Factors

SummaryIn view of reported associations between increased bleeding tendency and systemically decreased α2-antiplasmin in patients with systemic amyloid deposition we studied α2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with hereditary cerebral hemorrhage with amyloidosis - Dutch type (HCHWA-D).None of the factors measured in the quiescent phase of the disease was abnormal. In the acute phase, shortly after a stroke, only factor VIII: Ag was evidently elevated. We concluded that systemic abnormalities in the part of the fibrinolysis system studied are not likely to be responsible for multifocal and recurrent cerebral hemorrhages in HCHWA-D. The role of an elevated factor VIII: Ag level in the acute phase is unclear.

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E-024 acute cerebral hemorrhage with arteriovenous malformation (avm): role of angiographic – ct (dyna cta)

Journal of NeuroInterventional Surgery ◽

10.1136/neurintsurg-2015-011917.99 ◽

2015 ◽

Vol 7 (Suppl 1) ◽

pp. A52.3-A53

Author(s):

V Gupta ◽

G Goel ◽

R Parthasarathy ◽

A Gupta ◽

K Singh ◽

...

Keyword(s):

Arteriovenous Malformation ◽

Cerebral Hemorrhage ◽

Angiographic Ct

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Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. The role of amyloid in dementia and stroke

Alzheimer: 100 Years and Beyond - Research and Perspectives in Alzheimer’s Disease ◽

10.1007/978-3-540-37652-1_29 ◽

2006 ◽

pp. 243-246

Author(s):

Blas Frangione ◽

Jorge Ghiso

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cerebral Hemorrhage

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The role of ferritin and hemosiderin in the MR appearance of cerebral hemorrhage: a histopathologic biochemical study in rats.

American Journal of Roentgenology ◽

10.2214/ajr.154.5.2108542 ◽

1990 ◽

Vol 154 (5) ◽

pp. 1053-1059 ◽

Cited By ~ 20

Author(s):

K R Thulborn ◽

A G Sorensen ◽

N W Kowall ◽

A McKee ◽

A Lai ◽

...

Keyword(s):

Cerebral Hemorrhage ◽

Biochemical Study

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Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).

Bosnian Journal of Basic Medical Sciences ◽

10.17305/bjbms.2009.2791 ◽

2009 ◽

Vol 9 (4) ◽

pp. 342-248

Author(s):

Hilmi Islami ◽

Sadi Bexheti ◽

Ragip Shabani ◽

Bajram Nuraj ◽

Fehmi Zeqiri ◽

...

Keyword(s):

Respiratory System ◽

Cerebral Hemorrhage ◽

Meconium Aspiration Syndrome ◽

Tracheal Epithelium ◽

Control Group ◽

Meconium Aspiration ◽

Smooth Musculature ◽

Inflammatory Processes ◽

Tracheobronchial System

The role of meconium in the respiratory system was studied in newborns, who died from various causes (250 up to 3000 g of weight). We monitored tracheal rings response to dopamine, serotonin and ethanol in different concentrations (dopamine: 0,05 mg/ml, 0,5 mg/ml, 5 mg/ml; serotonin (5-HT): 10-4, 10-3, 10-2, 10-1 mol/dm3; ethanol: 0,02 ml, 0,5 ml, 1,0 ml; 96%). Tracheal smooth musculature tonus (TSM) was examined in 48 tracheal preparations taken after the newborn exitus due to different reasons. Based on functional researche of isolated preparations of tracheas, it may be concluded that: aspiration of me-conium has not changed the response of TSM to dopamine, serotonin and ethanol (p>0,1) in comparison with the control group, which have died due to different lung inflammatory processes (e.g. pneumonia, bronchopneumonia, atelectasis, cerebral hemorrhage). The results suggest that meconium does not potentiate the constricting action of dopamine, serotonin and ethanol in tracheobronchial system. Meconium causes mild relaxation of the TSM through a mechanism that is not intermediated by the products of cyclooxygenases (prostaglandins, prostacyclins) from the tracheal epithelium or proteins. Also, as it seems, the direct activity of many tested acids in the smooth musculature has no significant impact on increase of the airways tonus in MAS syndrome.

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