Knowledge, attitude, and behaviors toward liver health and viral hepatitis-related liver diseases in Thailand

Thrombocytopenia in liver diseases is considered to be due to splenic platelet pooling and accelerated destruction. Since thrombopoietin (TPO), a regulator of thrombopoiesis, is produced mainly in the liver, decreased production of TPO may account for thrombocytopenia in liver diseases. To address this issue, we measured serum TPO, using a sensitive sandwich ELISA, in 108 patients with chronic viral hepatitis, which included chronic hepatitis (CH) and liver cirrhosis (LC), and hepatocellular carcinoma (HCC), and in 29 normal controls. TPO mRNA in 78 liver samples was examined by reverse transcription (RT)-PCR. Platelet counts in CH, LC, HCC and controls were 176±15×109/l, 81±8×109/l, 99±7×109/l and 234±9×109/l respectively. Serum TPO levels in CH, LC and HCC were 2.79±0.4 fmol/ml, 1.49±0.2 fmol/ml and 1.97±0.2 fmol/ml, and were higher than those of controls. Serum TPO levels were positively correlated with prothrombin time and serum albumin (P < 0.05, in each case), and negatively correlated with Indocyanine Green test and Pugh score (P < 0.01 and P < 0.05 respectively). However, RT-PCR and immunohistochemistry showed that expression of TPO mRNA and protein were similar in the different liver diseases, suggesting that serum TPO is a reflection of the total mass of functional liver. Platelet counts were negatively correlated with spleen index, but not with serum TPO. These results suggest that thrombocytopenia in liver disease is not directly associated with serum TPO but is associated with hypersplenism.

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Bone density and metabolism in patients with viral hepatitis and cholestatic liver diseases before and after liver transplantation

The American Journal of Gastroenterology ◽

10.1111/j.1572-0241.2000.02269.x ◽

2000 ◽

Vol 95 (9) ◽

pp. 2343-2351 ◽

Cited By ~ 49

Author(s):

Christian Trautwein ◽

Martin Possienke ◽

Hans-Jorg Schlitt ◽

Klaus H.W. Boker ◽

Roland Horn ◽

...

Keyword(s):

Liver Transplantation ◽

Bone Density ◽

Viral Hepatitis ◽

Liver Diseases ◽

Before And After

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Liver disease

The ESC Handbook on Cardiovascular Pharmacotherapy ◽

10.1093/med/9780198759935.003.0022_update_001 ◽

2019 ◽

pp. 367-384

Author(s):

Nina Vodošek Hojs ◽

Aftab Ala ◽

Debasish Banerjee

Keyword(s):

Cardiovascular Disease ◽

Liver Disease ◽

Hepatitis C ◽

Fatty Liver ◽

Viral Hepatitis ◽

Liver Dysfunction ◽

Fatty Liver Disease ◽

Liver Diseases ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Cardiovascular disease in patients with liver disease, previously uncommon, is rising because of an increasing incidence of non-alcoholic fatty liver disease and better survival of patients with viral hepatitis, particularly hepatitis C. Liver dysfunction alters the pharmacokinetics and pharmacodynamics of many drugs, and hence careful use and dose adjustments are necessary. This chapter describes common cardiovascular conditions and the pharmacotherapy in patients with different liver diseases.

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Diagnostic Accuracy of Serological Markers in Viral Hepatitis and Non Alcoholic Fatty Liver Disease. A Comparative Study in Tertiary Care Hospital of Western Nepal

Nepal Journal of Epidemiology ◽

10.3126/nje.v1i2.5137 ◽

1970 ◽

Vol 1 (2) ◽

pp. 60-63

Author(s):

Ankush Mittal ◽

Brijesh Sathian ◽

Nishida Chandrasekharan ◽

Akshay Lekhi ◽

Shamim Mohammad Farooqui ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Viral Hepatitis ◽

Fatty Liver Disease ◽

Liver Diseases ◽

Serological Markers ◽

Alcoholic Fatty Liver ◽

Nonalcoholic Fatty Liver ◽

Non Invasive ◽

Alcoholic Fatty Liver Disease

Background: Liver diseases is apparently increasing and emerging as a major public health problem. Worldwide, chronic hepatitis B has become the tenth leading cause of death and persons infected with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV), are about 350 million and 125 million respectively. The aim of current retrospective comparative study was concerned primarily to evaluate the significance of non invasive serological markers for diagnosing liver diseases and their predictive implications in Pokhara valley. Materials and Methods: It was a hospital based retrospective study carried out using the data maintained in the Department of Biochemistry of the Manipal Teaching Hospital, Pokhara, Nepal between 1st June 2009 and 31st October 2010. The variables collected were total protein, albumin, AST, ALT, total bilirubin, direct bilirubin. Descriptive statistics and testing of hypothesis were used for the analysis. Data was analyzed using EPI INFO and SPSS 16 software. Results: Of 515 subjects, 120 were suffering from viral hepatitis and 88 had non alcoholic fatty liver disease. In cases of viral hepatitis, mean values of AST (CI 730.65 to 902.68) and ALT (CI 648.14 to 847.59) were markedly increased as compared to controls. Mild to moderate elevations in serum levels of aspartate aminotransferase (CI 43.42 to 49.49), alanine aminotransferase (CI 43.90 to 53.92) were the most common laboratory abnormalities found in patients with nonalcoholic fatty liver disease. Conclusion: Non invasive tests have demonstrated a reasonable ability to identify significant fibrosis, cirrhosis in particular, nor is it surprising that liver disease specialists and patients favour a non invasive approach.Key words: Viral hepatitis; Nonalcoholic fatty liver disease; Nepal.DOI: http://dx.doi.org/10.3126/nje.v1i2.5137 Nepal Journal of Epidemiology 2011;1 (2):60-63

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A systematic assessment of acute viral hepatitis and chronic liver diseases in northeast India with special reference to strengthening of laboratories in the region

Journal of Hepatology ◽

10.1016/s0168-8278(20)32122-x ◽

2020 ◽

Vol 73 ◽

pp. S840

Author(s):

Harpreet Kaur ◽

Vijaya Kumar Karra ◽

Sangit Dutta ◽

Lokeshwar Singh ◽

Kyrshanlang G Lynrah ◽

...

Keyword(s):

Special Reference ◽

Viral Hepatitis ◽

Liver Diseases ◽

Acute Viral Hepatitis ◽

Northeast India ◽

Chronic Liver ◽

Chronic Liver Diseases ◽

Systematic Assessment

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Knowledge, Attitudes, and Behaviors of Viral Hepatitis Among Recent African Immigrants in the United States: A Community Based Participatory Research Qualitative Study

Frontiers in Public Health ◽

10.3389/fpubh.2020.00025 ◽

2020 ◽

Vol 8 ◽

Cited By ~ 1

Author(s):

Essa A. Mohamed ◽

Nasra H. Giama ◽

Hassan M. Shaleh ◽

Linda Kerandi ◽

Abdul M. Oseini ◽

...

Keyword(s):

United States ◽

Qualitative Study ◽

Viral Hepatitis ◽

Participatory Research ◽

Community Based Participatory Research ◽

African Immigrants ◽

The United States ◽

Community Based ◽

Attitudes And Behaviors ◽

And Behaviors

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Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease

Gastroenterology Research and Practice ◽

10.1155/2015/717431 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 20

Author(s):

Tomonori Sugita ◽

Katsushi Amano ◽

Masanori Nakano ◽

Noriko Masubuchi ◽

Masahiro Sugihara ◽

...

Keyword(s):

Differential Diagnosis ◽

Liver Disease ◽

Bile Acid ◽

Viral Hepatitis ◽

Healthy Volunteers ◽

Biliary Tract ◽

Liver Diseases ◽

Biliary Tract Disease ◽

Serum Bile Acid ◽

Biliary Tract Diseases

Objectives. We determined the serum bile acid (BA) composition in patients with liver diseases and healthy volunteers to investigate the relationship between the etiologies of liver disease and BA metabolism.Material and Methods. Sera from 150 patients with liver diseases and 46 healthy volunteers were obtained. The serum concentrations of the 16 different BAs were determined according to the LC-MS/MS method and were compared between the different liver diseases.Results. A total of 150 subjects, including patients with hepatitis C virus (HCV) (n=44), hepatitis B virus (HBV) (n=23), alcoholic liver disease (ALD) (n=21), biliary tract disease (n=20), nonalcoholic fatty liver disease (NAFLD) (n=13), and other liver diseases (n=29), were recruited. The levels of UDCA and GUDCA were significantly higher in the ALD group, and the levels of DCA and UDCA were significantly lower in the biliary tract diseases group than in viral hepatitis group. In the UDCA therapy (−) subgroup, a significantly lower level of TLCA was observed in the ALD group, with lower levels of CDCA, DCA, and GLCA noted in biliary tract diseases group compared to viral hepatitis group.Conclusions. Analysis of the BA composition may be useful for differential diagnosis in liver disease.

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S-adenosylmethionine in Liver Health, Injury, and Cancer

Physiological Reviews ◽

10.1152/physrev.00047.2011 ◽

2012 ◽

Vol 92 (4) ◽

pp. 1515-1542 ◽

Cited By ~ 250

Author(s):

Shelly C. Lu ◽

José M. Mato

Keyword(s):

Liver Diseases ◽

Mammalian Cells ◽

Human Liver ◽

Normal Liver ◽

Experimental Models ◽

Chemopreventive Agent ◽

Liver Health ◽

Liver Transaminases ◽

Extrahepatic Tissues ◽

Cholestasis Of Pregnancy

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver. Biosynthesis of AdoMet requires the enzyme methionine adenosyltransferase (MAT). In mammals, two genes, MAT1A that is largely expressed by normal liver and MAT2A that is expressed by all extrahepatic tissues, encode MAT. Patients with chronic liver disease have reduced MAT activity and AdoMet levels. Mice lacking Mat1a have reduced hepatic AdoMet levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). In these mice, several signaling pathways are abnormal that can contribute to HCC formation. However, injury and HCC also occur if hepatic AdoMet level is excessive chronically. This can result from inactive mutation of the enzyme glycine N-methyltransferase (GNMT). Children with GNMT mutation have elevated liver transaminases, and Gnmt knockout mice develop liver injury, fibrosis, and HCC. Thus a normal hepatic AdoMet level is necessary to maintain liver health and prevent injury and HCC. AdoMet is effective in cholestasis of pregnancy, and its role in other human liver diseases remains to be better defined. In experimental models, it is effective as a chemopreventive agent in HCC and perhaps other forms of cancer as well.

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