Occurrence of and Risk Factors for Diabetes Mellitus in Chinese Patients With Chronic Pancreatitis

Background: Pancreatic cancer is a very rare cancer with age-adjusted rates ranging from about 5 to 10 new cases per 100,000 persons per year. It has one of the worst prognoses of any type of cancer, with a 5-year survival rate of only 4.6%. Several risk factors have been identified, including older age, smoking, familial history of pancreatic cancer, obesity, chronic pancreatitis, diabetes mellitus, and alcohol consumption.Method: This was a descriptive study describing the risk factors of patients who were diagnosed with pancreatic cancer in the period between 1 January 2014 – 1 January 2019 at the Cipto Mangunkusumo National Referral Hospital (RSCM) Jakarta. Data were obtained from the medical records and Endoscopic Retrograde Cholangiopancreatography (ERCP) database from the RSCM Gastrointestinal Endoscopy Center.Results: From January 2014 to January 2019 there were 123 patients with newly diagnosed pancreatic cancer in RSCM. The mean age was 52 years old. The incidence of pancreatic cancer is more common in men (53%) than women (47%). The most common risk factor identified is smoking which was found in 29% of patients, followed by obesity at 27.9% and a history of diabetes mellitus at 19.5%. Risk factors with a fairly low prevalence include alcohol consumption at 9.7% and chronic pancreatitis at 2.4%. No family history of pancreatic cancer is identified in any subject.Conclusion: Smoking, obesity, and diabetes mellitus are common risk factors in pancreatic cancer patients. In contrast, chronic pancreatitis, alcohol consumption, and family history of pancreatic cancer are less commonly identified in patients.

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Risk factors of recurrent erysipelas in adult Chinese patients: a prospective cohort study

BMC Infectious Diseases ◽

10.1186/s12879-020-05710-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ang Li ◽

Ni Wang ◽

Lingzhi Ge ◽

Hongyan Xin ◽

Wenfei Li

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Venous Insufficiency ◽

Proportional Hazards ◽

Univariate Analysis ◽

Cox Proportional Hazards ◽

Chinese Patients ◽

First Episode ◽

Common Skin

Abstract Background Erysipelas is a common skin infection that is prone to recur. Recurrent erysipelas has a severe effect on the quality of life of patients. The present study aimed to investigate the risk factors of recurrent erysipelas in adult Chinese patients. Methods A total of 428 Chinese patients with erysipelas who met the inclusion criteria were studied. The patients were divided into the nonrecurrent erysipelas group and the recurrent erysipelas group. Clinical data were collected on the first episode and relapse of erysipelas. The patients were followed up every 3 months. Statistical analysis was performed to analyze and determine the risk factors of erysipelas relapse. Results Univariate analysis was performed to analyze the data, including surgery, types of antibiotics administered in the first episode, obesity, diabetes mellitus, venous insufficiency, lymphedema, and malignancy. The differences between the groups were statistically significant (p < 0.05). The Cox proportional hazards regression model analysis showed that the final risk factors included surgery, obesity, diabetes mellitus, venous insufficiency, and lymphedema. Conclusions Surgery, obesity, diabetes mellitus, venous insufficiency, and lymphedema are considered as risk factors for recurrent erysipelas.

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Association of diabetic retinopathy and diabetic macular oedema with renal function in southern Chinese patients with type 2 diabetes mellitus: a single-centre observational study

BMJ Open ◽

10.1136/bmjopen-2019-031194 ◽

2019 ◽

Vol 9 (9) ◽

pp. e031194 ◽

Cited By ~ 5

Author(s):

Xuenan Zhuang ◽

Dan Cao ◽

Dawei Yang ◽

Yunkao Zeng ◽

Honghua Yu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Renal Function ◽

Diabetic Macular Oedema ◽

Chinese Patients ◽

Single Centre ◽

Southern Chinese

Background and objectivesThe association of diabetic retinopathy (DR) and diabetic macular oedema (DME) with renal function in southern Chinese patients with diabetes is poorly understood. So we aimed to study the correlation between stage of DR and DME with stage of estimated glomerular filtration rate (eGFR) and stage of urine albumin-to-creatinine ratio (UACR), and to explore the systemic risk factors for DR and DME.Design and settingThis single-centre retrospective observational study was conducted from December 2017 to November 2018.Participants413 southern Chinese patients with type 2 diabetes mellitus.Outcome measuresThe correlations between stage of DR and DME with stage of eGFR/UACR were assessed by Spearman’s or χ² analyses and represented with histograms. Risk factors associated with the occurrence of DR and DME were performed by logistic regression and represented with nomograms.ResultsStage of DR had a positive correlation with stage of eGFR (r=0.264, p<0.001) and stage of UACR (r=0.542, p<0.001). With the stage of eGFR/UACR being more severe, the prevalence of DME became higher as well (both p<0.001). The risk factors for DR were DM duration (OR 1.072; 95% CI 1.032 to 1.114; p<0.001), stage of UACR (OR 2.001; 95% CI 1.567 to 2.555; p<0.001) and low-density lipoprotein (LDL) (OR 1.301; 95% CI 1.139 to 1.485; p<0.001), while risk factors for DME were stage of UACR (OR 2.308; 95% CI 1.815 to 2.934; p<0.001) and LDL (OR 1.460; 95% CI 1.123 to 1.875; p=0.008).ConclusionsAmong southern Chinese patients, stage of DR and DME were positively correlated with renal function, while stage of UACR performed a better relevance than stage of eGFR.

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Relationship between healthy lifestyle behaviors and cardiovascular risk factors in Chinese patients with type 2 diabetes mellitus: a subanalysis of the CCMR-3B STUDY

Acta Diabetologica ◽

10.1007/s00592-017-0981-2 ◽

2017 ◽

Vol 54 (6) ◽

pp. 569-579 ◽

Cited By ~ 8

Author(s):

Yuxin Huang ◽

◽

Jihu Li ◽

Xiaolin Zhu ◽

Jiao Sun ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cardiovascular Risk ◽

Healthy Lifestyle ◽

Chinese Patients ◽

Lifestyle Behaviors ◽

Healthy Lifestyle Behaviors

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Pancreatic Cancer in a Young Male in His Twenties

Korean Journal of Medicine ◽

10.3904/kjm.2020.95.1.50 ◽

2020 ◽

Vol 95 (1) ◽

pp. 50-55

Author(s):

Seung-Ho Baek ◽

Seung Soo Lee ◽

Ji Hoon Kim ◽

So Hyun Kim ◽

Jihye Lim ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Pancreatic Cancer ◽

Chronic Pancreatitis ◽

Literature Review ◽

Elderly Patients ◽

Early Onset ◽

Young Male ◽

The Elderly ◽

Genetic Mutations

Pancreatic cancer is one of the most lethal malignancies worldwide. The risk of developing pancreatic cancer increases with age. Pancreatic cancer is seen mostly in the elderly; patients under the age of 30 years are rare. Known risk factors for pancreatic cancer include genetic mutations, smoking, chronic pancreatitis, and diabetes mellitus. We report a case of pancreatic cancer in a 27-year-old man without the PRSS1 mutation. Chronic pancreatitis and smoking may have contributed to the development of pancreatic cancer in this patient. We also conducted a literature review on early onset pancreatic cancer.

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Patient characteristics of hypoglycemia in type 2 diabetes mellitus in China: a retrospective cohort study and data analysis

10.21203/rs.2.11116/v1 ◽

2019 ◽

Author(s):

yongwen zhang ◽

Huanhuan Han ◽

Lanfang Chu

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cognitive Impairment ◽

Retrospective Cohort ◽

Severe Hypoglycemia ◽

Patient Characteristics ◽

Chinese Patients

Abstract Background: The goals of the present study were to quantify incidence rate of hypoglycemia, in-vestigate risk factors for hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and suggest preventive measures. Methods: This study was a retrospective cohort, multicenter, non-interventional study of hypogly-cemic events, used previously acquired data from 10,359 patients with T2DM, who were treated between March 2015 and March 2018. Two aspects of our research were investigated: (i) retrospec-tive study to assess the incidence of hypoglycemia during hospitalization; and (ii) to determine the relationship between hypoglycemia and risk factors such as age, HbA1c, complications, duration of DM, insulin and/or SU use, and cognitive impairment. Results: Overall, 9,993 patients were included in the full analysis set, 376 patients were identified hypoglycemia in the database. Demographic characteristics of patients with T2DM were similar between hypoglycemia and non-hypoglycemia groups, significant differences were not observed between the groups, except for cognitive impairment (p =0.037). The most common cause of hypo-glycemia was drug overdose/misuse (34.2%), irregular diet (21.3%), and excessive physical activity (13.8%). Most of the hypoglycemic episodes occurred before and after lunch (39.4% between 10:00 and 13:00). Retrospective rates (events per patient per month [PPPM]) of overall, severe, and noc-turnal hypoglycemia were 3.83 events PPPM (95% CI 1.90–5.80), 1.17 events PPPM (95% CI 0.78-1.56), and 0.07 events PPPM (95% CI 0.05-0.09). Multivariate model analysis showed that the use of SU (OR=3.162, p = 0.040) and insulin (OR= 2.414, p = 0.017) were associated with hypo-glycemic events. Logistic regression analysis of the variables revealed that significant positive as-sociation of the frequency of overall and severe hypoglycemia with age (beta=0.855, p=0.018; be-ta=1.343, p=0.015) and duration of DM (beta=1.248, p=0.025; beta=0.947, p=0.014). Conclusions: The present study shows that advanced age, duration of DM, cognitive dysfunction, and insulin and/or SU use are the main causes of hypoglycemia in Chinese patients with T2DM. Education on hypoglycemia, appropriate use of antidiabetic drugs and avoidance of related risk factors are essential for patients with DM.

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