scholarly journals Ending an HIV epidemic among persons who inject drugs (PWID) in a middle-income country

AIDS ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Don C. Des Jarlais ◽  
Huong Duong Thi ◽  
Oanh Khuat Thi Hai ◽  
Jonathan P. Feelemyer ◽  
Kamyar Arasteh ◽  
...  
PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259983
Author(s):  
Don C. Des Jarlais ◽  
Kamyar Arasteh ◽  
Duong Thi Huong ◽  
Khuat Thi Hai Oanh ◽  
Jonathan P. Feelemyer ◽  
...  

Aims To describe the use of large-scale respondent driven sampling (RDS) surveys to demonstrate the “end of an HIV epidemic” (HIV incidence < 0.5/100 person-years) among persons who inject drugs (PWID) in a middle-income country. Large sample sizes are needed to convincingly demonstrate very low incidence rates. Methods 4 large surveys (Ns approximately 1500 each) were conducted among PWID in Hai Phong, Vietnam in 2016–2019. Respondent driven sampling (RDS) with a modification to add snowball sampling was used for recruiting participants. HIV incidence was measured through recency testing, repeat participants across multiple surveys and in a cohort study of PWID recruited from the surveys. RDS analytics (time to equilibria and homophilies for major variables) were used to assess similarities/differences in RDS only versus RDS plus snowball recruiting. Characteristics were compared among respondents recruited through standard RDS recruitment versus through snowball sampling. An overall assessment of the robustness of RDS to modification was made when adding a snowball sampling recruitment. Results RDS recruiting was very efficient in the first 5 weeks of each survey with approximately 180 respondents recruited per week. Recruiting then slowed considerably, and snowball sampling (permitting an individual respondent to recruit large numbers of new respondents) was added to the existing RDS recruiting. This led to recruiting within 13–14 weeks of 1383, 1451, 1444 and 1268 respondents, close to the target of 1500 respondents/survey. Comparisons of participants recruited through standard RDS method and respondents recruited through snowball methods showed very few significant differences. RDS analytics (quickly reaching equilibria, low homophilies) were favorable for both RDS recruited and total numbers of participants in each survey. DRug use and Infections in ViEtnam (DRIVE) methods have now been officially adopted in other provinces. Conclusions RDS appears to be quite robust with respect to adding a modest number of participants recruited through snowball sampling. Large sample sizes can provide compelling evidence for “ending an HIV epidemic” to policy makers in a PWID population in a middle income country setting.


2019 ◽  
Author(s):  
Quan-Hoang Vuong

Valian rightly made a case for better recognition of women in science during the Nobel week in October 2018 (Valian, 2018). However, it seems most published views about gender inequality in Nature focused on the West. This correspondence shifts the focus to women in the social sciences and humanities (SSH) in a low- and middle-income country (LMIC).


Author(s):  
Bridget Pratt

Health research funded by organizations from HICs and conducted in low- and middle-income countries has grown significantly since 1990. Power imbalances and inequities frequently (but not always) exist at each stage of the international research process. Unsurprisingly then, a variety of ethical concerns commonly arise in the context of international health research, such as inequities in funding, the semi-colonial nature of international research models, the brain drain of low- and middle-income country researchers, and inequities in partnerships between HIC and low- and middle-income country researchers. In this chapter, these (and other) ethical concerns are introduced and the following ethical concepts to address the concerns are then discussed: responsiveness, standard of care, benefit sharing, community engagement, and social value. Existing guidance and remaining debates about how to specify each of the concepts are summarized. The chapter concludes by highlighting the existence of epistemic injustices within the field of international research ethics.


Author(s):  
Margo S Harrison

Abstract Background A secondary analysis was conducted of two separate datasets to observe the association between maternal age and interpregnancy interval (IPI). Methods The IPI in a middle-income country (Guatemala) was compared with that of a very-high-income country (USA) among women with two pregnancies. Results A regression model found that with each increasing year of age, the IPI increases by 1.26 months (p&lt;0.001) in Guatemala. A regression model found that IPI decreased as women aged in the USA. Conclusions It is hypothesized that as countries progress in their development indices, women may delay childbearing, which may result in reduced IPI, as was the case in the USA compared with Guatemala in these datasets.


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