scholarly journals Observations on the effects which take place from the destruction of the membrana tympani of the ear. By Mr. Astley Cooper. In a letter to Everard Home, Esq. F. R. S., by whom some remarks are added

Keyword(s):  

The case to which we owe the observations contained in this paper, is that of a youth, who at the age of ten was attacked with an inflammation and suppuration in the left ear, which continued discharging matter for several weeks; and who after the space of about a twelvemonth had the same symptoms in his right ear, the discharge in both cases being thin and fetid, and conveying many small bones and particles of bones. On probing the ears when the youth was about twenty years of age, it was found that the membrane tympani of the left ear was totally destroyed, and that but a small part of it remained in the right ear. So free was the passage through both the ears, that the patient, by closing his nostrils and contracting his cheeks, could with ease force the air from the mouth through the meatus auditorius; and yet what is most remarkable, the sense of hearing was by no means materially impaired by this imperfection; especially in the left ear, where the whole of the membrane was dissolved. The organ even retained a nice musical discrimination.

2019 ◽  
Vol 48 (2) ◽  
pp. 030006051985428 ◽  
Author(s):  
Yi-Ping Wei ◽  
Yu-Cheng Lai ◽  
Wei-Ning Chang

Management of pediatric septic coxarthritis and osteomyelitis of the femur is challenging, and the sequelae of multiplanar hip joint deformity with instability are difficult to reconstruct. The inadequacy of a suitable device for fixing small bones during pediatric osteotomy is a hindrance to the correction of subluxated hip joints and deformed femurs in children. Two-dimensional axial images and three-dimensional (3D) virtual models representing the patient’s individual anatomy are usually reserved for more complex cases of limb deformity. 3D printing technology can be used for preoperative planning of complex pediatric orthopedic surgery. However, there is a paucity of literature reports regarding the application of 3D-printed bone models for pediatric post-osteomyelitis deformity. We herein present a case of a 4-year-old boy who underwent treatment for post-osteomyelitis deformity. We performed corrective surgery with Pemberton osteotomy of the right hip, multilevel varus derotation osteotomy of the right femur, and immobilization with a hip spica cast. A 3D-printed bone model of this patient was used to simulate the surgery, determine the proper osteotomy sites, and choose the appropriate implant for the osteotomized bone. A satisfactory clinical outcome was achieved.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maryada Venkateshwar Reddy ◽  
Anjaneyulu Kandukuri ◽  
Vidyasagar Chandankere ◽  
Vinay Mathew Joseph ◽  
Annappareddy Venkata Gurava Reddy

Introduction: Bizarre parosteal osteochondromatous proliferation (BPOP) is a rare bone pathology affecting small bones of hand and feet. This benign lesion needs to be distinguished from many malignant bone tumors as it poses a diagnostic dilemma due to its clinical, radiological, and histological picture. We report three cases of BPOP affecting the hand and foot. Case 1: A 21-year-old gentleman presented with painful swelling in the long finger of the right hand. A plain radiograph showed a radio dense mass which was later excised and diagnosis confirmed in histopathology. There was no recurrence in 2 years of follow-up. Case 2: A 5-year-old boy presented with painful swelling over the right ankle with no history of antecedent trauma. Following radiological evaluation, the patient was successfully treated with excision. Case 3: A 35-year-old lady presented with a painful swelling on the dorsal aspect of her hand which was gradually increasing in size. After radiological evaluation, the patient was successfully treated with excision and lesion confirmed to be BPOP on histological examination. She was symptom free without recurrence in up to 2 years of follow-up. Conclusion: Nora’s lesion is a rare pathology requiring high index of suspicion. Excision is the recommended mode of treatment. All our cases responded well with excision with immediate pain relief following surgery and no recurrence in up to 2 years of follow-up. Keywords: Nora, bizarre parosteal osteochondromatous proliferation, neoplasm, tumor, benign.


PEDIATRICS ◽  
1948 ◽  
Vol 1 (6) ◽  
pp. 767-770
Author(s):  
MCLEMORE BIRDSONG ◽  
CAMILLUS S. L'ENGLE

MULTIPLE cystic tuberculous cranial lesions are uncommon. Meng and Wu have reported 40 cases involving the skull, and Gibson has described 32 cases involving multiple lesions over the skeletal system. These two reports point out that in countries where tuberculosis is prevalent, multiple tuberculous lesions of other bones are common. Jungling called attention to multiple cystic lesions in the bones in nine cases and chose to refer to the condition as osteitis tuberculosa multiplex cystica. The lesions he described were in the small bones of the hands and feet almost entirely, and occurred in adults. A large majority of the cases mentioned were not confirmed by recovery of the tubercle bacillus from the lesions. In recent years Lyford, Hsieh, et al, Stalmann, Kelly and Sailer, Law and Perham, Martin, Fox, Frost, and Martin and Fogel, have all reported cases of multiple tuberculous bone lesions. Most of these cases have sufficient information to confirm the diagnosis. However, since proven cases of multiple cystic tuberculosis are uncommon in pediatric literature, this being the fourteenth case reported, it seem worth while to record it. History: No. 222,524, T.B.E., a 13 months old white male child, was admitted with a complaint of subcutaneous swellings and fever for eight months' duration. Except for several episodes of diarrhea the child was well until he was five months of age. At that time it was noticed that he had swellings on both sides of the neck. During the eight months prior to admission swellings appeared in the axilla, in the groin, on the anterior surface of the right upper leg, on the fourth finger of the right hand, and on the right side of the head. Some of the swellings attained the size of 1.5 cm. They did not increase or decrease in size. They never suppurated nor drained. The swellings were quite tender. At times the nodes softened, only to harden again. After the eighth month of life the child neither gained nor lost weight though he ate fairly well. He ran an intermittent fever, and, for one month prior to admission here, he ran a daily fever as high as 38.8°C. The child had been treated elsewhere with penicillin and X-ray therapy. A biopsy specimen taken from a node on the right side of the neck was sent to this hospital, and was reported as tuberculous adenitis. Past history revealed no exposure to tuberculosis. The mother and father had had negative chest X-rays elsewhere. The child had always received raw cow's milk.


2019 ◽  
Vol 3 (1) ◽  
pp. 01-03
Author(s):  
J.A. Enríquez-Castroa ◽  
G. Estévez-Díazb ◽  
J.G. Segoviano-Parrac

Giant cell tumours (GCT) are usually benign, locally aggressive tumours. They tend to occur in long bones and rarely in small bones, with an incidence rate of 1.2 to 2.4% in the bones of the foot. The objective is to present a unique case in the literature of a GCT that only affected the first cuneiform. We present the case of a 35-year-old male patient seen at Hospital General de México (HGM) with seven months history of pain and increased volume in the medial region of the right foot, with X-ray and MRI images consistent with GCT in first cuneiform of the right foot. The excisional biopsy confirmed GCT. The definitive treatment consisted of curettage, cryotherapy with nitrogen and heterologous bone graft placement. Evolution was satisfactory, with no pain, no volume increase, normal gait and radiographic bone graft integration. Follow-up was at six years.


Author(s):  
J. Anthony VanDuzer

SummaryRecently, there has been a proliferation of international agreements imposing minimum standards on states in respect of their treatment of foreign investors and allowing investors to initiate dispute settlement proceedings where a state violates these standards. Of greatest significance to Canada is Chapter 11 of the North American Free Trade Agreement, which provides both standards for state behaviour and the right to initiate binding arbitration. Since 1996, four cases have been brought under Chapter 11. This note describes the Chapter 11 process and suggests some of the issues that may arise as it is increasingly resorted to by investors.


2019 ◽  
Vol 42 ◽  
Author(s):  
Guido Gainotti

Abstract The target article carefully describes the memory system, centered on the temporal lobe that builds specific memory traces. It does not, however, mention the laterality effects that exist within this system. This commentary briefly surveys evidence showing that clear asymmetries exist within the temporal lobe structures subserving the core system and that the right temporal structures mainly underpin face familiarity feelings.


Author(s):  
J. Taft∅

It is well known that for reflections corresponding to large interplanar spacings (i.e., sin θ/λ small), the electron scattering amplitude, f, is sensitive to the ionicity and to the charge distribution around the atoms. We have used this in order to obtain information about the charge distribution in FeTi, which is a candidate for storage of hydrogen. Our goal is to study the changes in electron distribution in the presence of hydrogen, and also the ionicity of hydrogen in metals, but so far our study has been limited to pure FeTi. FeTi has the CsCl structure and thus Fe and Ti scatter with a phase difference of π into the 100-ref lections. Because Fe (Z = 26) is higher in the periodic system than Ti (Z = 22), an immediate “guess” would be that Fe has a larger scattering amplitude than Ti. However, relativistic Hartree-Fock calculations show that the opposite is the case for the 100-reflection. An explanation for this may be sought in the stronger localization of the d-electrons of the first row transition elements when moving to the right in the periodic table. The tabulated difference between fTi (100) and ffe (100) is small, however, and based on the values of the scattering amplitude for isolated atoms, the kinematical intensity of the 100-reflection is only 5.10-4 of the intensity of the 200-reflection.


Author(s):  
Russell L. Steere ◽  
Michael Moseley

A redesigned specimen holder and cap have made possible the freeze-etching of both fracture surfaces of a frozen fractured specimen. In principal, the procedure involves freezing a specimen between two specimen holders (as shown in A, Fig. 1, and the left side of Fig. 2). The aluminum specimen holders and brass cap are constructed so that the upper specimen holder can be forced loose, turned over, and pressed down firmly against the specimen stage to a position represented by B, Fig. 1, and the right side of Fig. 2.


Author(s):  
K.S. McCarty ◽  
N.R. Wallace ◽  
W. Litaker ◽  
S. Wells ◽  
G. Eisenbarth

The production of adrenocorticotropic hormone by non-pituitary carcinomas has been documented in several tumors, most frequently small cell carcinoma of the lung, islet cell carcinomas of the pancreas, thymomas and carcinoids. Electron microscopy of these tumors reveals typical membrane-limited "neurosecretory" granules. Confirmation of the granules as adrenocorticotropin (ACTH) requires the use of OsO4 as a primary fixative to give the characteristic cored granule appearance in conjunction with immunohistochemical demonstration of the hormone peptide. Because of the rarity of ectopic ACTH production by mammary carcinomas and the absence of appropriate ultrastructural studies in the two examples of such ectopic hormone production in the literature of which we are aware (1,2), we present biochemical and ultrastructural data from a carcinoma of the breast with apparent ACTH production.The patient had her primary tumor in the right breast in 1969. The tumor recurred as visceral and subcutaneous metastases in 1976 and again in 1977.


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