scholarly journals The experience of time: neural mechanisms and the interplay of emotion, cognition and embodiment

2009 ◽  
Vol 364 (1525) ◽  
pp. 1809-1813 ◽  
Author(s):  
Marc Wittmann ◽  
Virginie van Wassenhove

Time research has been a neglected topic in the cognitive neurosciences of the last decades: how do humans perceive time? How and where in the brain is time processed? This introductory paper provides an overview of the empirical and theoretical papers on the psychological and neural basis of time perception collected in this theme issue. Contributors from the fields of cognitive psychology, psychiatry, neurology and neuroanatomy tackle this complex question with a variety of techniques ranging from psychophysical and behavioural experiments to pharmacological interventions and functional neuroimaging. Several (and some new) models of how and where in the brain time is processed are presented in this unique collection of recent research that covers experienced time intervals from milliseconds to minutes. We hope this volume to be conducive in developing a better understanding of the sense of time as part of complex set of brain–body factors that include cognitive, emotional and body states.

2019 ◽  
Vol 31 (12) ◽  
pp. 1796-1826 ◽  
Author(s):  
Andrea Nani ◽  
Jordi Manuello ◽  
Donato Liloia ◽  
Sergio Duca ◽  
Tommaso Costa ◽  
...  

During the last two decades, our inner sense of time has been repeatedly studied with the help of neuroimaging techniques. These investigations have suggested the specific involvement of different brain areas in temporal processing. At least two distinct neural systems are likely to play a role in measuring time: One is mainly constituted of subcortical structures and is supposed to be more related to the estimation of time intervals below the 1-sec range (subsecond timing tasks), and the other is mainly constituted of cortical areas and is supposed to be more related to the estimation of time intervals above the 1-sec range (suprasecond timing tasks). Tasks can then be performed in motor or nonmotor (perceptual) conditions, thus providing four different categories of time processing. Our meta-analytical investigation partly confirms the findings of previous meta-analytical works. Both sub- and suprasecond tasks recruit cortical and subcortical areas, but subcortical areas are more intensely activated in subsecond tasks than in suprasecond tasks, which instead receive more contributions from cortical activations. All the conditions, however, show strong activations in the SMA, whose rostral and caudal parts have an important role not only in the discrimination of different time intervals but also in relation to the nature of the task conditions. This area, along with the striatum (especially the putamen) and the claustrum, is supposed to be an essential node in the different networks engaged when the brain creates our sense of time.


2017 ◽  
Author(s):  
Cameron Parro ◽  
Matthew L Dixon ◽  
Kalina Christoff

AbstractCognitive control mechanisms support the deliberate regulation of thought and behavior based on current goals. Recent work suggests that motivational incentives improve cognitive control, and has begun to elucidate the brain regions that may support this effect. Here, we conducted a quantitative meta-analysis of neuroimaging studies of motivated cognitive control using activation likelihood estimation (ALE) and Neurosynth in order to delineate the brain regions that are consistently activated across studies. The analysis included functional neuroimaging studies that investigated changes in brain activation during cognitive control tasks when reward incentives were present versus absent. The ALE analysis revealed consistent recruitment in regions associated with the frontoparietal control network including the inferior frontal sulcus (IFS) and intraparietal sulcus (IPS), as well as consistent recruitment in regions associated with the salience network including the anterior insula and anterior mid-cingulate cortex (aMCC). A large-scale exploratory meta-analysis using Neurosynth replicated the ALE results, and also identified the caudate nucleus, nucleus accumbens, medial thalamus, inferior frontal junction/premotor cortex (IFJ/PMC), and hippocampus. Finally, we conducted separate ALE analyses to compare recruitment during cue and target periods, which tap into proactive engagement of rule-outcome associations, and the mobilization of appropriate viscero-motor states to execute a response, respectively. We found that largely distinct sets of brain regions are recruited during cue and target periods. Altogether, these findings suggest that flexible interactions between frontoparietal, salience, and dopaminergic midbrain-striatal networks may allow control demands to be precisely tailored based on expected value.


Author(s):  
Hugues Duffau

Investigating the neural and physiological basis of language is one of the most important challenges in neurosciences. Direct electrical stimulation (DES), usually performed in awake patients during surgery for cerebral lesions, is a reliable tool for detecting both cortical and subcortical (white matter and deep grey nuclei) regions crucial for cognitive functions, especially language. DES transiently interacts locally with a small cortical or axonal site, but also nonlocally, as the focal perturbation will disrupt the entire subnetwork sustaining a given function. Thus, in contrast to functional neuroimaging, DES represents a unique opportunity to identify with great accuracy and reproducibility, in vivo in humans, the structures that are actually indispensable to the function, by inducing a transient virtual lesion based on the inhibition of a subcircuit lasting a few seconds. Currently, this is the sole technique that is able to directly investigate the functional role of white matter tracts in humans. Thus, combining transient disturbances elicited by DES with the anatomical data provided by pre- and postoperative MRI enables to achieve reliable anatomo-functional correlations, supporting a network organization of the brain, and leading to the reappraisal of models of language representation. Finally, combining serial peri-operative functional neuroimaging and online intraoperative DES allows the study of mechanisms underlying neuroplasticity. This chapter critically reviews the basic principles of DES, its advantages and limitations, and what DES can reveal about the neural foundations of language, that is, the large-scale distribution of language areas in the brain, their connectivity, and their ability to reorganize.


Author(s):  
Mark A Thornton ◽  
Diana I Tamir

Abstract The social world buzzes with action. People constantly walk, talk, eat, work, play, snooze and so on. To interact with others successfully, we need to both understand their current actions and predict their future actions. Here we used functional neuroimaging to test the hypothesis that people do both at the same time: when the brain perceives an action, it simultaneously encodes likely future actions. Specifically, we hypothesized that the brain represents perceived actions using a map that encodes which actions will occur next: the six-dimensional Abstraction, Creation, Tradition, Food(-relevance), Animacy and Spiritualism Taxonomy (ACT-FAST) action space. Within this space, the closer two actions are, the more likely they are to precede or follow each other. To test this hypothesis, participants watched a video featuring naturalistic sequences of actions while undergoing functional magnetic resonance imaging (fMRI) scanning. We first use a decoding model to demonstrate that the brain uses ACT-FAST to represent current actions. We then successfully predicted as-yet unseen actions, up to three actions into the future, based on their proximity to the current action’s coordinates in ACT-FAST space. This finding suggests that the brain represents actions using a six-dimensional action space that gives people an automatic glimpse of future actions.


1997 ◽  
Vol 3 (4) ◽  
pp. 359-369 ◽  
Author(s):  
RUSSELL A. BARKLEY ◽  
SETH KOPLOWITZ ◽  
TAMARA ANDERSON ◽  
MARY B. McMURRAY

A recent theory of ADHD predicts a deficiency in sense of time in the disorder. Two studies were conducted to test this prediction, and to evaluate the effects of interval duration, distraction, and stimulant medication on the reproductions of temporal durations in children with ADHD. Study I: 12 ADHD children and 26 controls (ages 6–14 years) were tested using a time reproduction task in which subjects had to reproduce intervals of 12, 24, 36, 48, and 60 s. Four trials at each duration were presented with a distraction occurring on half of these trials. Control subjects were significantly more accurate than ADHD children at most durations and were unaffected by the distraction. ADHD children, in contrast, were significantly less accurate when distracted. Both groups became less accurate with increasing durations to be reproduced. Study II: Tested three doses of methylphenidate (MPH) and placebo on the time reproductions of the 12 ADHD children. ADHD children became less accurate with increasing durations and distraction was found to reduce accuracy at 36 s or less. No effects of MPH were evident. The results of these preliminary studies seem to support the prediction that sense of time is impaired in children with ADHD. The capacity to accurately reproduce time intervals in ADHD children does not seem to improve with administration of stimulant medication. (JINS, 1997, 3, 359–369.)


Agriculture ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 557
Author(s):  
Roberta Barrasso ◽  
Vincenzo Tufarelli ◽  
Edmondo Ceci ◽  
Francesco Luposella ◽  
Giancarlo Bozzo

The aim of this study was to evaluate the persistence of two signs of consciousness (rhythmic breathing and corneal reflex) in lambs slaughtered according to the traditional method and Halal ritual rite. A total of 240 lambs were examined and divided into two equal groups (n = 120 each). Lambs of group A were subjected to the stunning phase by the action of an electric current on the brain, while lambs of group B were slaughtered according to the religious Halal method without prior stunning. Rhythmic breathing (RB) and corneal reflex (CR) were used as indicators of prolonged brain function, and their evaluation was carried out by the operators in three subsequent steps at 15 s, 30 s, and 90 s post-bleeding, respectively. The stunning of the lambs reduced the animal’s state of consciousness and, consequently, reduced suffering, pain, and distress. Indeed, the lambs of group B showed longer duration consciousness than the animals stunned by electrodes. The permanence of the reflexes in Halal slaughter could be reduced by introducing a reversible stunning method to make the animal temporarily unconscious. Moreover, given that our results revealed consciousness also after 90 s post-cut, the assessment of the animal’s state of consciousness in wider time intervals than those commonly used is recommended.


2010 ◽  
Author(s):  
Αικατερίνη Χαραλαμποπούλου

In this study I have attempted to present a linguistic investigation into the nature and structure of time, based on proposals developed in Evans (2004). Accordingly, as linguistic structure and particularly patterns of elaboration reflect conceptual structure conventionalized into a format encodable in language, this study presents an examination of the human conceptual system for time. Indeed, an examination of the ways in which language lexicalizes time provides important insights into the nature and organization of time. That is, given the widely held assumption that semantic structure derives from and reflects, at least partially, conceptual structure, language offers a direct way of investigating the human conceptual system. However, how time is realized at the conceptual level, that is, how we represent time as revealed by the way temporal concepts are encoded in language, does not tell the whole story, if we are to uncover the nature and structure of time. Research in cognitive science suggests that phenomenological experience and the nature of the external world of sensory experience to which subjective experience constitutes a response, give rise to our pre- conceptual experience of time. In other words, as Evans (2004) says, time is not restricted to one particular layer of experience but it rather “constitutes a complex range of phenomena and processes which relate to different levels and kinds of experience” (ibid.: 5). Accordingly, while my focus in this study is on the temporal structure, which is to say the organization and structuring of temporal concepts, at the conceptual level, I have also attempted to present an examination of the nature of temporal experience at the pre-conceptual level (prior to representation in conceptual structure). In this regard, I have examined the results of research from neuroscience, cognitive psychology and social psychology. More specifically and with respect to evidence from neuroscience, it is suggested that temporal experience is ultimately grounded in neurological mechanisms necessary for regulating and facilitating perception (e.g., Pöppel 1994). That is, perceptual processing is underpinned by the occurrence of neurologically instantiated temporal intervals, the perceptual moments, which facilitate the integration of sensory information into coherent percepts. As we have seen, there is no single place in the brain where perceptual input derived from different modalities, or even information from within the same modality, can be integrated. In other words, there is no one place where spatially distributed sensory information associated with the distinct perceptual processing areas of the brain, are integrated in order to produce a coherent percept. Rather, what seems to be the case is that the integration of sensory information into coherent percepts is enabled by the phenomena of periodic perceptual moments. Such a mechanism enables us to perceive, in that the nature of our percepts are in an important sense ‘constructed’. Put another way, perception is a kind of constructive process which updates successive perceptual information to which an organism has access. The updating occurs by virtue of innate timing mechanisms, the perceptual moments, which occur at all levels of neurological processing and range from a fraction of second up to an outer limit of about three seconds. It is these timing mechanisms which form the basis of our temporal experience. As Gell says, “perception is intrinsically time-perception, and conversely, time-perception, or internal time-consciousness, is just perception itself...That is to say, time is not something we encounter as a feature of contingent reality, as if it lay outside us, waiting to be perceived along with tables and chairs and the rest of the perceptible contents of the universe. Instead, subjective time arises as inescapable feature of the perceptual process itself, which enters into the perception of anything whatsoever” (1992: 231). In other words, our experience of time is a consequence of the various innate ‘timing mechanisms' in the brain which give rise to a range of perceptual moments, which are in turn necessary for and underpin perceptual processing. In this way, time exists into the experience of everything as it is fundamental to the way in which perceptual process operates. […]


2021 ◽  
Vol 2021 (9) ◽  
pp. pdb.prot106872
Author(s):  
Ayako Yamaguchi

Understanding the neural basis of behavior is a challenging task for technical reasons. Most methods of recording neural activity require animals to be immobilized, but neural activity associated with most behavior cannot be recorded from an anesthetized, immobilized animal. Using amphibians, however, there has been some success in developing in vitro brain preparations that can be used for electrophysiological and anatomical studies. Here, we describe an ex vivo frog brain preparation from which fictive vocalizations (the neural activity that would have produced vocalizations had the brain been attached to the muscle) can be elicited repeatedly. When serotonin is applied to the isolated brains of male and female African clawed frogs, Xenopus laevis, laryngeal nerve activity that is a facsimile of those that underlie sex-specific vocalizations in vivo can be readily recorded. Recently, this preparation was successfully used in other species within the genus including Xenopus tropicalis and Xenopus victorianus. This preparation allows a variety of techniques to be applied including extracellular and intracellular electrophysiological recordings and calcium imaging during vocal production, surgical and pharmacological manipulation of neurons to evaluate their impact on motor output, and tract tracing of the neural circuitry. Thus, the preparation is a powerful tool with which to understand the basic principles that govern the production of coherent and robust motor programs in vertebrates.


2021 ◽  
Vol 2 (3) ◽  
pp. 146-158
Author(s):  
Nikolay N. Zavadenko

Dyslexia is the most common form of specific learning disabilities. Dyslexia is observed in 5-17.5 % of schoolchildren, and among children with specific learning disabilities, it accounts for about 70-80 %. Usually, dyslexia manifests itself as the inability to achieve an appropriate level of reading skills development that would be proportional to their intellectual abilities and writing and spelling skills. Secondary consequences of dyslexia may include problems in reading comprehension and reduced reading experience that can impede the growth of vocabulary and background skills. The review discusses neurological management of reading and writing as complex higher mental functions, including many components that are provided by various brain areas. The principles of dyslexia classification, the main characteristics of its traditionally defined forms are given: phonemic, optical, mnestic, semantic, agrammatic. The article analyzes the cerebral mechanisms of dyslexia development, the results of studies using neuropsychological methods, functional neuroimaging, and the study of the brain connectome. The contribution to dyslexia development of disturbances in phonological awareness, rapid automated naming (RAN), the volume of visual attention (VAS), components of the brain executive functions is discussed. The origin of emotional disorders in children with dyslexia, risk factors for dyslexia development (including genetic predisposition) are considered. Dyslexia manifestations in children are listed, about which their parents seek the advice of a specialist for the first time. In the process of diagnosing dyslexia, attention should be paid to the delay in the child’s speech development, cases of speech and language development disorders and specific learning disabilities among family members. It is necessary to consider possible comorbidity of dyslexia in a child with attention deficit hyperactivity disorder, dyscalculia, developmental dyspraxia, disorders of emotional control and brain executive functions. Timely diagnosis determines the effectiveness of early intervention programs based on an integrated multimodal approach.


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