scholarly journals Evaluation of the Lambs’ State of Consciousness Signs during Halal and Traditional Slaughtering

Agriculture ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 557
Author(s):  
Roberta Barrasso ◽  
Vincenzo Tufarelli ◽  
Edmondo Ceci ◽  
Francesco Luposella ◽  
Giancarlo Bozzo
Keyword(s):  
Electric Current ◽  
Brain Function ◽  
Traditional Method ◽  
Time Intervals ◽  
Corneal Reflex ◽  
Group A ◽  
Group B ◽  
The Brain

The aim of this study was to evaluate the persistence of two signs of consciousness (rhythmic breathing and corneal reflex) in lambs slaughtered according to the traditional method and Halal ritual rite. A total of 240 lambs were examined and divided into two equal groups (n = 120 each). Lambs of group A were subjected to the stunning phase by the action of an electric current on the brain, while lambs of group B were slaughtered according to the religious Halal method without prior stunning. Rhythmic breathing (RB) and corneal reflex (CR) were used as indicators of prolonged brain function, and their evaluation was carried out by the operators in three subsequent steps at 15 s, 30 s, and 90 s post-bleeding, respectively. The stunning of the lambs reduced the animal’s state of consciousness and, consequently, reduced suffering, pain, and distress. Indeed, the lambs of group B showed longer duration consciousness than the animals stunned by electrodes. The permanence of the reflexes in Halal slaughter could be reduced by introducing a reversible stunning method to make the animal temporarily unconscious. Moreover, given that our results revealed consciousness also after 90 s post-cut, the assessment of the animal’s state of consciousness in wider time intervals than those commonly used is recommended.

Regional blood flow in the brain and spinal cord of hypothermic rats

1989 ◽  
Vol 257 (3) ◽  
pp. H785-H790
Author(s):  
T. Sakamoto ◽  
W. W. Monafo
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Brain Stem ◽  
Regional Blood Flow ◽  
Experimental Conditions ◽  
Pentobarbital Sodium ◽  
Arterial Blood ◽  
Group A ◽  
Group B ◽  
The Brain

[14C]butanol tissue uptake was used to measure simultaneously regional blood flow in three regions of the brain (cerebral and cerebellar hemispheres and brain stem) and in five levels of the spinal cord in 10 normothermic rats (group A) and in 10 rats in which rectal temperature had been lowered to 27.7 +/- 0.3 degrees C by applying ice to the torso (group B). Pentobarbital sodium anesthesia was used. Mean arterial blood pressure varied minimally between groups as did arterial pH, PO2, and PCO2. In group A, regional spinal cord blood flow (rSCBF) varied from 49.7 +/- 1.6 to 62.6 +/- 2.1 ml.min-1.100 g-1; in brain, regional blood flow (rBBF) averaged 74.4 +/- 2.3 ml.min-1.100 g-1 in the whole brain and was highest in the brain stem. rSCBF in group B was elevated in all levels of the cord by 21-34% (P less than 0.05). rBBF, however, was lowered by 21% in the cerebral hemispheres (P less than 0.001) and by 14% in the brain as a whole (P less than 0.05). The changes in calculated vascular resistance tended to be inversely related to blood flow in all tissues. We conclude that rBBF is depressed in acutely hypothermic pentobarbital sodium-anesthetized rats, as has been noted before, but that rSCBF rises under these experimental conditions. The elevation of rSCBF in hypothermic rats confirms our previous observations.

PENGARUH KOMBINASI EKSTRAK JERUK BRASTAGI DAN WORTEL PER ORAL SEBELUM AKTIVITAS FISIK TERHADAP PENURUNAN KADAR MDA PLASMA MENCIT SETELAH AKTIVITAS FISIK

2017 ◽  
Vol 1 (1) ◽  
pp. 41
Author(s):  
Nurvidya Rachma Dewi ◽  
Ambrosius Purba ◽  
Beltasar Tarigan
Keyword(s):  
Physical Activity ◽  
Free Radicals ◽  
Cellular Level ◽  
Not Given ◽  
Time Intervals ◽  
Kolmogorov Smirnov ◽  
Group A ◽  
The Difference ◽  
Group B ◽  
Per Oral

Aerobic metabolism in the cellular level generates free radicals. Under normal condition,theres balance between free radicals and endogenous antioxidants. Excessive amount of freeradicals impair DNA, protein, fat, etc. The level of free radicals can be known by measuringplasma malondialdehyde level. Combination of Brastagis oranges and carrots juice asexogenous antioxidants supplementation expected to decrease free radicals level . The aim of thisstudy is to investigate the difference of plasma MDA level during several time intervals on micewhich is given and not given combination of Brastagis oranges and carrots juice before physicalactivity using mices treadmill for 20 minutes. The research method used in this study is anexperimental laboratory study. The objects of this study are 40 mice (mus musculus), whitecolored, male, weighting 25-30 grams, which is randomly chosen. The objects are divided into 2groups, Group A : 20 mice (given combination of Brastagis oranges and carrots juice beforephysical activity using mices treadmill) and group B : 20 mice (not given combination ofBrastagis oranges and carrots juice before physical activity using mices treadmill). Group Aare divided into 5 subgroups: A1 (measurement of plasma MDA level at 0 minute after treadmill),A2 (measurement of plasma MDA level at 15 minutes after treadmill), and A3 (measurement ofplasma MDA level at 30 minutes after treadmill), A4 (measurement of plasma MDA level at 60minutes after treadmill), and A5 (measurement of plasma MDA level at 240 minutes aftertreadmill). The same procedures are employed for the group B. Plasma MDA level measuredafter doing physical activity using mice treadmill. The homogenity of the result then was testedusing Levenes test and the normality of the result was tested using Kolmogorov-smirnov test (p>0.05). Further, the data was analyzed using independent t-test (p?0.05), one-way ANOVA(p?0.05) then Duncans test were used. The results reveal significant lowering plasma MDAconcentration in mice receiving combination of Brastagis oranges and carrots juice beforephysical activity, which is measured during several time intervals : 0,15,30,60, and 240 minutesafter physical activity than in mice not receiving combination of Brastagis oranges and carrotsjuice before physical activity. The MDA level differences between groups which is given and notgiven combination of Brastagis orange and carrots juice before physical activity measuredduring several intervals are 11,44% (0,8920 vs 1,0071) measured 0 minute after physical activity,15,47% (0,7902 vs 0,9348) measured 15 minutes after physical activity, 14,42% (0,7473 vs0,8732) measured 30 minutes after physical activity, 11,35% (0,6696 vs 0,7554) measured 60minutes after physical activity, and 13,60% (0,5786 vs 0,6696) measured 240 minutes afterphysical activity.The conclusion of the study suggested that combination of Brastagis orange andcarrots juice supplementation has lowering effect toward plasma MDA level measured duringseveral time intervals.

scholarly journals Different Shapes of The Human Pineal Gland – A Study On 60 Autopsy Cases

2015 ◽  
Vol 23 (2) ◽  
pp. 211-214
Author(s):  
Halima Afroz ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Mushfika Rahman ◽  
Nurun Nahar ◽  
Shamim Ara
Keyword(s):  
Pineal Gland ◽  
Postmortem Examination ◽  
Medical College ◽  
Pine Cone ◽  
Group A ◽  
Different Shapes ◽  
Group B ◽  
Human Brains ◽  
Group D ◽  
The Brain

Context: The pineal gland has been described as an endocrine or neuroendocrine gland; however, its functions in humans are still to be defined. Different shapes of the human pineal gland have been identified. Due to its small size and different shapes recognition of this gland is much critical. Besides, due to its cellularity it may be mistaken for a neoplasm. Hence, a sound knowledge on different shapes of the pineal gland is essential for neurosurgeons, radiologists and pathologists for better diagnosis and management of pineal disorders.Methods: A descriptive study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from July 2009 to June 2010, to see the morphological shape of the human pineal gland. The present study was performed on 60 human pineal glands collected from whole human brains of unclaimed dead bodies that were under postmortem examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The pineal gland was collected from the brain by meticulous dissection. Then, the shape of the pineal gland was observed under the magnifying glass.Results: In the present study, pea-shaped pineal glands were found 60% in group A, 30% in group B, 5% in both group C and D, while pine cone shaped were found 25% in group A, 37.5% in group B, 25% in group C and 12.5% in group D. Besides, fusiform shaped glands were found 18.2% in group A, 63.6% in group B, 9.1% in both group C and D, where as piriform shaped found 66.7% in group B, and 16.7% in both group C and D. Moreover, cone-shaped glands were found 28.6% in group B, 57.1% in group C and 14.3% in group D.J Dhaka Medical College, Vol. 23, No.2, October, 2014, Page 211-214

scholarly journals Prognosis in young women less than 40 years of age with brain metastasis from breast cancer

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
A. Mustillo ◽  
J. P. Ayoub ◽  
D. Charpentier ◽  
L. Yelle ◽  
M. Florescu
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Brain Metastasis ◽  
Young Women ◽  
Young Patients ◽  
Radiation Technology ◽  
Group A ◽  
Group B ◽  
Initial Metastasis ◽  
The Brain

Background Brain metastasis from breast cancer (bca) in young women is doubly devastating because both quality of life and life expectancy are significantly reduced. With new radiation technology and drugs that have emerged, survival is expected to increase for these young women.Methods Using the oacis and sardo patient databases, we identified 121 patients diagnosed with bca and brain metastasis between 2006 and 2016 at the University of Montreal Hospital Centre. Those patients were divided into Group A, patients who developed brain metastasis during the evolution of metastatic bca, and Group B, patients whose first metastasis was to the brain. For each group, we compared young patients (<40 years of age) with older patients (≥40 years of age).Results Among the 121 patients with brain metastasis, median overall survival (mos) was significantly longer for those less than 40 years of age than for those 40 or more years of age (18 months vs. 4 months, p < 0.001). With respect to the timing of brain metastasis, survival was significantly longer in Group B than in Group A (7 months vs. 4 months, p = 0.032). In Group A, mos was significantly longer for patients less than 40 years of age than for patients 40 or more years of age (18 months vs. 3 months, p = 0.0089). In Group B, the 2-year overall survival rate was 57% for patients less than 40 years of age and 12% for those 40 or more years of age (mos: not reached vs. 7 months; p = 0.259).Conclusions In our single-centre retrospective cohort of women with brain metastasis from bca, prognosis was better for young women (<40 years) than for older women (≥40 years). Survival was also longer for patients whose initial metastasis was to the brain than for patients whose brain metastasis developed later in the disease course. In patients who received systemic treatment, median survival remained significantly higher in women less than 40 years of age. Further studies are needed to validate those results.

scholarly journals Comparing efficacy and safety of sodium valproate with propranolol in paediatric migraine prophylaxis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Varsha Gajbhiye ◽  
Lamture Yashwant R ◽  
Sadama Quazi
Keyword(s):  
Sodium Valproate ◽  
Migraine Prophylaxis ◽  
Efficacy And Safety ◽  
Before And After ◽  
Propranolol Group ◽  
Paediatric Age ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
The Brain

Migraine is a common disorder of the paediatric age group. Propranolol has been used in prophylaxis for migraine.  The use of Sodium valproate in the prophylaxis of migraine is not known. It is postulated that it increases the level of GABA in the brain that will decrease events related to migraine in the cortex. All parents of the patient were advised to keep diaries for noting time, date, severity and duration of headache during the study period, which was for a period of 6 wks. The decreased frequency of headache more than in Group A was 68% and propranolol group was 68.89%. In group A(sodium valproate), patients showed a reduction in headache duration and 52% in Group B. 20% of them headache free in Group A and 18% in Group B. Decrease in the severity of headache in Group A was 52% while 50% in Group B. The mean headache frequency before and after treatment was reduced from 8 to 2.5 attacks per month in group A and from 8.2 to 2.6 in group B. The t-value is 11 for group A. Sodium valproate is more effective and safer in migraine prophylaxis as compared with propranolol.

scholarly journals GABAPENTIN

2018 ◽  
Vol 25 (12) ◽  
pp. 1892-1898
Author(s):  
Brig (Retd) Muhammad Boota ◽  
Sohail Nasir ◽  
Imran Hyder
Keyword(s):  
Heart Rate ◽  
Nasotracheal Intubation ◽  
Hemodynamic Response ◽  
Controlled Clinical Trial ◽  
P Value ◽  
Base Line ◽  
Time Intervals ◽  
Treatment Groups ◽  
Group A ◽  
Group B

Introduction: There have been several methods used to prevent or attenuate the adverse hemodynamic changes following endotracheal intubation, but not many studies have been done for the same purpose in patients undergoing nasotracheal intubation. Deepening of anaesthesia, omitting cholinergic premedication, pre-treatment with vasodilators such as nitroglycerine, beta blockers, calcium channel blockers and opioids are few of the different techniques used when trachea is intubated orally or nasally, to blunt significant swings in hemodynamic parameters. We assessed the effectiveness of oral gabapentin to determine changes in hemodynamic response in normotensive patients following nasotracheal intubationwith or without laryngoscopy for elective maxillofacial surgeries. Study Design: Randomized double blind, placebo-controlled clinical trial. Setting: Department of Anesthesia & Intensive Care, Fauji Foundation Hospital Rawalpindi. Period: 18 months after approval from the ethical committee. Material & Methods: Total 130 patients were included in the study. These patients were randomly divided into 2 groups. In Group-A patients were given 800 mg gabapentin and in Group-B patients were given placebo. Heart rate and mean arterial pressures were recorded just before intubation as base line values, and then average readings were taken at 1 minute, 3 minutes, 5 minutes and 10 minutes after intubation. Bradycardia and hypotension were adequately treated with intravenous atropine and vasopressors. Data entry and analysis was done by using SPSS 17. Results: Total 130 patients who underwent elective surgeries were included in the study and divided into 2 groups each group containing 65 patients each. At 1st minute MAP in Group-A (oral gabapentin) and in Group-B (Placebo) was 86.89±4.36 and 98.70±4.39. At 3rd minute MAP in Group-A, in Group-B was 83.40±4.05 and 92.93±4.79. At 5th minute MAP was 82.50±5.00 and 88.03±4.22 and lastly at 10th minute MAP was 79.81±5.37 in Group-A and 83.18±4.77 in Group-B respectively. P-value at 1st, 3rd, 5th and at 10th minutes showed that statistically MAP was different in both treatment groups at the above mentioned time intervals. 1st minute: p-value=0.042, 3rd minute: p-value=0.000, 5th minute: p-value=0.000 and at 10th minute: p-value=0.000. At 1st minute heart rate in Group-A and Group-B was 87.89±1.39 and 93.47±6.88 respectively. At 3rd minute heart rate in Group-A and Group-B was 83.47±5.47 and 89.70±6.76. At 5th minute heart rate was 82.10±5.01 and 84.60±5.91 and lastly at 10th minute heart rate was 78.09±6.79 in Group-A and 77.27±5.34 in Group-B respectively. P -value at 1st, 3rd and 5th minutes showed that statistically heart rate was different in both treatment groups at the above mentioned time intervals. But at 10th minute heart rate was statistically same in both treatment groups. 1st minute: p-value=0.144, 3rd minute: p-value=0.000, 5th minute: p-value=0.011 and at 10th minute: p-value=0.448. Conclusion: According to the results of this study it was observed that oral gabapentin is effective in modifying hemodynamic response to nasotracheal intubation in normotensive patients undergoing elective maxillofacial surgeries. MAP (10th Minute: Group-A vs. Group-B: 0.000) & Heart Rate (10th Minute: Group-A vs. Group-B:0.448)

scholarly journals A comparative study of efficacy of oral pregabalin and clonidine for attenuation of pressor response to intubation

2021 ◽  
Vol 10 (9) ◽  
pp. 1095
Author(s):  
Haramritpal Kaur ◽  
Jatin Gupta ◽  
Amandeep Singh ◽  
Gurpreet Singh ◽  
Anshul Dahuja ◽  
...  
Keyword(s):  
Endotracheal Intubation ◽  
Stress Responses ◽  
Pressor Response ◽  
Hemodynamic Parameters ◽  
Time Intervals ◽  
The Past ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Oral Premedication

Background: Endotracheal intubation is associated with hemodynamic stress responses. Various drugs have been used in the past to attenuate the pressor response; however, none has been proved to be ideal. Present study was planned to evaluate the oral pregabalin 150 mg and clonidine 200 µg for attenuation of pressor response to intubation.Methods: The study was conducted on 100 adult patients of either gender scheduled to undergo elective surgeries under general anaesthesia (GA). The patients were randomly allocated into 2 groups. In group A patients received pregabalin 150mg and in group B patients received clonidine 200µg orally. The hemodynamic parameters were recorded until 10 minutes after intubation. The sedation, anxiety and side effects were also assessed.Results: In clonidine group, the mean HR remained below the baseline value at all the time intervals. In pregabalin group, the mean HR remained below the baseline value at most of the time intervals but increased above baseline just after intubation (T0i) and 1 minute after intubation (T1i) where increase was only 1.488±1.20% and 0.45±1.16% respectively from baseline. In both pregabalin and clonidine groups, the mean SBP and MAP remained below the baseline value (Tb) at all the time intervals from T0.5 to T10i. Both clonidine and pregabalin provided adequate anxiolysis and sedation with pregabalin providing more pronounced sedation and anxiolysis than clonidine.Conclusions: Both clonidine and pregabalin are effective oral premedication drugs for attenuation of the pressor response to laryngoscopy and endotracheal intubation.  

scholarly journals In Vivo Study on Site of Action of Sinapine Thiocyanate following Acupoint Herbal Patching

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Shan Chen ◽  
Yu-Tong Jin ◽  
Zheng-Yang Zhu ◽  
Ling-Tao Wu ◽  
Ping Yang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Wistar Rats ◽  
Pharmacokinetic Profile ◽  
Time Intervals ◽  
Site Of Action ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Group D

Objective. To investigate the site of action of sinapine thiocyanate (ST), following acupoint herbal patching (AHP). Methods. Twenty Wistar rats were randomized into five groups (groups A, B, C, D, and E), and all groups received the same AHP in vivo. Skin samples were excised at 2 h, 4 h, 6 h, 10 h, and 26 h after AHP administration from group A to group E separately and the concentrations of ST in the skin were determined using a liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method. A pharmacokinetic profile of ST following AHP was performed at the same time in a group of five Wistar rats to detect plasma levels at the same time intervals. Results. The mean ± SD ST concentrations (ng/ml) at 2 h (group A), 4 h (group B), 6 h (group C), 10 h (group D), and 26 h (group E) after AHP administration were 250.01±61.99, 61.01±30.41, 40.12±26.94, 78.66±59.43, and 19.55±18.95, respectively. No ST was detected in rats’ plasma samples at the same time points. Conclusions. The site of action of ST following AHP is in the skin.

Analysing the effect of the use of 3D simulations on the performance of engineering students in a robotics course: Findings from a pilot study

2018 ◽  
Vol 56 (2) ◽  
pp. 163-178 ◽  
Author(s):  
Gerardo Loreto-Gómez ◽  
Jorge Rodríguez-Arce ◽  
Salvador González-García ◽  
Victor M Montaño-Serrano
Keyword(s):  
Academic Performance ◽  
Traditional Method ◽  
Engineering Students ◽  
Teaching Method ◽  
3D Models ◽  
Industrial Robots ◽  
Theoretical Concepts ◽  
3D Simulations ◽  
Group A ◽  
Group B

During the last decade, students of mechanical engineering, electrical engineering, and mechatronics have been interested in studying robotics. It is a challenge for robotics course professors to get students to clearly understand the basic theoretical concepts for its correct application to solve problems, and to motivate them to achieve the best performance. Previous works proposed the use of 3D models to perform the simulation of industrial robots in class and consequently to reinforce the students’ theoretical and practical concepts. However, it has not yet been clearly demonstrated how the use of robots and simulations helps improve students’ academic performance. In this paper, the main contribution consists of a formal evaluation in which the comparison between the use of two teaching methods was carried out. In the first teaching method (traditional method), the professor used PowerPoint presentations and oral explanations to teach theoretical concepts and solve exercises (Group A). In the second teaching method, the professor added the use of 3D simulations together with the traditional method to teach theoretical concepts and solve exercises (Group B). Students of both groups performed the same written exam about forward kinematics in order to study and analyse the differences between the methodology used with Group A and the methodology used with Group B. This exam consisted of solving three exercises with different robot complexity levels. The results demonstrate that the performance of the students in group B is significantly better than that of the students in group A. In other words, the use of 3D simulations improves student’s academic performance, and provides a teaching tool to enhance the way the professors teach.

SP1.2.5Robot-assisted Colorectal Surgery: Short-term Outcome of First 70 cases at Different Time-intervals along the Learning Curve

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Sandeep Singh ◽  
William Rea ◽  
Shaun Nai ◽  
Tamas Sollei ◽  
Neil Kukreja ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Learning Curve ◽  
Operating Time ◽  
Total Duration ◽  
Time Intervals ◽  
Term Outcome ◽  
Female Ratio ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Aim To analyse the evolution of robot-assisted colorectal surgery (RACS). Methods All the patients who underwent RACS between June 2018 and December 2020 were selected. Study period was divided into 3 intervals along the learning curve; group A represents the 1st 10 months, group B 2nd 10 and group C last 11. Results Over the 31-month study period, 70 RACS were performed. Male to female ratio was 4:3, with mean age of 66 years and BMI 28.7. ASA score was reported as 1-2 in 65% patients and 35% as 3. Indication was malignancy for 89% patients and the remainder benign pathology. High or low anterior resection performed were 72%, right hemicolectomies 21%, Hartmann’s 3%, abdominoperineal resections 3%, and left hemicolectomy 1%. RACS performed in group A was 20 compared to 19 in B and 31 C. Type of RACS performed, BMI, ASA, complications, anastomotic leaks, R0 resections and harvested lymph nodes were unrelated to selected time-intervals along learning curve. Mean total duration of procedure dropped down to 247 minutes in group C from 375 in group A (p = &lt;0.001). No significant difference in mean length of stay and readmission rate was observed in 3 groups (p = 0.7, p = 0.59). Conclusion The study demonstrates that introduction of this new surgical technique is safe even in the early phase of adoption with no significant difference in pre-and post-operative morbidities. Significant difference in time taken for surgery was observed with reduction of 88 minutes in average operating time between the start and end of the study.

Sign in / Sign up

Export Citation Format

Share Document