Phaeohyphomycosis caused by Diaporthe phaseolorum in an immunocompetent patient in Thailand: a case report

Phaeohyphomycosis is caused by a large, heterogeneous group of darkly pigmented fungi. It is an infrequent infection in humans. However, the prevalence has been increasing in recent years especially in immunocompromised patients. Diaporthe phaseolorum is a common black fungal pathogen of plants, which rarely causes human infection. We report the first case of cutaneous infection caused by Diaporthe phaseolorum in an immunocompetent host and the first in Asia. Although, the review of the literature revealed two previous cases of cutaneous infection caused by this organism, both of them were in immunocompromised hosts. A slow-growing asymptomatic nodule was the major clinical feature. Histopathological examination showed granulomatous inflammation and pigmented septate hyphae and yeast-like cells. The fungal isolation was identified by morphological characteristics and DNA sequencing. The lesion was resolved after complete surgical excision and oral fluconazole for two months. This report highlights the potential role of Diaporthe phaseolorum as an emerging cause of infection in immunocompetent patients.

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Secretory Carcinoma Ex Pleomorphic Adenoma: A Case Report

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqz113.092 ◽

2019 ◽

Vol 152 (Supplement_1) ◽

pp. S74-S75

Author(s):

Erika Egal ◽

Reydson Souza ◽

João Scarini ◽

Antonio Martins ◽

Andre Casarini ◽

...

Keyword(s):

Submandibular Gland ◽

Pleomorphic Adenoma ◽

Histopathological Examination ◽

Morphological Characteristics ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Dystrophic Calcification ◽

Parotid Glands ◽

Secretory Carcinoma ◽

Submandibular Region ◽

First Case

Abstract The objective of this study is to report a case of carcinoma ex pleomorphic adenoma subclassified as secretory carcinoma ex pleomorphic adenoma frankly invasive. A 60-year-old male patient attended our service for cervical injury assessment, painless with slow and progressive growth for about 3 years. At the clinical examination, an increase in volume in the submandibular region and a lesion in the region of the nasolabial sulcus were observed. A biopsy of the lesion was performed and the morphological characteristics were compatible with secretory carcinoma of the salivary gland. The patient underwent a radical cervical emptying, excision of the left submandibular gland, and removal of the lesion in the left nasogastric sulcus. At the macroscopic examination, the submandibular gland presented a hardened, heterogeneous nodule, poorly delimited, with gross calcification at the center, measuring 2.0 × 1.5 × 1.5 cm. At the histopathological examination, eosinophilic cells containing intracytoplasmic vacuoles, with a ductal formation and solid arrangement and dystrophic calcification, were observed corresponding to the old hyalinized areas of residual PA. In view of these findings, the diagnosis was secretory carcinoma ex adenoma pleomorphic frankly invasive of the submandibular gland with extension to the nasogenian sulcus. Complementary immunohistochemical examination was carried out evidencing positivity for mammaglobin, S100, and CK7 in tumor cells and negativity for calponin, 1A4, and p63. Conclusion: Although CXPA is a rare lesion and is more common in parotid glands, it may affect other locations. Several histopathological phenotypes may arise from the malignant transformation of the PA, but to the best of our understanding, this is the first case of secretory carcinoma ex pleomorphic adenoma reported in the literature.

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FIRST CASE OF HUMAN INFECTION BY Bertiella studeri (Blanchard, 1891) Stunkard,1940 (Cestoda; Anoplocephalidae) IN BRAZIL

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652015000500015 ◽

2015 ◽

Vol 57 (5) ◽

pp. 447-450 ◽

Cited By ~ 4

Author(s):

Valeriana Valadares LOPES ◽

Hudson Andrade dos SANTOS ◽

Amália Verônica Mendes da SILVA ◽

Gilberto FONTES ◽

Gabriela Lisboa VIEIRA ◽

...

Keyword(s):

Stool Sample ◽

Morphometric Analysis ◽

Morphological Characteristics ◽

Average Diameter ◽

Human Infection ◽

Human Beings ◽

The Third ◽

Round Shape ◽

First Case ◽

Minas Gerais State

SUMMARY Cestodes of the Bertiella genus are parasites of non-human primates found in Africa, Asia, Oceania and the Americas. Species Bertiella studeri and Bertiella mucronatacould, accidentally, infect human beings. The infection occurs from ingestion of mites from the Oribatida order containing cysticercoid larvae of the parasite. The objective of this report is to register the first case of human infection by Bertiella studeri in Brazil. Proglottids of the parasite, found in the stool sample of a two-and-a-half-year-old child, were fixed, stained and microscopically observed to evaluate its morphological characteristics. Eggs obtained from the proglottids were also studied. The gravid proglottids examined matched the description of the genus Bertiella. The eggs presented a round shape, with the average diameter of 43.7 µm, clearly showing the typical pyriform apparatus of B. studeri. The authors concluded that the child was infected with Bertiella studeri,based on Stunkard's (1940) description of the species. This is the fifth case of human Bertiellosis described in Brazil through morphometric analysis of the parasite, the third in Minas Gerais State and the first diagnosed case of Bertiella studeriin Brazil.

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Fungus ball paranasal sinuses: pattern of histopathology and culture characteristics

Oto Rhino Laryngologica Indonesiana ◽

10.32637/orli.v49i20.315 ◽

2019 ◽

Vol 49 (20) ◽

Author(s):

Nugroho Suharsono

Keyword(s):

Aspergillus Niger ◽

Paranasal Sinus ◽

Paranasal Sinuses ◽

Histopathological Examination ◽

Morphological Characteristics ◽

Sinus Surgery ◽

Nasal Discharge ◽

Fungus Ball ◽

Methenamine Silver ◽

Fungus Balls

Background: Fungal infection of the nose and paranasal sinuses is an uncommon condition which is now being increasingly recognized. The clinical presentation is not specific with various symptoms such as nasal obstruction, purulent nasal discharge, facial pain, and chronic cough. Only unilaterality may alert the clinician. Purpose: To find the morphological characteristics of the fungus in patients with paranasal sinus fungus ball. Methods: A retrospective study of 13 paranasal sinus fungus balls cases which underwent endoscopic sinus surgery at Department of Otorhinolaryngology Head and Neck Surgery St. Vincentius A Paulo Hospital Surabaya from March, 2012 until December, 2013. Age, sex, histopathology and fungal cultur were analysed. Histopathologic sections of all the patients were stained with hematoxylin and eosin (H&E), and Gomori methenamine silver (GMS). The specimens were then cultured on Sabouraud dextrose agar plates and incubated at 30°C for 1 month. At the end of the incubation period, the samples were evaluated microscopically to detect fungi and identify their species. Results: The age reported of the 13 patients, was ranging from 36 to 63 years old. There was a significant female predominance, 10 female patients (76.92%) and 3 male patients (23.08%). Histopathological examination showed that most causative agents were Aspergillus species 92.31% (12/13). Culture test was positive for 69.23% (9/13). Aspergillus niger (61.54%, 8/13) is the most frequent fungus reported to cause fungus balls. Conclusion: Pattern of histopathologic on HE and GMS is very helpful and sensitive to identify fungi. The most common isolated mould in our study was Aspergillus niger.Keywords: fungus ball, histopathology and culture, Aspergillus nigerABSTRAK Latar Belakang: Infeksi jamur di hidung dan sinus paranasal merupakan kondisi yang jarang terjadi, namun kini lebih sering ditemukan. Gejala klinisnya tidak spesifik dapat berupa obstruksi hidung, sekret dari hidung, nyeri wajah, dan batuk kronis. Bila terjadi unilateral, patut diwaspadai oleh para klinisi. Tujuan: Untuk mengetahui karakteristik morfologi fungus yang didapati pada pasien sinusitis jamur yang kami teliti. Metode: Dilakukan penelitian retrospektif pada 13 pasien sinusitis jamur yang menjalani bedah sinus endoskopi di Departemen Otorinolaringologi-Kepala Leher Rumah Sakit St. Vincentius A Paulo Surabaya dari bulan Maret 2012 sampai dengan Desember 2013. Dilakukan analisis usia, jenis kelamin, histopatologi dan kultur jamur. Pewarnaan preparat histopatologi menggunakan Hematoxylin dan eosin (H&E) dan Gomori Methenamine Silver (GMS). Kemudian spesimen diletakkan pada piring agar Sabouraud dextrose, dan dilakukan inkubasi pada suhu 30°C selama satu bulan. Pada akhir masa inkubasi, sampel dievaluasi dengan mikroskop untuk mendeteksi jamur dan spesiesnya. Hasil: Didapati usia 13 penderita berkisar dari 36-63 tahun. Wanita lebih dominan sebanyak 10 penderita (76,92 %) dan 3 penderita laki-laki (23,08%). Hasil pemeriksaan histopatologi menunjukkan spesies Aspergillus sebagai penyebab utama (92,31%) pada 12 penderita (12/13).Tes kultur positif pada 69,23% (9/13). Jamur yang paling sering menyebabkan bola jamur pada sinus adalah Aspergillus niger (61,54%, 8/13). Kesimpulan: Pewarnaan preparat histopatologi menggunakan Hematoxylin dan eosin (H&E) dan Gomori Methenamine Silver (GMS) sangat berguna dan sensitif dalam mendeteksi adanya jamur. Jenis jamur yang paling banyak ditemukan pada penelitian kami adalah Aspergillus niger.

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Intestinal Heterotopic Pancreas Involved by Simultaneous PanIN-2 Lesion and Endocrine Microadenoma: a Unique Case

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.262.pan ◽

2017 ◽

Vol 26 (2) ◽

pp. 199-202

Author(s):

Remus Cornea ◽

Sorina Taban ◽

Cristian Suciu ◽

Codruta Lazureanu ◽

Alis Dema

Keyword(s):

Histopathological Examination ◽

Intraepithelial Neoplasia ◽

Heterotopic Pancreas ◽

Pancreatic Intraepithelial Neoplasia ◽

Unique Case ◽

Intraductal Papillary Mucinous Neoplasms ◽

Pancreatic Endocrine Neoplasm ◽

First Case ◽

Mucinous Neoplasms

We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. In this area, two pathological distinct lesions were identified, one histologically compatible with pancreatic intraepithelial neoplasia (PanIN) type 2 lesion and the other with morphologic criteria for endocrine microadenoma. To our knowledge, this is the first case that evidences the presence of a concomitant premalignant exocrine lesion and benign endocrine lesion in a heterotopic pancreas (HP).Abbreviations: HP: heterotopic pancreas; IPMN: Intraductal Papillary Mucinous Neoplasms; PanIN: Pancreatic Intraepithelial Neoplasia; PEN: pancreatic endocrine neoplasm.

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Primary stromal sarcoma of breast: A case report and literature review

Breast Disease ◽

10.3233/bd-201012 ◽

2021 ◽

pp. 1-7

Author(s):

Mohammad Al-Wiswasy ◽

Mahmoud Al-Balas ◽

Raith Al-Saffar ◽

Hamzeh Al-Balas

Keyword(s):

Malignant Tumors ◽

Histopathological Examination ◽

Prognostic Significance ◽

Total Duration ◽

Young Patients ◽

Soft Tissue Sarcomas ◽

Breast Mass ◽

Resection Margins ◽

Stromal Sarcoma ◽

First Case

INTRODUCTION: Primary breast sarcoma (PBS) was first described in 1887 as a rare heterogeneous neoplasm arising from the mesenchymal tissue of the mammary gland accounting for less than 5% of all body soft-tissue sarcomas and less than 0.1% of all malignant tumors of the breast. CASE PRESENTATION: A 31-year old lady presented with left breast mass which she felt four years before during which the mass increased in size from 1 to 6 cm in the largest diameter, diagnosed clinically as a benign fibroadenoma without any further cytological or histopathological confirmation. Histopathological examination of the excised breast mass reveals undifferentiated, primary stromal sarcoma of the breast (PSSB), which was followed by mastectomy three weeks later with reconstructive breast surgery with a total duration of follow-up of 3 years thereafter. This is the first case of PSSB reported in Jordan. DISCUSSION/CONCLUSION: PSSB is the generic term given to malignant breast tumors thought to arise from the specialized mesenchymal stroma of the breast but lacking an epithelial component with a phylloides pattern. PSSB is difficult to diagnose preoperatively due to its rarity and inadequate imaging methods to establish an exact diagnosis. The histology of the patient mass may be the leading factor for the management of these tumors. Even in very young patients, a progressively growing breast mass should alert the clinician to investigate for malignancy and verify the results by biopsy. Surgery with adequate resection margins represents the only potentially curative modality with prognostic significance. Adjuvant chemotherapy and radiotherapy are not very beneficial. The prognosis is dismal for patients with lymph node involvement and the size of the tumor has a lesser bearing on the outcome.

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Fetus in fetu: two case reports from North African country

Egyptian Pediatric Association Gazette ◽

10.1186/s43054-020-00049-5 ◽

2021 ◽

Vol 69 (1) ◽

Author(s):

Moutaz Ragab ◽

Omar Nagy Abdelhakeem ◽

Omar Mansour ◽

Mai Gad ◽

Hesham Anwar Hussein

Keyword(s):

Histopathological Examination ◽

Case Reports ◽

Abdominal Mass ◽

Mature Teratoma ◽

Surgical Techniques ◽

Rare Condition ◽

Mass Effect ◽

Fetus In Fetu ◽

Vascular Connection ◽

First Case

Abstract Background Fetus in fetu is a rare congenital anomaly. The exact etiology is unclear; one of the mostly accepted theories is the occurrence of an embryological insult occurring in a diamniotic monochorionic twin leading to asymmetrical division of the blastocyst mass. Commonly, they present in the infancy with clinical picture related to their mass effect. About 80% of cases are in the abdomen retroperitoneally. Case presentation We present two cases of this rare condition. The first case was for a 10-year-old girl that presented with anemia and abdominal mass, while the second case was for a 4-month-old boy that was diagnosed antenatally by ultrasound. Both cases had vertebrae, recognizable fetal organs, and skin coverage. Both had a distinct sac. The second case had a vascular connection with the host arising from the superior mesenteric artery. Both cases were intra-abdominal and showed normal levels of alpha-fetoprotein. Histopathological examination revealed elements from the three germ layers without any evidence of immature cells ruling out teratoma as a differential diagnosis. Conclusions Owing to its rarity, fetus in fetu requires a high degree of suspicion and meticulous surgical techniques to avoid either injury of the adjacent vital structures or bleeding from the main blood supply connection to the host. It should be differentiated from mature teratoma.

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Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle: A Case of Relapse Treated with Proton Beam Therapy

Diagnostics ◽

10.3390/diagnostics11050903 ◽

2021 ◽

Vol 11 (5) ◽

pp. 903

Author(s):

Antonella Cacchione ◽

Angela Mastronuzzi ◽

Andrea Carai ◽

Giovanna Stefania Colafati ◽

Francesca Diomedi-Camassei ◽

...

Keyword(s):

Adjuvant Therapy ◽

Proton Beam ◽

Fourth Ventricle ◽

Histopathological Examination ◽

Local Level ◽

Proton Beam Therapy ◽

Disease Recurrence ◽

Glioneuronal Tumor ◽

First Case ◽

Cystic Component

Rosette-forming glioneuronal tumors (RGNTs) are rare, grade I, central nervous system (CNS) tumors typically localized to the fourth ventricle. We describe a 9-year-old girl with dizziness and occipital headache. A magnetic resonance imaging (MRI) revealed a large hypodense posterior fossa mass lesion in relation to the vermis, with cystic component. Surgical resection of the tumor was performed. A RGNT diagnosis was made at the histopathological examination. During follow-up, the patient experienced a first relapse, which was again surgically removed. Eight months after, MRI documented a second recurrence at the local level. She was a candidate for the proton beam therapy (PBT) program. Three years after the end of PBT, the patient had no evidence of disease recurrence. This report underlines that, although RGNTs are commonly associated with an indolent course, they may have the potential for aggressive behavior, suggesting the need for treatment in addition to surgery. Controversy exists in the literature regarding effective management of RGNTs. Chemotherapy and radiation are used as adjuvant therapy, but their efficacy management has not been adequately described in the literature. This is the first case report published in which PBT was proposed for adjuvant therapy in place of chemotherapy in RGNT relapse.

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Do Animals Play a Role in the Transmission of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)? A Commentary

Animals ◽

10.3390/ani11010016 ◽

2020 ◽

Vol 11 (1) ◽

pp. 16

Author(s):

Anna Costagliola ◽

Giovanna Liguori ◽

Danila d’Angelo ◽

Caterina Costa ◽

Francesca Ciani ◽

...

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Neutralizing Antibodies ◽

Experimental Studies ◽

Infectious Agent ◽

Human Infection ◽

Farm Animals ◽

Partial Protection ◽

Management Measures ◽

First Case ◽

And Behavior

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belongs to the Beta-coronavirus genus. It is 96.2% homologous to bat CoV RaTG13 and 88% homologous to two bat SARS-like coronaviruses. SARS-CoV-2 is the infectious agent responsible for the coronavirus disease (COVID-19), which was first reported in the Hubei province of Wuhan, China, at the beginning of December 2019. Human transmission from COVID-19 patients or incubation carriers occurs via coughing, sneezing, speaking, discharge from the nose, or fecal contamination. Various strains of the virus have been reported around the world, with different virulence and behavior. In addition, SARS-CoV-2 shares certain epitopes with some taxonomically related viruses, with tropism for the most common synanthropic animals. By elucidating the immunological properties of the circulating SARS-CoV-2, a partial protection due to human–animal interactions could be supposed in some situations. In addition, differential epitopes could be used for the differential diagnosis of SARS-CoV-2 infection. There have been cases of transmission from people with COVID-19 to pets such as cats and dogs. In addition, wild felines were infected. All These animals were either asymptomatic or mildly symptomatic and recovered spontaneously. Experimental studies showed cats and ferrets to be more susceptible to COVID-19. COVID-19 positive dogs and felines do not transmit the infection to humans. In contrast, minks at farms were severely infected from people with COVID-19. A SARS-Cov-2 variant in the Danish farmed mink that had been previously infected by COVID-19 positive workers, spread to mink workers causing the first case of animal-to-human infection transmission that causes a moderate decreased sensitivity to neutralizing antibodies. Thus, more investigations are necessary. It remains important to understand the risk that people with COVID-19 pose to their pets, as well as wild or farm animals so effective recommendations and risk management measures against COVID-19 can be made. A One Health unit that facilitates collaboration between public health and veterinary services is recommended.

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Scytalidium dimidiatum associated invasive fungal sinusitis in an immunocompetent patient

The Journal of Laryngology & Otology ◽

10.1017/s002221511400214x ◽

2014 ◽

Vol 128 (11) ◽

pp. 1018-1021 ◽

Cited By ~ 1

Author(s):

A Hariri ◽

N Choudhury ◽

H A Saleh

Keyword(s):

Corticosteroid Treatment ◽

Fruit Trees ◽

Immunocompetent Patient ◽

Human Infection ◽

Functional Endoscopic Sinus Surgery ◽

Sinus Surgery ◽

Fungal Sinusitis ◽

Endemic Region ◽

Invasive Fungal Sinusitis ◽

First Case

AbstractBackground:Scytalidium dimidiatum is a soil and plant pathogen that frequently affects fruit trees, but can also cause human infection. There are only two reported cases of invasive fungal sinusitis involving this rare micro-organism.Objective:This paper reports the first case of invasive fungal sinusitis caused by Scytalidium dimidiatum occurring in a young immunocompetent patient from a non-endemic region, and discusses potential sources of exposure and relevance of local factors.Method:Case report.Results:The patient was treated successfully with a combination of functional endoscopic sinus surgery, and antifungal and corticosteroid treatment.Conclusion:This paper describes the first reported case of invasive fungal sinusitis secondary to Scytalidium dimidiatum in a young immunocompetent patient from a non-endemic region. Importance is placed on following a systematic process of investigation and management, and adhering to well-defined basic surgical principles.

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A Case of Incidental Schwannoma Mimicking Necrotic Metastatic Lymph Node from Bladder Cancer

Medicina ◽

10.3390/medicina57070728 ◽

2021 ◽

Vol 57 (7) ◽

pp. 728

Author(s):

Jeong-Hyouk Choi ◽

Koo-Han Yoo ◽

Dong-Gi Lee ◽

Gyeong-Eun Min ◽

Gou-Young Kim ◽

...

Keyword(s):

Histopathological Examination ◽

Metastatic Lymph Node ◽

Imaging Study ◽

Surgical Excision ◽

The Body ◽

Pathological Examination ◽

Cystic Tumor ◽

Complete Surgical Excision ◽

Ultrasound Computed Tomography ◽

Retroperitoneal Schwannoma

Background and Objectives: Retroperitoneal schwannoma is a very rare case of schwannoma which commonly occurs in the other part of the body. However, it is difficult to distinguish schwannoma from other tumors before pathological examination because they do not show specific characteristics on imaging study such as ultrasound, computed tomography (CT), and magnetic resonance image (MRI). Case summary: A 60-year-old male showed a retroperitoneal cystic tumor which is found incidentally during evaluation of coexisted bladder tumor. Neurogenic tumor was suspicious for the retroperitoneal tumor through pre-operative imaging study. Finally, a schwannoma was diagnosed by immunohistochemical examination after complete surgical excision laparoscopically. Conclusion: As imaging technology is developed, there may be more chances to differentiate schwannoma from other neoplasm. However, still surgical resection and histopathological examination is feasible for diagnosis of schwannoma.

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