Pivot-and-bond model explains microtubule bundle formation
Keyword(s):
ABSTRACTDuring mitosis, bundles of microtubules form a spindle, but the physical mechanism of bundle formation is still not known. Here we show that random angular movement of microtubules around the spindle pole and forces exerted by passive cross-linking proteins are sufficient for the formation of stable microtubule bundles. We test these predictions by experiments in wild-type and ase1Δ fission yeast cells. In conclusion, the angular motion drives the alignment of microtubules, which in turn allows the cross-linking proteins to connect the microtubules into a stable bundle.
2007 ◽
Vol 18
(6)
◽
pp. 2216-2225
◽
Keyword(s):
1991 ◽
Vol 114
(3)
◽
pp. 515-532
◽
Keyword(s):
2020 ◽
Keyword(s):
1990 ◽
Vol 110
(5)
◽
pp. 1617-1621
◽
Keyword(s):
1988 ◽
Vol 34
(12)
◽
pp. 1338-1343
◽
Keyword(s):
2018 ◽
Vol 29
(11)
◽
pp. 1332-1345
◽
Keyword(s):