scholarly journals Association of a biomarker-based frailty index with telomere length in older US adults: Findings from NHANES 1999-2002

2017 ◽  
Author(s):  
Ghalib A. Bello ◽  
Yueh-Hsiu M. Chiu ◽  
Gerard G. Dumancas
Keyword(s):  
Linear Regression ◽  
Laboratory Test ◽  
Telomere Length ◽  
Cellular Senescence ◽  
Frailty Index ◽  
Cellular Aging ◽  
Leukocyte Telomere Length ◽  
Study Results ◽  
Multiple Covariates ◽  
The Relationship

ABSTRACTObjectivesTo study the link between frailty and cellular senescence, we examine the association of leukocyte telomere length (LTL) with a recently introduced measure of subclinical frailty that is based entirely on laboratory test biomarkers (FI-LAB).MethodsThis study was conducted on a random sample of 1890 Americans aged 60+. Multiple Linear Regression was used to examine the relationship between FI-LAB and LTL.ResultsA statistically significant association was found between FI-LAB and LTL after adjusting for multiple covariates, indicating that higher FI-LAB scores are associated with shorter telomeres.DiscussionOur study results establish a link between subclinical frailty (FI-LAB) and cellular aging, which may help elucidate the pathophysiological mechanisms giving rise to frailty.

scholarly journals Delay discounting, genetic sensitivity, and leukocyte telomere length

2016 ◽  
Vol 113 (10) ◽  
pp. 2780-2785 ◽  
Author(s):  
Onn-Siong Yim ◽  
Xing Zhang ◽  
Idan Shalev ◽  
Mikhail Monakhov ◽  
Songfa Zhong ◽  
...  
Keyword(s):  
Decision Making ◽  
Estrogen Receptor ◽  
Telomere Length ◽  
Delay Discounting ◽  
Receptor Gene ◽  
Cellular Aging ◽  
Leukocyte Telomere Length ◽  
Psychological Resources ◽  
Oxytocin Receptor Gene ◽  
The Relationship

In a graying world, there is an increasing interest in correlates of aging, especially those found in early life. Leukocyte telomere length (LTL) is an emerging marker of aging at the cellular level, but little is known regarding its link with poor decision making that often entails being overly impatient. Here we investigate the relationship between LTL and the degree of impatience, which is measured in the laboratory using an incentivized delay discounting task. In a sample of 1,158 Han Chinese undergraduates, we observe that steeper delay discounting, indexing higher degree of impatience, is negatively associated with LTL. The relationship is robust after controlling for health-related variables, as well as risk attitude—another important determinant of decision making. LTL in females is more sensitive to impatience than in males. We then asked if genes possibly modulate the effect of impatient behavior on LTL. The oxytocin receptor gene (OXTR) polymorphism rs53576, which has figured prominently in investigations of social cognition and psychological resources, and the estrogen receptor β gene (ESR2) polymorphism rs2978381, one of two gonadal sex hormone genes, significantly mitigate the negative effect of impatience on cellular aging in females. The current results contribute to understanding the relationship between preferences in decision making, particularly impatience, and cellular aging, for the first time to our knowledge. Notably, oxytocin and estrogen receptor polymorphisms temper accelerated cellular aging in young females who tend to make impatient choices.

Depressive and anxiety disorders and short leukocyte telomere length: mediating effects of metabolic stress and lifestyle factors

2016 ◽  
Vol 46 (11) ◽  
pp. 2337-2349 ◽  
Author(s):  
D. Révész ◽  
J. E. Verhoeven ◽  
Y. Milaneschi ◽  
B. W. J. H. Penninx
Keyword(s):  
Cigarette Smoking ◽  
Anxiety Disorders ◽  
Telomere Length ◽  
Symptom Severity ◽  
Lifestyle Factors ◽  
Lifestyle Changes ◽  
Cellular Aging ◽  
Leukocyte Telomere Length ◽  
Metabolic Alterations ◽  
The Relationship

BackgroundDepressive and anxiety disorders are associated with shorter leukocyte telomere length (LTL), an indicator of cellular aging. It is, however, unknown which pathways underlie this association. This study examined the extent to which lifestyle factors and physiological changes such as inflammatory or metabolic alterations mediate the relationship.MethodWe applied mediation analysis techniques to data from 2750 participants of the Netherlands Study of Depression and Anxiety. LTL was assessed using quantitative polymerase chain reaction. Independent variables were current depressive (30-item Inventory of Depressive Symptoms – Self Report) and anxiety (21-item Beck's Anxiety Inventory) symptoms and presence of a depressive or anxiety disorder diagnosis based on DSM-IV; mediator variables included physiological stress systems, metabolic syndrome components and lifestyle factors.ResultsShort LTL was associated with higher symptom severity (B = −2.4, p = 0.002) and current psychiatric diagnosis (B = −63.3, p = 0.024). C-reactive protein, interleukin-6, waist circumference, triglycerides, high-density lipoprotein cholesterol and cigarette smoking were significant mediators in the relationship between psychopathology and LTL. When all significant mediators were included in one model, the effect sizes of the relationships between LTL and symptom severity and current diagnosis were reduced by 36.7 and 32.7%, respectively, and the remaining direct effects were no longer significant.ConclusionsPro-inflammatory cytokines, metabolic alterations and cigarette smoking are important mediators of the association between depressive and anxiety disorders and LTL. This calls for future research on intervention programs that take into account lifestyle changes in mental health care settings.

scholarly journals Higher Chocolate Candy Intake Is Associated with Longer Telomere Length Among Adolescents (P01-018-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Li Chen ◽  
Haidong Zhu ◽  
Bernard Gutin ◽  
Howard Sesso ◽  
Yanbin Dong
Keyword(s):  
Telomere Length ◽  
Healthy Eating ◽  
Sexual Development ◽  
Intervention Studies ◽  
Healthy Eating Index ◽  
Cellular Aging ◽  
Leukocyte Telomere Length ◽  
Dietary Recall ◽  
Funding Sources ◽  
The Relationship

Abstract Objectives Chocolate intake has been shown to improve lipid profiles, which is associated with longer leukocyte telomere length (LTL). But the relationship between chocolate candy intake and cellular aging has not been investigated. We aimed to examine the association between chocolate intake and LTL in adolescents with comprehensive assessments of dietary, lifestyle, and clinical risk factors. Methods The dietary chocolate candy intake information were available in 660 adolescents aged from 14 to 18 years (51% girls and 48% blacks). The chocolate candy intake was estimated by seven independent 24 h dietary recalls and divided into three groups, which were none, less than 2 servings/week, and 2 servings/week or more. Multiple linear regression was performed to investigate the association between chocolate intake and LTL. Results Among the adolescents, 383 (58%) didn't take any chocolate during dietary recall periods, 165 (25%) consumed chocolate less than 2 servings/week (1.1 ± 0.5 servings/week), and 122 (17%) consumed chocolate of 2 servings/week or more (4.7 ± 4.0 servings/week). Body mass index (BMI) or % body fat was inversely related to chocolate intake in a dose-response fashion (ps < 0.01). Chocolate consumption was also positively associated with ApoA1 (P = 0.024) and ApoA1/HDL (P = 0.036). In addition, ApoA1 and ApoA1/HDL were positively associated with LTL (ps = 0.044 and 0.003, respectively). Compared to non-consumers, adolescents who consumed chocolate of ≥2 servings/week had 0.26 standard deviation longer LTL (P = 0.016) when adjusted for age, sex and race. The association remained significant after further adjustment of BMI, energy intake, the Alternate Healthy Eating Index (AHEI), non-chocolate candy intake, physical activity, family SES and sexual development. Conclusions Adolescents who consume 2 servings/week or more of chocolate have longer LTL compared with non-consumers, and ApoA1-HDL pathway might be underlying the chocolate-LTL relationship. Further intervention studies are warranted to verify the beneficial effect of chocolate candy intake on the cellular aging process. Funding Sources Study was in part supported by the National Institute of Health, grant number HL064157.

scholarly journals Cellular Aging Reflected by Leukocyte Telomere Length Predicts Advanced Atherosclerosis and Cardiovascular Disease Risk

2010 ◽  
Vol 30 (8) ◽  
pp. 1649-1656 ◽  
Author(s):  
Peter Willeit ◽  
Johann Willeit ◽  
Anita Brandstätter ◽  
Silvia Ehrlenbach ◽  
Agnes Mayr ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Telomere Length ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cellular Aging ◽  
Leukocyte Telomere Length

Abstract MP64: High Sodium Intake is Associated with Short Leukocyte Telomere Length in Overweight and Obese Adolescents

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Haidong Zhu ◽  
Jigar Bhagatwala ◽  
Norman Pollock ◽  
Bernard Gutin ◽  
Jeffrey Thomas ◽  
...  
Keyword(s):  
Physical Activity ◽  
Telomere Length ◽  
Weight Status ◽  
Sodium Intake ◽  
Vigorous Physical Activity ◽  
Cellular Aging ◽  
Dietary Sodium ◽  
Leukocyte Telomere Length ◽  
High Sodium ◽  
High Sodium Intake

Introduction: The aging process in children and adolescents is accelerated resulting in the premature development of “adult” diseases such as hypertension and diabetes. Telomere shortening plays a key role in human aging; identifying factors that regulate this process is important for developing effective lifestyle interventions so as to prevent and treat age-associated diseases. In vitro and in vivo studies demonstrate that high salt content markedly decreases life span, and accelerates cellular aging through increased DNA breakage. However, the effect of high salt diet on telomere length, a marker of biological aging, remains unknown. Therefore, we aimed to test the hypothesis that high dietary sodium intake is inversely associated with leukocyte telomere length, especially in the context of obesity. Methods: Leukocyte telomere length (T/S ratio) was assessed by a quantitative polymerase chain reaction method in 766 adolescents aged 14-18 years (50% female, 49% African Americans). Diet was assessed with three to seven 24-h recalls, and physical activity was determined by accelerometry. Participants were classified according to low vs. high sodium intake (below or above the median), and according to weight status (normal vs. overweight/obese). Analysis of covariance and linear regression analyses were used to determine the effects of sodium intake and weight status on leukocyte telomere length. Results: After controlling for age, sex, race, energy intake, Tanner stage, and vigorous physical activity, a statistically significant sodium intake by weight status interaction was observed, such that leukocyte telomere length was significantly shorter in the high sodium intake vs. low sodium intake subjects from the overweight/obese group (1.24 ± 0.22 vs. 1.32 ± 0.21, p=0.02), but not the normal weight group (1.29 ± 0.24 vs. 1.30 ± 0.24, p=0.69). Consistent with the low vs. high sodium intake group data, multiple linear regression analyses, adjusting for age, sex, race, energy intake, Tanner stage and vigorous physical activity, revealed that higher dietary sodium intake was associated with shorter leukocyte telomere length in the overweight/obese group (β=-0.37, p=.045), but not the normal weight group. Conclusion: High dietary sodium intake is associated with shorter telomere length in overweight and obese adolescents suggesting that high sodium intake and obesity may act synergistically to accelerate cellular aging. Longitudinal studies are warranted to determine the synergistic effect of high sodium intake and obesity on telomere shortening over time.

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