Comprehensive assessment of PINK1 variants in Parkinson’s disease
Keyword(s):
The Past
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AbstractMultiple genes have been associated with monogenic Parkinson’s disease and Parkinsonism syndromes. Mutations in PINK1 (PARK6) have been shown to result in autosomal recessive early onset Parkinson’s disease. In the past decade, several studies have suggested that carrying a single heterozygous PINK1 mutation is associated with increased risk for Parkinson’s disease. Here we comprehensively assess the role of PINK1 variants in Parkinson’s disease susceptibility using several large datasets totalling 376,558 individuals including: 13,708 Parkinson’s disease cases and 362,850 controls. After combining these data, we did not find evidence to support a role for heterozygous PINK1 mutations as a risk factor for Parkinson’s disease.
2019 ◽
Vol 32
(2)
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pp. 218-230
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Keyword(s):
2013 ◽
Vol 2013
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pp. 1-9
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2003 ◽
Vol 100
(16)
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pp. 9256-9261
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2007 ◽
Vol 65
(1)
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pp. 5-10
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Keyword(s):
2004 ◽
Vol 112
(9)
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pp. 1249-1254
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