scholarly journals A framework to quantify phenotypic and genotypic parallel evolution

2020 ◽  
Author(s):  
Maddie E. James ◽  
Melanie J. Wilkinson ◽  
Henry L. North ◽  
Jan Engelstädter ◽  
Daniel Ortiz-Barrientos
Keyword(s):  
Natural Selection ◽  
Parallel Evolution ◽  
Model Organisms ◽  
Biological Functions ◽  
Narrow Sense ◽  
Ongoing Debate ◽  
Common Framework ◽  
Repeated Evolution ◽  
The Way

AbstractThe independent and repeated adaptation of populations to similar environments often results in the evolution of similar forms. This phenomenon creates a strong correlation between phenotype and environment and is referred to as parallel evolution. However, there is ongoing debate as to when we should call a system either phenotypically or genotypically ‘parallel.’ Here, we suggest a novel and simple framework to quantify parallel evolution at the genotypic and phenotypic levels. Our framework combines both traditional and new approaches to measure parallel evolution, and categorizes them into broad- and narrow-sense scales. We then apply this framework to coastal ecotypes of an Australian wildflower, Senecio lautus, that have evolved in parallel. Our findings show that S. lautus populations inhabiting similar environments have evolved strikingly similar phenotypes. These phenotypes have arisen via mutational changes occurring in different genes, although many share the same biological functions. Our work paves the way towards a common framework to study the repeated evolution of forms in nature.Author summaryWhen organisms face similar ecological conditions, they often evolve similar phenotypic solutions. When this occurs in closely related taxa, it is referred to as parallel evolution. Systems of parallel evolution provide some of the most compelling evidence for the role of natural selection in evolution, as they can be used as natural replicates of the adaptation process. However, there is debate as to when we should call a system ‘parallel’. This debate stems back to the mid 1900s, and although there have been multiple attempts within the literature to clarify terminology, controversy still remains. In this study, we propose a novel framework to quantify phenotypic and genotypic parallel evolution within empirical systems, partitioning parallelism into broad- and narrow-sense components. Our framework is applicable to non-model organisms and provides a common set of analyses to measure parallel evolution, enabling researchers to compare the extent of parallel evolution across different study systems. In turn, this helps to reduce confusion surrounding the term ‘parallel evolution’ at both the phenotypic and genotypic levels. We then apply our framework to two coastal ecotypes of an Australian plant, Senecio lautus. We show that similar phenotypes within each ecotype have evolved via mutational changes in different genes, though some are involved in similar biological functions. Our research not only helps to consolidate the field of parallel evolution, but paves the way to understanding the role of natural selection in the repeated evolution of similar phenotypes within nature.

Response and Composition in Archaic Greek Poetry

Antichthon ◽  
2011 ◽  
Vol 45 ◽  
pp. 58-76 ◽  
Author(s):  
Diana Burton
Keyword(s):  
Subject Matter ◽  
The Other ◽  
Ongoing Debate ◽  
Greek Poetry ◽  
The Subject ◽  
The Way ◽  
Archaic Greek Poetry

AbstractThis paper discusses a series of archaic poems in which one poet responds directly to the work of another, identifying the other by name or by direct allusion (for example, Simonides frag. 542 PMG, Solon frag. 20 West, Sappho frag. 137 Voigt). Such responses often disagree with their models, and this disagreement is frequently constructed in terms of a correction, not only to the subject matter, but also to the way in which the original is composed. These responses, therefore, not only reflect the pattern of improvisation and ‘capping’ common to much Greek poetry, but form an ongoing debate on the nature and role of the poet and his poetry. The construction of such responses also serves to underline both the importance of improvisation and the permanency of the fame conveyed by the completed poem.

Hegel's Organizational Account of Biological Functions

2020 ◽  
pp. 1-19
Author(s):  
Edgar Maraguat
Keyword(s):  
Natural Selection ◽  
Biological Function ◽  
The Other ◽  
Proper Function ◽  
Biological Functions ◽  
Real Work ◽  
Organizational Account ◽  
Philosophical Debates ◽  
Self Production

Abstract Two concepts have polarized the philosophical debates on functions since the 1970s. One is Millikan's concept of ‘proper function’, meant to capture the aetiology of biological organs and artefacts. The other is Cummins's concept of ‘dispositional function’, designed to account for the real work that functional devices perform within a system. In this paper I locate Hegel's concept of biological function in the context of those debates. Admittedly, Hegel's concept is ‘etiological’, since in his account the existence of purposive organs is explained by appeal to their purpose, yet, against Millikan's concept, Hegel's does not presuppose the phenomenon of natural selection nor derives the function of tokens from the function of types. So, my aim is, first, to present Hegel's approach to biological functions as one neither purely etiological nor purely dispositional. It will appear rather as an example of an organizational account (as those advocated today by McLaughlin, Mossio and others), that attributes function according to present performances (unlike etiological accounts) and emphasizes the role of functional parts in their self-production within the system they belong to (unlike dispositional accounts). Finally, I briefly discuss how Hegel's concept performs against common objections to organizational accounts.

scholarly journals Inferring the mode and strength of ongoing selection

2021 ◽  
Author(s):  
Gustavo Valadares Barroso ◽  
Kirk Lohmueller
Keyword(s):  
Natural Selection ◽  
Human Genetics ◽  
State Of The Art ◽  
Sequence Data ◽  
Model Organisms ◽  
Uk Biobank ◽  
Related Individuals ◽  
The Uk ◽  
Improve Health ◽  
The Way

Genome sequence data is no longer scarce. The UK Biobank alone comprises 200,000 individual genomes, with more on the way, leading the field of human genetics towards sequencing entire populations. Within the next decades, other model organisms will follow suit, especially domesticated species such as crops and livestock. Having sequences from most individuals in a population will present new challenges for using these data to improve health and agriculture in the pursuit of a sustainable future. Existing population genetic methods are designed to model hundreds of randomly sampled sequences, but are not optimized for extracting the information contained in the larger and richer datasets that are beginning to emerge, with thousands of closely related individuals. Here we develop a new method called TIDES (Trio-based Inference of Dominance and Selection) that uses data from tens of thousands of family trios to make inferences about natural selection acting in a single generation. TIDES further improves on the state-of-the-art by making no assumptions regarding demography, linkage or dominance. We discuss how our method paves the way for studying natural selection from new angles.

MANUSCRIPT EVIDENCE FOR ALPHABET-SWITCHING IN THE WORKS OF CICERO: COMMON NOUNS AND ADJECTIVES

2018 ◽  
Vol 68 (2) ◽  
pp. 498-516
Author(s):  
Neil O'Sullivan
Keyword(s):  
Recent Work ◽  
Code Switching ◽  
Consistent Pattern ◽  
Current Interest ◽  
Reliable Transmission ◽  
Accurate Record ◽  
The Way

Of the hundreds of Greek common nouns and adjectives preserved in our MSS of Cicero, about three dozen are found written in the Latin alphabet as well as in the Greek. So we find, alongside συμπάθεια, also sympathia, and ἱστορικός as well as historicus. This sort of variation has been termed alphabet-switching; it has received little attention in connection with Cicero, even though it is relevant to subjects of current interest such as his bilingualism and the role of code-switching and loanwords in his works. Rather than addressing these issues directly, this discussion sets out information about the way in which the words are written in our surviving MSS of Cicero and takes further some recent work on the presentation of Greek words in Latin texts. It argues that, for the most part, coherent patterns and explanations can be found in the alphabetic choices exhibited by them, or at least by the earliest of them when there is conflict in the paradosis, and that this coherence is evidence for a generally reliable transmission of Cicero's original choices. While a lack of coherence might indicate unreliable transmission, or even an indifference on Cicero's part, a consistent pattern can only really be explained as an accurate record of coherent alphabet choice made by Cicero when writing Greek words.

The adaptation of design thinking in auditing

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Linda MEIJER-WASSENAAR ◽  
Diny VAN EST
Keyword(s):  
The Netherlands ◽  
Design Thinking ◽  
Public Organizations ◽  
Design Framework ◽  
The Right ◽  
The Way

How can a supreme audit institution (SAI) use design thinking in auditing? SAIs audit the way taxpayers’ money is collected and spent. Adding design thinking to their activities is not to be taken lightly. SAIs independently check whether public organizations have done the right things in the right way, but the organizations might not be willing to act upon a SAI’s recommendations. Can you imagine the role of design in audits? In this paper we share our experiences of some design approaches in the work of one SAI: the Netherlands Court of Audit (NCA). Design thinking needs to be adapted (Dorst, 2015a) before it can be used by SAIs such as the NCA in order to reflect their independent, autonomous status. To dive deeper into design thinking, Buchanan’s design framework (2015) and different ways of reasoning (Dorst, 2015b) are used to explore how design thinking can be adapted for audits.

Bad Dreams and Secret Artists: Translating Freud into Literature

2002 ◽  
Vol 4 (2) ◽  
pp. 127-139 ◽  
Author(s):  
Ian Patterson
Keyword(s):  
Sigmund Freud ◽  
Ordinary Language ◽  
Close Reading ◽  
Careful Attention ◽  
Popular Approach ◽  
English Reader ◽  
Creative Writer ◽  
The Many ◽  
The Way

This article addresses the increasingly popular approach to Freud and his work which sees him primarily as a literary writer rather than a psychologist, and takes this as the context for an examination of Joyce Crick's recent translation of The Interpretation of Dreams. It claims that translation lies at the heart of psychoanalysis, and that the many interlocking and overlapping implications of the word need to be granted a greater degree of complexity. Those who argue that Freud is really a creative writer are themselves doing a work of translation, and one which fails to pay sufficiently careful attention to the role of translation in writing itself (including the notion of repression itself as a failure to translate). Lesley Chamberlain's The Secret Artist: A Close Reading of Sigmund Freud is taken as an example of the way Freud gets translated into a novelist or an artist, and her claims for his ‘bizarre poems' are criticized. The rest of the article looks closely at Crick's new translation and its claim to be restoring Freud the stylist, an ordinary language Freud, to the English reader. The experience of reading Crick's translation is compared with that of reading Strachey's, rather to the latter's advantage.

Prawne aspekty eutanazji w Holandii

2016 ◽  
Vol 14 (3) ◽  
pp. 243-253
Author(s):  
Grzegorz Stefanowicz
Keyword(s):  
The Netherlands ◽  
Assisted Suicide ◽  
Public Authority ◽  
Dutch Society ◽  
On Demand ◽  
Limited Length ◽  
The Law ◽  
Death On Demand ◽  
The Way

This article undertakes to show the way that has led to the statutory decriminalization of euthanasia-related murder and assisted suicide in the Kingdom of the Netherlands. It presents the evolution of the views held by Dutch society on the euthanasia related practice, in the consequence of which death on demand has become legal after less than thirty years. Due attention is paid to the role of organs of public authority in these changes, with a particular emphasis put on the role of the Dutch Parliament – the States General. Because of scarcity of space and limited length of the article, the change in the attitudes toward euthanasia, which has taken place in the Netherlands, is presented in a synthetic way – from the first discussions on admissibility of a euthanasia-related murder carried out in the 1970s, through the practice of killing patients at their request, which was against the law at that time, but with years began more and more acceptable, up to the statutory decriminalization of euthanasia by the Dutch Parliament, made with the support of the majority of society.

The Role of Music and Allied Arts in Public Writings on Cultural Diversity: “People of Sri Lanka”

2020 ◽  
Vol 6 ◽  
pp. 93-100
Author(s):  
Gisa Jähnichen
Keyword(s):  
Sri Lanka ◽  
Cultural Diversity ◽  
South Asia ◽  
Case Studies ◽  
Sri Lankan ◽  
Culturally Different ◽  
The World ◽  
Official Languages ◽  
The Way

The Sri Lankan Ministry of National Coexistence, Dialogue, and Official Languages published the work “People of Sri Lanka” in 2017. In this comprehensive publication, 21 invited Sri Lankan scholars introduced 19 different people’s groups to public readers in English, mainly targeted at a growing number of foreign visitors in need of understanding the cultural diversity Sri Lanka has to offer. This paper will observe the presentation of these different groups of people, the role music and allied arts play in this context. Considering the non-scholarly design of the publication, a discussion of the role of music and allied arts has to be supplemented through additional analyses based on sources mentioned by the 21 participating scholars and their fragmented application of available knowledge. In result, this paper might help improve the way facts about groups of people, the way of grouping people, and the way of presenting these groupings are displayed to the world beyond South Asia. This fieldwork and literature guided investigation should also lead to suggestions for ethical principles in teaching and presenting of culturally different music practices within Sri Lanka, thus adding an example for other case studies.

Something Gleaming

Theoria ◽  
2020 ◽  
Vol 67 (165) ◽  
pp. 92-117
Author(s):  
Bronwyn Leebaw
Keyword(s):  
The Political ◽  
Political Role ◽  
Common Concern ◽  
The Way

What kinds of lessons can be learned from stories of those who resisted past abuses and injustices? How should such stories be recovered, and what do they have to teach us about present day struggles for justice and accountability? This paper investigates how Levi, Broz, and Arendt formulate the political role of storytelling as response to distinctive challenges associated with efforts to resist systematic forms of abuse and injustice. It focuses on how these thinkers reflected on such themes as witnesses, who were personally affected, to varying degrees, by atrocities under investigation. Despite their differences, these thinkers share a common concern with the way that organised atrocities are associated with systemic logics and grey zones that make people feel that it would be meaningless or futile to resist. To confront such challenges, Levi, Arendt and Broz all suggest, it is important to recover stories of resistance that are not usually heard or told in ways that defy the expectations of public audiences. Their distinctive storytelling strategies are not rooted in clashing theories of resistance, but rather reflect different perspectives on what is needed to make resistance meaningful in contexts where the failure of resistance is intolerable.

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