scholarly journals The Male Fertility Gene Atlas – A web tool for collecting and integrating data about epi-/genetic causes of male infertility

2020 ◽  
Author(s):  
H. Krenz ◽  
J. Gromoll ◽  
T. Darde ◽  
F. Chalmel ◽  
M. Dugas ◽  
...  
Keyword(s):  
Male Infertility ◽  
Male Fertility ◽  
Cell Types ◽  
Study Data ◽  
Web Tool ◽  
Scientific Publications ◽  
Data Repositories ◽  
Research Results ◽  
Fertility Gene ◽  
Meta Information

AbstractInterconnecting results of previous OMICs studies is of major importance for identifying novel underlying causes of male infertility. To date, information can be accessed mainly through literature search engines and raw data repositories. However, both have limited capacity in identifying relevant publications based on aggregated research results e.g. genes mentioned in images and supplements. To address this gap, we present the Male Fertility Gene Atlas (MFGA), a web tool that enables standardised representation and search of aggregated result data of scientific publications. An advanced search function is provided for querying research results based on study conditions/phenotypes, meta information and genes returning the exact tables and figures from the publications fitting the search request as well as a list of most frequently investigated genes. As basic prerequisite, a flexible data model that can accommodate and structure a very broad range of meta information, data tables and images was designed and implemented for the system. The first version of the system is published at the URL https://mfga.uni-muenster.de and contains a set of 46 representative publications. Currently, study data for 28 different tissue types, 32 different cell types and 20 conditions is available. Also, ∼5,000 distinct genes have been found to be mentioned in at least ten of the publications. As a result, the MFGA is a valuable addition to available tools for research on the epi-/genetics of male infertility. The MFGA enables a more targeted search and interpretation of OMICs data on male infertility and germ cells in the context of relevant publications. Moreover, its capacity for aggregation allows for meta-analyses and data mining with the potential to reveal novel insights into male infertility based on available data.

scholarly journals The Male Fertility Gene Atlas: a web tool for collecting and integrating OMICS data in the context of male infertility

2020 ◽  
Vol 35 (9) ◽  
pp. 1983-1990 ◽  
Author(s):  
Henrike Krenz ◽  
Jörg Gromoll ◽  
Thomas Darde ◽  
Frederic Chalmel ◽  
Martin Dugas ◽  
...  
Keyword(s):  
Male Infertility ◽  
Clinical Research ◽  
Germ Cells ◽  
Male Fertility ◽  
Literature Search ◽  
Research Unit ◽  
Male Germ Cells ◽  
Raw Data ◽  
Fertility Gene ◽  
Clinical Research Unit

Abstract STUDY QUESTION How can one design and implement a system that provides a comprehensive overview of research results in the field of epi-/genetics of male infertility and germ cells? SUMMARY ANSWER Working at the interface of literature search engines and raw data repositories, the newly developed Male Fertility Gene Atlas (MFGA) provides a system that can represent aggregated results from scientific publications in a standardized way and perform advanced searches, for example based on the conditions (phenotypes) and genes related to male infertility. WHAT IS KNOWN ALREADY PubMed and Google Scholar are established search engines for research literature. Additionally, repositories like Gene Expression Omnibus and Sequence Read Archive provide access to raw data. Selected processed data can be accessed by visualization tools like the ReproGenomics Viewer. STUDY DESIGN, SIZE, DURATION The MFGA was developed in a time frame of 18 months under a rapid prototyping approach. PARTICIPANTS/MATERIALS, SETTING, METHODS In the context of the Clinical Research Unit ‘Male Germ Cells’ (CRU326), a group of around 50 domain experts in the fields of male infertility and germ cells helped to develop the requirements engineering and feedback loops. They provided a set of 39 representative and heterogeneous publications to establish a basis for the system requirements. MAIN RESULTS AND THE ROLE OF CHANCE The MFGA is freely available online at https://mfga.uni-muenster.de. To date, it contains 115 data sets corresponding to 54 manually curated publications and provides an advanced search function based on study conditions, meta-information and genes, whereby it returns the publications’ exact tables and figures that fit the search request as well as a list of the most frequently investigated genes in the result set. Currently, study data for 31 different tissue types, 32 different cell types and 20 conditions are available. Also, ∼8000 and ∼1000 distinct genes have been found to be mentioned in at least 10 and 15 of the publications, respectively. LARGE SCALE DATA Not applicable because no novel data were produced. LIMITATIONS, REASONS FOR CAUTION For the most part, the content of the system currently includes the selected publications from the development process. However, a structured process for the prospective literature search and inclusion into the MFGA has been defined and is currently implemented. WIDER IMPLICATIONS OF THE FINDINGS The technical implementation of the MFGA allows for accommodating a wide range of heterogeneous data from aggregated research results. This implementation can be transferred to other diseases to establish comparable systems and generally support research in the medical field. STUDY FUNDING/COMPETING INTEREST(S) This work was carried out within the frame of the German Research Foundation (DFG) Clinical Research Unit ‘Male Germ Cells: from Genes to Function’ (CRU326). The authors declare no conflicts of interest.

The mechanisms involved in obesity-induced male infertility

2020 ◽  
Vol 16 ◽  
Author(s):  
Hamed Heydari ◽  
Rafighe Ghiasi ◽  
Saber Ghaderpour ◽  
Rana Keyhanmanesh
Keyword(s):  
Oxidative Stress ◽  
Metabolic Disease ◽  
Male Infertility ◽  
Male Fertility ◽  
Reproductive Function ◽  
Disease Development ◽  
Significant Evidence ◽  
Male Reproductive Function ◽  
Negative Effect ◽  
And Oxidative Stress

Introduction: Obesity resulted by imbalance between the intake of energy and energy consumption can lead to growth and metabolic disease development in people. Both in obese men and animal models, several studies indicate that obesity leads to male infertility. Objective: This review has discussed some mechanisms involved in obesity-induced male infertility. Method: Online documents were searched through Science Direct, Pubmed, Scopus, and Google Scholar websites dating from 1959 to recognize studies on obesity, kisspeptin, leptin, and infertility. Results: Obesity induced elevated inflammatory cytokines and oxidative stress can affect male reproductive functions including spermatogenesis disorders, reduced male fertility power and hormones involved in hypothalamus-pituitarygonadal axis. Conclusion: There is significant evidence that obesity resulted in male infertility. obesity has negative effect on male reproductive function via several mechanisms such as inflammation and oxidative stress.

scholarly journals Transcription of gypsy Elements in a Y-Chromosome Male Fertility Gene of Drosqbhila hydei

Genetics ◽  
1996 ◽  
Vol 142 (2) ◽  
pp. 437-446
Author(s):  
Ron Hochstenbach ◽  
Harry Harhangi ◽  
Karin Schouren ◽  
Petra Bindels ◽  
Ron Suijkerbuijk ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Male Fertility ◽  
Fluorescent In Situ Hybridization ◽  
Primary Spermatocyte ◽  
Transcription Unit ◽  
Major Constituent ◽  
Fertility Gene ◽  
Sequence Types ◽  
Gypsy Retrotransposons

Abstract We have found that defective gypsy retrotransposons are a major constituent of the lampbrush loop pair Nooses in the short arm of the Y chromosome of Drosophila hydei. The loop pair is formed by male fertility gene Q during the primary spermatocyte stage of spermatogenesis, each loop being a single transcription unit with an estimated length of 260 kb. Using fluorescent in situ hybridization, we show that throughout the loop transcripts gypsy elements are interspersed with blocks of a tandemly repetitive Y-specific DNA sequence, ay1. Nooses transcripts containing both sequence types show a wide size range on Northern blots, do not migrate to the cytoplasm, and are degraded just before the first meiotic division. Only one strand of ay1 and only the coding strand of gypsy can be detected in the loop transcripts. However, as cloned genomic DNA fragments also display opposite orientations of ay1 and gypsy, such DNA sections cannot be part of the Nooses. Hence, they are most likely derived from the flanking heterochromatin. The direction of transcription of ayl and gypsy thus appears to be of a functional significance.

Infertility and the Military Male

2019 ◽  
Vol 37 (01) ◽  
pp. 005-011
Author(s):  
Amanda B. Reed-Maldonado ◽  
Kristin C. Madden
Keyword(s):  
Male Infertility ◽  
Military Service ◽  
Clinical Investigation ◽  
Male Factor Infertility ◽  
Military Population ◽  
Male Factor ◽  
Scientific Publications ◽  
Military Service Members ◽  
Infertile Couples ◽  
The Military

AbstractMale infertility is a condition that affects approximately 50% of infertile couples and about 30% of those couples have only male factor infertility identified. There has been speculation that male military service members may have an even greater lifetime prevalence of infertility as compared to the general population, but very few scientific publications focus on male factor infertility in the military population specifically. This review will discuss many of the unique considerations regarding male infertility in the military and highlight future opportunities for research. The military/federal health system has the potential to serve as a leader in both the delivery of health care for male factor infertility and in the clinical investigation into the etiologies of and treatments for male factor infertility.

KEPUTUSAN WISATAWAN PRANCIS BERLIBUR KE BALI PADA ERA NEW NORMAL

2021 ◽  
Vol 15 (01) ◽  
Author(s):  
Ferhadius Endi ◽  
Danang Prasetyo
Keyword(s):  
Descriptive Study ◽  
Study Data ◽  
New Normal ◽  
Research Results ◽  
Travel Agents ◽  
Service Business ◽  
Questions And Answers ◽  
Qualitative Descriptive ◽  
Tourism Service

This study discusses the decision of French tourists on their planned visit to Bali in the new normal era in 2021. This research is a qualitative descriptive study. Data was obtained by means of online interviews and questions and answers via email to 35 potential tourists. Based on the results of research that has been done, it was found that two decisions of French tourists regarding their vacation plans to Bali, namely: (1) Cancellation of tour trips with the consideration of (a) changes in tourist budgets and financial plans, (b) health reasons for tourists, (c) difficulty in managing time, and (d) the uncertainty of the global situation. (2) Delay or reschedule Tour trips. The factors that influence tourists to continue their travel agenda to Bali with a note of rescheduling, namely: (a) Advances that have been paid to travel agents, (b) the need for post-lockdown holidays during 2020, and ( c) vaccination as an effort to protect the tourists from Covid-19. The hope is that the exposure of the research results can be a reference for researchers, tourism service business actors, and tourists to work together to implement health protocols in all tourism activities for a better Indonesian tourism. Keywords: French Tourists, Bali Tourism, New Normal

scholarly journals Importance of Genetic Factors in Male Fertility Disorders, Clinical Relevance of Epigenetic Markers in Male Infertility

2019 ◽  
Vol 70 (7) ◽  
pp. 2566-2570
Author(s):  
Dragos Botezatu ◽  
Cristina Popescu ◽  
Andrei-Dan Korodi ◽  
Cristian Furau ◽  
Gheorghe Furau ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Male Infertility ◽  
Male Fertility ◽  
Complex Problem ◽  
The Body ◽  
Control Group ◽  
Global Methylation ◽  
Methylation Of Dna ◽  
Genome Methylation ◽  
Methylation Patterns

Male infertility is a common and complex problem affecting 1 out of 20 men. Despite extensive research in this area, in many cases, the underlying causes are unknown. Epigenetic changes control a series of processes within the body, including male fertility. Classification of infertile men using a more detailed analysis of DNA methylation patterns could reveal a new level of low rates of fertilization, implantation, or pregnancy. In this context, it seemed to us to use the techniques available to evaluate the degree of global methylation of DNA in infertile patients who have modified sperm counts, but also those who apparently do not have a clear cause of infertility. For this we used the Quest 5mC-Zymoresaerch-ELISA kit that can detect within about 5 hours the global level of genome methylation. Claims on which common illnesses have an epigenetic base are still open to speculation, but if true, it can imprint a new direction in medicine. Our data, although from a pilot study, are consistent with those in the literature. A recent study has shown that DNA methylation levels were significantly higher in oligoasthenoteratozoospermia patients than in the control group and the increase in global DNA methylation and histone retention in men with oligoasthenoteratozoospermia.

scholarly journals A Keyword-Based Literature Review Data Generating Algorithm—Analyzing a Field from Scientific Publications

Symmetry ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 903
Author(s):  
Junchao Wang ◽  
Guodong Su ◽  
Chengrui Wan ◽  
Xiwei Huang ◽  
Lingling Sun
Keyword(s):  
Lab On A Chip ◽  
Future Trend ◽  
Research Field ◽  
Levenshtein Distance ◽  
Scientific Publications ◽  
Scientific Review ◽  
The Past ◽  
Communication Engineering ◽  
Chip Technology ◽  
Meta Information

A scientific review is a type of article that summarizes the current state of a specific field, which is crucial for promoting the advancement of our science community. Authors need to read hundreds of research articles to prepare the data and insights for a comprehensive review, which is time-consuming and labor-intensive. In this work, we present an algorithm that can automatically extract keywords from the meta-information of each article and generate the basic data for review articles. Two different fields—communication engineering, and lab on a chip technology—were analyzed as examples. We first built an article library by downloading all the articles from the target journal using a python-based crawler. Second, the rapid automatic keyword extraction algorithm was implemented on the title and abstract of each article. Finally, we classified all extracted keywords into class by calculating the Levenshtein distance between each of them. The results demonstrated its capability of not only finding out how communication engineering and lab on a chip were evolved in the past decades but also summarizing the analytical outcomes after data mining of the extracted keywords. Our algorithm is more than a useful tool for researchers during the preparation of a review article, it can also be applied to quantitatively analyze the past, present and help authors predict the future trend of a specific research field.

scholarly journals Regulation of Male Fertility by the Renin-Angiotensin System

2020 ◽  
Vol 21 (21) ◽  
pp. 7943
Author(s):  
Marta Gianzo ◽  
Nerea Subirán
Keyword(s):  
Blood Pressure ◽  
Male Infertility ◽  
Male Fertility ◽  
Seminal Fluid ◽  
Renin Angiotensin System ◽  
Design Tools ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Plasma Electrolytes ◽  
Sperm Functions

The renin-angiotensin system (RAS) is a peptidic system known mainly for its roles in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, several tissues and cells have been described to possess an intrinsic RAS that acts locally through different paracrine and autocrine mechanisms. In the male reproductive system, several components of this system have been observed in various organs and tissues, such as the testes, spermatozoa and seminal fluid. Some functions attributed to this local RAS are maintenance of seminal plasma electrolytes, regulation of steroidogenesis and spermatogenesis, and sperm functions. However, their specific actions in these locations are not fully understood. Therefore, a deep knowledge of the functions of the RAS at both the testicular and seminal levels could clarify its roles in male infertility and sperm physiology, and the different RAS elements could be used to design tools enabling the diagnosis and/or treatment of male infertility.

FERTILITY COMPENSATION OF CORNERSTONE MALE STERILITY OF WHEAT BY RYE

Genetics ◽  
1983 ◽  
Vol 104 (1) ◽  
pp. 181-189
Author(s):  
M A Hossain ◽  
C J Driscoll
Keyword(s):  
Male Sterility ◽  
Male Fertility ◽  
Wheat Chromosome ◽  
Hybrid Wheat ◽  
Specific Expression ◽  
Entire Chromosome ◽  
Chromosome Arm ◽  
Fertility Gene

ABSTRACT The genome of rye is known to compensate for the lost male-fertility gene(s) of wheat chromosome arm 4Aα in the Cornerstone male-sterility mutant. A search for the rye chromosome(s) involved in this compensation showed that chromosomes 2R and 4R are responsible. Only the short arms of these two chromosomes are the operative ones. Chromosome arm 4RS compensates in an erratic way, whereas 2RS compensates in a full and consistent way. The entire chromosome 2R compensates less well than the 2RS telocentric which reflects an antifertility factor(s) on 2RL. This may be a specific expression of the 2R genes for poor vigor which are located on only the long arm. 2RS will be a valuable piece of chromatin for the XYZ system of producing hybrid wheat.

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