scholarly journals Role of Chloroquine and Hydroxychloroquine in the Treatment of COVID-19 Infection- A Systematic Literature Review

2020 ◽  
Author(s):  
Krishan Mohan Kapoor ◽  
Aanandita Kapoor
Keyword(s):  
Systematic Review ◽  
Clinical Evidence ◽  
Public Health Emergency ◽  
Limited Information ◽  
Global Public Health ◽  
Long Time ◽  
Coronavirus Infection ◽  
Meta Analyses ◽  
Insight Into

AbstractBackgroundCoronavirus pandemic is currently a global public health emergency. At present, no pharmacological treatment is known to treat this condition, and there is a need to review the available treatments.ObjectiveWhile there have been studies to describe the role of chloroquine and hydroxychloroquine in various viral conditions, there is limited information about the use of them in COVID-19. This systematic review aims to summarize the available evidence regarding the role of chloroquine in treating coronavirus infection.MethodsThe preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were used for this review. A literature search was performed using PUBMED & Google Scholar to find articles about the role of CQ in COVID-19 patients.ResultsWe included 19 publications (Five published articles, three letters/correspondence, one commentary, five pre-proofs of accepted articles, one abstract of yet to be published article, and four were pre-prints (not yet peer-reviewed) articles) in this systematic review. All the articles mentioned about the role of chloroquine and /or hydroxychloroquine in limiting the infection with SARS-CoV-2 (the virus causing COVID-19).ConclusionsThere is theoretical, experimental, preclinical and clinical evidence of the effectiveness of chloroquine in patients affected with COVID-19. There is adequate evidence of drug safety from the long-time clinical use of chloroquine and hydroxychloroquine in other indications. More data from ongoing and future trials will add more insight into the role of chloroquine and hydroxychloroquine in COVID-19 infection.

scholarly journals Impacts of E-Micromobility on the Sustainability of Urban Transportation—A Systematic Review

2021 ◽  
Vol 11 (13) ◽  
pp. 5851
Author(s):  
Buket Şengül ◽  
Hamid Mostofi
Keyword(s):  
Systematic Review ◽  
Urban Transportation ◽  
Research Data ◽  
Modal Shift ◽  
Comprehensive Overview ◽  
Average Travel Time ◽  
Sharp Growth ◽  
Travel Behaviors ◽  
Insight Into

When considering the sharp growth rate of the use of e-micromobility vehicles, such as e-scooters and e-bikes, it is necessary to investigate whether these emerging modes of transport play a sustainable role in cities in terms of their energy efficiency, emissions, and their relationship with other modes of mobility, such as public transport. This paper aims to provide a comprehensive overview of the impacts of e-micromobility through a systematic review of relevant studies in the field of e-scooters and e-bikes. We followed the steps of PRISMA to conduct a systematic literature review, including identification, screening, eligibility and inclusion steps. One hundred forty-six studies were reviewed and compiled, and 29 of these studies were selected for the focus of this review and their research data were synthesized. The impacts of e-micromobilities were categorized into four categories—travel behaviors, energy consumption, environmental impacts, and safety and related regulations. The category of travel behaviors includes the analysis of the purposes of travel, modal shift from different modes of transport to e-micromobility vehicles, average travel time, and distance. In this review, the findings of relevant studies in different cities around world are compared to each other and synthesized to give an insight into the role of e-micromobility in the present and in the future of urban transportation.

Update on hypnotherapy for psychiatrists

2021 ◽  
pp. 1-7
Author(s):  
Natalie A. Chan ◽  
Zhisong Zhang ◽  
Guoxing Yin ◽  
Zhimeng Li ◽  
Roger C. Ho
Keyword(s):  
Psychiatric Disorders ◽  
Practice Guidelines ◽  
Review Article ◽  
Outcome Studies ◽  
Evidence Based ◽  
High Quality ◽  
Long Time ◽  
Meta Analyses ◽  
Evidence Based Therapy

SUMMARY Although hypnosis has played a part in psychotherapy for a long time, it is not yet seen as an evidence-based therapy and is absent from many practice guidelines when it comes to the treatment of psychiatric disorders. At present, the applications and methods of hypnotherapy are poorly understood and other methods of psychotherapy tend to be favoured. This review article aims to introduce the role of hypnotherapy and its application for certain common psychiatric presentations, as well as examine its efficacy by summarising recent evidence from high-quality outcome studies and meta-analyses.

scholarly journals Personality Factors in Colorectal Cancer: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Federica Galli ◽  
Ludovica Scotto ◽  
Simona Ravenda ◽  
Maria Giulia Zampino ◽  
Gabriella Pravettoni ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Emotional Regulation ◽  
Cochrane Collaboration ◽  
Personality Factors ◽  
Intervention Plan ◽  
Long Time ◽  
Newcastle Ottawa Scale ◽  
The Cochrane Collaboration

Background: The role of personality in cancer incidence and development has been studied for a long time. As colorectal cancer (CRC) is one of the most prevalent cancer types and linked with lifestyle habits, it is important to better understand its psychological correlates, in order to design a more specific prevention and intervention plan. The aim of this systematic review is to analyze all the studies investigating the role of personality in CRC incidence.Methods: All studies on CRC and personality up to November 2020 were scrutinized according to the Cochrane Collaboration and the PRISMA statements. Selected studies were additionally evaluated for the Risk of Bias according to the Newcastle-Ottawa Scale (NOS).Results: Eight studies met the inclusion criteria and were eventually included in this review. Two main constructs have been identified as potential contributors of CRC incidence: emotional regulation (anger) and relational style (egoism).Conclusion: Strong conclusions regarding the influence of personality traits on the incidence of CRC are not possible, because of the small number and the heterogeneity of the selected studies. Further research is needed to understand the complexity of personality and its role in the incidence of CRC and the interaction with other valuable risk factors.

scholarly journals Role of Statues in the Artistic Commemoration of African Political Leaders: Analysis of 20 Selected National Statues in African Countries

2021 ◽  
Vol 3 (1) ◽  
pp. 40-77
Author(s):  
Kamau Wango
Keyword(s):  
Public Art ◽  
The Political ◽  
Human Beings ◽  
Political Leaders ◽  
African Countries ◽  
Long Time ◽  
The Subject ◽  
Visual Impact ◽  
Insight Into

Artistic commemoration of leaders and other iconic personalities has been in existence for centuries. Statues in particular have been used as a fitting avenue for the commemoration of political leaders and other luminaries in many fields. The premise upon which statues are made is that the subjects featured initiated and attained, in their lifetimes, concrete achievements that significantly impacted upon the lives of their fellow human beings. Other criteria for commemoration include proven integrity, dedication and selflessness in the service of the country and citizens. Statues as an integral part of public art have often generated substantial controversy on various fronts in many countries. Some of these gravitate around issues such as disputed likeness, queries about the fundamental achievements cited of the subject, at times open protests on the actions, character and integrity of the subject as well as the location of the statues. Other areas of contention include the implication of the presence of statues upon the political psyche of the country and their long-time impact on history, the youth and posterity. This paper examines the extent to which African countries have embraced this mode of artistic rendition to commemorate African political leaders in a way that is commensurate to their achievements. It is outside the scope of this paper to delve into the intricate web of back-and-forth arguments about the ‘concreteness’ of the legacies of the featured leaders who are mainly founding political figures of the respective countries. The paper, however, analyses the artistic essence of the selected statues in terms of their visual impact and whether they are indeed useful in articulating the legacies of the subjects and further, whether they ultimately bear ‘enduring visual value’ that spurs conversation and insight into these legacies. Statues must, at the very least, spur debate and conversation into the legacy of the featured subject. It becomes a form of constant interrogation as history itself takes its course; controversy is not necessarily a negative occurrence since it forms part of this discourse. The concept of immortalization, which is what initiators of statues often hope for is much harder to achieve and difficult to define. The paper examines 20 statues of African political leaders in different African Countries.

scholarly journals Detecting Emotions through Electrodermal Activity in Learning Contexts: A Systematic Review

Sensors ◽  
2021 ◽  
Vol 21 (23) ◽  
pp. 7869
Author(s):  
Anne Horvers ◽  
Natasha Tombeng ◽  
Tibor Bosse ◽  
Ard W. Lazonder ◽  
Inge Molenaar
Keyword(s):  
Systematic Review ◽  
Learning Outcomes ◽  
Educational Research ◽  
Electrodermal Activity ◽  
Physiological Arousal ◽  
Strong Increase ◽  
Guidelines And Standards ◽  
Methodological Aspects ◽  
Insight Into

There is a strong increase in the use of devices that measure physiological arousal through electrodermal activity (EDA). Although there is a long tradition of studying emotions during learning, researchers have only recently started to use EDA to measure emotions in the context of education and learning. This systematic review aimed to provide insight into how EDA is currently used in these settings. The review aimed to investigate the methodological aspects of EDA measures in educational research and synthesize existing empirical evidence on the relation of physiological arousal, as measured by EDA, with learning outcomes and learning processes. The methodological results pointed to considerable variation in the usage of EDA in educational research and indicated that few implicit standards exist. Results regarding learning revealed inconsistent associations between physiological arousal and learning outcomes, which seem mainly due to underlying methodological differences. Furthermore, EDA frequently fluctuated during different stages of the learning process. Compared to this unimodal approach, multimodal designs provide the potential to better understand these fluctuations at critical moments. Overall, this review signals a clear need for explicit guidelines and standards for EDA processing in educational research in order to build a more profound understanding of the role of physiological arousal during learning.

Gonadotrophic Hormones – An Overview of their Involvement in Gonadal and Extragonadal Tumours

2010 ◽  
Vol 7 (1) ◽  
pp. 8 ◽  
Author(s):  
Ilpo Huhtaniemi ◽  
Maria Alevizaki ◽  
◽  
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Clinical Evidence ◽  
Critical Evaluation ◽  
Regulatory Action ◽  
Experimental Animal Models ◽  
Direct Involvement ◽  
Long Time

The concept of the direct involvement of gonadotrophins in tumorigenesis has been around for a long time. First, because the gonads are direct targets of gonadotrophin action, their tumours have been proposed to be gonadotrophin-dependent. Second, the recent findings of gonadotrophin receptors in extragonadal tissues has prompted the hypothesis that some extragonadal tumours (e.g. breast, uterus, prostate, pituitary and adrenal) could also be under the direct regulatory action of gonadotrophins. However, although supported by numerousin vitroexperiments and experimental animal models, the clinical evidence for a direct tumorigenic role of gonadotrophins remains weak. The purpose of this brief review is to present a critical evaluation of current information, both clinical and experimental, about the involvement of gonadotrophins in the induction and growth of gonadal and extragonadal tumours.

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