scholarly journals COVIDier: A Deep-learning Tool For Coronaviruses Genome And Virulence Proteins Classification

Author(s):  
Peter T. Habib ◽  
Alsamman M. Alsamman ◽  
Maha Saber-Ayad ◽  
Sameh E. Hassanein ◽  
Aladdin Hamwieh

AbstractCOVID-19, caused by SARS-CoV-2 infection, has already reached pandemic proportions in a matter of a few weeks. At the time of writing this manuscript, the unprecedented public health crisis caused more than 2.5 million cases with a mortality range of 5-7%. The SARS-CoV-2, also called novel Coronavirus, is related to both SARS-CoV and bat SARS. Great efforts have been spent to control the pandemic that has become a significant burden on the health systems in a short time. Since the emergence of the crisis, a great number of researchers started to use the AI tools to identify drugs, diagnosing using CT scan images, scanning body temperature, and classifying the severity of the disease. The emergence of variants of the SARS-CoV-2 genome is a challenging problem with expected serious consequences on the management of the disease. Here, we introduce COVIDier, a deep learning-based software that is enabled to classify the different genomes of Alpha coronavirus, Beta coronavirus, MERS, SARS-CoV-1, SARS-CoV-2, and bronchitis-CoV. COVIDier was trained on 1925 genomes, belonging to the three families of SARS retrieved from NCBI Database to propose a new method to train deep learning model trained on genome data using Multi-layer Perceptron Classifier (MLPClassifier), a deep learning algorithm, that could blindly predict the virus family name from the genome of by predicting the statistically similar genome from training data to the given genome. COVIDier able to predict how close the emerging novel genomes of SARS to the known genomes with accuracy 99%. COVIDier can replace tools like BLAST that consume higher CPU and time.

2020 ◽  
pp. 1-17
Author(s):  
Yanhong Yang ◽  
Fleming Y.M. Lure ◽  
Hengyuan Miao ◽  
Ziqi Zhang ◽  
Stefan Jaeger ◽  
...  

Background: Accurate and rapid diagnosis of coronavirus disease (COVID-19) is crucial for timely quarantine and treatment. Purpose: In this study, a deep learning algorithm-based AI model using ResUNet network was developed to evaluate the performance of radiologists with and without AI assistance in distinguishing COVID-19 infected pneumonia patients from other pulmonary infections on CT scans. Methods: For model development and validation, a total number of 694 cases with 111,066 CT slides were retrospectively collected as training data and independent test data in the study. Among them, 118 are confirmed COVID-19 infected pneumonia cases and 576 are other pulmonary infections cases (e.g. tuberculosis cases, common pneumonia cases and non-COVID-19 viral pneumonia cases). The cases were divided into training and testing datasets. The independent test was performed by evaluating and comparing the performance of three radiologists with different years of practice experience in distinguishing COVID-19 infected pneumonia cases with and without the AI assistance. Results: Our final model achieved an overall test accuracy of 0.914 with an area of the receiver operating characteristic (ROC) curve (AUC) of 0.903 in which the sensitivity and specificity are 0.918 and 0.909, respectively. The deep learning-based model then achieved a comparable performance by improving the radiologists’ performance in distinguish COVOD-19 from other pulmonary infections, yielding better average accuracy and sensitivity, from 0.941 to 0.951 and from 0.895 to 0.942, respectively, when compared to radiologists without using AI assistance. Conclusion: A deep learning algorithm-based AI model developed in this study successfully improved radiologists’ performance in distinguishing COVID-19 from other pulmonary infections using chest CT images.


2018 ◽  
Vol 7 (2.25) ◽  
pp. 37
Author(s):  
K S. Harish Kumar ◽  
Dijo Micheal Jerald ◽  
A Emmanuel

A good treatment is dependent on the accuracy of the diagnosis. The cure for the disease starts with the process of diagnosis. All these years, the grade and standard of the medical field has been increasing exponentially, yet there has been no significant downfall in the rate of unintentional medical errors. These errors can be avoided using Deep learning algorithm to predict the disease. The Deep Learning algorithm scans analyses and compares the patient's report with its dataset and predicts the nature and severity of the disease. The test results from the patient’s report are extracted by using PDF processing. More the medical reports analyzed, more will be the intelligence gained by the algorithm. This will be of great assistance to the doctors as they can interpret their diagnosis with the results predicted by the algorithm.  


2021 ◽  
Vol 5 (4) ◽  
pp. 74
Author(s):  
Ervin Gubin Moung ◽  
Chong Joon Hou ◽  
Maisarah Mohd Sufian ◽  
Mohd Hanafi Ahmad Hijazi ◽  
Jamal Ahmad Dargham ◽  
...  

The COVID-19 pandemic has resulted in a global health crisis. The rapid spread of the virus has led to the infection of a significant population and millions of deaths worldwide. Therefore, the world is in urgent need of a fast and accurate COVID-19 screening. Numerous researchers have performed exceptionally well to design pioneering deep learning (DL) models for the automatic screening of COVID-19 based on computerised tomography (CT) scans; however, there is still a concern regarding the performance stability affected by tiny perturbations and structural changes in CT images. This paper proposes a fusion of a moment invariant (MI) method and a DL algorithm for feature extraction to address the instabilities in the existing COVID-19 classification models. The proposed method incorporates the MI-based features into the DL models using the cascade fusion method. It was found that the fusion of MI features with DL features has the potential to improve the sensitivity and accuracy of the COVID-19 classification. Based on the evaluation using the SARS-CoV-2 dataset, the fusion of VGG16 and Hu moments shows the best result with 90% sensitivity and 93% accuracy.


2021 ◽  
Vol 8 (3) ◽  
pp. 619
Author(s):  
Candra Dewi ◽  
Andri Santoso ◽  
Indriati Indriati ◽  
Nadia Artha Dewi ◽  
Yoke Kusuma Arbawa

<p>Semakin meningkatnya jumlah penderita diabetes menjadi salah satu faktor penyebab semakin tingginya penderita penyakit <em>diabetic retinophaty</em>. Salah satu citra yang digunakan oleh dokter mata untuk mengidentifikasi <em>diabetic retinophaty</em> adalah foto retina. Dalam penelitian ini dilakukan pengenalan penyakit diabetic retinophaty secara otomatis menggunakan citra <em>fundus</em> retina dan algoritme <em>Convolutional Neural Network</em> (CNN) yang merupakan variasi dari algoritme Deep Learning. Kendala yang ditemukan dalam proses pengenalan adalah warna retina yang cenderung merah kekuningan sehingga ruang warna RGB tidak menghasilkan akurasi yang optimal. Oleh karena itu, dalam penelitian ini dilakukan pengujian pada berbagai ruang warna untuk mendapatkan hasil yang lebih baik. Dari hasil uji coba menggunakan 1000 data pada ruang warna RGB, HSI, YUV dan L*a*b* memberikan hasil yang kurang optimal pada data seimbang dimana akurasi terbaik masih dibawah 50%. Namun pada data tidak seimbang menghasilkan akurasi yang cukup tinggi yaitu 83,53% pada ruang warna YUV dengan pengujian pada data latih dan akurasi 74,40% dengan data uji pada semua ruang warna.</p><p> </p><p><em><strong>Abstract</strong></em></p><p class="Abstract"><em>Increasing the number of people with diabetes is one of the factors causing the high number of people with diabetic retinopathy. One of the images used by ophthalmologists to identify diabetic retinopathy is a retinal photo. In this research, the identification of diabetic retinopathy is done automatically using retinal fundus images and the Convolutional Neural Network (CNN) algorithm, which is a variation of the Deep Learning algorithm. The obstacle found in the recognition process is the color of the retina which tends to be yellowish red so that the RGB color space does not produce optimal accuracy. Therefore, in this research, various color spaces were tested to get better results. From the results of trials using 1000 images data in the color space of RGB, HSI, YUV and L * a * b * give suboptimal results on balanced data where the best accuracy is still below 50%. However, the unbalanced data gives a fairly high accuracy of 83.53% with training data on the YUV color space and 74,40% with testing data on all color spaces.</em></p><p><em><strong><br /></strong></em></p>


2021 ◽  
Vol 54 (3-4) ◽  
pp. 439-445
Author(s):  
Chih-Ta Yen ◽  
Sheng-Nan Chang ◽  
Cheng-Hong Liao

This study used photoplethysmography signals to classify hypertensive into no hypertension, prehypertension, stage I hypertension, and stage II hypertension. There are four deep learning models are compared in the study. The difficulties in the study are how to find the optimal parameters such as kernel, kernel size, and layers in less photoplethysmographyt (PPG) training data condition. PPG signals were used to train deep residual network convolutional neural network (ResNetCNN) and bidirectional long short-term memory (BILSTM) to determine the optimal operating parameters when each dataset consisted of 2100 data points. During the experiment, the proportion of training and testing datasets was 8:2. The model demonstrated an optimal classification accuracy of 76% when the testing dataset was used.


Author(s):  
Rafly Indra Kurnia ◽  
◽  
Abba Suganda Girsang

This study will classify the text based on the rating of the provider application on the Google Play Store. This research is classification of user comments using Word2vec and the deep learning algorithm in this case is Long Short Term Memory (LSTM) based on the rating given with a rating scale of 1-5 with a detailed rating 1 is the lowest and rating 5 is the highest data and a rating scale of 1-3 with a detailed rating, 1 as a negative is a combination of ratings 1 and 2, rating 2 as a neutral is rating 3, and rating 3 as a positive is a combination of ratings 4 and 5 to get sentiment from users using SMOTE oversampling to handle the imbalance data. The data used are 16369 data. The training data and the testing data will be taken from user comments MyTelkomsel’s application from the play.google.com site where each comment has a rating in Indonesian Language. This review data will be very useful for companies to make business decisions. This data can be obtained from social media, but social media does not provide a rating feature for every user comment. This research goal is that data from social media such as Twitter or Facebook can also quickly find out the total of the user satisfaction based from the rating from the comment given. The best f1 scores and precisions obtained using 5 classes with LSTM and SMOTE were 0.62 and 0.70 and the best f1 scores and precisions obtained using 3 classes with LSTM and SMOTE were 0.86 and 0.87


Author(s):  
S. Rajkumar ◽  
P. V. Rajaraman ◽  
Haree Shankar Meganathan ◽  
V. Sapthagirivasan ◽  
K. Tejaswinee ◽  
...  

The novel coronavirus (COVID-19) was first reported in the Wuhan City of China in 2019 and became a pandemic. The outbreak has caused shocking effects to the people across the globe. It is important to screen a majority of the population in every country and for the respective governments to take appropriate action. There is a need for a rapid screening system to triage and recommend the patients for appropriate treatment. Chest X-ray imaging is one of the potential modalities, which has ample advantages such as wide availability even in the villages, portability, fast data sharing option from the point of capturing to the point of investigation, etc. The aim of the proposed work is to develop a deep learning algorithm for screening COVID-19 cases by leveraging the widely available X-ray imaging. We have built a deep learning Convolutional Neural Network model utilizing a combination of the public domain (open-source COVID-19) and private data (pneumonia and normal cases). The dataset was used before and after the segmentation of the lung region for training and testing. The outcome of the classification after lung segmentation resulted in significant superiority. The average accuracy achieved by the proposed system was 96%. The heat maps incorporated in the system were helpful for our radiologists to cross-verify whether the appropriate features are identified. This system (COVID-Detect) can be used in remote places in the countries affected by COVID-19 for mass screening of suspected cases and suggesting appropriate actions, such as recommending confirmatory tests.


Electronics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 112
Author(s):  
Fangzhou Xu ◽  
Fenqi Rong ◽  
Yunjing Miao ◽  
Yanan Sun ◽  
Gege Dong ◽  
...  

This study describes a method for classifying electrocorticograms (ECoGs) based on motor imagery (MI) on the brain–computer interface (BCI) system. This method is different from the traditional feature extraction and classification method. In this paper, the proposed method employs the deep learning algorithm for extracting features and the traditional algorithm for classification. Specifically, we mainly use the convolution neural network (CNN) to extract the features from the training data and then classify those features by combing with the gradient boosting (GB) algorithm. The comprehensive study with CNN and GB algorithms will profoundly help us to obtain more feature information from brain activities, enabling us to obtain the classification results from human body actions. The performance of the proposed framework has been evaluated on the dataset I of BCI Competition III. Furthermore, the combination of deep learning and traditional algorithms provides some ideas for future research with the BCI systems.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Prashant Sadashiv Gidde ◽  
Shyam Sunder Prasad ◽  
Ajay Pratap Singh ◽  
Nitin Bhatheja ◽  
Satyartha Prakash ◽  
...  

AbstractSARS-CoV2 pandemic exposed the limitations of artificial intelligence based medical imaging systems. Earlier in the pandemic, the absence of sufficient training data prevented effective deep learning (DL) solutions for the diagnosis of COVID-19 based on X-Ray data. Here, addressing the lacunae in existing literature and algorithms with the paucity of initial training data; we describe CovBaseAI, an explainable tool using an ensemble of three DL models and an expert decision system (EDS) for COVID-Pneumonia diagnosis, trained entirely on pre-COVID-19 datasets. The performance and explainability of CovBaseAI was primarily validated on two independent datasets. Firstly, 1401 randomly selected CxR from an Indian quarantine center to assess effectiveness in excluding radiological COVID-Pneumonia requiring higher care. Second, curated dataset; 434 RT-PCR positive cases and 471 non-COVID/Normal historical scans, to assess performance in advanced medical settings. CovBaseAI had an accuracy of 87% with a negative predictive value of 98% in the quarantine-center data. However, sensitivity was 0.66–0.90 taking RT-PCR/radiologist opinion as ground truth. This work provides new insights on the usage of EDS with DL methods and the ability of algorithms to confidently predict COVID-Pneumonia while reinforcing the established learning; that benchmarking based on RT-PCR may not serve as reliable ground truth in radiological diagnosis. Such tools can pave the path for multi-modal high throughput detection of COVID-Pneumonia in screening and referral.


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