scholarly journals Temporal Analysis of COVID-19 Convalescent Plasma Donations Reveals Significant Decrease in Neutralizing Capacity Over Time

2020 ◽  
Author(s):  
Roxie C. Girardin ◽  
Alan P. Dupuis ◽  
Anne F. Payne ◽  
Timothy J. Sullivan ◽  
Donna Strauss ◽  
...  
Keyword(s):  
Gold Standard ◽  
Infectious Virus ◽  
Neutralization Test ◽  
Temporal Analysis ◽  
Therapy Efficacy ◽  
Neutralizing Capacity ◽  
Seriously Ill Patients ◽  
The Relationship ◽  
Seriously Ill ◽  
Over Time

AbstractCOVID-19 convalescent plasma (CCP) received approval for use under an Emergency Use Authorization by the FDA for treatment of seriously ill patients. Use of CCP units with a signal-to-cutoff ratio of ≥12 using the Ortho VITROS SARS-CoV-2 IgG test (OVSARS2IgG) is authorized. Little is known about the relationship between this ratio and the neutralizing capacity of plasma/sera against genuine SARS-CoV-2 virus. We measured the neutralizing capacity of 981 samples from 196 CCP donors 7-119 days post initial donation (DPID). Neutralizing capacity was assessed for 50% (PRNT50) and 90% (PRNT90) reduction of infectious virus using the gold standard plaque reduction neutralization test (PRNT). Importantly, while 32.7%/79.5% (PRNT90/PRNT50) of donations met the FDA minimum titer of 1:80 initially, only 14.0%/48.8% (PRNT90/PRNT50) met this cut-off ≥85 DPID. A subset of 91 donations were evaluated using the OVSARS2IgG and compared to PRNT titers for diagnostic accuracy. The correlation of OVSARS2IgG results to neutralizing capacity allowed extrapolation to CCP therapy efficacy results. CCP with OVSARS2IgG ratios in the therapeutically beneficial group had neutralizing titers of ≥1:640 (PRNT50) and/or ≥1:80 (PRNT90). This information provides a new basis for refining the recommended properties of CCP that is used to treat severe COVID-19.

Earlier identification of seriously ill patients: an implementation case series

2019 ◽  
Vol 10 (4) ◽  
pp. e31-e31 ◽  
Author(s):  
Joshua R Lakin ◽  
Meghna Desai ◽  
Kyle Engelman ◽  
Nina O'Connor ◽  
Winifred G Teuteberg ◽  
...  
Keyword(s):  
Palliative Care ◽  
Patient Selection ◽  
Case Series ◽  
Healthcare Systems ◽  
Ongoing Research ◽  
Starting Point ◽  
Seriously Ill Patients ◽  
Analytical Approaches ◽  
Seriously Ill ◽  
Over Time

ObjectiveTo describe the strategies used by a collection of healthcare systems to apply different methods of identifying seriously ill patients for a targeted palliative care intervention to improve communication around goals and values.MethodsWe present an implementation case series describing the experiences, challenges and best practices in applying patient selection strategies across multiple healthcare systems implementing the Serious Illness Care Program (SICP).ResultsFive sites across the USA and England described their individual experiences implementing patient selection as part of the SICP. They employed a combination of clinician screens (such as the ‘Surprise Question’), disease-specific criteria, existing registries or algorithms as a starting point. Notably, each describes adaptation and evolution of their patient selection methodology over time, with several sites moving towards using more advanced machine learning–based analytical approaches.ConclusionsInvolving clinical and programme staff to choose a simple initial method for patient identification is the ideal starting place for selecting patients for palliative care interventions. However, improving and refining methods over time is important and we need ongoing research into better patient selection methodologies that move beyond mortality prediction and instead focus on identifying seriously ill patients—those with poor quality of life, worsening functional status and medical care that is negatively impacting their families.

The relationship of nausea and dyspnea to pain in seriously ill patients

Pain ◽  
1997 ◽  
Vol 71 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Norman A. Desbiens ◽  
Nancy Mueller-Rizner ◽  
Alfred F. Connors ◽  
Neil S. Wenger
Keyword(s):  
Seriously Ill Patients ◽  
Relationship Of ◽  
The Relationship ◽  
Seriously Ill

Investment Traits and Intelligence in Adulthood

2013 ◽  
Vol 34 (2) ◽  
pp. 82-89 ◽  
Author(s):  
Sophie von Stumm
Keyword(s):  
Individual Differences ◽  
Personality Traits ◽  
Fluid Intelligence ◽  
Need For Cognition ◽  
Openness To Experience ◽  
Intelligence Tests ◽  
Crystallized Intelligence ◽  
New Knowledge ◽  
The Relationship ◽  
Over Time

Intelligence-as-knowledge in adulthood is influenced by individual differences in intelligence-as-process (i.e., fluid intelligence) and in personality traits that determine when, where, and how people invest their intelligence over time. Here, the relationship between two investment traits (i.e., Openness to Experience and Need for Cognition), intelligence-as-process and intelligence-as-knowledge, as assessed by a battery of crystallized intelligence tests and a new knowledge measure, was examined. The results showed that (1) both investment traits were positively associated with intelligence-as-knowledge; (2) this effect was stronger for Openness to Experience than for Need for Cognition; and (3) associations between investment and intelligence-as-knowledge reduced when adjusting for intelligence-as-process but remained mostly significant.

Power Values and Power Distance Moderate the Relationship Between Workplace Supervisory Power and Job Satisfaction

2020 ◽  
Vol 19 (3) ◽  
pp. 135-141
Author(s):  
Kenneth D. Locke
Keyword(s):  
Job Satisfaction ◽  
Multilevel Modeling ◽  
Power Distance ◽  
European Social Survey ◽  
Social Survey ◽  
The Relationship ◽  
Workplace Power ◽  
Over Time

Abstract. Person–job (or needs–supplies) discrepancy/fit theories posit that job satisfaction depends on work supplying what employees want and thus expect associations between having supervisory power and job satisfaction to be more positive in individuals who value power and in societies that endorse power values and power distance (e.g., respecting/obeying superiors). Using multilevel modeling on 30,683 European Social Survey respondents from 31 countries revealed that overseeing supervisees was positively associated with job satisfaction, and as hypothesized, this association was stronger among individuals with stronger power values and in nations with greater levels of power values or power distance. The results suggest that workplace power can have a meaningful impact on job satisfaction, especially over time in individuals or societies that esteem power.

Emotional Impact Feedback Changes How We Remember Negative Autobiographical Experiences

2010 ◽  
Vol 57 (5) ◽  
pp. 354-359 ◽  
Author(s):  
Melanie K. T. Takarangi ◽  
Deryn Strange
Keyword(s):  
Well Being ◽  
The Other ◽  
Personal Perspective ◽  
Emotional Impact ◽  
Potential Mechanism ◽  
Negative Experiences ◽  
Negative Memory ◽  
The Relationship ◽  
Negative Memories ◽  
Over Time

When people are told that their negative memories are worse than other people’s, do they later remember those events differently? We asked participants to recall a recent negative memory then, 24 h later, we gave some participants feedback about the emotional impact of their event – stating it was more or less negative compared to other people’s experiences. One week later, participants recalled the event again. We predicted that if feedback affected how participants remembered their negative experiences, their ratings of the memory’s characteristics should change over time. That is, when participants are told that their negative event is extremely negative, their memories should be more vivid, recollected strongly, and remembered from a personal perspective, compared to participants in the other conditions. Our results provide support for this hypothesis. We suggest that external feedback might be a potential mechanism in the relationship between negative memories and psychological well-being.

Rethinking social remittances and the migration-development nexus from the perspective of time

2013 ◽  
Vol 10 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Peggy Levitt ◽  
Deepak Lamba-Nieves
Keyword(s):  
Social Influence ◽  
Change Over Time ◽  
Social Remittances ◽  
The Relationship ◽  
Migration And Development ◽  
Over Time

This article explores how the conceptualization, management, and measurement of time affect the migration-development nexus. We focus on how social remittances transform the meaning and worth of time, thereby changing how these ideas and practices are accepted and valued and recalibrating the relationship between migration and development. Our data reveal the need to pay closer attention to how migration’s impacts shift over time in response to its changing significance, rhythms, and horizons. How does migrants’ social influence affect and change the needs, values, and mind-frames of non-migrants? How do the ways in which social remittances are constructed, perceived, and accepted change over time for their senders and receivers?

Changing Places: Rock Art and Holocene Landscapes in the Wadi al-Ajal, South-West Libya

2014 ◽  
Vol 12 (2) ◽  
pp. 165-182 ◽  
Author(s):  
Tertia Barnett ◽  
Maria Guagnin
Keyword(s):  
Spatial Analysis ◽  
Surface Water ◽  
Rock Art ◽  
Human Settlement ◽  
Gis Model ◽  
South West ◽  
Settlement Location ◽  
Central Sahara ◽  
The Relationship ◽  
Over Time

This article examines the relationship between rock art and landscape use by pastoral groups and early settled communities in the central Sahara from around 6000 BC to 1000 AD. During this period the region experienced significant climatic and environmental fluctuations. Using new results from a systematic survey in the Wadi al-Ajal, south-west Libya, our research combines data from over 2000 engraved rock art panels with local archaeological and palaeoenvironmental evidence within a GIS model. Spatial analysis of these data indicates a correspondence between the frequency of rock art sites and human settlement over time. However, while changes in settlement location were guided primarily by the constraints on accessibility imposed by surface water, the distribution of rock art relates to the availability of pasture and patterns of movement through the landscape. Although the reasons for these movements undoubtedly altered over time, natural routes that connected the Wadi al-Ajal and areas to the south continued to be a focus for carvings over several thousand years.

Principles of care for seriously ill patients in palliative office

2020 ◽  
pp. 15-18
Author(s):  
Nina Tishchenko
Keyword(s):  
Palliative Care ◽  
The State ◽  
State Budget ◽  
Oncological Patients ◽  
Seriously Ill Patients ◽  
Seriously Ill

The article reflects the importance and importance of the work of nurses of the Department of Palliative Care for Oncological Patients of the State Budget Health Establishment «Samara Regional Clinical Oncological Clinic». Important stages and features of care when dealing with seriously ill patients.

Soil and Stream Water Chemistry During Spring Snowmelt

1992 ◽  
Vol 23 (1) ◽  
pp. 13-26 ◽  
Author(s):  
W. H. Hendershot ◽  
L. Mendes ◽  
H. Lalande ◽  
F. Courchesne ◽  
S. Savoie
Keyword(s):  
Stream Water ◽  
Base Cations ◽  
Stream Chemistry ◽  
Stream Water Chemistry ◽  
The Matrix ◽  
Adsorption Desorption ◽  
The Relationship ◽  
Best Fit ◽  
Spring Snowmelt ◽  
Over Time

In order to determine how water flowpath controls stream chemistry, we studied both soil and stream water during spring snowmelt, 1985. Soil solution concentrations of base cations were relatively constant over time indicating that cation exchange was controlling cation concentrations. Similarly SO4 adsorption-desorption or precipitation-dissolution reactions with the matrix were controlling its concentrations. On the other hand, NO3 appeared to be controlled by uptake by plants or microorganisms or by denitrification since their concentrations in the soil fell abruptly as snowmelt proceeded. Dissolved Al and pH varied vertically in the soil profile and their pattern in the stream indicated clearly the importance of water flowpath on stream chemistry. Although Al increased as pH decreased, the relationship does not appear to be controlled by gibbsite. The best fit of calculated dissolved inorganic Al was obtained using AlOHSO4 with a solubility less than that of pure crystalline jurbanite.

Sign in / Sign up

Export Citation Format

Share Document