scholarly journals An all-solid-state heterojunction oxide transistor for the rapid detection of biomolecules and SARS-CoV-2 spike S1 protein

2021 ◽  
Author(s):  
Yen-Hung Lin ◽  
Yang Han ◽  
Abhinav Sharma ◽  
Wejdan S. AlGhamdi ◽  
Chien-Hao Liu ◽  
...  
Keyword(s):  
Solid State ◽  
Real Time ◽  
High Sensitivity ◽  
Cost Effective ◽  
High Electron ◽  
Real Time Detection ◽  
Bioanalytical Applications ◽  
Detection Of Biomolecules ◽  
Dimensional Electron Gas ◽  
Sensitivity Specificity

AbstractSolid-state transistor sensors that can detect biomolecules in real time are highly attractive for emerging bioanalytical applications. However, combining cost-effective manufacturing with high sensitivity, specificity and fast sensing response, remains challenging. Here we develop low-temperature solution-processed In2O3/ZnO heterojunction transistors featuring a geometrically engineered tri-channel architecture for rapid real-time detection of different biomolecules. The sensor combines a high electron mobility channel, attributed to the quasi-two-dimensional electron gas (q2DEG) at the buried In2O3/ZnO heterointerface, in close proximity to a sensing surface featuring tethered analyte receptors. The unusual tri-channel design enables strong coupling between the buried q2DEG and the minute electronic perturbations occurring during receptor-analyte interactions allowing for robust, real-time detection of biomolecules down to attomolar (aM) concentrations. By functionalizing the tri-channel surface with SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) antibody receptors, we demonstrate real-time detection of the SARS-CoV-2 spike S1 protein down to attomolar concentrations in under two minutes.

Perylene diimide–Cu2+ based fluorescent nanoparticles for the detection of spermine in clinical and food samples: a step toward the development of a diagnostic kit as a POCT tool for spermine

2019 ◽  
Vol 7 (45) ◽  
pp. 7218-7227 ◽  
Author(s):  
Kapil Kumar ◽  
Sandeep Kaur ◽  
Satwinderjeet Kaur ◽  
Gaurav Bhargava ◽  
Subodh Kumar ◽  
...  
Keyword(s):  
Real Time ◽  
Cost Effective ◽  
Food Samples ◽  
Fermented Food ◽  
Perylene Diimide ◽  
Fluorescent Nanoparticles ◽  
Solution Form ◽  
Cost Effective Method ◽  
Real Time Detection

EA-PDI∩Cu2+ complex can be established as cost-effective method to develop diagnostic kit for POCT of spermine for real time detection of spermine in vapor and solution form released from fermented food samples.

scholarly journals Right ventricular thrombus, a challenge in imaging diagnostics: a case series

2021 ◽  
Author(s):  
Massimo Barbagallo ◽  
Daryl Naef ◽  
Pascal Köpfli ◽  
Urs Hufschmid ◽  
Tilo Niemann ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Case Series ◽  
General Medicine ◽  
High Sensitivity ◽  
Cost Effective ◽  
Ventricular Thrombus ◽  
Threatening Condition ◽  
Life Threatening ◽  
Therapeutic Decision Making ◽  
Sensitivity Specificity

Abstract Background Presence of right ventricular thrombus (RVT) is a rare but life-threatening condition, thus immediate diagnosis and therapy are mandatory. Unfortunately, detection and distinction from intraventricular tumor masses or vegetations represents a complex task. Furthermore, consecutive therapy is principally led by clinical presentation without considering morphological features of the thrombus. Current literature suggests a multimodal non-invasive imaging approach. In this paper, we discuss the role of cardiac magnetic resonance (CMR) for the detection of RVT in patients with pulmonary embolism (PE). We consider the relatively expensive and not broadly available imaging procedure and weigh it up to its assumed high sensitivity, specificity and importance for differential diagnosis and therapeutic decision making. Case Summary In this case series we report three cases of RVT with concomitant PE, whereof two were missed during routine cardiac workup by transthoracic echocardiography (TTE) and computer tomography (CT). CMR led to detection and further characterization of the thrombi in both cases. These patients were diagnosed and treated at the Cantonal Hospital of Baden in the division of General Medicine. Conclusions CMR reliably detects and characterizes RVT, even under unfavourable conditions for echocardiography such as arrhythmia, adiposity or in posterior position of RVT. Obtained information could facilitate the choice of therapeutic approach (anticoagulation vs. systemic lysis, vs. surgical thrombectomy). Future risk-stratification scores will promote cost-effective use of CMR.

A differential extended gate-AlGaN/GaN HEMT sensor for real-time detection of ionic pollutants

2019 ◽  
Vol 11 (31) ◽  
pp. 3981-3986 ◽  
Author(s):  
Lei Zhao ◽  
Xinsheng Liu ◽  
Bin Miao ◽  
Zhiqi Gu ◽  
Jin Wang ◽  
...  
Keyword(s):  
Real Time ◽  
Electron Mobility ◽  
High Electron Mobility Transistor ◽  
High Electron ◽  
High Electron Mobility ◽  
Gan Hemt ◽  
Real Time Detection

In this study, we propose a differential extended gate (DEG)-AlGaN/GaN high electron mobility transistor (HEMT) sensor to detect ionic pollutants in solution.

Electrospun Fibers as a Solid-State Real-Time Zinc Ion Sensor with High Sensitivity and Cell Medium Compatibility

2012 ◽  
Vol 23 (12) ◽  
pp. 1566-1574 ◽  
Author(s):  
Jia-Hao Syu ◽  
Yi-Kai Cheng ◽  
Wun-Yan Hong ◽  
Hsing-Ping Wang ◽  
Yu-Chao Lin ◽  
...  
Keyword(s):  
Solid State ◽  
Real Time ◽  
High Sensitivity ◽  
Zinc Ion ◽  
Electrospun Fibers ◽  
Ion Sensor ◽  
Cell Medium

scholarly journals Sliding wire detection system of electric lock screw tool based on motor characteristics

2021 ◽  
Vol 2137 (1) ◽  
pp. 012009
Author(s):  
Ning Zhang ◽  
Yinxin Yan ◽  
Houcheng Yang ◽  
Zhangsi Yu
Keyword(s):  
Real Time ◽  
Detection System ◽  
Low Cost ◽  
High Sensitivity ◽  
High Accuracy ◽  
Normal Operation ◽  
Automatic Assembly ◽  
The Real ◽  
Current Change ◽  
Real Time Detection

Abstract This paper presents a sliding wire detection system of electric screw locking tool based on the characteristics of motor. The system can judge whether the screw has sliding wire through the current change of motor during normal operation, and realize the real-time detection and alarm of sliding wire. The system has the advantages of high sensitivity, low cost and high accuracy. It can be widely used in automatic assembly and other fields.

scholarly journals ULTRASONOGRAPHY

2008 ◽  
Vol 15 (01) ◽  
pp. 26-32
Author(s):  
TAHIR MALIK ◽  
ZAFAR AMIN ◽  
TAHIR MALIK
Keyword(s):  
Acute Abdomen ◽  
Imaging Modality ◽  
Tertiary Care ◽  
High Sensitivity ◽  
Cost Effective ◽  
Military Hospital ◽  
Care Hospital ◽  
Radiation Hazards ◽  
Sensitivity Specificity

) To determine the role of ultrasonography as the primaryimaging modality in patients of acute abdomen. (2) To evaluate the sensitivity, specificity, positive and negativepredictive value of ultrasonography in acute abdomen. Design: A hospital based descriptive study. Setting: InCombined Military Hospital Lahore which is a tertiary care hospital. Period: From 1 Jan 2003 to 30 Dec 2003. stSubjects: A total of 100 consecutive patients of acute abdomen were selected for the study. There were 61 malepatients and 39 female patients. The patients’ age ranged from 02 years to 70 years. Ultrasonography was done usingALOKA SSD-5500 machine with high resolution probes. Results: During my study of patients of acute abdomen mostcommon conditions encountered were renal colic due to renal and ureteric stones followed by gut perforation,cholecystitis, appendicitis and cholelithiasis. My study revealed a sensitivity of 79.7% and specificity of 88.4% ofultrasonography in patients with acute abdomen. The positive predictive value was 95.1% and a negative predictivevalue was 60.5%. Conclusion: Ultrasonography helped in prompt decision making in most of the cases of acuteabdomen with a high sensitivity and specificity in skilled and experienced hands, as well as high positive predictivevalue. Hence, in our setup it can be used as a primary imaging modality for patients presenting with acute abdomenin any age group, as it is readily available, cost effective and free of any radiation hazards. Ultrasonography not onlyhelps in diagnosing the cause of pain but also ruling out other possibilities.

An electronic enzyme-linked immunosorbent assay platform for protein analysis based on magnetic beads and AlGaN/GaN high electron mobility transistors

The Analyst ◽  
2020 ◽  
Vol 145 (7) ◽  
pp. 2725-2730 ◽  
Author(s):  
Jin Wang ◽  
Zhiqi Gu ◽  
Xinsheng Liu ◽  
Lei Zhao ◽  
Huoxiang Peng ◽  
...  
Keyword(s):  
Electron Mobility ◽  
Magnetic Beads ◽  
High Sensitivity ◽  
High Electron Mobility Transistors ◽  
High Electron Mobility Transistor ◽  
Fast Response ◽  
Enzyme Linked Immunosorbent Assay ◽  
High Electron ◽  
High Electron Mobility ◽  
Detection Of Biomolecules

The AlGaN/GaN high electron mobility transistor (HEMT) biosensors have the characteristics of high sensitivity, stability and fast response in the detection of biomolecules.

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