scholarly journals Data-Driven Patterns in Protective Effects of Ibuprofen and Ketorolac on Hospitalized Covid-19 Patients

2021 ◽  
Author(s):  
Benjamin J Lengerich ◽  
Rich Caruana ◽  
Yin J Aphinyanaphongs
Keyword(s):  
New York ◽  
Protective Effect ◽  
Data Driven ◽  
Patient Treatment ◽  
Protective Effects ◽  
Hospital System ◽  
York Hospital ◽  
Inflammatory Drugs ◽  
The Impact ◽  
The Relationship

The impact of nonsteroidal anti-inflammatory drugs (NSAIDs) on patients with Covid-19 has been unclear. A major reason for this uncertainty is the confounding between treatments, patient comorbidities, and illness severity. Here, we perform an observational analysis of over 3000 patients hospitalized for Covid-19 in a New York hospital system to identify the relationship between in-patient treatment with Ibuprofen or Ketorolac and mortality. Our analysis finds evidence consistent with a protective effect for Ibuprofen and Ketorolac, with evidence stronger for a protective effect of Ketorolac than for a protective effect of Ibuprofen.

scholarly journals Gastrointestinal endoscopy during the coronavirus pandemic in the New York area: results from a multi-institutional survey

2020 ◽  
Vol 08 (12) ◽  
pp. E1865-E1871
Author(s):  
Srihari Mahadev ◽  
Olga C. Aroniadis ◽  
Luis H. Barraza ◽  
Emil Agarunov ◽  
Michael S. Smith ◽  
...  
Keyword(s):  
New York ◽  
Clinical Care ◽  
Patient Characteristics ◽  
Feeding Tube ◽  
Tube Placement ◽  
Peak Time ◽  
City Region ◽  
Peak Period ◽  
Hospital System ◽  
The Impact

Abstract Background and study aims The coronavirus disease 2019 (COVID-19), and measures taken to mitigate its impact, have profoundly affected the clinical care of gastroenterology patients and the work of endoscopy units. We aimed to describe the clinical care delivered by gastroenterologists and the type of procedures performed during the early to peak period of the pandemic. Methods Endoscopy leaders in the New York region were invited to participate in an electronic survey describing operations and clinical service. Surveys were distributed on April 7, 2020 and responses were collected over the following week. A follow-up survey was distributed on April 20, 2020. Participants were asked to report procedure volumes and patient characteristics, as well protocols for staffing and testing for COVID-19. Results Eleven large academic endoscopy units in the New York City region responded to the survey, representing every major hospital system. COVID patients occupied an average of 54.5 % (18 – 84 %) of hospital beds at the time of survey completion, with 14.5 % (2 %-23 %) of COVID patients requiring intensive care. Endoscopy procedure volume and the number of physicians performing procedures declined by 90 % (66 %-98 %) and 84.5 % (50 %-97 %) respectively following introduction of restricted practice. During this period the most common procedures were EGDs (7.9/unit/week; 88 % for bleeding; the remainder for foreign body and feeding tube placement); ERCPs (5/unit/week; for cholangitis in 67 % and obstructive jaundice in 20 %); Colonoscopies (4/unit/week for bleeding in 77 % or colitis in 23 %) and least common were EUS (3/unit/week for tumor biopsies). Of the sites, 44 % performed pre-procedure COVID testing and the proportion of COVID-positive patients undergoing procedures was 4.6 % in the first 2 weeks and up to 19.6 % in the subsequent 2 weeks. The majority of COVID-positive patients undergoing procedures underwent EGD (30.6 % COVID +) and ERCP (10.2 % COVID +). Conclusions COVID-19 has profoundly impacted the operation of endoscopy units in the New York region. Our data show the impact of a restricted emergency practice on endoscopy volumes and the proportion of expected COVID positive cases during the peak time of the pandemic.

scholarly journals Links between exercise/nutrition and antioxidants - protective effects on immune/respiratory systems as defense against viral infections

2020 ◽  
Vol 8 (36) ◽  
pp. 23-31
Author(s):  
Abdurrahman Kharbat ◽  
Stephen Rossettie ◽  
Mimi Zumwalt
Keyword(s):  
Viral Infections ◽  
Viral Disease ◽  
Antioxidant Systems ◽  
Protective Effects ◽  
Enzymatic Antioxidant ◽  
Optimal Dosing ◽  
Open Window ◽  
The Impact ◽  
The Relationship ◽  
Harmful Effects

This paper discusses factors involved in COVID-19 pathophysiology, with a focus on nutrition, exercise, enzymatic antioxidant systems, and the interplay between immune tolerance and resistance. Of all the supplements, zinc has the most evidence for effectiveness against viruses. However, these data were based primarily on studies measuring duration of the common cold rather than on COVID-19, and optimal dosing remains unclear. Exercise has been shown to have protective tolerogenic effects against viral infection due to the impact of extracellular superoxide dismutases (EC-SODs). Exercise may have a combination of beneficial and harmful effects on outright resistance to viruses in the short term, but taken as a whole it likely has a net protective effect on the immune system. The evidence is examined through the lens of the open window theory and a thorough investigation of the relationship between EC-SODs and exercise/diet. By better understanding the host-virus relationship, clinicians and researchers alike can collaborate to establish guiding principles regarding the steps that individuals can take to protect against some of the deleterious effects of viral infections. More research in this area is needed to understand the relationships among exercise, nutrition, and viral disease. Keywords: COVID-19, SARS CoV-2, nutrition, zinc, EC-SODs, superoxide dismutase, exercise, enzymatic antioxidant/immune systems

The Impact of the United Nations Upon Africa

1978 ◽  
Vol 16 (4) ◽  
pp. 565-578 ◽  
Author(s):  
Frederick H. Gareau
Keyword(s):  
New York ◽  
Latin America ◽  
United Nations ◽  
The World ◽  
The United Nations ◽  
The Impact ◽  
The Relationship ◽  
World Organisation

Observers have been intrigued by the relationship which has developed between the United Nations and Africa, a continent that now houses one-third of the membership of the world institution. Investigators have been seduced by subjects such as African frustration with the world organisation,1 African cohesion on Assembly roll-calls,2 African co-operation with Latin America in New York,3 or the impact of Mother Africa's offspring upon the United Nations.4 A few authors have sensed the magnitude of the impact which the world organisation has had upon the continent5, and several have detailed discrete instances of what has happened. What we have not seen is a general assessment of this impact with supporting data. My aim is to fill this gap in the literature, and to determine to what extent the existence of the United Nations has made a difference for Africa.

scholarly journals Ageism and Perceptions of Vulnerability: Framing of Age During the COVID-19 Pandemic

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 134-134
Author(s):  
Jasmin Tahmaseb McConatha ◽  
Jordan Broussard ◽  
Jacki Magnerelli
Keyword(s):  
New York ◽  
New York Times ◽  
Media Representations ◽  
News Article ◽  
Washington Post ◽  
Social Scientists ◽  
Media Frames ◽  
The Media ◽  
The Impact ◽  
The Relationship

Abstract Media representations of the Covid-19 pandemic and its devastating consequences have shaped people’s fears, anxiety, and perceptions of vulnerability. Social scientists have examined the consequences of how information is “framed.” Framing theory asserts that issues can be portrayed differently by emphasizing or de-emphasizing aspects and information. According to Lakoff (2004) the impact of a message is not based on what is said but how it is said. Theories of framing focus on how the media frames issues, which then structure and shape attitudes and policies. A news article serves as a frame for an intended message. The purpose of this project is to analyze the ways that “age” has been framed during the Covid-19 pandemic. One of the most dominant frames in terms of COVID-19 coverage is how the pandemic has been analyzed through the lens of age and framed in terms of age discrimination. Method: A thematic analysis of New York Times and Washington Post news articles addressing older adults and illness vulnerability was conducted. The results of news articles appearing in these prominent newspapers indicated that the perceptions of older men and women tended to focus on the relationship between age and vulnerabilities to severe consequences from Covid-19. The frames in which these new articles were presented indicated ageist tones and messages that had the potential to either reinforce or lead to age stereotyping and discrimination.

scholarly journals Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System

2020 ◽  
Vol 10 (7) ◽  
pp. 935-941 ◽  
Author(s):  
Vikas Mehta ◽  
Sanjay Goel ◽  
Rafi Kabarriti ◽  
Daniel Cole ◽  
Mendel Goldfinger ◽  
...  
Keyword(s):  
New York ◽  
Cancer Patients ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Fatality Rate ◽  
Hospital System ◽  
York Hospital

Impact of leucovorin shortage on patient treatment.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e17566-e17566
Author(s):  
Mina Samir Erian Hanna ◽  
Peter Kozuch ◽  
Molly Thorn ◽  
Janna Roitman ◽  
Michael L. Grossbard ◽  
...  
Keyword(s):  
New York ◽  
Low Dose ◽  
Economic Effect ◽  
Patient Characteristics ◽  
Patient Treatment ◽  
Additional Patient ◽  
Drug Shortage ◽  
Chi Square ◽  
Nccn Guidelines ◽  
The Impact

e17566 Background: Shortages of intravenous leucovorin were initially reported in late 2008, and availability plummeted nationally and at Continuum Cancer Centers of New York (CCCNY) in late 2011. NCCN guidelines recommend either the use of levoleucovorin or low dose leucovorin during the shortage. The impact of the leucovorin shortage on patient therapy remains unknown. Methods: We reviewed patient charts for all outpatients treated with leucovorin at CCCNY between April and September of 2010, 2011, and 2012. We recorded patient characteristics, and leucovorin use (dose, number of treatments); and calculated descriptive statistics. We classified each dose as either low (20-40 mg/m2) or high (200-500mg/m2) and compared leucovorin use between years with Chi Square and ANOVA tests. We also reviewed pharmacy purchasing data to evaluate the economic effect of the leucovorin shortage. Results: We identified 55 patients treated with 313 doses of leucovorin in 2010, 99 patients treated with 582 doses in 2011 and 118 patients treated with 742 doses in 2012. No patients received levoleucovorin. Patient characteristics, disease and stage were similar between years with colorectal cancer accounting for 78%, 69%, and 70% of patients in 2010, 2011, and 2012 (p=0.87). Low dose leucovorin was used in 30.0% of doses in 2010, 30.4% in 2011, and 99.1% in 2012 (p<0.0001). The mean dose/treatment (SD) was 459 mg (296), 499 mg (328), and 47 mg (89), in 2010, 2011, 2012, respectively (p<0.0001). Among patients treated for colon cancer we found no association between stage (III vs. IV) and use of low dose leucovorin in 2010 or 2011. Quantity of leucovorin purchased at one hospital decreased by 63% from 171.75 g in 2010 and 157.50g in 2011 to 63.00 g in 2012. The price of leucovorin was similar at 0.017 $/mg in 2011 and 0.013 $/mg in 2012. Conclusions: Worsening leucovorin drug shortage was associated with a profound change in leucovorin use at CCCNY between 2011 and 2012. In accordance with NCCN guidelines, physicians used more low dose leucovorin. The price of leucovorin remained constant despite limited supply. Additional patient follow up is warranted to evaluate the outcomes of patients treated during the shortage.

scholarly journals The Association between Shelter Rules and Psychosocial Outcomes among Homeless Youth Residing in Family Shelters

2017 ◽  
Vol 98 (2) ◽  
pp. 113-120 ◽  
Author(s):  
Nisha Beharie ◽  
Lauren Jessell ◽  
Hadiza Osuji ◽  
Mary M. McKay
Keyword(s):  
New York ◽  
New York City ◽  
Substance Use ◽  
Depressive Symptoms ◽  
York City ◽  
Homeless Youth ◽  
Psychosocial Outcomes ◽  
Well Being ◽  
The Impact ◽  
The Relationship

Despite growing numbers of homeless youth living in shelters with caregivers, little research has explored the impact of the shelter environment on emotional well-being. As such, this study assesses the relationship between shelter rules and two psychosocial outcomes among youth in New York City family shelters. Additionally, the direct effect of trauma and the moderating effect of difficulty following shelter rules on psychosocial outcomes was assessed. Youth with difficulty following shelter rules reported significantly more depressive symptoms, but less substance use. Trauma was found to be associated with increased depression and substance use. Difficulty following shelter rules was found to moderate the association between trauma and substance use. Recommendations for future interventions and the creation of shelter policies are discussed.

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