scholarly journals Links between exercise/nutrition and antioxidants - protective effects on immune/respiratory systems as defense against viral infections

2020 ◽  
Vol 8 (36) ◽  
pp. 23-31
Author(s):  
Abdurrahman Kharbat ◽  
Stephen Rossettie ◽  
Mimi Zumwalt
Keyword(s):  
Viral Infections ◽  
Viral Disease ◽  
Antioxidant Systems ◽  
Protective Effects ◽  
Enzymatic Antioxidant ◽  
Optimal Dosing ◽  
Open Window ◽  
The Impact ◽  
The Relationship ◽  
Harmful Effects

This paper discusses factors involved in COVID-19 pathophysiology, with a focus on nutrition, exercise, enzymatic antioxidant systems, and the interplay between immune tolerance and resistance. Of all the supplements, zinc has the most evidence for effectiveness against viruses. However, these data were based primarily on studies measuring duration of the common cold rather than on COVID-19, and optimal dosing remains unclear. Exercise has been shown to have protective tolerogenic effects against viral infection due to the impact of extracellular superoxide dismutases (EC-SODs). Exercise may have a combination of beneficial and harmful effects on outright resistance to viruses in the short term, but taken as a whole it likely has a net protective effect on the immune system. The evidence is examined through the lens of the open window theory and a thorough investigation of the relationship between EC-SODs and exercise/diet. By better understanding the host-virus relationship, clinicians and researchers alike can collaborate to establish guiding principles regarding the steps that individuals can take to protect against some of the deleterious effects of viral infections. More research in this area is needed to understand the relationships among exercise, nutrition, and viral disease. Keywords: COVID-19, SARS CoV-2, nutrition, zinc, EC-SODs, superoxide dismutase, exercise, enzymatic antioxidant/immune systems

The impact of vitamin C on the relationship among inflammation, lipid peroxidation and platelet activation during analgesic nephropathy in rats

2017 ◽  
Vol 28 (5) ◽  
Author(s):  
Nikola Hadzi-Petrushev ◽  
Dine Mitrov ◽  
Vladimir Kostovski ◽  
Mitko Mladenov
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Renal Function ◽  
Vitamin C ◽  
Platelet Activation ◽  
Analgesic Nephropathy ◽  
Plasma Urea ◽  
Enzymatic Antioxidant ◽  
The Impact ◽  
The Relationship

AbstractBackground:Oxidative stress and inflammation are involved in the pathogenesis of paracetamol-induced renal damage. This study examines the relationship between 8-iso-prostaglandin FMethods:Analgesic nephropathy was induced in Wistar rats. Renal function markers and the activity of antioxidant enzymes were determined spectrophotometrically. Immunoassays were used to measure the pro-inflammatory markers and the markers of lipid peroxidation and platelet activation.Results:The chronic treatment with paracetamol led to renal dysfunction, represented by the elevation of plasma urea and creatinine and the decline in the enzymatic antioxidant status, but did not cause a significant increase in TNF-α and IL-1β. The paracetamol-induced lipid peroxidation and enhanced production of 8-iso-PGFConclusions:Our results suggest that oxidative stress cannot circumvent the need of stimulation by circulatory cytokines in order to induce inflammatory response and changes in platelet activation during analgesic nephropathy. Vitamin C proved to be beneficial in restoring the renal function markers to normal, increasing the renal enzymatic antioxidant potential, inhibiting lipid peroxidation, and lowering cytokine production and 11-dehydro thromboxane B

scholarly journals Alterations in Intestinal Microbiota Composition in Mice Treated With Vitamin D3 or Cathelicidin

2021 ◽  
Vol 11 ◽  
Author(s):  
Yu Jiang ◽  
Yue Wan ◽  
Jing Li ◽  
Yueshui Zhao ◽  
Yongshun Ma ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Antimicrobial Peptide ◽  
Intestinal Microbiota ◽  
Vitamin D3 ◽  
Metabolic Pathways ◽  
Antimicrobial Activities ◽  
Protective Effects ◽  
Rrna Sequencing ◽  
The Impact ◽  
Harmful Effects

Gut microbiota is a complex aggregation of microbial organisms, which offers diverse protective benefits to the host. Dysbiosis of intestinal microbiota is frequently associated with many diseases. Vitamin D3 (VD), which was originally associated with bone health, also possesses antimicrobial activities and can act through antimicrobial peptide. Cathelicidin is a type of antimicrobial peptide in host to maintain the balance of gut microbiome. Our current study sought to evaluate the protective effect of VD and cathelicidin in mice intestines by administration of VD or mCRAMP-encoding L. lactis. We herein provided a comprehensive profile of the impact of VD and mCRAMP on gut microbiota using 16S rRNA sequencing, followed by bioinformatics and statistical analysis. Our results revealed an increased richness of bacterial community in mice intestines due to VD administration. Moreover, we showed a beneficial effect of VD and mCRAMP by enhancing the colonization of bacterial taxa that are associated with protective effects to the host but repressing the propagation of bacterial taxa that are associated with harmful effects to the host. Various metabolic pathways related to amino acid and lipid metabolism were affected in this process. We further established a bacterial panel as a reliable biomarker to evaluate the efficacy of remodeling the mice gut microbiota by VD and mCRAMP administration. The uncovered effects will deepen the comprehension about the antibacterial mechanisms of VD and mCRAMP and provide new insights for therapeutic implication of them.

scholarly journals Unraveling the Relationship of Asthma and COVID-19

2021 ◽  
Vol 11 (12) ◽  
pp. 1374
Author(s):  
Agamemnon Bakakos ◽  
Petros Bakakos ◽  
Nikoletta Rovina
Keyword(s):  
Molecular Mechanisms ◽  
Viral Infections ◽  
Asthma Severity ◽  
Current Evidence ◽  
Asthma Exacerbations ◽  
Inflammatory Phenotypes ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

Viral infections are one of the main causes of asthma exacerbations. During the COVID-19 era, concerns regarding the relationship of SARS-CoV2 with asthma have been raised. The concerns are both for COVID severity and asthma exacerbations. Many studies on COVID-19 epidemiology and comorbidities have assessed whether asthma represents a risk factor for SARS-CoV2 infection and/or more severe course of the disease. This review covers the current evidence on the prevalence of asthma in COVID-19 and its association with susceptibility to and severity of SARS-CoV2 infection. It will examine the possible role of underlying asthma severity in COVID-19 related outcomes as well as the molecular mechanisms involved in the co-existence of these entities. The possible role of asthma inflammatory phenotypes will also be evaluated. Finally, the impact of asthma comorbidities and the implications of asthma medication on COVID-19 will be addressed.

scholarly journals Bacterial inoculations can perturb the growth trajectory of diatoms with an existing microbiome

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e8352
Author(s):  
Lydia J. Baker ◽  
Paul F. Kemp
Keyword(s):  
Growth Medium ◽  
Growth Trajectory ◽  
Bacterial Strains ◽  
Batch Cultures ◽  
Negative Impacts ◽  
Peak Abundance ◽  
The Impact ◽  
The Relationship ◽  
Harmful Effects

Inoculation of axenic diatom monocultures with individual bacterial strains has been used effectively to examine the relationship between bacteria and a diatom host. Both beneficial and harmful effects on diatom fitness have been observed. Yet, diatoms commonly host a consortium of bacteria that could influence their response to perturbation by bacterial inoculations. In this study, diatom cultures with an existing microbiome were inoculated with individual bacterial strains. Strains of two genera of bacteria commonly found associated with diatoms (Alteromonas and Marinobacter) were isolated from a culture of the diatom Chaetoceros sp. KBDT20. To evaluate whether bacterial inoculations can impact the growth, peak abundance, or decline of diatoms with an intact microbiome, individual bacterial strains were inoculated into batch cultures of the original host as well as two non-origin diatom hosts (Chaetoceros sp. KBDT32 and Amphiprora sp. KBDT35). Inoculations were repeated under vitamin-replete and vitamin-deficient conditions to assess whether vitamin concentration modulates the impact of bacterial inoculations on the host. The origin Chaetoceros culture was largely unperturbed by bacterial inoculations. In contrast, non-origin hosts experienced long-term impacts on their growth trajectory, and those impacts were found to be dependent on the concentration of vitamins in the growth medium. For the non-origin Chaetoceros, all positive impacts were observed in vitamin-replete conditions and all negative impacts were observed in vitamin-deficient conditions. Amphiprora was only impacted by inoculation with Marinobacter strains in vitamin-deficient conditions, and the effect was negative. Neither individual bacterial strains nor genera resulted in exclusively beneficial nor detrimental impacts, and the magnitude of effect varied among bacterial strains. This study demonstrates that bacterial inoculations can have long-lasting impacts on the growth trajectory of diatoms with an existing microbiome, that this impact can differ even between congeneric diatoms, and that the impact can be significantly modulated by vitamin concentration.

scholarly journals Data-Driven Patterns in Protective Effects of Ibuprofen and Ketorolac on Hospitalized Covid-19 Patients

2021 ◽  
Author(s):  
Benjamin J Lengerich ◽  
Rich Caruana ◽  
Yin J Aphinyanaphongs
Keyword(s):  
New York ◽  
Protective Effect ◽  
Data Driven ◽  
Patient Treatment ◽  
Protective Effects ◽  
Hospital System ◽  
York Hospital ◽  
Inflammatory Drugs ◽  
The Impact ◽  
The Relationship

The impact of nonsteroidal anti-inflammatory drugs (NSAIDs) on patients with Covid-19 has been unclear. A major reason for this uncertainty is the confounding between treatments, patient comorbidities, and illness severity. Here, we perform an observational analysis of over 3000 patients hospitalized for Covid-19 in a New York hospital system to identify the relationship between in-patient treatment with Ibuprofen or Ketorolac and mortality. Our analysis finds evidence consistent with a protective effect for Ibuprofen and Ketorolac, with evidence stronger for a protective effect of Ketorolac than for a protective effect of Ibuprofen.

scholarly journals The Moderating Role of Rational Beliefs in the Relationship between Irrational Beliefs and Posttraumatic Stress Symptomology

2013 ◽  
Vol 42 (3) ◽  
pp. 312-326 ◽  
Author(s):  
Philip Hyland ◽  
Mark Shevlin ◽  
Gary Adamson ◽  
Daniel Boduszek
Keyword(s):  
Posttraumatic Stress ◽  
Irrational Beliefs ◽  
Cognitive Vulnerability ◽  
Negative Impact ◽  
Protective Effects ◽  
Direct Impact ◽  
Rational Beliefs ◽  
Behaviour Therapy ◽  
The Impact ◽  
The Relationship

Background: Rational Emotive Behaviour Therapy (REBT) assumes that rational beliefs act as cognitive protective factors against the development of psychopathology; however little empirical evidence exists regarding the nature of the possible protective effects that they offer. Aims: The current study investigates whether rational beliefs moderate the impact of irrational beliefs on posttraumatic stress symptomology (PTS). Method: Three hundred and thirteen active law enforcement, military, and related emergency service personnel took part in the current study. Sequential moderated multiple regression analysis was employed to investigate: (i) the direct impact of irrational beliefs on PTS; (ii) the direct impact of rational beliefs on PTS; (iii) the moderating effects of rational beliefs in the relationship between irrational beliefs and PTS. Results: The irrational beliefs predicted by REBT theory emerged as critical predictors of PTS symptomology, in particular Depreciation beliefs. Rational beliefs (Preferences, and Acceptance beliefs) had a direct, negative impact on levels of PTS, and Acceptance beliefs moderated the impact of Catastrophizing beliefs on PTS. Conclusions: Irrational beliefs are important cognitive vulnerability factors in symptoms of PTS, while rational beliefs (Acceptance) appear to have a protective role in the emergence of PTS symptoms, both directly and by moderating the impact of Catastrophizing beliefs.

scholarly journals Probiotic supplementation: A prospective approach in the treatment of COVID-19

2021 ◽  
pp. 026010602110496
Author(s):  
Atiyeh Nayebi ◽  
Jamshid Gholizadeh Navashenaq ◽  
Davood Soleimani ◽  
Seyyed Mostafa Nachvak
Keyword(s):  
Immune Responses ◽  
Viral Infections ◽  
Inflammatory Responses ◽  
Thrombus Formation ◽  
Gastrointestinal Symptoms ◽  
Viral Disease ◽  
The Body ◽  
Gastrointestinal Infections ◽  
Inflammatory Conditions ◽  
The Impact

Background: Despite strategies based on social distancing, the coronavirus disease 2019 (COVID-19) expands globally, and so far, many attempts have been made to achieve effective treatment for patients with COVID-19. This disease infects the lower respiratory tract and may lead to severe acute respiratory syndrome coronavirus (SARS-CoV). COVID-19 also can cause gastrointestinal infections. Therefore, COVID-19 patients with gastrointestinal symptoms are more likely to be complicated by SARS-CoV. In this disease, acquired immune responses are impaired, and uncontrolled inflammatory responses result in cytokine storms, leading to acute lung injury and thrombus formation. Probiotics are living microorganisms that contribute to the health of the host if administered in appropriate doses. Aim: This study aimed to provide evidence to show the importance of gut dysbiosis in viral disease, especially COVID-19. Therefore, we have focused on the impact of probiotics consumption on preventing severe symptoms of the disease. Methods: We have entirely searched SCOPUS, PubMed, and Google Scholar databases to collect evidence regarding the relationship between probiotics and viral infections to expand this relationship to the COVID-19. Results: It has been shown that probiotics directly counteract SARS-CoV in the gastrointestinal and respiratory tracts. Moreover, probiotics suppress severe immune responses and prevent cytokine storms to inhibit pathologic inflammatory conditions in the body via modulation of immune responses. Conclusion: According to available evidence based on their antiviral and respiratory activities, using probiotics might be an adjuvant therapy to reduce the burden and severity of this disease.

scholarly journals Is there evidence that BCG vaccination has non-specific protective effects for COVID 19 infections or is it an illusion created by lack of testing?

2020 ◽  
Author(s):  
Shivendu Shivendu ◽  
Saurav Chakraborty ◽  
Agnieszka Onuchowska ◽  
Ankit Patidar ◽  
Arpit Srivastava
Keyword(s):  
Statistical Evidence ◽  
Protective Effects ◽  
National Immunization Program ◽  
Immunization Program ◽  
Bcg Vaccination ◽  
National Immunization ◽  
Disease Pattern ◽  
The Impact ◽  
The Relationship ◽  
Analyze Data

AbstractThe goal of this paper is to showcase that the COVID-19 disease pattern is evolving and to study the relationship between mandatory BCG policy and caseload/million or death/per million. We analyze seven recent publications on the impact of BCG vaccinations on the development of COVID19 illness and extend presented findings using the latest data from April 10, 2020. We analyze data from 98 countries and we extend existing models by adding the dimension of COVID-19-related testing conducted by the analyzed countries. Similarly to prior studies, we find that COVID-19 attributable case and death incidences across countries share a relationship with a country’s BCG vaccination inclusion in the national immunization program when testing is not taken into consideration. However, this relationship vanishes when we add the dimension of testing. We observe that case and death incidences conditional on testing do not get affected by the countries’ BCG vaccination inclusion in the national immunization program. Therefore, we show that there is no statistical evidence to support the assertion that inclusion of BCG vaccination in national immunization program (NIP) has any impact of COVID 19 infections (cases) or mortality.

scholarly journals Placental Sampling for Understanding Viral Infections — A Simplified Protocol for the COVID-19 Pandemic

2021 ◽  
Vol 43 (05) ◽  
pp. 377-383
Author(s):  
Guilherme de Moraes Nobrega ◽  
José Paulo Siqueira Guida ◽  
Rodolfo Rosa Japecanga ◽  
Arthur Antolini-Tavares ◽  
Indira Mysorekar ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Viral Infections ◽  
Placental Tissue ◽  
Viral Disease ◽  
Adequate Sampling ◽  
Adequate Evaluation ◽  
Obstetric Population ◽  
The Impact ◽  
And Storage ◽  
Critical Aspects

Abstract Objective The coronavirus disease 2019 (COVID-19) is a pandemic viral disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The impact of the disease among the obstetric population remains unclear, and the study of the placenta can provide valuable information. Adequate sampling of the placental tissue can help characterize the pathways of viral infections. Methods A protocol of placental sampling is proposed, aiming at guaranteeing representativity of the placenta and describing the adequate conservation of samples and their integrity for future analysis. The protocol is presented in its complete and simplified versions, allowing its implementation in different complexity settings. Results Sampling with the minimum possible interval from childbirth is the key for adequate sampling and storage. This protocol has already been implemented during the Zika virus outbreak. Conclusion A protocol for adequate sampling and storage of placental tissue is fundamental for adequate evaluation of viral infections on the placenta. During the COVID-19 pandemic, implementation of this protocol may help to elucidate critical aspects of the SARS-CoV-2 infection.

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