scholarly journals A live yeast supplementation to gestating ewes improves bioactive molecules composition in colostrum with no impact on its bacterial composition and beneficially affects immune status of the offspring

2021 ◽  
Author(s):  
Lysiane Duniere ◽  
Justin B Renaud ◽  
Michael A Steele ◽  
Caroline S Achard ◽  
Evelyne Forano ◽  
...  
Keyword(s):  
Bacterial Population ◽  
Immune Status ◽  
Negative Impact ◽  
Passive Transfer ◽  
Bioactive Molecules ◽  
Bacterial Composition ◽  
Igg Level ◽  
Metabolomic Approach ◽  
Over Time ◽  
Live Yeast

Colostrum quality is of paramount importance in the management of optimal ruminant growth and infectious disease prevention in early life. Live yeast supplementation effect during the last month of gestation was evaluated on ewes colostrum composition. Two groups of ewes (n=14) carrying twin lambs were constituted and twins were separated into groups (mothered or artificially-fed) 12h after birth. Nutrient, oligosaccharides (OS), IgG and lactoferrin concentrations were measured over 72h after lambing, and bacterial community was described in colostrum collected at parturition (T0). Immune passive transfer was evaluated through IgG measurement in lamb serum. In both groups, colostral nutrient, OS concentrations and IgG concentrations in colostrum and lamb serum decreased over time, (p < 0.01) except for lactose, which slightly increased (p < 0.001) and lactoferrin which remained stable. Bacterial population was stable over time with high relative abundances of Aerococcaceae, Corynebacteriaceae, Moraxellaceae and Staphylococcaceae in T0-colostrum. No effect of supplementation was observed in nutrient and lactoferrin concentrations. In supplemented ewes, colostral IgG level was higher at T0 and a higher level of serum IgG was observed in lambs born from supplemented mothers and artificially-fed, while no effect of supplementation was observed in the mothered lambs groups. Using a metabolomic approach, we showed that supplementation affected OS composition with significantly higher levels of colostral Neu-5Gc compounds up to 5h after birth. No effect of supplementation was observed on bacterial composition. Our data suggest that live yeast supplementation offsets the negative impact of early separation and incomplete colostrum feeding in neonate lambs.

The Negative Impact of Biological Variation in the Effect and Clearance of Warfarin on Methods for Prediction of Dose Requirements

1986 ◽  
Vol 56 (03) ◽  
pp. 371-375 ◽  
Author(s):  
Peretz Weiss ◽  
Hillel Halkin ◽  
Shlomo Almog
Keyword(s):  
Individual Variation ◽  
Negative Impact ◽  
Warfarin Dose ◽  
Empirical Therapy ◽  
Maintenance Phase ◽  
Individual Variability ◽  
Dose Prediction ◽  
Group I ◽  
Over Time ◽  
Variance Explained

SummaryWithin-individual variation over time in the clearance (Cl) and effect (PT%) of warfarin, was measured in 25 inpatients (group I) studied after standard single or individualized split loading doses and 1-3 times (n = 16) 8-16 weeks later during maintenance. Mean Cl (2.5 α 0.9 ml/min) was similar in both phases but significant changes occurred in 6/16 patients, exceeding those expected from within-individual variation alone (defined by its 95% tolerance limits -24% to +62%). Initial PT% (21 α 5) was unaffected by dosing schedule, total or free plasma warfarin, varying between patients by only 18-24%. Mean initial and maintenance dose-PT% ratios (8.2 mg/d: 21% and 4.1 mg/d: 40%) were similar but significant changes in sensitivity to warfarin occurred in 4/16 patients. In group I and 64 other outpatients on maintenance therapy, between-individual variability was 36-52% for Cl and 49-56% for effect. PT% correlated best (r = 0.56) with free and total plasma warfarin but poorly with dose (r = 0.29), with only 30% of PT% variance explained at best, due to high between patient variability.Warfarin dose prediction whether based on extrapolation from initial effects to the maintenance phase, or on iterative methods not allowing for between- or within-patient variation in warfarin clearance or effect which may occur independently over time, have not improved on empirical therapy. This, due to the elements of biological variability as well as the intricacy of the warfarin - prothrombin complex interaction not captured by any kinetic-dynamic model used for prediction to date.

Has Aid Helped in Pakistan?

1997 ◽  
Vol 36 (4II) ◽  
pp. 947-957 ◽  
Author(s):  
Shahrukh Rafi Khan
Keyword(s):  
Economic Growth ◽  
Negative Impact ◽  
Negative Association ◽  
Causal Impact ◽  
The Impact ◽  
Over Time

This paper has a two-fold objective: first, to examine the terms on which Pakistan receives aid and whether its debt situation is sustainable, and second, to examine the impact of aid and debt on economic growth. It is found that there is little encouraging that can be said about how the terms on which Pakistan has received aid over time have changed, and its current debt situation is not sustainable. Also reported is the analysis done elsewhere which shows that aid has a negative (Granger) causal impact on GDP, and aid has a robust negative impact on economic growth after controlling for supplyside shocks. We provide various reasons for this negative association.

scholarly journals A New Paradigm in the Relationship between Melatonin and Breast Cancer: Gut Microbiota Identified as a Potential Regulatory Agent

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3141
Author(s):  
Aurora Laborda-Illanes ◽  
Lidia Sánchez-Alcoholado ◽  
Soukaina Boutriq ◽  
Isaac Plaza-Andrades ◽  
Jesús Peralta-Linero ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gut Microbiota ◽  
Bacterial Population ◽  
Kynurenine Pathway ◽  
New Paradigm ◽  
Bacterial Composition ◽  
Glucuronidase Activity ◽  
The One ◽  
The Relationship ◽  
Melatonin Production

In this review we summarize a possible connection between gut microbiota, melatonin production, and breast cancer. An imbalance in gut bacterial population composition (dysbiosis), or changes in the production of melatonin (circadian disruption) alters estrogen levels. On the one hand, this may be due to the bacterial composition of estrobolome, since bacteria with β-glucuronidase activity favour estrogens in a deconjugated state, which may ultimately lead to pathologies, including breast cancer. On the other hand, it has been shown that these changes in intestinal microbiota stimulate the kynurenine pathway, moving tryptophan away from the melatonergic pathway, thereby reducing circulating melatonin levels. Due to the fact that melatonin has antiestrogenic properties, it affects active and inactive estrogen levels. These changes increase the risk of developing breast cancer. Additionally, melatonin stimulates the differentiation of preadipocytes into adipocytes, which have low estrogen levels due to the fact that adipocytes do not express aromatase. Consequently, melatonin also reduces the risk of breast cancer. However, more studies are needed to determine the relationship between microbiota, melatonin, and breast cancer, in addition to clinical trials to confirm the sensitizing effects of melatonin to chemotherapy and radiotherapy, and its ability to ameliorate or prevent the side effects of these therapies.

scholarly journals The perception of biopsychosocial impacts of COVID-19 during lockdown restrictions over time in the UK – a mixed methods study

2021 ◽  
Vol 4 (Special2) ◽  
pp. 402-414
Author(s):  
Samuel Grimwood ◽  
Kaz Stuart ◽  
Ruth Browning ◽  
Elaine Bidmead ◽  
Thea Winn-Reed
Keyword(s):  
Social Issues ◽  
Negative Impact ◽  
Mixed Methods Study ◽  
Biological Domain ◽  
Data Points ◽  
Integrated Recovery ◽  
Biopsychosocial Health ◽  
The Uk ◽  
The Impact ◽  
Over Time

Background: The COVID-19 pandemic has profoundly impacted the health of individuals physically, mentally, and socially. This study aims to gain a deeper understanding of this impact across the pandemic from a biopsychosocial stance. Methods: A survey created by the research team was employed between November 2020 and February 2021 across social media, relevant organizations, and networks. The survey incorporated 5-time points across the different stages of the pandemic, covering biological, psychological, and social. There were 5 items for each survey (Very Positive affect to Very Negative affect), and analysis was undertaken using SPSS version 16. Descriptive statistics and non-parametric Friedman and Wilcoxon Tests, as well as correlations between the three domains, were implemented. Results: This study included 164 participants (77.0% female and 35.0% male) across 24 out of 38 counties in the UK. The impact of COVID-19 on biological domain was significant across the five data points χ2(4) = 63.99, p < 0.001, psychological χ2(4) = 118.939, p <0.001 and socially χ2(4) = 186.43, p <0.001. Between the 5 data points, 4 out of 5 had a negative impact, however between the first stage of lockdown and the easing of restrictions, findings for biological (Z=-2.35, p <0.05), psychological (Z=-6.61, p < 0.001), and socially (Z = -8.61, p <0.001) were positive. Negative correlations between the three domains across the pandemic are apparent, but in later stages, the biological domain had a positive correlation r = 0.52, p < 0.001. Conclusion: The data shows a negative impact from the self-reported perception of wellbeing from a biopsychosocial stance over time, as well as perceiving the three domains to interact negatively. To address these biopsychosocial issues, the research implies a place-based integrated recovery effort is needed, addressing biological, psychological, and social issues simultaneously. Further research should investigate biopsychosocial health among a more generalizable population.

STUDY ON EFFECTS OF DISTRUTIVE AGENTS ON THE ARTWORKS

2017 ◽  
Vol 31 (1) ◽  
pp. 75-81
Author(s):  
Valeria Mirela Brezoczki ◽  
◽  
Emese Bonta ◽  
Keyword(s):  
Negative Impact ◽  
Art Museum ◽  
External Factors ◽  
Cultural Value ◽  
Negative Effects ◽  
Active Monitoring ◽  
Baia Mare ◽  
Different Types ◽  
The Impact ◽  
Over Time

The paper describes a series of effects created by the impact of environmental factors on artworks in museums, as well as the way that active monitoring of these destructive agents (temperature and relative humidity) is done. Over time, artefacts exhibited within museums are subject to a series of degradations caused by external factors (air components, humidity, temperature, sunlight, bacteria, molds or fungi etc.), which can leave a negative impact on these goods with cultural value. The main observed negative effects are directly and intimate related to the deterioration of wood sculptures by the occurrence of cracks and the installation of different types of bacteria; the appearance of brownish-red spots on the surface of the paper and the increase in its reliability; various types of corrosion of artworks from different metals; color losses and cracks on paintings etc. The study brings to the fore the damaging effects produced on the different cultural works hosted within the County Art Museum - Art Center Baia Mare.

Facebooking for Good: Online Contact to Address Offline Conflict

2019 ◽  
pp. 089443931987405 ◽  
Author(s):  
Brandon C. Bouchillon
Keyword(s):  
Social Capital ◽  
Negative Impact ◽  
Negative Association ◽  
Web Survey ◽  
Neighborhood Diversity ◽  
Time Diversity ◽  
Average Person ◽  
Novel Interactions ◽  
Over Time

The present study examined the benefits of meeting new people on Facebook for social capital. Results of a two-wave national web survey ( N = 387) indicate that using the site to meet and interact with new people relates to trusting more in the average person over time. Facebook sociability also moderates the negative association between neighborhood diversity and trust over time. Diversity has less of a negative impact on trust locally for users who interact with new people online. Novel interactions on sites like Facebook improve perceptions of difference, demonstrating value for reconnecting the populace.

scholarly journals Phytochemical Profile, Mineral Content, and Bioactive Compounds in Leaves of Seed-Propagated Artichoke Hybrid Cultivars

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3795
Author(s):  
Gabriele Rocchetti ◽  
Luigi Lucini ◽  
Giandomenico Corrado ◽  
Giuseppe Colla ◽  
Mariateresa Cardarelli ◽  
...  
Keyword(s):  
Mineral Content ◽  
Sesquiterpene Lactones ◽  
Bioactive Molecules ◽  
Globe Artichoke ◽  
Ultra High Pressure ◽  
Flight Mass Spectrometry ◽  
Phytochemical Profile ◽  
Phytochemical Profiles ◽  
Work Supports ◽  
Metabolomic Approach

The globe artichoke (Cynara cardunculus L. subsp. Scolymus (L.) Hegi) is a multi-year species rich in various classes of phytochemicals with known nutritional and pharmacological properties, such as polyphenols, sesquiterpene lactones, and terpenoids. Over the last decade, hybrids cultivars are transforming the artichoke market for their higher uniformity and stability over the traditional landraces, further increasing the potential of the artichoke as a source of commercial extracts and bioactive molecules. Our aim was to investigate the mineral and phytochemical profiles of leaves from seven seed-propagated hybrids by using an untargeted metabolomic approach based on ultra-high-pressure liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. Metabolomics identified several compounds in the tested varieties, namely 98 polyphenols, 123 sesquiterpene lactones, and 221 other metabolites. The phenolic content ranged from 3.01 mg Eq./g fw (for ‘Opera’) to 4.71 mg Eq./g fw (for ‘Opal’). Sesquiterpene lactones were, on average, 2.11 mg Eq./g fw. Multivariate statistics (HCA, PCA and OPLS-DA) highlighted the main metabolomics differences among cultivars, which weakly correlated with their agronomic classification. The seven cultivars showed distinctive metabolomics profiles, with ‘Opal’ and ‘Istar’ being the most valuable hybrids. The 3-hydroxyphenyl-valeric acid (a medium-chain fatty acid) and the 6-Gingesulfonic acid (a methoxyphenol) were the most discriminant markers. Our findings illustrated the quantitative and qualitative variation of several classes of phytochemicals in seed-propagated artichoke cultivars and allowed identifying distinctive metabolic signatures for both phenolic compounds and sesquiterpene lactones. This work supports the exploitation of the artichoke leaves from hybrid cultivars as a rich source of bioactive phytochemicals.

scholarly journals The Effect of Chronic Wasting Disease on Resident Deer Hunting Permit Demand in Wisconsin

Animals ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1096
Author(s):  
Dane Erickson ◽  
Carson Reeling ◽  
John G. Lee
Keyword(s):  
Chronic Wasting Disease ◽  
Negative Impact ◽  
The State ◽  
Prior Work ◽  
Wasting Disease ◽  
Deer Hunting ◽  
On Demand ◽  
Permit Price ◽  
Over Time ◽  
Hunter Recruitment

Chronic wasting disease (CWD) has had a negative impact on deer license demand in Wisconsin since it was first found in the state in 2002. Prior work evaluates the effect of CWD on hunting permit sales, but only in the period immediately after the disease was discovered. We use data on hunting permit sales, permit price, and other demand shifters to estimate a model of deer permit demand for the period 1966–2015. We use the estimated model to quantify the effect of CWD on (1) hunter demand for deer permits; (2) hunter surplus from hunting; and (3) lost hunting permit revenues. Hunter participation declined by 5.4% after CWD was detected in 2002. Hunter surplus decreased by $96 million over this period, while permit revenues declined by nearly $17 million. The effect of CWD was greater on demand for firearm permits than for archery permits. We also find that the effects of CWD diminish over time in absolute terms. This is because permit demand would have started to decline in 2008 even in the absence of CWD. This finding implies efforts to control CWD and efforts at hunter recruitment are economic complements and should be pursued jointly to maximize hunter welfare.

scholarly journals 1005. HIV-Associated Bloodstream Infection (BSI): Trends Over 7 Years

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S299-S299
Author(s):  
Babak Hooshmand ◽  
Rebeca Witherell ◽  
Kathleen Riederer ◽  
Leonard Johnson ◽  
Riad Khatib
Keyword(s):  
Escherichia Coli ◽  
African Americans ◽  
Immune Status ◽  
Compliance Rate ◽  
Pneumococcal Vaccination ◽  
Hiv Status ◽  
Hiv Patients ◽  
Patient Demographics ◽  
Community Onset ◽  
Over Time

Abstract Background Patients with HIV are known to be at risk for bacteremia. Whether the type of organisms changed over time is uncertain. We present a review of bacteremia in HIV-patients during 2010–2016. Methods We reviewed blood culture (BC) results (January 1, 2010–December 31, 2016), selected patients with BSI, defined their HIV status, the place of onset (community onset [CO]: 0–3 days after admission; hospital onset [HO]: ≥4 days), patient demographics, the source and organism distribution and compared patients with and without HIV. Results We encountered 5,179 BSI episodes, 93 were among 73 HIV-patients (table). HIV patients were younger, and more likely to be African Americans. Majority of cases were community onset (79.1% and 74.5% in cases with/without HIV, respectively). The three most common organisms in HIV patients were Staphylococcus aureus (SA), Escherichia coli (EC) and Streptococcus pneumoniae (SPN) and in non-HIV patients SA, EC, and Klebsiella pneumoniae (KP). While the rate of SA (25.3%–22.0%), SPN (2%–3%), and KP (10.2%–8.4%) remained stable during the study period, EC rate increased (18.5–25.7; P = 0.002). HIV patients were more likely to have the respiratory tract as the source of BSI. Conclusion HIV-patients remain at higher risk for SPN and to have a respiratory source of BSI but the top causes of BSI in patients with and without HIV are SA and EC. Whether the higher rate of SPN among HIV patients is related to poor compliance with vaccination or suboptimal immune status is uncertain. Further studies are needed to compare pneumococcal vaccination compliance rate in patients with or without HIV. African Americans; vascular; Soft tissue/bone; urinary tract; respiratory. Disclosures All authors: No reported disclosures.

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