scholarly journals Replacement of the Gamma by the Delta variant in Brazil: impact of lineage displacement on the ongoing pandemic

Author(s):  
Marta Giovanetti ◽  
Vagner Fonseca ◽  
Eduan Wilkinson ◽  
Houriiyah Tegally ◽  
Emmanuel James San ◽  
...  

The COVID-19 epidemic in Brazil was driven mainly by the spread of Gamma (P.1), a locally emerged Variant of Concern (VOC) that was first detected in early January 2021. This variant was estimated to be responsible for more than 96% of cases reported between January and June 2021, being associated with increased transmissibility and disease severity, a reduction in neutralization antibodies and effectiveness of treatments or vaccines, as well as diagnostic detection failure. Here we show that, following several importations predominantly from the USA, the Delta variant rapidly replaced Gamma after July 2021. However, in contrast to what was seen in other countries, the rapid spread of Delta did not lead to a large increase in the number of cases and deaths reported in Brazil. We suggest that this was likely due to the relatively successful early vaccination campaign coupled with natural immunity acquired following prior infection with Gamma. Our data reinforces reports of the increased transmissibility of the Delta variant and, considering the increasing concern due to the recently identified Omicron variant, argues for the necessity to strengthen genomic monitoring on a national level to quickly detect and curb the emergence and spread of other VOCs that might threaten global health.

2021 ◽  
pp. 097359842110420
Author(s):  
Shreejita Biswas

The recent outbreak of the COVID-19 pandemic demands imperative discussions in the field of health security and global governance. Traditional studies on health care and global governance have acknowledged the significance of “global” as it rested on the fact that epidemics and pandemics are not restricted within national boundaries. The COVID-19 pandemic has challenged the hierarchical division of norm diffusion. Despite the structural inequalities, the patterns of behavior of various countries, such as China, the USA, Italy, South Korea, and India, in managing the crisis suggest a favorable ground for bringing in the importance of national-level decision-making in the global versus local debate. Building upon the arguments from norm theories of diffusion, the article contributes to our understanding that for an effective analysis of the politics of global health governance, the power of local channels in the diffusion of essential health norms cannot be undermined. The article studies the role played by the local-level diffusion processes, in this case, the national state actors in reshaping and integrating essential health norms to make it workable for broader global relevance. As a result, following the norm theories of diffusion, this article analyzes the global–local dynamics with regard to public health in the context of the spread of the COVID-19 health security threat.


2003 ◽  
Vol 1 (1) ◽  
pp. 49-59
Author(s):  
Mark Tomita

The Global Health Disparities CD-ROM Project reaffirmed the value of professional associations partnering with academic institutions to build capacity of the USA public health education workforce to meet the challenges of primary prevention services. The Society for Public Health Education (SOPHE) partnered with the California State University, Chico to produce a CD-ROM that would advocate for global populations that are affected by health disparities while providing primary resources for public health educators to use in programming and professional development. The CD-ROM development process is discussed.


2019 ◽  
Vol 4 (5) ◽  
pp. e001853 ◽  
Author(s):  
Bethany L Hedt-Gauthier ◽  
Herve Momo Jeufack ◽  
Nicholas H Neufeld ◽  
Atalay Alem ◽  
Sara Sauer ◽  
...  

BackgroundCollaborations are often a cornerstone of global health research. Power dynamics can shape if and how local researchers are included in manuscripts. This article investigates how international collaborations affect the representation of local authors, overall and in first and last author positions, in African health research.MethodsWe extracted papers on ‘health’ in sub-Saharan Africa indexed in PubMed and published between 2014 and 2016. The author’s affiliation was used to classify the individual as from the country of the paper’s focus, from another African country, from Europe, from the USA/Canada or from another locale. Authors classified as from the USA/Canada were further subclassified if the author was from a top US university. In primary analyses, individuals with multiple affiliations were presumed to be from a high-income country if they contained any affiliation from a high-income country. In sensitivity analyses, these individuals were presumed to be from an African country if they contained any affiliation an African country. Differences in paper characteristics and representation of local coauthors are compared by collaborative type using χ² tests.ResultsOf the 7100 articles identified, 68.3% included collaborators from the USA, Canada, Europe and/or another African country. 54.0% of all 43 429 authors and 52.9% of 7100 first authors were from the country of the paper’s focus. Representation dropped if any collaborators were from USA, Canada or Europe with the lowest representation for collaborators from top US universities—for these papers, 41.3% of all authors and 23.0% of first authors were from country of paper’s focus. Local representation was highest with collaborators from another African country. 13.5% of all papers had no local coauthors.DiscussionIndividuals, institutions and funders from high-income countries should challenge persistent power differentials in global health research. South-South collaborations can help African researchers expand technical expertise while maintaining presence on the resulting research.


BMJ ◽  
2020 ◽  
pp. m2322 ◽  
Author(s):  
Marco Springmann ◽  
Luke Spajic ◽  
Michael A Clark ◽  
Joseph Poore ◽  
Anna Herforth ◽  
...  

AbstractObjectiveTo analyse the health and environmental implications of adopting national food based dietary guidelines (FBDGs) at a national level and compared with global health and environmental targets.DesignModelling study.Setting85 countries.ParticipantsPopulation of 85 countries.Main outcome measuresA graded coding method was developed and used to extract quantitative recommendations from 85 FBDGs. The health and environmental impacts of these guidelines were assessed by using a comparative risk assessment of deaths from chronic diseases and a set of country specific environmental footprints for greenhouse gas emissions, freshwater use, cropland use, and fertiliser application. For comparison, the impacts of adopting the global dietary recommendations of the World Health Organization and the EAT-Lancet Commission on Healthy Diets from Sustainable Food Systems were also analysed. Each guideline’s health and sustainability implications were assessed by modelling its adoption at both the national level and globally, and comparing the impacts to global health and environmental targets, including the Action Agenda on Non-Communicable Diseases, the Paris Climate Agreement, the Aichi biodiversity targets related to land use, and the sustainable development goals and planetary boundaries related to freshwater use and fertiliser application.ResultsAdoption of national FBDGs was associated with reductions in premature mortality of 15% on average (95% uncertainty interval 13% to 16%) and mixed changes in environmental resource demand, including a reduction in greenhouse gas emissions of 13% on average (regional range −34% to 35%). When universally adopted globally, most of the national guidelines (83, 98%) were not compatible with at least one of the global health and environmental targets. About a third of the FBDGs (29, 34%) were incompatible with the agenda on non-communicable diseases, and most (57 to 74, 67% to 87%) were incompatible with the Paris Climate Agreement and other environmental targets. In comparison, adoption of the WHO recommendations was associated with similar health and environmental changes, whereas adoption of the EAT-Lancet recommendations was associated with 34% greater reductions in premature mortality, more than three times greater reductions in greenhouse gas emissions, and general attainment of the global health and environmental targets. As an example, the FBDGs of the UK, US, and China were incompatible with the climate change, land use, freshwater, and nitrogen targets, and adopting guidelines in line with the EAT-Lancet recommendation could increase the number of avoided deaths from 78 000 (74 000 to 81 000) to 104 000 (96 000 to 112 000) in the UK, from 480 000 (445 000 to 516 000) to 585 000 (523 000 to 646 000) in the USA, and from 1 149 000 (1 095 000 to 1 204 000) to 1 802 000 (1 664 000 to 1 941 000) in China.ConclusionsThis analysis suggests that national guidelines could be both healthier and more sustainable. Providing clearer advice on limiting in most contexts the consumption of animal source foods, in particular beef and dairy, was found to have the greatest potential for increasing the environmental sustainability of dietary guidelines, whereas increasing the intake of whole grains, fruits and vegetables, nuts and seeds, and legumes, reducing the intake of red and processed meat, and highlighting the importance of attaining balanced energy intake and weight levels were associated with most of the additional health benefits. The health results were based on observational data and assuming a causal relation between dietary risk factors and health outcomes. The certainty of evidence for these relations is mostly graded as moderate in existing meta-analyses.


2021 ◽  
Vol 8 (9) ◽  
pp. 210699
Author(s):  
Calistus N. Ngonghala ◽  
James R. Knitter ◽  
Lucas Marinacci ◽  
Matthew H. Bonds ◽  
Abba B. Gumel

Dynamic models are used to assess the impact of three types of face masks (cloth masks, surgical/procedure masks and respirators) in controlling the COVID-19 pandemic in the USA. We showed that the pandemic would have failed to establish in the USA if a nationwide mask mandate, based on using respirators with moderately high compliance, had been implemented during the first two months of the pandemic. The other mask types would fail to prevent the pandemic from becoming established. When mask usage compliance is low to moderate, respirators are far more effective in reducing disease burden. Using data from the third wave, we showed that the epidemic could be eliminated in the USA if at least 40% of the population consistently wore respirators in public. Surgical masks can also lead to elimination, but requires compliance of at least 55%. Daily COVID-19 mortality could be eliminated in the USA by June or July 2021 if 95% of the population opted for either respirators or surgical masks from the beginning of the third wave. We showed that the prospect of effective control or elimination of the pandemic using mask-based strategy is greatly enhanced if combined with other non-pharmaceutical interventions (NPIs) that significantly reduce the baseline community transmission. By slightly modifying the model to include the effect of a vaccine against COVID-19 and waning vaccine-derived and natural immunity, this study shows that the waning of such immunity could trigger multiple new waves of the pandemic in the USA. The number, severity and duration of the projected waves depend on the quality of mask type used and the level of increase in the baseline levels of other NPIs used in the community during the onset of the third wave of the pandemic in the USA. Specifically, no severe fourth or subsequent wave of the pandemic will be recorded in the USA if surgical masks or respirators are used, particularly if the mask use strategy is combined with an increase in the baseline levels of other NPIs. This study further emphasizes the role of human behaviour towards masking on COVID-19 burden, and highlights the urgent need to maintain a healthy stockpile of highly effective respiratory protection, particularly respirators, to be made available to the general public in times of future outbreaks or pandemics of respiratory diseases that inflict severe public health and socio-economic burden on the population.


Author(s):  
Daniel Diaz ◽  
Pavel Eduardo Hernandez-Carreño ◽  
Diana Zuleika Velazquez ◽  
Miguel Angel Chaidez-Ibarra ◽  
Arnulfo Montero-Pardo ◽  
...  

Poultry and poultry-derived products such as meat and eggs are among the main sources of non-typhoidal Salmonella (NTS) transmission to the human. Therefore, we performed a systematic review and used random-effects meta-analyses to 1) estimate the prevalence of NTS in poultry samples from birds, products and subproducts, and environmental samples, 2) examine the diversity and frequency of their serovars, and 3) estimate the prevalence and profiles of antimicrobial resistance (AMR) in NTS isolates reported in studies from the Americas. We included 157 studies from 15 countries comprising 261,408 poultry samples and estimated an overall pooled prevalence of 17.9% (95% CI: 10.8–26.3) in birds, 21.8% (17.7–26.1) in products and subproducts, and 29.5% (24.2–35.1) in environmental samples. At the national level, the prevalence of NTS was heterogenous across countries with the highest values in Mexico, the USA, and Canada. In total, 131 serovars were identified from 13,388 isolates, Heidelberg, Kentucky, Enteritidis, and Typhimurium were the most prevalent in the overall top 10 ranking (range 6.5–20.8%). At the national level, Enteritidis and Typhimurium were identified in most of the countries, though with national differences in their ranks. The prevalence of AMR increased from 24.1% for 1 antibiotic, to 36.2% for 2-3 antibiotics, and 49.6% for ≥ 4 antibiotics. Kentucky, Heidelberg, Typhimurium, and Enteritidis were the serovars with the highest prevalence of AMR and tetracycline, ampicillin, streptomycin, ceftiofur, and amoxicillin-clavulanic acid were the top five antibiotics to which NTS isolates were resistant. In conclusion, NTS was distributed through the avian production chain with high and heterogenous values of prevalence in poultry samples. Besides, there were distinctive patterns of serovars distribution across countries and an alarming prevalence of AMR among zoonotic serovars.


2018 ◽  
Vol 2 (4) ◽  
Author(s):  
S. M. Dhawan ◽  
B.M. Gupta ◽  
Sudhanshu Bhusan

The paper maps quantum computing research on various publication and citation indicators, using data from Scopus database covering 10-year period 2007-16. Quantum computing research cumulated 4703 publications in 10 years, registered a slow 3.39% growth per annum, and averaged 14.30 citations per paper during the period. Top 10 countries dominate the field with 93.15% global publications share. The USA accounted for the highest 29.98% during the period. Australia tops in relative citation index (2.0).  International collaboration has been a major driver of research in the subject; 14.10% to 62.64% of national level output of top 10 countries appeared as international collaborative publications. Computer Science is one of the most popular areas of research in quantum computing research. The study identifies top 30 most productive organizations and authors, top 20 journals reporting quantum computing research, and 124 highly cited papers with 100+ citations per paper.


2019 ◽  
Vol 29 (1/2) ◽  
pp. 168-177
Author(s):  
Guanyan Fan

Purpose This paper aims to examine the situation of organizational information governance (IG) and its relationship with e-discovery in China. Design/methodology/approach This study collects laws, court opinions, cases and relevant literature as data and analyzes their content under the guidance of the framework of Information Governance Reference Model of the Electronic Discovery Reference Model (EDRM). Findings Inspired by discussions on the challenges of e-discovery and, in particular, the relationships between organizational IG and e-discovery in English literature, the present study attempts an examination of the relevant situations in China. It is the belief of the study that the connection between IG and the legal risk as framed in the EDRM is a necessary one for China as the country is opening its door wider and continues to seek multilateral cooperation. The study found out, through observations and analyses, the following distinctions of e-discovery and its relationship with IG in China. Despite the very similar US and Chinese digital technological environments and the similar acceptance of electronic evidence into litigations, the situations with e-discovery/electronically stored information (ESI) and IG are different within a Chinese context. Legal provisions regarding electronic evidence are brief and vague, litigating procedures rely on the explanations of the Supreme Court and the Supreme Procuratorate and, most relevantly, there is only a small portion of litigations that features a large quantity of ESI in the context of dramatically increased cases involving electronic evidence. The evidentiary qualifications of ESI, e.g. authenticity and reliability, are discussed intensively in academic writings, which, however, was done in a rather isolated manner, without referring to the relationships between and among them. The concept of proportionality, which was one of the key constructions in e-discovery discussions in English literature, was not found in these writings. As a result, organizational IG in China is not discussed in relation to e-discovery or electronic evidence, raising the question as to how e-discovery of a large quantity of ESI will be handled, should such cases emerge. Research limitations/implications Extracted mainly from available literature in legal and information fields, this study is necessarily neither exhaustive nor definitive. However, it can be used to further strengthen other empirical data studies. It could be extended within a Chinese context with interviews with legal and IG professionals. In this regard, the reasons that lead to the distinctions as exhibited in the findings could be explored in future investigations. This study does serve as a marker of the position in China compared to the USA. This research suggests that there is an opportunity for comparable studies at a national level, thus generating complementary knowledge for the IG and e-discovery community internationally. Practical implications The findings of the study may be instructive to countries with similar situations, that is, a weak linkage between IG and e-discovery. It may serve as a call for more comparable studies, thus generating complementary knowledge for the IG and e-discovery community internationally. Originality/value The study reported in this paper is the first of its kind in terms of exploring the relationships between IG and e-discovery in the Chinese context.


2019 ◽  
Vol 7 (1) ◽  
pp. e000621 ◽  
Author(s):  
Estelle Everett ◽  
Nestoras Nicolas Mathioudakis

ObjectiveTo identify patient and hospital predictors of recurrent diabetic ketoacidosis (DKA) admissions in adults in the USA with type 1 diabetes, focusing on socioeconomic indicators.Research design and methodsThis cross-sectional study used the National Readmission Database to identify adult patients with type 1 diabetes admitted for DKA between 2010 and 2015. The index DKA admission was defined as the first admission within the calendar year and the primary outcome was recurrent DKA admission(s) within the same calendar year. Multivariable logistic regression analysis was performed using covariates of patient and hospital factors at the index admission to determine the odds of DKA readmission(s).ResultsAmong 181 284 index DKA admissions, 39 693 (22%) had at least one readmission within the calendar year, of which 33 931 (86%) and 5762 (14%) had 1–3 and ≥4 DKA readmissions, respectively. When compared with the highest income quartile, patients in the first and second income quartiles had 46% (95% CI 30% to 64%) and 34% (95% CI 19% to 51%) higher odds of four or more DKA readmissions, respectively. Medicaid and Medicare insurance were both associated with a 3.3-fold adjusted risk (95% CI 3.0 to 3.7) for ≥4 readmissions compared with private insurance, respectively. Younger age, female sex, and discharge against medical advice were also predictive.ConclusionsLower socioeconomic status and Medicaid insurance are strong predictors of DKA readmissions in adults with type 1 diabetes in the USA. Further studies are needed to understand the mediators of this association to inform multilevel interventions for this high-risk population.Significance of the studyThe association of socioeconomic status (SES) and hospital admission for DKA has been studied in pediatrics with type 1 diabetes, but the data in adults are limited, and studies evaluating recurrent DKA admissions are scarcer. To our knowledge, this is the first study to describe predictors of recurrent DKA admissions in adults with type 1 diabetes on a national level in the USA. We found that those at highest risk of recurrent DKA are young women with low SES who had Medicaid or Medicare insurance. These findings should prompt further studies to explore the mediators of these disparities in patients with type 1 diabetes, as recurrent DKA results in high healthcare utilization and increased risk of long-term complications.


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