Importance of linear combination modeling for quantification of Glutathione and GABA levels using Hadamard-edited MRS

Purpose: Two main approaches are used for spectral analysis of edited data: simple peak fitting and linear combination modeling (LCM) with a simulated basis set. Recent consensus recommended LCM as the method of choice for the spectral analysis of edited data. The aim of this study is to compare the performance of simple peak fitting and LCM in a test-retest dataset, hypothesizing that the more sophisticated LCM approach will improve quantification of HERMES data compared with simple peak fitting. Methods: A test-retest dataset was re-analyzed using Gannet (simple peak fitting) and Osprey (LCM). These data were obtained from the dorsal anterior cingulate cortex of twelve healthy volunteers, with TE 80 ms for HERMES and TE 120 ms for MEGA-PRESS of glutathione (GSH). Within-subject coefficients of variance (CVs) were calculated to quantify between-scan reproducibility of each metabolite estimate. Results: The reproducibility of HERMES GSH estimates was substantially improved using LCM compared to simple peak fitting, from a CV of 19.0% to 9.9%. For MEGA-PRESS data, the GSH reproducibility was similar using LCM and simple peak fitting, with CVs of 7.3% and 8.8% respectively. Conclusion: Linear combination modeling with simulated basis functions substantially improves the reproducibility of GSH quantification for HERMES data.

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(S)-ketamine increases prefrontal cerebral blood flow but not glutamate levels in anterior cingulate cortex in healthy volunteers

Intrinsic Activity ◽

10.25006/ia.4.s2-a18.22 ◽

2016 ◽

Vol 4 (Suppl. 2) ◽

pp. A18.22

Author(s):

Kirsten B. Bojesen

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Healthy Volunteers ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate

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Improvements in error-monitoring and symptoms following low-frequency rTMS of dorsal anterior cingulate cortex in obsessive compulsive disorder; a randomized, sham-controlled study

Brain and Cognition ◽

10.1016/j.bandc.2021.105809 ◽

2021 ◽

Vol 154 ◽

pp. 105809

Author(s):

Benjamin P. Meek ◽

Aryandokht Fotros ◽

Mohamed Abo Aoun ◽

Mandana Modirrousta

Keyword(s):

Anterior Cingulate Cortex ◽

Obsessive Compulsive Disorder ◽

Low Frequency ◽

Anterior Cingulate ◽

Controlled Study ◽

Error Monitoring ◽

Obsessive Compulsive ◽

Dorsal Anterior Cingulate Cortex ◽

Compulsive Disorder ◽

Low Frequency Rtms

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Dorsal anterior cingulate cortex intrinsic functional connectivity linked to electrocortical measures of error-monitoring

10.1101/2020.10.21.348649 ◽

2020 ◽

Author(s):

Hayley Gilbertson ◽

Lin Fang ◽

Jeremy A. Andrzejewski ◽

Joshua M. Carlson

Keyword(s):

Functional Connectivity ◽

Anterior Cingulate Cortex ◽

Flanker Task ◽

Monitoring Network ◽

Cingulate Cortex ◽

Event Related Potential ◽

Anterior Cingulate ◽

Functional Coupling ◽

Error Monitoring ◽

Dorsal Anterior Cingulate Cortex

AbstractThe error-related negativity (ERN) is a response-locked event-related potential, occurring approximately 50 ms following an erroneous response at frontocentral electrode sites. Source localization and functional magnetic resonance imaging (fMRI) research indicate that the ERN is likely generated by activity in the dorsal anterior cingulate cortex (dACC). The dACC is thought to be a part of a broader network of brain regions that collectively comprise an error-monitoring network. However, little is known about how intrinsic connectivity within the dACC-based error-monitoring network contributes to variability in ERN amplitude. The purpose of this study was to assess the relationship between dACC functional connectivity and ERN amplitude. In a sample of 53 highly trait-anxious individuals, the ERN was elicited in a flanker task and functional connectivity was assessed in a 10-minute resting-state fMRI scan. Results suggest that the strength of dACC seeded functional connectivity with the supplementary motor area is correlated with the ΔERN (i.e., incorrect – correct responses) amplitude such that greater ΔERN amplitude was accompanied by greater functional coupling between these regions. In addition to the dACC, exploratory analyses found that functional connectivity in the caudate, cerebellum, and a number of regions in the error-monitoring network were linked to variability in ΔERN amplitude. In sum, ERN amplitude appears to be related to the strength of functional connectivity between error-monitoring and motor control regions of the brain.

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Altered resting-state dorsal anterior cingulate cortex functional connectivity in patients with post-traumatic stress disorder

Australian & New Zealand Journal of Psychiatry ◽

10.1177/0004867418812674 ◽

2018 ◽

Vol 53 (1) ◽

pp. 68-79 ◽

Cited By ~ 6

Author(s):

Hui Juan Chen ◽

Li Zhang ◽

Jun Ke ◽

Rongfeng Qi ◽

Qiang Xu ◽

...

Keyword(s):

Functional Connectivity ◽

Anterior Cingulate Cortex ◽

Post Traumatic Stress Disorder ◽

Traumatic Stress ◽

Stress Disorder ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Post Traumatic Stress ◽

Dorsal Anterior Cingulate Cortex ◽

Post Traumatic

Objective: The brain functional alterations at regional and network levels in post-traumatic stress disorder patients are still unclear. This study explored brain functional alterations at regional and network levels in post-traumatic stress disorder patients with resting-state functional magnetic resonance imaging and evaluated the relationship between brain function and clinical indices in post-traumatic stress disorder. Methods: Amplitude of low-frequency fluctuation and seed-based functional connectivity analyses were conducted among typhoon survivors with ( n = 27) and without post-traumatic stress disorder ( n = 33) and healthy controls ( n = 30) to assess the spontaneous brain activity and network-level brain function. Pearson correlation analyses were performed to examine the association of brain function with clinical symptom and social support. Results: Both the post-traumatic stress disorder group and the trauma-exposed control group showed decreased amplitude of low-frequency fluctuation in the dorsal anterior cingulate cortex relative to the healthy control group. The post-traumatic stress disorder group showed increased dorsal anterior cingulate cortex functional connectivity with the right paracentral lobule and bilateral precentral gyrus/postcentral gyrus relative to both control groups. Both traumatized groups exhibited decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus and left cerebellum relative to the healthy control group. More decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus was found in the post-traumatic stress disorder group. The Checklist-Civilian Version score positively correlated with functional connectivity between the dorsal anterior cingulate cortex and the right paracentral lobule as well as between the dorsal anterior cingulate cortex and the right precentral gyrus/postcentral gyrus. The social support was associated with functional connectivity between the dorsal anterior cingulate cortex and the bilateral precentral gyrus/postcentral gyrus as well as the dorsal anterior cingulate cortex and the left middle frontal gyrus. Conclusion: Trauma exposure may result in aberrant local and network-level functional connectivity in individuals with or without post-traumatic stress disorder. Altered amplitude of low-frequency fluctuation in the dorsal anterior cingulate cortex may be a predisposing risk factor for post-traumatic stress disorder development following trauma exposure. More prominent decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus might be specific in the post-traumatic stress disorder group. Improvement of social support might possibly be significant for post-traumatic stress disorder patients.

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