scholarly journals Effects of periodic bottlenecks on the dynamics of adaptive evolution in microbial populations

2021 ◽  
Author(s):  
Minako Izutsu ◽  
Devin M. Lake ◽  
Zachary W. D. Matson ◽  
Jack P. Dodson ◽  
Richard E. Lenski
Keyword(s):  
Simple Model ◽  
The Other ◽  
Population Bottlenecks ◽  
Final Size ◽  
Beneficial Mutations ◽  
Resource Limited ◽  
Long Term Experiment ◽  
The One ◽  
The Impact

Population bottlenecks are common in nature, and they can impact the rate of adaptation in evolving populations. On the one hand, each bottleneck reduces the genetic variation that fuels adaptation. On the other hand, fewer founders can undergo more generations and leave more descendants in a resource-limited environment, which allows surviving beneficial mutations to spread more quickly. Here we investigate the impact of repeated bottlenecks on the dynamics of adaptation in experimental populations of Escherichia coli. We propagated 48 populations under four dilution regimes (2-, 8-, 100-, and 1000-fold), all reaching the same final size each day, for 150 days. A simple model in which adaptation is limited by the supply rate of beneficial mutations predicts that fitness gains should be maximized with ~8-fold dilutions. The model also assumes that selection acts only on the overall growth rate and is otherwise identical across dilution regimes. However, we found that selection in the 2-fold regime was qualitatively different from the other treatments. Moreover, we observed earlier and greater fitness gains in the populations subjected to 100- and 1000-fold dilutions than in those that evolved in the 8 fold regime. We also ran simulations using parameters estimated independently from a long-term experiment using the same ancestral strain and environment. The simulations produced dynamics similar to our empirical results under these regimes, and they indicate that the simple model fails owing to the assumption that the supply of beneficial mutations limits adaptation.

Evaluating the Impact of Population Bottlenecks in Experimental Evolution

Genetics ◽  
2002 ◽  
Vol 162 (2) ◽  
pp. 961-971 ◽  
Author(s):  
Lindi M Wahl ◽  
Philip J Gerrish ◽  
Ivan Saika-Voivod
Keyword(s):  
Experimental Evolution ◽  
Evolutionary Dynamics ◽  
Population Bottlenecks ◽  
Dilution Ratio ◽  
Beneficial Mutation ◽  
Serial Transfer ◽  
Beneficial Mutations ◽  
Resource Limited ◽  
Total Fraction ◽  
The Impact

AbstractExperimental evolution involves severe, periodic reductions in population size when fresh media are inoculated during serial transfer. These bottlenecks affect the dynamics of evolution, reducing the probability that a beneficial mutation will reach fixation. We quantify the impact of these bottlenecks on the evolutionary dynamics, for populations that grow exponentially between transfers and for populations in which growth is curbed by a resource-limited environment. We find that in both cases, mutations that survive bottlenecks are equally likely to occur, per unit time, at all times during the growth phase. We estimate the total fraction of beneficial mutations that are lost due to bottlenecks during experimental evolution protocols and derive the “optimal” dilution ratio, the ratio that maximizes the number of surviving beneficial mutations. Although more severe dilution ratios are often used in the literature, we find that a ratio of 0.1-0.2 minimizes the chances that rare beneficial mutations are lost. Finally, we provide a number of useful approximate results and illustrate our approach with applications to experimental evolution protocols in the literature.

DESIGNING OF HUMAN FROM THE PERSPECTIVE OF MODERN BIOMEDICINE: PANIC EXPECTATIONS, EUPHORIA AND CAUTIOUS FORECASTS

Chelovek RU ◽  
2020 ◽  
pp. 244-254
Author(s):  
Svetlana Khmelevskaya ◽  
Keyword(s):  
Human Rights ◽  
Human Body ◽  
Rapid Development ◽  
The Other ◽  
Formation Processes ◽  
Biomedical Technologies ◽  
Long Term Consequences ◽  
The One ◽  
The Impact

The article attempts to conduct a balanced analysis of the impact of modern biomedical technologies on human corporeality from the perspective of its formation processes. On the one hand, there is a panic mood about the loss of the human proper in man due to the rapid development of biomedical technolo-gies and the construction of human corporeality using them, and as a result, the adoption of measures to prevent radical modification of such corporeality. On the other hand, there are also excessive expecta-tions for modern biomedical technologies that are ultimately, as supposed, to be able to make humans immortal. The task of the author of the article is to show that the scientists involved in biomedical are rather cautious about radical changes in human body, seeing the real risks from such intervention and the lack of clarity about the long-term consequences. At the same time, any interference with a person 's body must be based on respect for and observance of human rights and human dignity.

Radioimmunotherapy for treatment of acute myeloid leukaemia and myelodysplastic syndrome

2005 ◽  
Vol 44 (03) ◽  
pp. 107-117
Author(s):  
R. G. Meyer ◽  
W. Herr ◽  
A. Helisch ◽  
P. Bartenstein ◽  
I. Buchmann
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Primary Tumour ◽  
The Other ◽  
Haematopoietic Stem Cell ◽  
Other Hand ◽  
Primary Reduction ◽  
The One ◽  
Acute Myeloid

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.

Hidden “holes” in the capital of banks and the supply of credit to the real sector of economy

2018 ◽  
pp. 49-68 ◽  
Author(s):  
M. E. Mamonov
Keyword(s):  
Credit Risk ◽  
The Other ◽  
Real Sector ◽  
Capital Management ◽  
Loan Loss ◽  
Short Term ◽  
The Real ◽  
Ex Post ◽  
The One

Our analysis documents that the existence of hidden “holes” in the capital of not yet failed banks - while creating intertemporal pressure on the actual level of capital - leads to changing of maturity of loans supplied rather than to contracting of their volume. Long-term loans decrease, whereas short-term loans rise - and, what is most remarkably, by approximately the same amounts. Standardly, the higher the maturity of loans the higher the credit risk and, thus, the more loan loss reserves (LLP) banks are forced to create, increasing the pressure on capital. Banks that already hide “holes” in the capital, but have not yet faced with license withdrawal, must possess strong incentives to shorten the maturity of supplied loans. On the one hand, it raises the turnovers of LLP and facilitates the flexibility of capital management; on the other hand, it allows increasing the speed of shifting of attracted deposits to loans to related parties in domestic or foreign jurisdictions. This enlarges the potential size of ex post revealed “hole” in the capital and, therefore, allows us to assume that not every loan might be viewed as a good for the economy: excessive short-term and insufficient long-term loans can produce the source for future losses.

Interrelationships between municipal spatial policy strategy and airport operation and development. Lodz Airport case study

2018 ◽  
Vol 59 (1) ◽  
pp. 65-79
Author(s):  
Katarzyna Nikorowicz-Zatorska
Keyword(s):  
Land Use ◽  
Urban Planning ◽  
Cultural Development ◽  
The Other ◽  
Local Authorities ◽  
Spatial Management ◽  
The One ◽  
Surrounding Areas

Abstract The present paper focuses on spatial management regulations in order to carry out investment in the field of airport facilities. The construction, upgrades, and maintenance of airports falls within the area of responsibility of local authorities. This task poses a great challenge in terms of organisation and finances. On the one hand, an active airport is a municipal landmark and drives local economic, social and cultural development, and on the other, the scale of investment often exceeds the capabilities of local authorities. The immediate environment of the airport determines its final use and prosperity. The objective of the paper is to review legislation that affects airports and the surrounding communities. The process of urban planning in Lodz and surrounding areas will be presented as a background to the problem of land use management in the vicinity of the airport. This paper seeks to address the following questions: if and how airports have affected urban planning in Lodz, does the land use around the airport prevent the development of Lodz Airport, and how has the situation changed over the time? It can be assumed that as a result of lack of experience, land resources and size of investments on one hand and legislative dissonance and peculiar practices on the other, aviation infrastructure in Lodz is designed to meet temporary needs and is characterised by achieving short-term goals. Cyclical problems are solved in an intermittent manner and involve all the municipal resources, so there’s little left to secure long-term investments.

Laughter on the Fringes

2019 ◽  
Author(s):  
Anna Peterson
Keyword(s):  
The Other ◽  
Literary Canon ◽  
Autobiographical Writing ◽  
Treasure Trove ◽  
Old Comedy ◽  
Other Hand ◽  
Aggressive Humor ◽  
The One ◽  
The Individual ◽  
The Impact

This book examines the impact that Athenian Old Comedy had on Greek writers of the Imperial era. It is generally acknowledged that Imperial-era Greeks responded to Athenian Old Comedy in one of two ways: either as a treasure trove of Atticisms, or as a genre defined by and repudiated for its aggressive humor. Worthy of further consideration, however, is how both approaches, and particularly the latter one that relegated Old Comedy to the fringes of the literary canon, led authors to engage with the ironic and self-reflexive humor of Aristophanes, Eupolis, and Cratinus. Authors ranging from serious moralizers (Plutarch and Aelius Aristides) to comic writers in their own right (Lucian, Alciphron), to other figures not often associated with Old Comedy (Libanius) adopted aspects of the genre to negotiate power struggles, facilitate literary and sophistic rivalries, and provide a model for autobiographical writing. To varying degrees, these writers wove recognizable features of the genre (e.g., the parabasis, its agonistic language, the stage biographies of the individual poets) into their writings. The image of Old Comedy that emerges from this time is that of a genre in transition. It was, on the one hand, with the exception of Aristophanes’s extant plays, on the verge of being almost completely lost; on the other hand, its reputation and several of its most characteristic elements were being renegotiated and reinvented.

Preaching and Sermons

2017 ◽  
Author(s):  
Robert H. Ellison
Keyword(s):  
Eighteenth Century ◽  
North Atlantic ◽  
Religious Revival ◽  
Early Nineteenth Century ◽  
Denominational Identity ◽  
The North ◽  
The North Atlantic ◽  
The One ◽  
The Impact

Prompted by the convulsions of the late eighteenth century and inspired by the expansion of evangelicalism across the North Atlantic world, Protestant Dissenters from the 1790s eagerly subscribed to a millennial vision of a world transformed through missionary activism and religious revival. Voluntary societies proliferated in the early nineteenth century to spread the gospel and transform society at home and overseas. In doing so, they engaged many thousands of converts who felt the call to share their experience of personal conversion with others. Though social respectability and business methods became a notable feature of Victorian Nonconformity, the religious populism of the earlier period did not disappear and religious revival remained a key component of Dissenting experience. The impact of this revitalization was mixed. On the one hand, growth was not sustained in the long term and, to some extent, involvement in interdenominational activity undermined denominational identity; on the other hand, Nonconformists gained a social and political prominence they had not enjoyed since the middle of the seventeenth century and their efforts laid the basis for the twentieth-century explosion of evangelicalism in Africa, Asia, and South America.

The ‘Zen’ in the western monochrome

2020 ◽  
Vol 6 (1-2) ◽  
pp. 55-78
Author(s):  
Simon Morley
Keyword(s):  
Zen Buddhism ◽  
Historical Context ◽  
The Other ◽  
Binary Opposition ◽  
Middle Way ◽  
The 1950S ◽  
The One ◽  
Contemporary Painting ◽  
The Impact

I look at the impact of Zen Buddhism on western painters during the 1950s and 1960s, focusing on the monochrome in particular, in order to create a historical context for the consideration of transcultural dialogue in relation to contemporary painting. I argue that a consideration of Zen can offer a ‘middle way’ between conceptions of the monochrome (and art in general) often hobbled by models of interpretation that function within a binary opposition between ‘literalist/sensory’ on the one hand, and ‘intellectual/non-sensory’ readings on the other.

The effects of direct drilling, shallow cultivation and ploughing on some soil physical properties in a long-term experiment on spring barley

1985 ◽  
Vol 104 (1) ◽  
pp. 125-133 ◽  
Author(s):  
K. Chaney ◽  
D. R. Hodgson ◽  
M. A. Braim
Keyword(s):  
Spring Barley ◽  
The Other ◽  
Clay Loam ◽  
Average Value ◽  
Structural Problems ◽  
Physical Measurements ◽  
Long Term Experiment ◽  
Direct Drilling ◽  
Air Capacity

SummaryPhysical measurements were made on the soil of a long-term cultivation experiment comparing direct drilling, tine cultivation and mouldboard ploughing for spring barley to investigate possible reasons for differences in yield. The soil was a typical argillio brown earth, approximately 90 cm of sandy clay loam topsoil and clay loam subsoil overlying magnesian limestone. For the three periods 1971–4, 1975–7 and 1978–80 the mean grain yields were marginally lower after direct drilling than after shallow cultivation or ploughing. There was an average decline in yield of 1·33 t/ha from the first to the last period, the decline being greater for direct drilling than the other two tillage systems. Although the surface horizon (0–5 cm) of direct-drilled soil had a higher content of organic matter than the ploughed, this did not increase the stability of the aggregates. Slaking tests had shown the soil to be inherently unstable and likely to suffer from structural problems. After the first 3 years bulk density of direct-drilled soil (0–15 cm) increased markedly to ca. l·5 g/cm8 and then remained relatively stable. In the ploughed soil, density increased steadily over the period to an average value of co. 1·45 g/cm8. Tine cultivation to 7–8 cm reduced cone resistance values in the surface compared with direct-drilled soil but below 15 cm there were no significant differences. Ploughing gave significantly lower values than direct drilling to a depth of 30 cm. Measurements of pore sizes in direct-drilled and ploughed soil were highly variable with few significant differences. Mean air capacity values (1978–80) tended to be lower in direct-drilled than in ploughed topsoil particularly for plots direct drilled after 7 years of deep tine cultivation. A limited number of root measurements in 1978 and 1980 showed that the length of root per unit of ground area was much less after direct drilling than after ploughing. Shallow cultivation, surprisingly, gave most root with a greater proportion of the root system below 20 cm than in the other two treatments. The classification of this soil according to its suitability for direct drilling cereals is discussed.

scholarly journals The role of SMEs in innovation-oriented economic development

2017 ◽  
pp. 95-99
Author(s):  
Tamás Köpeczi-Bócz ◽  
Mónika Lőrincz
Keyword(s):  
Rural Areas ◽  
Tertiary Education ◽  
National Level ◽  
Business Environment ◽  
The Other ◽  
Sectoral Structure ◽  
Other Hand ◽  
Knowledge Intensive ◽  
The One

Both at European and national level tertiary and quaternary sectors are concentrated in the metropolitan centre. In the rural areas only the sites of such sectors can be found the premises of which temporarily transform the sectoral structure of these areas, but from the regional development aspect they did not prove to be an effective strategy.The European Commission is now focusing on growth from innovation, which could become the driving force behind productivity growth and the economy’s long-term trend. The innovation-oriented economic development’s key players are on the one hand the knowledge-intensive enterprises, on the other hand the universities. Tertiary education can play a role – among others – in shaping and creating the development of knowledge intensive business environment and conditions, on the other hand it can assist the development of network contacts – another precondition of employment growth.

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