scholarly journals Central Role of Cognitive Control Networks in Weight Loss During Voluntary Calorie Restriction

2017 ◽  
Author(s):  
Selin Neseliler ◽  
Wen Hu ◽  
Kevin Larcher ◽  
Maria Zacchia ◽  
Mahsa Dadar ◽  
...  
Keyword(s):  
Weight Loss ◽  
Calorie Restriction ◽  
Cue Reactivity ◽  
Brain Regions ◽  
Self Control ◽  
Food Cues ◽  
Control Networks ◽  
Restriction Diet ◽  
Brain Fmri

SummaryInsufficient responses to hypocaloric diets have been attributed to hormonal adaptations that override self-control of food intake. We tested this hypothesis by measuring brain fMRI reactivity to food cues and circulating energy-balance hormones in 24 overweight/obese participants before, and 1 and 3 months after starting a calorie restriction diet. Increased activity in prefrontal regions at month 1 correlated with weight loss at months 1 and 3. Weight loss was also correlated with increased plasma ghrelin and decreased leptin at month 1, and these changes were associated with greater food cue reactivity in reward-related brain regions. However, the reduction in leptin did not counteract weight loss; indeed, it was correlated with further weight loss at month 3. Activation in a network of prefrontal regions associated with self-control could contribute to individual differences in weight loss and maintenance, whereas we failed to find that the hormonal adaptations play a major role.

Online weight-loss services and a calculative practice of slimming

2015 ◽  
Vol 21 (4) ◽  
pp. 409-424 ◽  
Author(s):  
Mari Niva
Keyword(s):  
Weight Loss ◽  
Calorie Restriction ◽  
Healthy Eating ◽  
Lifestyle Change ◽  
Control Device ◽  
Healthy Lifestyles ◽  
Structured Interviews ◽  
Theories Of Practice

This study examines the slimming practice produced by Internet-based weight-loss services and their use. Drawing on theories of practice, the study analyses the script of use that is constructed by the services, and the meanings, materialities and competences that are enacted in their use. Based on 20 semi-structured interviews with women who were users of two Finnish online weight-loss services, the study concludes that the services transform food into quantitative depictions of calories and nutrition. They configure slimmers as calculative agents and slimming as a practice based on incessant recording and monitoring. For online slimmers, the services acted in the double role of a control device with a focus on calorie restriction, and a learning device used to develop a skill of healthy eating. In the latter role, online slimming was hoped to result in an internalisation of a lifestyle change that would make calculation and constant monitoring unnecessary and the services redundant for their users. The results suggest that for its practitioners, online slimming is temporary rather than long-standing, but it may and is expected to act as a mediary in establishing other practices related to healthy lifestyles.

scholarly journals Brain Connectivity, and Hormonal and Behavioral Correlates of Sustained Weight Loss in Obese Patients after Laparoscopic Sleeve Gastrectomy

2020 ◽  
Author(s):  
Yang Hu ◽  
Gang Ji ◽  
Guanya Li ◽  
Peter Manza ◽  
Wenchao Zhang ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Cognitive Control ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Cue Reactivity ◽  
Structural Connectivity ◽  
Anterior Cingulate ◽  
Food Cues ◽  
Sustained Weight Loss ◽  
High Calorie

Abstract The biological mediators that support cognitive-control and long-term weight-loss after laparoscopic sleeve gastrectomy (LSG) remain unclear. We measured peripheral appetitive hormones and brain functional-connectivity (FC) using magnetic-resonance-imaging with food cue-reactivity task in 25 obese participants at pre, 1 month, and 6 month after LSG, and compared with 30 normal weight controls. We also used diffusion-tensor-imaging to explore whether LSG increases brain structural-connectivity (SC) of regions involved in food cue-reactivity. LSG significantly decreased BMI, craving for high-calorie food cues, ghrelin, insulin, and leptin levels, and increased self-reported cognitive-control of eating behavior. LSG increased FC between the right dorsolateral prefrontal cortex (DLPFC) and the pregenual anterior cingulate cortex (pgACC) and increased SC between DLPFC and ACC at 1 month and 6 month after LSG. Reduction in BMI correlated negatively with increased FC of right DLPFC-pgACC at 1 month and with increased SC of DLPFC-ACC at 1 month and 6 month after LSG. Reduction in craving for high-calorie food cues correlated negatively with increased FC of DLPFC-pgACC at 6 month after LSG. Additionally, SC of DLPFC-ACC mediated the relationship between lower ghrelin levels and greater cognitive control. These findings provide evidence that LSG improved functional and structural connectivity in prefrontal regions, which contribute to enhanced cognitive-control and sustained weight-loss following surgery.

scholarly journals Evaluation of Three New Strategies to Fight Obesity in Families

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
C. Luley ◽  
A. Blaik ◽  
S. Aronica ◽  
J. Dierkes ◽  
S. Kropf ◽  
...  
Keyword(s):  
Weight Loss ◽  
Calorie Restriction ◽  
Financial Incentive ◽  
Obese Children ◽  
Restriction Diet ◽  
Diet Versus ◽  
Design And Methods ◽  
Weight Loss Strategy ◽  
New Strategies ◽  
Low Glycemic Index

Aims. To evaluate 3 strategies to reduce weight in obese families.Research design and methods. 142 obese parents and 119 obese children kept a fat-calorie restriction diet. On top of this diet, the families were randomized in a three-factorial design to one or more of three weight-loss strategies: (1) an additional diet preferring carbohydrates having a low glycemic index (dual diet), (2) financial incentive, and (3) telemonitoring of weight and physical activity.Results. All children improved their BMI-SDS by0.18±0.25(P<.001) independently of the weight-loss strategy. In parents, relative losses of weight (kg) were−6.4% versus−4.0% for dual diet versus calorie restriction (P=.029),−6.9% versus−3.4% for with or without financial incentive (P=.002), and−8.0% versus−4.8% for with or without telemonitoring (P=.033). The weight loss after financial incentive plus dual diet plus telemonitoring was−14.4%.Conclusions. All strategies were effective in adults, in particular when combined. Children improved their BMI-SDS regardless of the strategy.

scholarly journals Altered prefrontal signaling during inhibitory control in a salient drug context in human cocaine addiction

2021 ◽  
Author(s):  
Ahmet O. Ceceli ◽  
Muhammad A. Parvaz ◽  
Sarah King ◽  
Matthew Schafer ◽  
Pias Malaker ◽  
...  
Keyword(s):  
Drug Addiction ◽  
Inhibitory Control ◽  
Dorsolateral Prefrontal Cortex ◽  
Cue Reactivity ◽  
Self Control ◽  
Food Cues ◽  
Drug Cues ◽  
Dorsolateral Prefrontal ◽  
Valence And Arousal ◽  
Drug Cue

AbstractDrug addiction is characterized by impaired Response Inhibition and Salience Attribution (iRISA), where the salience of drug cues is postulated to overpower that of other reinforcers with a concomitant decrease in self-control. However, the neural underpinnings of the interaction between the salience of drug cues and inhibitory control in drug addiction remain unclear. We developed a novel stop-signal fMRI task where the stop-signal reaction time (SSRT—a classical inhibitory control measure) was tested under different salience conditions (modulated by drug, food, threat or neutral words) in individuals with cocaine use disorder (CUD; n=26) vs. demographically matched healthy control participants (HC; n=26). Despite similarities in drug cue-related SSRT and valence and arousal word ratings between groups, the dorsolateral prefrontal cortex (dlPFC) activity was diminished during the successful inhibition of drug versus food cues in CUD, and was correlated with lower frequency of recent use, lower craving, and longer abstinence (Z > 3.1, p < .05 corrected). Results suggest reduced involvement of cognitive control regions (e.g., dlPFC) during inhibitory control under a drug context, relative to an alternative reinforcer, in CUD. Supporting the iRISA model, these results elucidate the direct impact of drug-related cue-reactivity on the neural signature of inhibitory control in drug addiction.Significance statementExcessive salience attribution to drugs and related cues at the expense of nondrug reinforcers and cues and inhibitory control impairments are hallmark symptoms of drug addiction. Although these neuropsychological functions have been investigated independently, brain representations of their interaction are less clear. We illustrate that, despite matched behavioral performance and valence and arousal ratings, the dorsolateral prefrontal cortex—a key node of the cognitive control network also associated with craving—exhibits decreased signaling when successfully inhibiting responses to drug compared to nondrug (food) cues (words) in cocaine-addicted individuals. Modulating salience while taxing self-control permits the study of their combined impact, an ecologically valid examination of the addiction experience. Better understanding inhibitory control under drug cue-reactivity may refine targeted neuromodulatory interventions.

scholarly journals The Intestinal Microbiome Predicts Weight Loss on a Calorie-Restricted Diet and Is Associated With Improved Hepatic Steatosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Tien S. Dong ◽  
Kayti Luu ◽  
Venu Lagishetty ◽  
Farzaneh Sedighian ◽  
Shih-Lung Woo ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Clinical Response ◽  
Hepatic Steatosis ◽  
Calorie Restriction ◽  
Intestinal Microbiome ◽  
Composition Analysis ◽  
Rrna Gene ◽  
Restricted Diet

Background: The microbiome has been shown in pre-clinical and epidemiological studies to be important in both the development and treatment of obesity and metabolic associated fatty liver disease (MAFLD). However, few studies have examined the role of the microbiome in the clinical response to calorie restriction. To explore this area, we performed a prospective study examining the association of the intestinal microbiome with weight loss and change in hepatic steatosis on a calorie-restricted diet.Methods: A prospective dietary intervention study of 80 overweight and obese participants was performed at the Greater West Los Angeles Veterans Affair Hospital. Patients were placed on a macronutrient standardized diet for 16 weeks, including 14 weeks of calorie restriction (500 calorie deficit). Body composition analysis by impedance, plasma lipid measurements, and ultrasound elastography to measure hepatic steatosis were performed at baseline and week 16. Intestinal microbiome composition was assessed using 16S rRNA gene sequencing. A per protocol analysis was performed on all subjects completing the trial (n = 46).Results: Study completers showed significant reduction in weight, body mass index, total cholesterol, low density lipoprotein, and triglyceride. Subjects who lost at least 5% of their body weight had significantly greater reduction in serum triglyceride and hepatic steatosis than those with &lt;5% body weight loss. Enterococcus and Klebsiella were reduced at the end of the trial while Coprococcus and Collinsella were increased. There were also significant baseline microbiome differences between patients who had at least 5% weight loss as compared to those that did not. Lachnoclostridium was positively associated with hepatic steatosis and Actinomyces was positively associated with hepatic steatosis and weight. Baseline microbiome profiles were able to predict which patients lost at least 5% of their body weight with an AUROC of 0.80.Conclusion: Calorie restriction alters the intestinal microbiome and improves hepatic steatosis in those who experience significant weight loss. Baseline microbiome differences predict weight loss on a calorie–restricted diet and are associated with improvement in hepatic steatosis, suggesting a role of the gut microbiome in mediating the clinical response to calorie restriction.

scholarly journals Obesity and Dietary Added Sugar Interact to Affect Postprandial GLP-1 and Its Relationship to Striatal Responses to Food Cues and Feeding Behavior

2021 ◽  
Vol 12 ◽  
Author(s):  
Sabrina Jones ◽  
Shan Luo ◽  
Hilary M. Dorton ◽  
Alexandra G. Yunker ◽  
Brendan Angelo ◽  
...  
Keyword(s):  
Feeding Behavior ◽  
Cue Reactivity ◽  
Brain Regions ◽  
Plain Water ◽  
Food Cues ◽  
Brain Response ◽  
Added Sugar ◽  
Low Calorie ◽  
Sugar Intake ◽  
High Calorie

It has been hypothesized that the incretin hormone, glucagon-like peptide-1 (GLP-1), decreases overeating by influencing mesolimbic brain regions that process food-cues, including the dorsal striatum. We previously showed that habitual added sugar intake was associated with lower glucose-induced circulating GLP-1 and a greater striatal response to high calorie food cues in lean individuals. Less is known about how dietary added sugar and obesity may interact to affect postprandial GLP-1 and its relationship to striatal responses to food cues and feeding behavior. The current study aimed to expand upon previous research by assessing how circulating GLP-1 and striatal food cue reactivity are affected by acute glucose consumption in participants with varied BMIs and amounts of habitual consumption of added sugar. This analysis included 72 participants from the Brain Response to Sugar Study who completed two study visits where they consumed either plain water or 75g glucose dissolved in water (order randomized; both drinks were flavored with non-caloric cherry flavoring) and underwent repeated blood sampling, a functional magnetic resonance imaging (fMRI) based food-cue task, and an ad-libitum buffet meal. Correlations between circulating GLP-1 levels, striatal food-cue reactivity, and food intake were assessed, and interactions between obesity and added sugar on GLP-1 and striatal responses were examined. An interaction between BMI and dietary added sugar was associated with reduced post-glucose GLP-1 secretion. Participants who were obese and consumed high levels of added sugar had the smallest increase in plasma GLP-1 levels. Glucose-induced GLP-1 secretion was correlated with lower dorsal striatal reactivity to high-calorie versus low-calorie food-cues, driven by an increase in reactivity to low calorie food-cues. The increase in dorsal striatal reactivity to low calorie food-cues was negatively correlated with sugar consumed at the buffet. These findings suggest that an interaction between obesity and dietary added sugar intake is associated with additive reductions in postprandial GLP-1 secretion. Additionally, the results suggest that changes to dorsal striatal food cue reactivity through a combination of dietary added sugar and obesity may affect food consumption.

Physiological and Therapeutic Outcomes of Intermittent Fasting versus Calorie-Restriction Diet in Patients suffering from Metabolic Syndrome

2019 ◽  
Vol 3 (1) ◽  
pp. 4-19
Author(s):  
Doreen Susanne Micallef
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Blood Glucose ◽  
Calorie Restriction ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Intermittent Fasting ◽  
Retrospective Case ◽  
Restriction Diet

The main objective of this study was to determine whether an intermittent fasting diet in combination with a CR diet results in better outcomes on risk factors associated with metabolic syndrome (such as lowering of triglycerides, fasting blood glucose, and blood pressure decrease in abdominal obesity and an increase in HDL-cholesterol and related weight loss for both male and female patients) than with a conventional CR diet alone. A 12-week retrospective case-control study was carried out and involved 78 females and 22 males who exhibited or were receiving medications for three or more conditions related to metabolic syndrome and who completed the study out of 120 participants at baseline. These were randomly assigned to either a conventional calorie-restriction diet or to an intermittent-fasting diet. Relevant baseline parameters were measured during the first encounter and were then repeated after twelve weeks. Professional contact was maintained on a fortnightly basis for both groups. Subjects randomly assigned to the intermittent fasting diet lost more weight than subjects on a conventional calorie-restriction diet after 12 weeks (mean ± SD, 5.7 ± 3.2 kg vs 11.4 ± 6.4 kg; p < 0.001). There were also statistically significant decreases in waist circumference (10.1 ± 7.2 cm vs 4.5 ± 3.3 cm; p < 0.001), serum triglycerides (0.31 ± 0.29 mmol/l vs 0.16 ± 0.16 mmol/l; p = 0.002), and systolic blood pressure (11.1 ± 8.2 mm Hg vs 5.2 ± 4.8 mm Hg; p < 0.001) and an increase in HDL-cholesterol (0.25 ± 0.16 vs 0.14 ± 0.15 mmol/l; p = 0.001). However, no statistically significant changes in diastolic blood pressure and fasting blood glucose were recorded. The intermittent fasting diet gave better weight loss outcomes (6.67% vs 12.35%) than did the conventional calorie restriction diet when compared to the baseline weight after the conclusion of the 12-week programme. The intermittent fasting diet was also associated with statistically significant improvements in four out of the six parameters measured and associated with metabolic syndrome. Longer-term studies are required to determine whether these outcomes will be maintained over longer periods of time assuming that there is compliance by the participants.

scholarly journals A common limiter circuit for opioid choice and relapse identified in a rodent addiction model

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jasper A. Heinsbroek ◽  
Giuseppe Giannotti ◽  
Mitchel R. Mandel ◽  
Megan Josey ◽  
Gary Aston-Jones ◽  
...  
Keyword(s):  
Dendritic Spines ◽  
Food Reinforcement ◽  
Brain Regions ◽  
Infralimbic Cortex ◽  
Nucleus Accumbens Shell ◽  
Food Cues ◽  
Behavioral Constructs ◽  
Relapse Rates ◽  
Subsequent Relapse

AbstractActivity in numerous brain regions drives heroin seeking, but no circuits that limit heroin seeking have been identified. Furthermore, the neural circuits controlling opioid choice are unknown. In this study, we examined the role of the infralimbic cortex (IL) to nucleus accumbens shell (NAshell) pathway during heroin choice and relapse. This model yielded subpopulations of heroin versus food preferring rats during choice, and choice was unrelated to subsequent relapse rates to heroin versus food cues, suggesting that choice and relapse are distinct behavioral constructs. Supporting this, inactivation of the IL with muscimol produced differential effects on opioid choice versus relapse. A pathway-specific chemogenetic approach revealed, however, that the IL-NAshell pathway acts as a common limiter of opioid choice and relapse. Furthermore, dendritic spines in IL-NAshell neurons encode distinct aspects of heroin versus food reinforcement. Thus, opioid choice and relapse share a common addiction-limiting circuit in the IL-NAshell pathway.

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