scholarly journals Introduce a New Approach to Detect Genes Associated to Oral Squamous Cell Carcinoma

2018 ◽  
Author(s):  
Jianqiang Li ◽  
Caiyun Yang ◽  
Yang Ji-Jiang ◽  
Shi Chen ◽  
Qing Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Gene Expression Omnibus ◽  
New Approach ◽  
Kegg Pathways ◽  
Gene Probes ◽  
The World ◽  
Oral Neoplasms

AbstractOral squamous cell carcinoma (OSCC) represents the most frequent of all oral neoplasms in the world. Genetics plays an important role in the etiopathogenesis of OSCC. However, the investigation of the molecular mechanism of OSCC is still incomplete. In this article, we introduced a new approach to detect OSCC-associated genes, in which we not only compare mean difference, but also variance difference between cases and controls. Based on two OSCC datasets from Gene Expression Omnibus, we identified 456 differentially variable (DV) gene probes, in addition to 2,375 differentially expressed (DE) gene probes. There are 2,193 DE-only probes, 274 DV-only probes, and 182 DE-and-DV probes. DAVID functional analysis showed that genes corresponding to DE-only, DV-only, and DE-and-DV probes were enriched in different KEGG pathways, indicating they play different roles in OSCC. This new approach can be used to investigate the genetic risk factors for other complex human diseases.

scholarly journals Evidences Suggesting Involvement of Viruses in Oral Squamous Cell Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-17 ◽  
Author(s):  
Kanupriya Gupta ◽  
Rashmi Metgud
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oncogenic Viruses ◽  
Major Health Problem ◽  
Oral Neoplasms ◽  
Potential Factors

Oral cancer is one of the most common cancers and it constitutes a major health problem particularly in developing countries. Oral squamous cell carcinoma (OSCC) represents the most frequent of all oral neoplasms. Several risk factors have been well characterized to be associated with OSCC with substantial evidences. The etiology of OSCC is complex and involves many factors. The most clearly defined potential factors are smoking and alcohol, which substantially increase the risk of OSCC. However, despite this clear association, a substantial proportion of patients develop OSCC without exposure to them, emphasizing the role of other risk factors such as genetic susceptibility and oncogenic viruses. Some viruses are strongly associated with OSCC while the association of others is less frequent and may depend on cofactors for their carcinogenic effects. Therefore, the exact role of viruses must be evaluated with care in order to improve the diagnosis and treatment of OSCC. Although a viral association within a subset of OSCC has been shown, the molecular and histopathological characteristics of these tumors have yet to be clearly defined.

scholarly journals Ultrasound-guided FNA Efficiency in Diagnosing of Metastatic Nodes of Oral Squamous Cell Carcinoma; Article Review

2021 ◽  
Author(s):  
Sona Rafieyan ◽  
Yousef Kananizadeh ◽  
Elahe Reyhani
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Critical Issue ◽  
Lymph Node Status ◽  
Depth Of Invasion ◽  
Nodal Disease ◽  
Oral Neoplasms ◽  
Pattern Differentiation

Oral cancer comprises a group of neoplasms affecting any fields of the oral cavity, pharyngeal regions and salivary glands. However, this term tends to be used interchangeably with oral squamous cell carcinoma (OSCC), which represents the most common of all oral neoplasms. It is estimated that more than 90% of all oral neoplasms are OSCC. Oral SCC prefers to spread through the lymphatic system than the bloodstream, and in this region tongue tumors have the greatest potential for neck metastases.Primary tumor’s histopathologic features like depth of invasion, thickness, growth pattern, differentiation, lymphovascular or vascular invasion have a limited prognostic value for nodal disease. cervical lymph node status accurate assessment in HNSCC patients is critical issue because of its influences on prognosis and treatment decisions, USgFNAC proved widely accepted not only because of safety and availability in diagnosis but also it is repeatable, minimally invasive and cost-effectiveness.

scholarly journals Oral Squamous Cell Carcinoma: Diagnosis and Treatment Planning

2021 ◽  
pp. 1853-1867
Author(s):  
Vijay Deshmukh ◽  
Kishore Shekar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Treatment Planning ◽  
Squamous Cell ◽  
The Other ◽  
Diagnosis And Treatment ◽  
Premalignant Lesions ◽  
The World

AbstractThe incidence of Oral Squamous Cell Carcinoma (OSCC) is on the rise. Association with tobacco and alcohol is well established. Transformation rates in premalignant lesions and conditions vary in the available literature. Oral cancer in other parts of the world has different etiology in contrast to Indian oral cancer. Because of this Indian OSCC may require different parameters for treatment than that of the other oral cancer. Its prognosis also may not be comparable to others.

scholarly journals Comparison of Ferroptosis Related Genes expression in Human Oral Squamous Cell Carcinoma and Normal oral tissues

2021 ◽  
Author(s):  
Rooban Thavarajah ◽  
Elizabeth Joshua ◽  
Kannan Ranganathan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Human Cancer ◽  
Gene Expression Omnibus ◽  
Cancer Genome ◽  
Differentially Expressed ◽  
Genome Dataset

Introduction: Evasion of programmed cell death (PCD) is a hall mark of oncogenesis. There are different types of PCD. Iron related PCD, ferroptosis is being increasingly associated with neoplastic process. There are very few reports that investigate the role of ferroptosis in Oral Squamous Cell Carcinoma (OSCC). An attempt is made to compare the ferroptosis related genes(FRGs) expression in human OSCC and normal oral tissues. Materials and Methods: Gene Expression Omnibus repository was scanned for OSCC mRNA datasets along with normal control tissues. Datasets fulfilling inclusion and exclusion criteria as well as that fulfilled the statistical correlation requirements were considered for this study. Differentially expressed mRNAs were identified. From the literature and ferroptosis database, FRGs were identified and those FRGs were differentially expressed were validated using The Human Cancer Genome dataset. Results: In all 44 FRGs were identified to be differentially expressed between OSCC and control tissues. Of the 44, 21 were that promoted ferroptosis including 18 drivers of ferroptosis. Of the 21 FRGs that drives ferroptosis, 9 were found significantly elevated in controls while the remaining 12 were elevated in OSCC. The role of the differentially expressed FRGs were also studied. Of the 44 FRGs, 36 were validated using the human cancer genome dataset. Discussion and Conclusion: Drivers and suppressors of ferroptosis were differentially expressed in OSCC and controls. This reflects that ferroptosis has a dual role in oncogenesis, both as a promoter and a suppressor. The identified specific FRGs in this studied would help to understand the role of PCD in OSCC progression and help in designing better treatment.

scholarly journals PDL-1 expression in oral squamous cell carcinoma and implications for treatment.

2019 ◽  
Vol 5 (suppl) ◽  
pp. 82-82
Author(s):  
Vijay Kumar Srinivasalu ◽  
Narayana Subramaniam ◽  
Subramania Iyer ◽  
Ajit Nambiar ◽  
Manzoor Koyakutty ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Tumour Microenvironment ◽  
Gene Expression Omnibus ◽  
The Cancer Genome Atlas ◽  
Expression Levels ◽  
Key Factor

82 Background: PDL-1 expression has been shown in multiple tumours to be a key factor in treatment response and immunogenicity. In oral squamous cell carcinoma (OSCC), its role is controversial; the expression levels, prognostic significance and therapeutic relevance are unclear. This study was performed to determine the incidence of PDL-1 expression in OSCC, and to determine its correlation with demographic, clinical and pathological features, recurrence and survival. Methods: PDL1 expression levels were determined by immunohistochemistry (DAKO kit) on 64 samples of OSCC obtained during resection on tumour (T) and tumour infiltrating lymphocytes (TILs). Statistical analysis was performed for corelation with clinicopathological features and survival. We also analysed PD1/PDL1 expression on the mRNA-seq data from The Cancer Genome Atlas (TCGA) (n = 527) and Gene Expression Omnibus (GEO) (n = 61) for validation. Results: PDL1 expression of < 1% was the most common for T (92%) and TILs (56%). Tumour PDL-1 expression < 1% had higher lymphovascular invasion (LVI) (p = 0.044) and bone invasion (p = 0.010). TIL PDL-1 expression < 1% was more common in patients < 45 years (p = 0.023) with more local recurrences (p = 0.020). For TCGA data, overall survival (OS) in the young ( < 45 years) was reduced in patients with low ( < 1%) PD1 expression (p = 0.010) while GEO data showed that older patients ( > 45 years) had a significantly higher PD1 expression level (p = 0.044). Conclusions: PDL1 expression in OSCC was low. Low TIL PDL1 expression was more common in patients with age < 45 years, with a higher chance of local recurrence. Genomic data also validated a potential link between PD1 expression and age. On the tumour, PD1 expression may be an important prognosticator, while on TILs, PDL1 is likely more relevant. Moreover PDL1 expression on the tumour is likely to be heterogeneous, so TIL PDL1 expression may be more representative of the tumour microenvironment and a better prognostic marker.

scholarly journals Clinical profile of the patients with oral squamous cell carcinoma: a tertiary institutional study

2020 ◽  
Vol 6 (4) ◽  
pp. 628
Author(s):  
Deep Jyoti ◽  
Arti . ◽  
Padam Jamwal ◽  
Sonika Kotwal ◽  
Kunzes Dolma
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Economic Status ◽  
Young Generation ◽  
Chewing Tobacco ◽  
Female Ratio ◽  
Factors Affecting ◽  
Oral Neoplasms

<p class="abstract"><strong>Background:</strong> Oral cancer consists of a group of neoplasms affecting any region of the oral cavity. This term is commonly used interchangeably with oral squamous cell carcinoma (OSCC), representing the most frequent of all oral neoplasms. Factors affecting the development of the oral squamous cell carcinoma are tobacco use, alcohol consumption, low socio-economic status, poor hygiene, poor diet, viral infection like HPV, ill-fitting dentures, jagged teeth.</p><p class="abstract"><strong>Methods:</strong> An institution based retrospective observational study was conducted in the department of ENT, GMC Jammu, including the records of the patients with oral squamous cell carcinoma admitted from June 2016 to July 2019. 80 patients of oral carcinoma were included in the study.</p><p class="abstract"><strong>Results:</strong> Male to female ratio was 5.1:1. Mean age of presentation was 49.2±4.1 with most of the cases presenting in the 6<sup>th</sup> decade. 27 (33.75%) patients had history of chewing tobacco alone, 17 (21%) had smoking with chewing tobacco and 10 (12.5 %) smoking with alcohol. 52% patients presented with growth of tongue (52%) followed by buccal mucosa (17.5%) and other sites. Histopathological grading of OSCC showed predominance of well differentiated cancer in 44 cases (55%).</p><p class="abstract"><strong>Conclusions:</strong> Cases of OSCC are increasing day by day in young generation due to increasing exposure to the risk habits which are easily accessible to them.</p>

scholarly journals Only a Plate? Nine-Year Follow-Up After Partial Mandibulectomy and Reconstruction With Titanium Plate

2021 ◽  
Vol 6 ◽  
pp. 247275122110328
Author(s):  
Helya Hashemi ◽  
Andreas Thor
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Options ◽  
Free Flaps ◽  
Treatment Method ◽  
Surgical Interventions ◽  
Vascularized Fibula ◽  
Oral Neoplasms

Background: Oral squamous cell carcinoma is the main malignancy of the oral cavity; floor of the mouth and the lateral border of the tongue being the most affected sites. This kind of oral neoplasms may require mandibular resection and reconstruction. Treatment options for such mandibular defects include bone grafts, free flaps, and reconstruction plates. Today, the commonly used treatment method is vascularized fibula flaps due to its many advantages when compared to other methods. However, it is a complex procedure and demands much of both practitioners and the patient. Case Presentation: In this report, we present a case of oral squamous cell carcinoma of the gingiva of the mandible which was treated with a partial mandibulectomy and resection. Because of the patients age and fragility an immediate mandibular reconstruction with a pre-shaped reconstruction plate, without hard or soft tissue transfer, was performed. Yearly controls showed pleasing results both aesthetically and functionally and the patient showed no plate-related complications up until the patient’s death, 9 years later. Conclusion: With this case, we would like to illustrate that using reconstruction plates only may be a viable option in selected cases for continuity defects of the mandible, specifically in fragile patients less suitable for more demanding surgical interventions.

Role of Clinical Palpation in Evaluation of Cervical Lymph Node in Oral Squamous Cell Carcinoma

2013 ◽  
Vol 1 (2) ◽  
pp. 02-06
Author(s):  
SM Anwar Sadat ◽  
Sufia Nasrin Rita ◽  
Shoma Banik ◽  
Md Nazmul Hasan Khandker ◽  
Md Mahfuz Hossain ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Cervical Lymph Node ◽  
Betel Quid ◽  
Cervical Lymph Nodes

A cross sectional study of 29 cases of oral squamous cell carcinoma with or without  cervical lymph node metastasis was done among Bangladeshi patients from January 2006 to December 2007. Majority of the study subjects (34.5%) belonged to the age group of 40-49 years. 58.6% of the study subjects were male, while remaining 41.4% of them were female. 51.7% of the lesions were located in the alveolar ridge where the other common sites were buccal mucosa (27.6%) and retro molar area (13.8%). Half of the study subjects (51.7%) were habituated to betel quid chewing followed by 37.9% and 10.3% were habituated to smoking and betel quid-smoking respectively. Grade I lesions was most prevalent (75.9%) in the study subjects.  Majority of cases presented with Stage IV lesions (55.2%). The sensitivity, specificity, positive predictive value, negative predictive value & accuracy of clinical palpation method for determining metastatic cervical lymph nodes were 93.33%, 64.29%, 73.68%, 90% and 79.3% respectively. Careful and repeated clinical palpation plays important role in evaluation of cervical lymph nodes though several modern techniques may help additionally in the management of oral cancer.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13978 Update Dent. Coll. j. 2011: 1(2): 02-06

Management of Neck in Oral Squamous Cell Carcinoma

2011 ◽  
Vol 3 (6) ◽  
pp. 419-422
Author(s):  
Dr. Shool Rohit S Dr. Shool Rohit S ◽  
◽  
Dr. Anand P Zingade ◽  
Dr. Manish Kumar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell
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