scholarly journals Maternal biomarker patterns for metabolism and inflammation in pregnancy are influenced by multiple micronutrient supplementation and associated with childrens’s biomarker patterns and nutritional status at 9-12 years of age in Lombok, Indonesia

2019 ◽  
Author(s):  
Lidwina Priliani ◽  
Sukma Oktavianthi ◽  
Elizabeth L. Prado ◽  
Safarina G. Malik ◽  
Anuraj H. Shankar
Keyword(s):  
Nutritional Status ◽  
Binding Protein ◽  
Post Partum ◽  
Retinol Binding Protein ◽  
Long Term Effects ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Multiple Micronutrient ◽  
In Pregnancy

AbstractMaternal nutritional status influences fetal development and long-term risk for adult non-communicable diseases. The underlying mechanisms of these long-term effects remain poorly understood. We examined whether maternal biomarkers for metabolism and inflammation during pregnancy were associated with child biomarkers in the Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT, ISRCTN34151616) in Lombok, Indonesia wherein archived blood specimens and relevant data were available from pregnant women and their children 9-12 years after birth. Forty-four mother-child dyads comprising 132 specimens were analyzed by multiplex microbead immunoassays to quantify vitamin D-binding protein (D), adiponectin (A), retinol-binding protein 4 (R), C-reactive protein (C), and leptin (L). Principal component analysis (PCA) revealed distinct variance patterns, i.e. principal components (PC), for baseline pregnancy bp.pc1.D↓A↓R↓ and bp.pc2.C↓L↑; combined follow-up and post-partum dp-pp.pc1.D↑↓A↑R↑↓L↓ and dp-pp.pc2.A↑C↑L↑; and children ch.pc1.D↑R↑C↑ and ch.pc2.D↓A↑L↑. Maternal multiple micronutrient (MMN) supplementation modified the association between baseline maternal bp.pc2.C↓L↑ and post-supplementation maternal dp-pp.pc2.A↓C↑L↑ (p=0.022). Significant associations were found between maternal dp-pp.pc2.A↑C↑L↑ and increased child ‘s ch.pc1.D↑R↑C↑ (p=0.036), and decreased child ‘s BMI z-score (BMIZ) (p=0.022); and between maternal dp-pp.pc1.D↑↓A↑R↑↓L↑ and increased child ‘s BMIZ (p=0.036). Child ‘s ch.pc1.D↑R↑C↑ was associated with decreased birth weight (p=0.036), and increased child’s BMIZ (p=0.002); and ch.pc2.D↓A↑L↑ was associated with increased child’s BMIZ (p=0.005), decreased maternal height (p=0.030) and girls (p=0.002). Elevated adiponectin and leptin pattern in pregnancy was associated with increased C-reactive protein and vitamin A and D binding proteins pattern in children, suggesting biomarkers acting in concert may be more important than single biomarker effects. Patterns in pregnancy proximal to birth were more associated with child status, and child patterns were most frequently associated with child status, particularly child BMI. Although MMN supplementation and certain maternal biomarker patterns have effects on metabolism and inflammation in pregnancy and in the child, nevertheless, nutrition conditions after birth may have a greater impact.

scholarly journals Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein

Circulation ◽  
1999 ◽  
Vol 100 (3) ◽  
pp. 230-235 ◽  
Author(s):  
Paul M. Ridker ◽  
Nader Rifai ◽  
Marc A. Pfeffer ◽  
Frank Sacks ◽  
Eugene Braunwald
Keyword(s):  
Plasma Concentration ◽  
Long Term Effects ◽  
C Reactive Protein ◽  
Reactive Protein

Immune Markers in Pregnancy A Study on Neopterin, β2-Microglobulin, Deoxythymidine Kinase and C-Reactive Protein

Pteridines ◽  
1989 ◽  
Vol 1 (2) ◽  
pp. 125-128
Author(s):  
Margareta Norman ◽  
Katarina Bremme ◽  
Peter Eneroth
Keyword(s):  
Immune System ◽  
Plasma Levels ◽  
Post Partum ◽  
Maternal Serum ◽  
C Reactive Protein ◽  
Immune Markers ◽  
Maternal Circulation ◽  
Reactive Protein ◽  
Increased Activity ◽  
In Pregnancy

Summary Neopterin and β2-microglobulin but neither C-reactive protein nor deoxythymidine kinase increased in maternal serum from pregnancy week 20 to 40. Only maternal C-reactive protein concentrations changed during vaginal delivery and after 4 days post partum. Retroplacental plasma levels of neopterin, deoxythymidine kinase and β2-microglobulin were significantly higher than in maternal peripheral serum which was interpreted as an indication of increased activity of the immune system as influenced by the fetoplacental unit. The concentrations of neopterin, deoxythymidine kinase and β2-microglobulin were significantly higher in mixed artero-venous umbilical plasma than in the retroplacental plasma, possibly reflecting activation signals to immunocompetent cells in the neonates. The possibility of a transfer of these compounds from fetal to maternal circulation was also pointed out.

scholarly journals Rapid diagnostic testing platform for iron and vitamin A deficiency

2017 ◽  
Vol 114 (51) ◽  
pp. 13513-13518 ◽  
Author(s):  
Zhengda Lu ◽  
Dakota O’Dell ◽  
Balaji Srinivasan ◽  
Elizabeth Rey ◽  
Ruisheng Wang ◽  
...  
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Vitamin A Deficiency ◽  
Work Capacity ◽  
Diagnostic Methods ◽  
Retinol Binding Protein ◽  
Micronutrient Deficiencies ◽  
C Reactive Protein ◽  
Laptop Computer ◽  
Reactive Protein

Micronutrient deficiencies such as those of vitamin A and iron affect a third of the world’s population with consequences such as night blindness, higher child mortality, anemia, poor pregnancy outcomes, and reduced work capacity. Many efforts to prevent or treat these deficiencies are hampered by the lack of adequate, accessible, and affordable diagnostic methods that can enable better targeting of interventions. In this work, we demonstrate a rapid diagnostic test and mobile enabled platform for simultaneously quantifying iron (ferritin), vitamin A (retinol-binding protein), and inflammation (C-reactive protein) status. Our approach, enabled by combining multiple florescent markers and immunoassay approaches on a single test, allows us to provide accurate quantification in 15 min even though the physiological range of the markers of interest varies over five orders of magnitude. We report sensitivities of 88%, 100%, and 80% and specificities of 97%, 100%, and 97% for iron deficiency (ferritin <15 ng/mL or 32 pmol/L), vitamin A deficiency (retinol-binding protein <14.7 μg/mL or 0.70 μmol/L) and inflammation status (C-reactive protein >3.0 μg/mL or 120 nmol/L), respectively. This technology is suitable for point-of-care use in both resource-rich and resource-limited settings and can be read either by a standard laptop computer or through our previously developed NutriPhone technology. If implemented as either a population-level screening or clinical diagnostic tool, we believe this platform can transform nutritional status assessment and monitoring globally.

scholarly journals Faktor-Faktor yang Memengaruhi Status Nutrisi Akut Pascabedah

Sari Pediatri ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. 215
Author(s):  
Yusrina Istanti ◽  
Antonius Pudjiadi ◽  
Abdul Latief ◽  
Sri Martuti ◽  
Moh. Supriatna ◽  
...  
Keyword(s):  
Binding Protein ◽  
Retinol Binding Protein ◽  
C Reactive Protein ◽  
Reactive Protein

Latar belakang. Malnutrisi sering ditemukan pada pasien pascabedah dan berhubungan dengan penurunan fungsi otot, respirasi, imun serta penyembuhan luka yang terganggu. Tindakan pembedahan merupakan stresor yang memicu respons metabolik sehingga berpengaruh terhadap luaran, termasuk status nutrisi.Tujuan. Mengetahui faktor-faktor yang memengaruhi status nutrisi akut pascabedah.Metode. Penelitian observasional analitik dilakukan di ICU anak tiga rumah sakit, yaitu RS Cipto Mangunkusumo, RS Dr Kariadi, dan RSUD Dr Muwardi. Dilakukan pemeriksaan kadar retinol binding protein (RBP) hari ke-1 dan ke-5 pascabedah sebagai indikator status nutrisi, kortisol, dan C-reactive protein (CRP) sebagai marker respons inflamasi. Status nutrisi berdasarkan antropometri dinilai, jenis, dan lama pembedahan dicatat. Dilakukan uji korelasi untuk melihat hubungan antara kortisol, CRP, dan RBP dengan kadar RBP hari ke-5. Uji kai kuadrat untuk melihat hubungan status nutrisi, jenis dan lama pembedahan dengan kadar RBP hari ke-5.Hasil. Selama kurun waktu 6 bulan didapatkan 39 subjek yang memenuhi kriteria inklusi dan 4 subjek dieksklusi. Penurunan kadar RBP hari ke-5 dijumpai pada 12 (34,4%) subjek. Didapatkan hubungan antara kadar kortisol, CRP, dan RBP hari ke-1 dengan kadar RBP hari ke-5 [r=-0,35 (p=0,04); r=-0,53 (p=0,001); r=0,42 (p=0,01)]. Tidak terdapat hubungan antara status nutrisi berdasarkan antropometri serta jenis dan lama pembedahan dengan kadar RBP hari ke-5 (p>0,05).Kesimpulan. Terdapat hubungan antara kadar RBP hari ke-1 dan ke-5 sebagai parameter status nutrisi akut pascabedah. Kadar RBP hari ke-5 tidak dipengaruhi oleh status nutrisi prabedah serta jenis dan lama pembedahan, tetapi oleh kadar kortisol dan CRP sebagai marker respons stres.

scholarly journals Short Term Effects of Mild Severity COVID-19 on Left Ventricular Functions

2021 ◽  
Author(s):  
Osman Bektaş ◽  
Ahmet Karagöz ◽  
Feyza Nur Topçu Yenerçağ ◽  
Seçkin Dereli ◽  
Celali Kurt ◽  
...  
Keyword(s):  
Speckle Tracking Echocardiography ◽  
Left Ventricular ◽  
Long Term Effects ◽  
C Reactive Protein ◽  
Short Term ◽  
Reactive Protein ◽  
The Mean ◽  
And Gender

Abstract Purpose: We aimed to evaluate long term effects of COVID-19 disease on left ventricular function using speckle tracking echocardiography. Methods: In our study, 96 non-hospitalized patients who were diagnosed with COVID-19 disease in our center between 15 August 2020 and 01 September 2020 and 96 age and gender matched control subjects were included.Results:The mean follow up duration was 137 ± 7 days. White blood cell, neutrophile and lymphocyte were significantly lower and C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) were significantly higher in the COVID-19 group. (6.6 ± 2.8 vs. 24.4 ± 21.8, p <0.001 and 4.1 ± 2.5 vs. 7.1 ± 4, p <0.001, respectively). LV-GLS and LV-GCS were significantly lower in the COVID-19 group. (-20.1 ± 3.1 vs -15.9 ± 2, p <0.001 and -29.3 ± 2.1 vs -26.3 ± 2.1, p <0.001, respectively). LV-GLS and LV-GCS were found to be negatively correlated with CRP (rs = -0.515, p <0.001 and rs = 0.-466, p <0.001, respectively) and NLR (rs = -0.494, p <0.001 and rs = -434, p <0.001, respectively). Conclusion: Deteriorating effects of COVID-19 disease on both LV-GCS and LV-GLS can be seen even in the short term. These detrimental effects seem to be associated with CRP levels and NLR measured in the course of active infection.

scholarly journals Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients

2008 ◽  
Vol 101 (8) ◽  
pp. 1145-1149 ◽  
Author(s):  
An Pan ◽  
Wendy Demark-Wahnefried ◽  
Xingwang Ye ◽  
Zhijie Yu ◽  
Huaixing Li ◽  
...  
Keyword(s):  
Binding Protein ◽  
Retinol Binding Protein ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Retinol Binding Protein 4 ◽  
Reactive Protein ◽  
Type 2 Diabetics ◽  
Group 1

Elevated C-reactive protein (CRP), IL-6 and retinol-binding protein 4 (RBP4) levels are associated with insulin resistance and diabetes mellitus. Phytoestrogens (including lignans and isoflavones) may enhance the management of diabetes and are hypothesized to act through inflammation pathways. The present study explored the effects of flaxseed-derived lignan on inflammatory factors and RBP4 concentrations in type 2 diabetics, who have higher levels of these biomarkers. Seventy community-dwelling diabetic patients (twenty-six men and forty-four post-menopausal women) with mild hypercholesterolaemia completed a randomized, double-blind, placebo-controlled, cross-over trial of supplementation with flaxseed-derived lignan capsules (360 mg/d) or placebo for 12 weeks, separated by an 8-week wash-out period. The participants maintained their habitual diets and levels of physical activity. Baseline to follow-up concentrations of CRP increased significantly within the placebo group (1·42 (sem 0·19) v. 1·96 (sem 0·22) mg/l, P < 0·001), but were comparatively unchanged in the lignan-supplemented group (1·67 (sem 0·19) v. 1·90 (sem 0·26) mg/l, P = 0·94); a significant difference was observed between treatments ( − 0·45 (95 % CI − 0·76, − 0·08) mg/l, P = 0·021). This effect was confined to women (P = 0·016), but not observed in men (P = 0·49). No between-treatment differences were found with regard to IL-6 or RBP4; though IL-6 concentrations increased significantly from baseline to follow-up in both groups (P = 0·004 and P < 0·001 following lignan and placebo treatments, respectively). The study suggests that lignan might modulate CRP levels in type 2 diabetics. These results need to be confirmed by further large clinical trials of longer duration.

scholarly journals Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic Syndrome

2012 ◽  
Vol 31 (1) ◽  
pp. 40-46
Author(s):  
Nirupama Shivakumar ◽  
Meghanaa Kumar ◽  
Manasa Aswathanarayan ◽  
Maanasa Venkatesh ◽  
Manasa Sheshadri ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Asian Indians ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
C Reactive Protein ◽  
Retinol Binding Protein 4 ◽  
Reactive Protein ◽  
Potential Marker

Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic SyndromeRetinol-binding protein 4 is an adipocytokine separately implicated in the development of obesity-related insulin resistance and proatherogenic lipid profile, however, its role in humans is unclear. This study was carried out to assess the role of retinol-binding protein 4 as a potential marker of metabolic syndrome in obese Asian Indians (a high-risk population for diabetes). 52 obese (BMI >23 kg/m2) Asian Indians were grouped into those with and without metabolic syndrome based on IDF criteria and compared with healthy controls. The anthropometric and biochemical parameters (fasting blood sugar, lipid profile, serum insulin, high-sensitivity C-reactive protein, and retinol-binding protein 4) were estimated. The obese groups had significantly altered adiposity indices, insulin resistance parameters (fasting blood sugar (only in the metabolic syndrome group), serum insulin, HOMA-IR and QUICKI), index of inflammation (C-reactive protein) and proatherogenic dyslipidemic profile (serum triglycerides, VLDL-cholesterol, and triglyceride/HDL-cholesterol ratio). Retinol-binding protein 4 levels were elevated in the obese groups, but were not significant. Retinol-binding protein 4 levels were correlated with anthro-pometric parameters and atherogenic lipids, while C-reactive protein was correlated with anthropometric and insulin resistance parameters in the entire group of subjects. Although these correlations were not observed in the obese groups, in the control group, retinol-binding protein 4 was correlated to the lipid parameters and C-reactive protein to adiposity indices. Thus, the role of retinol-binding protein 4 as a potential marker of metabolic syndrome is limited to the prediction of proatherogenic risk among Asian Indians.

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