scholarly journals Recent development of SPR spectroscopy as potential method for diagnosis of dengue virus E-protein

Sensor Review ◽  
2018 ◽  
Vol 38 (1) ◽  
pp. 106-116 ◽  
Author(s):  
Nur Alia Sheh Omar ◽  
Yap Wing Fen
Keyword(s):  
Thin Films ◽  
Dengue Virus ◽  
Three Dimensional ◽  
Optical Biosensor ◽  
Future Research ◽  
Multilayer Thin Films ◽  
Content Type ◽  
Sensing Applications ◽  
E Protein ◽  
Wide Range

Purpose This paper aims to review the potential application of surface plasmon resonance (SPR) in diagnosis of dengue virus (DENV-2) E-protein and the development of SPR to become an alternative DENV sensor. Design/methodology/approach In this review, the existing standard laboratory techniques to diagnosis of DENV are discussed, together with their drawbacks. To overcome these drawbacks, SPR has been aimed to be a valuable optical biosensor for identification of antibodies to the DENV antigen. The review also includes the future studies on three-dimensional poly(amidoamine) (PAMAM) dendrimer-surface-assembled monolayer (SAM)-Au multilayer thin films, which are envisaged to have high potential sensitive and selective detection ability toward target E-proteins. Findings Application of SPR in diagnosis of DENV emerged over recent years. A wide range of immobilized biorecognition molecules have been developed to combine with SPR as an effective sensor. The detection limit, sensitivity and selectivity of SPR sensing in DENV have been enhanced from time to time, until the present. Originality/value The main purpose of this review is to provide authors with up-to-date and useful information on sensing DENV using SPR and to introduce a novel three-dimensional PAMAM-SAM-Au multilayer thin films for future research on SPR sensing applications.

Applications of 3D printing in critical care medicine: A scoping review

2021 ◽  
pp. 0310057X2097665
Author(s):  
Natasha Abeysekera ◽  
Kirsty A Whitmore ◽  
Ashvini Abeysekera ◽  
George Pang ◽  
Kevin B Laupland
Keyword(s):  
Critical Care ◽  
Scoping Review ◽  
A Priori ◽  
Three Dimensional ◽  
Critical Care Medicine ◽  
Future Research ◽  
Care Practice ◽  
Three Dimensional Printing ◽  
Wide Range ◽  
Dimensional Printing

Although a wide range of medical applications for three-dimensional printing technology have been recognised, little has been described about its utility in critical care medicine. The aim of this review was to identify three-dimensional printing applications related to critical care practice. A scoping review of the literature was conducted via a systematic search of three databases. A priori specified themes included airway management, procedural support, and simulation and medical education. The search identified 1544 articles, of which 65 were included. Ranging across many applications, most were published since 2016 in non – critical care discipline-specific journals. Most studies related to the application of three-dimensional printed models of simulation and reported good fidelity; however, several studies reported that the models poorly represented human tissue characteristics. Randomised controlled trials found some models were equivalent to commercial airway-related skills trainers. Several studies relating to the use of three-dimensional printing model simulations for spinal and neuraxial procedures reported a high degree of realism, including ultrasonography applications three-dimensional printing technologies. This scoping review identified several novel applications for three-dimensional printing in critical care medicine. Three-dimensional printing technologies have been under-utilised in critical care and provide opportunities for future research.

Fused filament printing of specialized biomedical devices: a state-of-the art review of technological feasibilities with PEEK

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Erfan Rezvani Ghomi ◽  
Saeideh Kholghi Eshkalak ◽  
Sunpreet Singh ◽  
Amutha Chinnappan ◽  
Seeram Ramakrishna ◽  
...  
Keyword(s):  
High Performance ◽  
State Of The Art ◽  
Three Dimensional ◽  
Patient Specific ◽  
Biomedical Devices ◽  
Fused Filament Fabrication ◽  
Content Type ◽  
Patient Specific Implants ◽  
Complex Design ◽  
Wide Range

Purpose The potential implications of the three-dimensional printing (3DP) technology are growing enormously in the various health-care sectors, including surgical planning, manufacturing of patient-specific implants and developing anatomical models. Although a wide range of thermoplastic polymers are available as 3DP feedstock, yet obtaining biocompatible and structurally integrated biomedical devices is still challenging owing to various technical issues. Design/methodology/approach Polyether ether ketone (PEEK) is an organic and biocompatible compound material that is recently being used to fabricate complex design geometries and patient-specific implants through 3DP. However, the thermal and rheological features of PEEK make it difficult to process through the 3DP technologies, for instance, fused filament fabrication. The present review paper presents a state-of-the-art literature review of the 3DP of PEEK for potential biomedical applications. In particular, a special emphasis has been given on the existing technical hurdles and possible technological and processing solutions for improving the printability of PEEK. Findings The reviewed literature highlighted that there exist numerous scientific and technical means which can be adopted for improving the quality features of the 3D-printed PEEK-based biomedical structures. The discussed technological innovations will help the 3DP system to enhance the layer adhesion strength, structural stability, as well as enable the printing of high-performance thermoplastics. Originality/value The content of the present manuscript will motivate young scholars and senior scientists to work in exploring high-performance thermoplastics for 3DP applications.

scholarly journals Helping auditors identify deception through psycholinguistics

2018 ◽  
Vol 25 (4) ◽  
pp. 1062-1076 ◽  
Author(s):  
Rebecca Nicolaides ◽  
Richard Trafford ◽  
Russell Craig
Keyword(s):  
Oral Language ◽  
Research Agenda ◽  
Relevant Literature ◽  
Bibliographic Databases ◽  
Future Research ◽  
Content Type ◽  
Fraud Risk ◽  
Critical Elements ◽  
Future Research Agenda ◽  
Wide Range

Purpose This paper reviews an array of psycholinguistic techniques that auditors can deploy to explore written and oral language for signs of deception. The review is drawn upon to propose some elements of a forward research agenda. Design/methodology/approach Relevant literature across several disciplines is identified through keyword searches of major bibliographic databases. Findings The techniques highlighted have considerable potential for use by auditors to identify audit contexts which merit closer audit investigation. However, the techniques need further contextual empirical investigation in audit contexts. Seven specific propositions are presented for empirical testing. Originality/value This paper assembles literature on deceptive communication from a wide range of disciplines and relates it to the audit context. Auditors’ attention is directed to potential linguistic signals of fraud risk, and opportunities for future research are suggested. The paper is consciousness-raising, has pedagogic purpose and suggests critical elements for a future research agenda.

Internal heat generation/or absorption phenomena in three-dimensional natural convection flow within enclosure filled with different working fluids

2018 ◽  
Vol 28 (4) ◽  
pp. 878-908
Author(s):  
Najib Hdhiri ◽  
Brahim Ben Beya
Keyword(s):  
Fluid Flow ◽  
Heat Generation ◽  
Average Nusselt Number ◽  
Thermal Field ◽  
Three Dimensional ◽  
Grashof Number ◽  
Content Type ◽  
Wide Range ◽  
Heat Generation Or Absorption ◽  
2D Model

Purpose The purpose of this study is to investigate the effects of heat generation or absorption on heat transfer and fluid flow within two- and three-dimensional enclosure for homogeneous medium filled with different metal liquid. Numerical results are presented and analyzed in terms of fluid flow, thermal field structures, as well as average Nusselt number profiles over a wide range of dimensionless quantities, Grashof number (Gr) (104 and 105), SQ (varied between −500 to 500) and Prandtl number (Pr = 0.015, 0.024 and 0.0321). The results indicate that when the conductive regime is established for a Grashof number Gr = 104, the 2D model is valid and predicts all three-dimensional results with negligible difference. This was not the case in the convective regime (Gr = 105) where the effect of the third direction becomes important, where a 2D-3D difference was seen with about 37 per cent. Also, in most cases, the authors find that the heat absorption phenomena have the opposite effect with respect to the heat generation. Design/methodology/approach Numerical results are presented and analyzed in terms of fluid flow, thermal field structures, as well as average Nusselt number profiles over a wide range of dimensionless quantities. Findings Grashof number (Gr) (104 and 105), SQ (varied between −500 to 500) and Prandtl number (Pr = 0.015, 0.024 and 0.0321). Originality/value The results indicate that when the conductive regime is established for a Grashof number Gr = 104, the 2D model is valid and predicts all three-dimensional results with negligible difference.

Analytical and 3D Finite Element Study of the Deflection of an Elastic Cantilever Bilayer Plate

2010 ◽  
Vol 78 (1) ◽  
Author(s):  
M. Chekchaki ◽  
V. Lazarus ◽  
J. Frelat
Keyword(s):  
Thin Films ◽  
Finite Element ◽  
Three Dimensional ◽  
Analytical Formula ◽  
Mechanical Stresses ◽  
Linear Elastic ◽  
Wide Range ◽  
Finite Element Calculations ◽  
Analytical Formulas ◽  
Three Dimensional Elasticity

The mechanical system considered is a bilayer cantilever plate. The substrate and the film are linear elastic. The film is subjected to isotropic uniform prestresses due for instance to volume variation associated with cooling, heating, or drying. This loading yields deflection of the plate. We recall Stoney’s analytical formula linking the total mechanical stresses to this deflection. We also derive a relationship between the prestresses and the deflection. We relax Stoney’s assumption of very thin films. The analytical formulas are derived by assuming that the stress and curvature states are uniform and biaxial. To quantify the validity of these assumptions, finite element calculations of the three-dimensional elasticity problem are performed for a wide range of plate geometries, Young’s and Poisson’s moduli. One purpose is to help any user of the formulas to estimate their accuracy. In particular, we show that for very thin films, both formulas written either on the total mechanical stresses or on the prestresses, are equivalent and accurate. The error associated with the misfit between our theorical study and numerical results are also presented. For thicker films, the observed deflection is satisfactorily reproduced by the expression involving the prestresses and not the total mechanical stresses.

scholarly journals Customer experience challenges: bringing together digital, physical and social realms

2018 ◽  
Vol 29 (5) ◽  
pp. 776-808 ◽  
Author(s):  
Ruth N. Bolton ◽  
Janet R. McColl-Kennedy ◽  
Lilliemay Cheung ◽  
Andrew Gallan ◽  
Chiara Orsingher ◽  
...  
Keyword(s):  
Conceptual Framework ◽  
Social Presence ◽  
Dimensional Space ◽  
New Technology ◽  
Three Dimensional ◽  
Customer Experience ◽  
Service Robots ◽  
Service Research ◽  
Future Research ◽  
Content Type

PurposeThe purpose of this paper is to explore innovations in customer experience at the intersection of the digital, physical and social realms. It explicitly considers experiences involving new technology-enabled services, such as digital twins and automated social presence (i.e. virtual assistants and service robots).Design/methodology/approachFuture customer experiences are conceptualized within a three-dimensional space – low to high digital density, low to high physical complexity and low to high social presence – yielding eight octants.FindingsThe conceptual framework identifies eight “dualities,” or specific challenges connected with integrating digital, physical and social realms that challenge organizations to create superior customer experiences in both business-to-business and business-to-consumer markets. The eight dualities are opposing strategic options that organizations must reconcile when co-creating customer experiences under different conditions.Research limitations/implicationsA review of theory demonstrates that little research has been conducted at the intersection of the digital, physical and social realms. Most studies focus on one realm, with occasional reference to another. This paper suggests an agenda for future research and gives examples of fruitful ways to study connections among the three realms rather than in a single realm.Practical implicationsThis paper provides guidance for managers in designing and managing customer experiences that the authors believe will need to be addressed by the year 2050.Social implicationsThis paper discusses important societal issues, such as individual and societal needs for privacy, security and transparency. It sets out potential avenues for service innovation in these areas.Originality/valueThe conceptual framework integrates knowledge about customer experiences in digital, physical and social realms in a new way, with insights for future service research, managers and public policy makers.

scholarly journals Cell-Fusing Agent Virus Reduces Arbovirus Dissemination in Aedes aegypti Mosquitoes In Vivo

2019 ◽  
Vol 93 (18) ◽  
Author(s):  
Artem Baidaliuk ◽  
Elliott F. Miot ◽  
Sebastian Lequime ◽  
Isabelle Moltini-Conclois ◽  
Fanny Delaigue ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Cell Line ◽  
Content Type ◽  
Cells In Culture ◽  
Mosquito Cells ◽  
Wide Range ◽  
Natural Hosts

ABSTRACT Aedes aegypti mosquitoes are the main vectors of arthropod-borne viruses (arboviruses) of public health significance, such as the flaviviruses dengue virus (DENV) and Zika virus (ZIKV). Mosquitoes are also the natural hosts of a wide range of viruses that are insect specific, raising the question of their influence on arbovirus transmission in nature. Cell-fusing agent virus (CFAV) was the first described insect-specific flavivirus, initially discovered in an A. aegypti cell line and subsequently detected in natural A. aegypti populations. It was recently shown that DENV and the CFAV strain isolated from the A. aegypti cell line have mutually beneficial interactions in mosquito cells in culture. However, whether natural strains of CFAV and DENV interact in live mosquitoes is unknown. Using a wild-type CFAV isolate recently derived from Thai A. aegypti mosquitoes, we found that CFAV negatively interferes with both DENV type 1 and ZIKV in vitro and in vivo. For both arboviruses, prior infection by CFAV reduced the dissemination titer in mosquito head tissues. Our results indicate that the interactions observed between arboviruses and the CFAV strain derived from the cell line might not be a relevant model of the viral interference that we observed in vivo. Overall, our study supports the hypothesis that insect-specific flaviviruses may contribute to reduce the transmission of human-pathogenic flaviviruses. IMPORTANCE The mosquito Aedes aegypti carries several arthropod-borne viruses (arboviruses) that are pathogenic to humans, including dengue and Zika viruses. Interestingly, A. aegypti is also naturally infected with insect-only viruses, such as cell-fusing agent virus. Although interactions between cell-fusing agent virus and dengue virus have been documented in mosquito cells in culture, whether wild strains of cell-fusing agent virus interfere with arbovirus transmission by live mosquitoes was unknown. We used an experimental approach to demonstrate that cell-fusing agent virus infection reduces the propagation of dengue and Zika viruses in A. aegypti mosquitoes. These results support the idea that insect-only viruses in nature can modulate the ability of mosquitoes to carry arboviruses of medical significance and that they could possibly be manipulated to reduce arbovirus transmission.

The simulation of single wraparound fin on a semi-cylindrical missile body

2020 ◽  
Vol 92 (3) ◽  
pp. 418-427 ◽  
Author(s):  
Nayhel Sharma ◽  
Rakesh Kumar
Keyword(s):  
Research Study ◽  
Cfd Simulation ◽  
Three Dimensional ◽  
Future Research ◽  
Aerodynamic Coefficients ◽  
Content Type ◽  
Computational Fluid Dynamics Cfd ◽  
Predicted Values ◽  
Characteristic Trend ◽  
Practical Implications

Purpose The purpose of this paper is to establish a freestream computational fluid dynamics (CFD) model of a three-dimensional non-spinning semi-cylindrical missile model with a single wrap around fin in Mach 2.70-3.00M range and 0° angle of attack, and ultimately establishing itself for future research study. Design/methodology/approach In this study, the behaviour of flow around the fin was investigated using a κ-ϵ turbulence model of second-order of discretization. This was done using a highly structured mesh. Additionally, an inviscid CFD simulation involving the same boundary conditions have also been carried out for comparison. Findings The obtained values of aerodynamic coefficients and pressure contours visualizations are compared against their experimental and computational counterparts. A typical missile aerodynamic characteristic trend can be seen in the current CFD. Practical implications The predicted values of the aerodynamic coefficients of this single fin model have also been compared to those of the full missile body comprising of four fins from the previous research studies, and a similar aerodynamic trend can be seen. Originality/value This study explores the possibility of the use of turbulence modelling in a single fin model of a missile and provides a basic computational model for further understanding the flow behaviour near the fin.

scholarly journals Reflection on success and failures: scale development and validation

2020 ◽  
Vol 32 (8) ◽  
pp. 615-626
Author(s):  
Makoto Matsuo
Keyword(s):  
Positive Psychology ◽  
Work Engagement ◽  
Convergent Validity ◽  
Structural Equation ◽  
Discriminant Validity ◽  
Equation Modeling ◽  
Future Research ◽  
Content Type ◽  
Strengths Use ◽  
Wide Range

Purpose Although positive psychology emphasizes the importance of reflecting on success in promoting strengths use and self-efficacy, no research has developed a measure of reflection on success. The purpose of this study is to develop and validate the scales for reflection on success and failures. Design/methodology/approach Study 1 was conducted to extract the dimensions of reflection on success and failures using survey data from nurses (n = 298), whereas Study 2 involved validation of the scales using a two-wave survey of physical therapists (n = 291). Findings In Study 1, the factors of “reflection on success” and “reflection on failures” were extracted by exploratory factor analysis. In Study 2, the discriminant validity of the two scales was established via confirmatory factor analyses. The structural equation modeling results indicated that reflection on success promoted work authenticity, work engagement and strengths use, while reflection on failures only promoted work engagement, indicating the convergent validity of the scales. Research limitations/implications As the research subjects were medical professionals in Japan, the scales need to be validated with samples from a wide range of occupations and cultural backgrounds, in future research. Originality/value The present research expands the literature on reflection and strengths-based approach by introducing the “success–failures” dimension based on positive psychology, broaden-and-build theory and job demands–resources theory.

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