Mathematical modeling of the scanning laser stimulation of biologically active points

Человека давно интересует вопрос о том, как умственная нагрузка влияет на организм. Известно, что при длительной умственной работе преобразуется сила процессов возбуждения и торможения, изменяется соотношение между ними. С возникновением утомления в головном мозгу нарушаются взаимосвязи между корой больших полушарий и подкорковыми образованиями. При этом наблюдается снижение регулирующего влияния больших полушарий на все функции организма и уменьшение активизирующих воздействий подкорковых отделов мозга. Кроме того, длительное сидячие положение, состояние низкой двигательной активности ведут к значительному уменьшению центростремительных импульсов с рецепторов мышц, сухожилий, суставов. В исследовании приняли участие 17 относительно здоровые, имеющие стабильное физиологическое состояние девушек-студенток в возрасте от 21 до 25 лет. Для исследования были взяты 16 биологически активных точек на стандартных меридианах, связаных с определенным органом. Для оценки физиологического состояния органов до и после умственной нагрузки были исследованы показатели ЭП БАТ на коже. Выявлено снижение показателей каждого органа после умственной нагрузки по сравнению с показателями до ее выполнения со статистической достоверностью во всех исследуемых органах (р<0,05). Особенно низкие значения показателей ЭП БАТ после умственной нагрузки были выявлены в биоактивных точках меридиана печени F.3 Тай-Чун, меридиана толстой кишки GI.5 Ян-Си и GI.4 Хэ-Гу, меридиана сердца С.7 Шэнь-Мэнь, меридиана тонкой кишки IG.1 Шао-Цзе и IG.2 Цянь-Гу, меридиана почек R.1 Юн-Цюань и Р.2 Жань-Гу. Humans has long been interested in the question of how mental activity affects the body It is known that with prolonged mental work, the strength of the processes of excitation and inhibition is transformed, the ratio between them changes. With the onset of fatigue in the brain, the relationship between the cerebral cortex and subcortical formations is disrupted. At the same time, there is a decrease in the regulatory influence of the large hemispheres on all body functions and a decrease in the activating effects of the subcortical parts of the brain. In addition, prolonged sitting, a state of low motor activity leads to a significant decrease in centripetal impulses from the receptors of muscles, tendons, and joints. The study involved 17 relatively healthy, stable physiological condition of female students aged 21 to 25 years. For the study, 16 biologically active points were taken from standard meridians associated with a specific organ. To assess the physiological state of the organs before and after the load of mental labor, the indicators of EC BAP on the skin. A decrease in the indicators of each organ after mental labor was revealed in comparison with the indicators before mental labor with statistical reliability in all the studied organs (p˂0.05). Especially low values of the EC BAP values after a load of mental labor were found in the bioactive points of the liver meridian F. 3 Tai-Chun, the colon meridian GI.5 Yang-Si and GI. 4 He-Gu, the heart meridian C. 7 Shen-Men, the small intestine meridian IG.1 Shao-tse and IG.2 Qian-Gu, the meridian of the kidneys R. 1 Yun-Chuan and R. 2 Zhan-Gu.

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Transient Optical Nerve Stimulation: Concepts and Methodology of Pulsed Infrared Laser Stimulation of the Peripheral Nerve In Vivo

Neuroengineering ◽

10.1201/9780849381850-27 ◽

2007 ◽

pp. 331-350

Keyword(s):

Peripheral Nerve ◽

Nerve Stimulation ◽

Infrared Laser ◽

Laser Stimulation ◽

Stimulation Of

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Prostaglandin E2-binding sites and cAMP production in porcine fundic mucosa

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1981.241.4.g313 ◽

1981 ◽

Vol 241 (4) ◽

pp. G313-G320

Author(s):

B. L. Tepperman ◽

B. D. Soper

Keyword(s):

Adenylate Cyclase ◽

Prostaglandin E2 ◽

Binding Site ◽

Binding Sites ◽

Biologically Active ◽

Cyclase Activity ◽

Adenylate Cyclase Activity ◽

Scatchard Analysis ◽

Fundic Mucosa ◽

Stimulation Of

Biologically active [3H]prostaglandin E2 (PGE2) bound rapidly and specifically to membrane fractions from hog fundic mucosa. Optimal binding occurred in the 30,000-g membrane preparation at 37 degrees C (pH 5.0). Scatchard analysis of specific PgE2 binding revealed the presence of a heterogeneous population of binding sites with Kd values and binding site concentrations of approximately 1 X 10(-9) M and 1 fmol/mg prot and 2 X 10(-8) M and 20 fmol/mg prot, respectively. Specific binding was inhibited by the following agents in descending order of potency: PGE1, PGA2, PGD2, 6-keto-PGF1 alpha, and thromboxane B2. Trypsin treatment or boiling reduced or abolished specific PGE2 binding. PGE2 stimulated cAMP formation in the 2,500-g fraction, with an approximate Km of 1 X 10(-6) M, but stimulation of adenylate cyclase activity by PG was not evident in the 16,000-g or 30,000-g tissue preparations. These results suggest that a specific PGE2-binding site exists in the 16,000-g and 30,000-g fractions of porcine fundic mucosa, although an increase in cAMP-forming capacity could not b of 1 X 10(-6) M, but stimulation of adenylate cyclase activity by PG was not evident in the 16,000-g or 30,000-g tissue preparations. These results suggest that a specific PGE2-binding site exists in the 16,000-g and 30,000-g fractions of porcine fundic mucosa, although an increase in cAMP-forming capacity could not b of 1 X 10(-6) M, but stimulation of adenylate cyclase activity by PG was not evident in the 16,000-g or 30,000-g tissue preparations. These results suggest that a specific PGE2-binding site exists in the 16,000-g and 30,000-g fractions of porcine fundic mucosa, although an increase in cAMP-forming capacity could not be localized in these fractions in vitro.

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Mathematical modeling method of cell tension and compression based on multi-modal mechanical signals

Journal of Intelligent & Fuzzy Systems ◽

10.3233/jifs-189422 ◽

2020 ◽

pp. 1-10

Author(s):

Dongyang Pan ◽

Jingrui Liu

Keyword(s):

Mathematical Modeling ◽

Stem Cells ◽

Elastic Modulus ◽

Human Health ◽

Mechanical Stimulation ◽

Cell Morphology ◽

Cell Mechanics ◽

Modeling Method ◽

Mechanical Signals ◽

Stimulation Of

Mechanical biology is the study of the influence of the mechanical environment on human health, disease, or injury. To study the mechanism of the organism’s perception and response to mechanical signals can promote the development of biomedical basic and clinical research, and promote human health. The purpose of this paper is to study the mathematical modeling method of the effect of multimodal mechanical signals on cell stretching and compression. This article first established a cell mechanics model based on the generalization of membrane theory, introduced the micro-manipulation techniques used to characterize cell mechanics and the method of cell mechanics loading, and then explained why mathematical modeling was established. Finally, according to the multi-modality During the mechanical preparation process, the effects of multi-modal mechanical signals on the stretching and compression of annulus fibrosus stem cells were studied. The experimental results in this paper show that after planting fibrous stem cells with different elastic modulus, the cell proliferation is obvious after the tensile mechanical stimulation of different conditions, and the different elastic modulus scaffolds are stimulated by the tensile mechanical stimulation of 2% tensile amplitude. The cell morphology is different. The low elastic modulus is round-like, and the high elastic modulus is fusiform-like. After 5% and 12% stretch amplitude, the cells are oriented at different elastic modulus. Arranged, there is no obvious difference in cell morphology.

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Erythropoiesis in steel mutant mice: effects of erythropoietin in vitro

Blood ◽

10.1182/blood.v45.3.427.427 ◽

1975 ◽

Vol 45 (3) ◽

pp. 427-433 ◽

Cited By ~ 5

Author(s):

DH Chui ◽

BV Loyer

Keyword(s):

Culture System ◽

Marrow Cell ◽

Biologically Active ◽

Mutant Mice ◽

Erythroid Cell ◽

Biochemical Modification ◽

Normochromic Anemia ◽

Stimulation Of

Abstract Adult SI/SI-d mutant mice have severe macrocytic, normochromic anemia. Moreover these animals are unresponsive to the stimulation of erythropoietin in vivo. By means of a bone marrow cell suspension culture system, the present investigation shows that in adult SI/SI-d marrow, there are cells capable of responding in vitro to erythropoietin in a normal fashion. Moreover, the erythropoietin present in SI/SI-d serum is biologically active in vitro without any prior biochemical modification. These observations support the suggestion that there is a defect in differentiation in the erythroid cell lines of SI/SI-d mice in vivo due to an abnormal hemopoietic microenvironment.

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