Erythropoiesis in steel mutant mice: effects of erythropoietin in vitro
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Abstract Adult SI/SI-d mutant mice have severe macrocytic, normochromic anemia. Moreover these animals are unresponsive to the stimulation of erythropoietin in vivo. By means of a bone marrow cell suspension culture system, the present investigation shows that in adult SI/SI-d marrow, there are cells capable of responding in vitro to erythropoietin in a normal fashion. Moreover, the erythropoietin present in SI/SI-d serum is biologically active in vitro without any prior biochemical modification. These observations support the suggestion that there is a defect in differentiation in the erythroid cell lines of SI/SI-d mice in vivo due to an abnormal hemopoietic microenvironment.
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2019 ◽
Vol 25
(37)
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pp. 4888-4902
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2019 ◽
Vol 5
(4)
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pp. 270-277
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2019 ◽
Vol 20
(18)
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pp. 4556
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1997 ◽
Vol 200
(22)
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pp. 2881-2892
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