Artificial Classification System for Urothelial Carcinoma

Author(s):  
Yu-Chieh Chen ◽  
Chih-Chieh Huang ◽  
Da-Ren Liu ◽  
Chi-Hung Hwang ◽  
Wei-Chen Lin ◽  
...  
Author(s):  
P.F. Stevens

Linnaeus was educated in Sweden, and became a doctor of medicine in Harderwijk, Holland, in 1735. He visited other European countries then, but he never left Sweden after his return in 1738. After practising as a physician in Stockholm, he moved to Uppsala University as professor of medicine and botany in 1741. He articulated four different but complementary ways of understanding nature – through two kinds of classification, and through what can be called developmental and functional/ecological interactions. Linnaeus is best known for his classificatory work, for which he received material from all over the world. His classificatory precepts are elaborated in the Philosophia botanica of 1751, an enlarged version of the 365 aphorisms of his Fundamenta botanica of 1735; the other aspects of his work are diffused through his writings. His artificial classification system, initially very popular, was replaced by the ’natural’ system, more slowly in botany than in zoology, and more slowly in England than in some other countries. Current biological nomenclature is based on his Species plantarum, edition 1 (for plants), and Systema naturae, edition 10 (for animals). His codification of botanical terms remains influential. Almost 200 dissertations, most written by Linnaeus, were defended by his students. In these and other less well-known works, including the unpublished Nemesis divina (Stories of Divine Retribution), he covered a wide range of subjects. Quinarian thinking is noticeable in Linnaeus’ work – there are five ranks in systems, five years’ growth in flowers – and in some of the occult works that he knew. He also shows a strong combinatorial bent and a tendency to draw close analogies between the parts of animals and plants.


2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 471-471
Author(s):  
Alla Kozubenko ◽  
Sonali Arora ◽  
Robert B. Montgomery ◽  
Jonathan L. Wright ◽  
Hung-Ming Lam ◽  
...  

471 Background: Molecular subtyping of cancer based on gene expression is a new prognostic tool with potential to guide treatment in the future. Urothelial carcinoma is one such cancer for which numerous molecular subtyping systems have been developed, but the diversity of these systems has hindered their clinical application. Recently, a consensus classification system was derived from six independent systems, defining six molecular classes with distinct oncogenic mechanisms and mutations (Kamoun A, et al. 2020). Considering the high heterogeneity in urothelial carcinoma, we hypothesized that molecular subtype variation may occur between primary and metastatic samples. We further evaluated whether variation in subtype was associated with any unique patient characteristics. Methods: As part of the University of Washington Bladder Cancer Rapid Autopsy Program (BCRAP), primary and metastatic tumor tissue samples were acquired from 14 deceased patients with urothelial carcinoma within 6 hours of death. Patient history was collected and deidentified for analysis. RNA exome sequencing was used for assigning molecular subtype for each of the 61 tumor samples, using the consensus and six comprising systems. Results: Molecular subtype variation within metastatic tumors according to any classification system was detected in 8 out of 14 patients, independent of histologic morphologies. Amongst the patients with variation, on average 2.1 out of 7 classification systems identified a major difference in subtype between sites. Patients with variation (mean age 70 years (SD 7 years)) were older than those without variation (mean age 59 years (SD 11 years), P = 0.04). Furthermore, patients with variation tended to have decreased survival from diagnosis and received less chemotherapy, although these were not statistically significant (p > 0.05). Conclusions: Molecular subtype variation within metastasis is relatively common amongst BCRAP patients with urothelial carcinoma. Older patients are more likely to have variation, possibly due to a higher tumor mutation burden. Potential variation must be taken into account when considering prognosis and developing a recommended drug regimen specific to molecular subtypes.


Author(s):  
Ella Inglebret ◽  
Amy Skinder-Meredith ◽  
Shana Bailey ◽  
Carla Jones ◽  
Ashley France

The authors in this article first identify the extent to which research articles published in three American Speech-Language-Hearing Association (ASHA) journals included participants, age birth to 18 years, from international backgrounds (i.e., residence outside of the United States), and go on to describe associated publication patterns over the past 12 years. These patterns then provide a context for examining variation in the conceptualization of ethnicity on an international scale. Further, the authors examine terminology and categories used by 11 countries where research participants resided. Each country uses a unique classification system. Thus, it can be expected that descriptions of the ethnic characteristics of international participants involved in research published in ASHA journal articles will widely vary.


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