Paramagnetic defect creation and charge trapping in SIMOX films at high and very high dose levels

2002 ◽  
Author(s):  
R.A.B. Devine ◽  
J.L. Leray ◽  
J. Margail
Keyword(s):  
Charge Trapping ◽  
High Dose ◽  
Paramagnetic Defect ◽  
Defect Creation ◽  
Dose Levels ◽  
Very High

Formation of Oxide Layers by High Dose Implantation into Silicon

1983 ◽  
Vol 27 ◽  
Author(s):  
S.S. Gill ◽  
I. H. Wilson
Keyword(s):  
Oxide Layer ◽  
Single Crystal Silicon ◽  
High Dose ◽  
Surface Oxide Layer ◽  
Crystal Silicon ◽  
Implantation Energy ◽  
Oxygen Ions ◽  
Oxygen Profile ◽  
Dose Levels ◽  
Very High

ABSTRACTSingle crystal silicon was implanted with 80, 120, 160 and 240 keV oxygen ions. Rutherford backscattering (RBS) analysis was used to obtain the implanted oxygen profile and the oxygen to silicon ratio in the implanted layer for doses in the range 1016 to 1.5 × 1018 O2+ cm−2 for room temperature implants. The depth and the thickness of the buried oxide layer has been measured as a function of implantation energy and oxygen dose. Chemical formation of stoichiometric SiO2 was confirmed by infra-red (IR) spectroscopy. Both RBS and IR indicate that once a surface oxide layer is formed for very high dose levels, the layer thickness decreases with increasing implanted dose beyond a critical dose level.

HOMOLOGOUS RADIOIMMUNOASSAY FOR CANINE PROLACTIN AND ITS APPLICATION IN VARIOUS PHYSIOLOGICAL STATES

1977 ◽  
Vol 75 (1) ◽  
pp. 93-103 ◽  
Author(s):  
K.-J. GRÄF ◽  
E. FRIEDREICH ◽  
S. MATTHES ◽  
S. H. HASAN
Keyword(s):  
Late Pregnancy ◽  
Significant Inhibition ◽  
Serum Prolactin ◽  
Normal Male ◽  
High Dose ◽  
Normal Female ◽  
Serum Progesterone ◽  
Basal Serum ◽  
Dose Levels ◽  
Very High

The purification of canine prolactin and the development of an homologous radioimmunoassay including several physiological studies in the Beagle dog are described. The assay measured immunoreactive canine prolactin with a sensitivity limit of 0·6 ng/ml. Purified canine luteinizing hormone gave no significant inhibition in the assay whereas purified canine growth hormone inhibited the binding of 125I-labelled canine prolactin to antiserum only at very high dose levels. In Beagle dogs, basal serum prolactin concentrations were in the range 1–2 ng/ml in normal male, normal female (metoestrus and anoestrus) and oophorectomized–hysterectomized female dogs. The prolactin concentration in one sample of amniotic fluid was in the same range, while in hypophysectomized male dogs no serum prolactin could be detected by our assay system. Serum prolactin concentrations tended to increase during late pregnancy and parturition, remaining high during the first 9 days of lactation. In consequence, a negative correlation was suggested between serum prolactin and serum progesterone concentrations.

Field dependent charge trapping effects in SIMOX and buried oxides at very high dose

1992 ◽  
Vol 39 (6) ◽  
pp. 2132-2138 ◽  
Author(s):  
O. Flament ◽  
D. Herve ◽  
O. Musseau ◽  
P. Bonnel ◽  
M. Raffaelli ◽  
...  
Keyword(s):  
Charge Trapping ◽  
High Dose ◽  
Field Dependent ◽  
Very High ◽  
Trapping Effects

scholarly journals Quantifying prescribed high dose opioids in the community and risk of overdose

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Joe Schofield ◽  
Deborah Steven ◽  
Rebecca Foster ◽  
Catriona Matheson ◽  
Alexander Baldacchino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Service Improvement ◽  
High Dose ◽  
Opioid Overdose ◽  
Opioid Prescribing ◽  
Patient Level ◽  
Strong Opioid ◽  
High Doses ◽  
Strong Opioids ◽  
Very High

Abstract Background Opioid prescribing for a range of health issues is increasing globally. The risk of fatal and non-fatal overdose is increased among people prescribed strong opioids: in high doses in the context of polypharmacy (the use of multiple medications at the same time), especially with other sedatives; and among people with multiple morbidities including cardiorespiratory, hepatic and renal conditions. This study described and quantified the prescribing of strong opioids, comorbidities and other overdose risk factors among those prescribed strong opioids, and factors associated with high/very high opioid dosage in a regional health authority in Scotland as part of a wider service improvement exercise. Methods Participating practices ran searches to identify patients prescribed strong opioids and their characteristics, polypharmacy, and other overdose risk factors. Data were anonymised before being analysed at practice and patient-level. Morphine Equivalent Doses were calculated for patients based on drug/dose information and classed as Low/Medium/High/Very High. Descriptive statistics were generated on the strong opioid patient population and overdose risk factors. The relationship between the prescribing of strong opioids and practice/patient-level factors was investigated using linear and logistic regression models. Results Eighty-five percent (46/54) of GP practices participated. 12.4% (42,382/341,240) of individuals in participating practices were prescribed opioids and, of these, one third (14,079/42,382) were prescribed strong opioids. The most common comorbidities and overdose risk factors among strong opioid recipients were pain (67.2%), cardiovascular disease (43.2%), and mental health problems (39.3%). There was a positive significant relationship between level of social deprivation among practice caseload and level of strong opioid prescribing (p < 0.001). People prescribed strong opioids tended to be older (mean 59.7 years) and female (8638, 61.4%) and, among a subset of patients, age, gender and opioid drug class were significantly associated with prescribing of High/Very High doses. Conclusions Our findings have identified a large population at potential risk of prescription opioid overdose. There is a need to explore pragmatic models of tailored interventions which may reduce the risk of overdose within this group and clinical practice may need to be tightened to minimise overdose risk for individuals prescribed high dose opioids.

Effects of piperonyl butoxide on spontaneous behavior in F1-generation mice

2009 ◽  
Vol 25 (7) ◽  
pp. 489-497 ◽  
Author(s):  
Toyohito Tanaka ◽  
Osamu Takahashi ◽  
Shinshi Oishi ◽  
Akio Ogata
Keyword(s):  
Dose Group ◽  
Female Offspring ◽  
Piperonyl Butoxide ◽  
High Dose Group ◽  
High Dose ◽  
Adult Females ◽  
Developmental Parameters ◽  
Spontaneous Behavior ◽  
Dose Levels ◽  
F1 Generation

Piperonyl butoxide was given in the diet to provide levels of 0 (control), 0.02%, 0.06%, and 0.18% from 5 weeks of age of the F0 generation to 12 weeks of age of the F1 generation in mice. Select reproductive and neurobehavioral parameters were then measured. In exploratory behavior in the F0 generation, vertical time of adult females increased significantly in a dose-related manner. In behavioral developmental parameters, cliff avoidance was delayed significantly in the high-dose group in male offspring, and this effect was significantly dose-related. In female offspring, surface righting was significantly delayed in the high-dose group, and this effect was significantly dose-related. In spontaneous behavior in the F1 generation, females showed more activities in some variables in the high-dose group. Dose levels of piperonyl butoxide used in the present study produced several adverse effects in neurobehavioral parameters in mice.

A Successful Venous Thromboprophylaxis in a Patient with Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT): a case report of the first reported case in Thailand

2021 ◽  
Author(s):  
Archrob Khuhapinant ◽  
Tarinee Rungjirajittranon ◽  
Bundarika Suwanawiboon ◽  
Yingyong Chinthammitr ◽  
Theera Ruchutrakool
Keyword(s):  
Asian Population ◽  
High Dose ◽  
Severe Thrombocytopenia ◽  
Imaging Studies ◽  
Fatal Complication ◽  
Platelet Factor ◽  
High Dose Dexamethasone ◽  
Prophylactic Dose ◽  
Spontaneous Platelet Aggregation ◽  
Very High

Abstract BackgroundVaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but fatal complication of Coronavirus Disease 2019 vaccine. Many reports of VITT have mostly been in the Caucasian population. Here, we present first reported case from an oriental population.Case presentationA 26-year-old female who had severe headache and severe thrombocytopenia 8 days after administration of the ChAdOx1 nCoV-19 vaccine developed by AstraZeneca. Although no thrombosis was demonstrated by imaging studies, she had very highly elevated d-dimer level during hospitalization. Serology for antibody against platelet factor 4 was positive on several days with very high optical density readings. Furthermore, we found the antibody could induce spontaneous platelet aggregation without the presence of heparin. We decided to treat her with intravenous immunoglobulin, high-dose dexamethasone, and a prophylactic dose of apixaban. She improved rapidly and was discharged from the hospital 6 days after admission. Neither thrombocytopenia nor thrombosis was subsequently detected at three weeks follow-up.ConclusionsDespite lower rate of thrombosis, VITT can present in Asian population. Early detection and prompt treatment of VITT can improve patients’ clinical outcome. Thromboprophylaxis of non-heparin anticoagulants also results in prevention of clot formation.

One-generation reproduction toxicity study of Dithane M-45 (mancozeb) and lead acetate

2002 ◽  
Vol 50 (3) ◽  
pp. 365-371 ◽  
Author(s):  
L. Várnagy ◽  
P. Budai ◽  
E. Molnár ◽  
Keyword(s):  
Body Weight ◽  
Lead Acetate ◽  
Clinical Symptoms ◽  
Reproductive Toxicity ◽  
The Body ◽  
High Dose ◽  
Lactation Period ◽  
Treatment Groups ◽  
Body Weight Increase ◽  
Dose Levels

The reproductive toxicity of lead acetate and of a fungicide formulation (Dithane M-45) containing 80% mancozeb was studied on rats. Lead acetate was applied in the feed in the following dose groups: control, 1,000, 5,000 and 10,000 mg/kg of diet. The three treatment groups received, in addition to the above doses of lead acetate, 4,500 mg/kg Dithane M-45 in the diet. The method was based on the OECD Guideline for Testing of Chemicals No. 415 (1981). Clinical symptoms and mortality were not found in the parent generation. The body weight of female animals decreased significantly before the pregnancy period. This tendency was also seen in males after the combination treatment. At the two high dose levels a remarkable body weight increase was seen in the female animals during the lactation period. As a result of treatment, decreased body weight of offspring was measured during the lactation period. No gross pathological changes were seen. Histological examination showed general tubulonephrosis in the experimental animals. It can be established that the administration of Dithane M-45 did not enhance the reproductive toxicity of lead acetate.

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