Towards Early Detection of Novel Attack Patterns through the Lens of a Large-Scale Darknet

2016 ◽  
Author(s):  
Tao Ban ◽  
Shaoning Pang ◽  
Masashi Eto ◽  
Daisuke Inoue ◽  
Koji Nakao ◽  
...  
Keyword(s):  
Early Detection ◽  
Large Scale ◽  
Attack Patterns

Use of score sheets for welfare assessment of transgenic mice

2001 ◽  
Vol 35 (4) ◽  
pp. 379-389 ◽  
Author(s):  
M. van der Meer ◽  
A. Rolls ◽  
V. Baumans ◽  
B. Olivier ◽  
L. F. M. van Zutphen
Keyword(s):  
Early Detection ◽  
Transgenic Mice ◽  
Large Scale ◽  
Transgenic Animal ◽  
Daily Routine ◽  
Careful Monitoring ◽  
Welfare Assessment ◽  
Daily Care ◽  
Routine Monitoring ◽  
Transgenic Lines

The use of transgenic mice has increased dramatically in recent years and continues to increase further. However, because transgenesis may alter a balanced genotype and produce unpredictable effects, careful monitoring of health and welfare of the transgenic animal is advised. The present study assessed the feasibility of the use of score sheets for monitoring transgenic mice, as part of daily routine, in a transgenic unit. The score sheets used were based on parameters which are sensitive and easy to determine. The score sheets were used by two animal technicians and a thorough evaluation showed that the score sheets, as described in this paper, are useful for routine monitoring in a transgenic unit and may result in the early detection of animal welfare problems. However, notwithstanding the limited number of parameters included and the restricted age-span covered by the screening, the monitoring system was considered to be time consuming. Large-scale implementation of such a scoring system during the first weeks of life would increase daily care time by at least 15-20 min for an average litter of 4-6 pups. Nevertheless, the use of score sheets seems to be a prerequisite for monitoring the animal's welfare in the course of producing transgenic lines.

scholarly journals A Large‐scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma

Hepatology ◽  
2018 ◽  
Vol 67 (2) ◽  
pp. 662-675 ◽  
Author(s):  
Ping Luo ◽  
Peiyuan Yin ◽  
Rui Hua ◽  
Yexiong Tan ◽  
Zaifang Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Detection ◽  
Large Scale ◽  
Biomarker Identification

scholarly journals Identification of urine protein biomarkers with the potential for early detection of lung cancer

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Hongjuan Zhang ◽  
Jing Cao ◽  
Lin Li ◽  
Yanbin Liu ◽  
Hong Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Mouse Model ◽  
Large Scale ◽  
Relative Reduction ◽  
Healthy Population ◽  
Protein Biomarkers ◽  
Lung Cancer Patients ◽  
Tumor Bearing ◽  
Low Dose Computed Tomography

Abstract Lung cancer is the leading cause of cancer-related deaths and has an overall 5-year survival rate lower than 15%. Large-scale clinical trials have demonstrated a significant relative reduction in mortality in high-risk individuals with low-dose computed tomography screening. However, biomarkers capable of identifying the most at-risk population and detecting lung cancer before it becomes clinically apparent are urgently needed in the clinic. Here, we report the identification of urine biomarkers capable of detecting lung cancer. Using the well-characterized inducible Kras (G12D) mouse model of lung cancer, we identified alterations in the urine proteome in tumor-bearing mice compared with sibling controls. Marked differences at the proteomic level were also detected between the urine of patients and that of healthy population controls. Importantly, we identified 7 proteins commonly found to be significantly up-regulated in both tumor-bearing mice and patients. In an independent cohort, we showed that 2 of the 7 proteins were up-regulated in urine samples from lung cancer patients but not in those from controls. The kinetics of these proteins correlated with the disease state in the mouse model. These tumor biomarkers could potentially aid in the early detection of lung cancer.

Early detection of spamming accounts in large-Scale service provider networks

2018 ◽  
Vol 142 ◽  
pp. 241-255 ◽  
Author(s):  
Yehonatan Cohen ◽  
Daniel Gordon ◽  
Danny Hendler
Keyword(s):  
Early Detection ◽  
Service Provider ◽  
Large Scale ◽  
Provider Networks

scholarly journals Early detection of dynamic harmful cascades in large-scale networks

2018 ◽  
Vol 28 ◽  
pp. 304-317 ◽  
Author(s):  
Chuan Zhou ◽  
Wei-Xue Lu ◽  
Jingzun Zhang ◽  
Lei Li ◽  
Yue Hu ◽  
...  
Keyword(s):  
Early Detection ◽  
Large Scale ◽  
Large Scale Networks

scholarly journals The Nonmydriatic Fundus Camera in Diabetic Retinopathy Screening: A Cost-Effective Study with Evaluation for Future Large-Scale Application

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Giuseppe Scarpa ◽  
Francesca Urban ◽  
Stela Vujosevic ◽  
Michele Tessarin ◽  
Giovanni Gallo ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Early Detection ◽  
Large Scale ◽  
Screening Programme ◽  
Cost Effective ◽  
Diabetic Patients ◽  
Local Health Authority ◽  
Local Health ◽  
Fundus Camera ◽  
Diabetic Retinopathy Screening

Aims. The study aimed to present the experience of a screening programme for early detection of diabetic retinopathy (DR) using a nonmydriatic fundus camera, evaluating the feasibility in terms of validity, resources absorption, and future advantages of a potential application, in an Italian local health authority. Methods. Diabetic patients living in the town of Ponzano, Veneto Region (Northern Italy), were invited to be enrolled in the screening programme. The “no prevention strategy” with the inclusion of the estimation of blindness related costs was compared with screening costs in order to evaluate a future extensive and feasible implementation of the procedure, through a budget impact approach. Results. Out of 498 diabetic patients eligible, 80% was enrolled in the screening programme. 115 patients (34%) were referred to an ophthalmologist and 9 cases required prompt treatment for either proliferative DR or macular edema. Based on the pilot data, it emerged that an extensive use of the investigated screening programme, within the Greater Treviso area, could prevent 6 cases of blindness every year, resulting in a saving of €271,543.32 (−13.71%). Conclusions. Fundus images obtained with a nonmydriatic fundus camera could be considered an effective, cost-sparing, and feasible screening tool for the early detection of DR, preventing blindness as a result of diabetes.

scholarly journals Autoantibody to GNAS in Early Detection of Hepatocellular Carcinoma: A Large-Scale Sample Study Combined with Verification in Serial Sera from HCC Patients

Biomedicines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 97
Author(s):  
Xiao Wang ◽  
Keyan Wang ◽  
Cuipeng Qiu ◽  
Bofei Wang ◽  
Xiaojun Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Detection ◽  
Large Scale ◽  
Early Stage ◽  
Decompensated Cirrhosis ◽  
Compensated Cirrhosis ◽  
Autoantibody Response ◽  
Potential Biomarker ◽  
Early Hcc ◽  
Normal Controls

The aim of this study was to explore the value of autoantibody to GNAS in the early detection of hepatocellular carcinoma (HCC). In a large-scale sample set of 912 participants (228 cases in each of HCC, liver cirrhosis (LC), chronic hepatitis B (CHB), and normal controls (NCs) groups), autoantibody to GNAS was detected with a positive result in 47.8% of HCC patients, which was significantly higher than that in patients with LC (35.1%), CHB (19.7%), and NCs (19.7%). Further analysis showed that the frequency of autoantibody to GNAS started increasing in compensated cirrhosis patients (37.0%) with a jump in decompensated cirrhosis patients (53.2%) and reached a peak in early HCC patients (62.4%). The increasing autoantibody response to GNAS in patients at different stages was closely associated with the progression of chronic liver lesions. The result from 44 human serial sera demonstrated that 5 of 11 (45.5%) HCC patients had elevated autoantibody to GNAS before and/or at diagnosis of HCC. Moreover, 46.1% and 62.4% of high positive rates in alpha-fetoprotein (AFP) negative and early-stage HCC patients can supplement AFP in early detection of HCC. These findings suggest that autoantibody to GNAS could be used as a potential biomarker for the early detection of HCC.

scholarly journals Rapid, Large-Scale Wastewater Surveillance and Automated Reporting System Enable Early Detection of Nearly 85% of COVID-19 Cases on a University Campus

mSystems ◽  
2021 ◽  
Author(s):  
Smruthi Karthikeyan ◽  
Andrew Nguyen ◽  
Daniel McDonald ◽  
Yijian Zong ◽  
Nancy Ronquillo ◽  
...  
Keyword(s):  
High Resolution ◽  
Early Detection ◽  
Large Scale ◽  
Reporting System ◽  
Spatial Sampling ◽  
Campus Community ◽  
University Campus ◽  
University Campuses ◽  
Insight Into

Wastewater-based epidemiology can be particularly valuable at university campuses where high-resolution spatial sampling in a well-controlled context could not only provide insight into what affects campus community as well as how those inferences can be extended to a broader city/county context. In the present study, a large-scale wastewater surveillance was successfully implemented on a large university campus enabling early detection of 85% of COVID-19 cases thereby averting potential outbreaks.

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