Evaluation of Skin Surface as an Alternative Source of Reference DNA Samples: A Pilot Study

2017 ◽  
Vol 63 (1) ◽  
pp. 227-233 ◽  
Author(s):  
Mohammed H. Albujja ◽  
Abdul Aziz Bin Dukhyil ◽  
Abdul Rauf Chaudhary ◽  
Ahmed Ch. Kassab ◽  
Ahmed M. Refaat ◽  
...  
2021 ◽  
Vol 30 (8) ◽  
pp. 632-641
Author(s):  
Sumiati Tarigan ◽  
Saldy Yusuf ◽  
Yuliana Syam

Objective: This study aimed to evaluate the interface pressure and skin surface temperature in relation to the incidence of pressure injury (PI) using three different turning schedules. Method: This was a pilot study with a three-armed randomised clinical trial design. Participants at risk of PI and treated in the high dependency care unit in a regional hospital in Makassar, Indonesia participated in this study. Patients were repositioned at three different turning schedules (two-, three- and four-hourly intervals). Interface pressure measurement and skin surface temperature were measured between 14:00 and 18:00 every three days. The incidence of PI was assessed during the two-week observation period. Results: A total of 44 participants took part in the study. A one-way ANOVA test revealed no difference in interface pressure among the three different turning schedule groups within two weeks of observations: day zero, p=0.56; day four, p=0.95; day seven, p=0.56; day 10, p=0.63; and day 14, p=0.92. Although the average periumbilical temperature and skin surface temperature were not significant (p>0.05), comparison between these observation sites was significant on all observation days (p<0.05). Regarding the incidence of PI, the proportional hazard test for the development of PI in the three groups was considered not different (hazard ratio: 1.46, 95% confidence interval: 0.43–4.87, p=0.54). Conclusion: No difference in interface pressure and incidence of PI on the three turning schedules was observed; however, there was a potential increase in skin surface temperature in comparison with periumbilical temperature for all three turning schedules.


2021 ◽  
Vol 15 (3) ◽  
pp. 037101
Author(s):  
Tasneem Shetewi ◽  
Melissa Finnegan ◽  
Shane Fitzgerald ◽  
Shuai Xu ◽  
Emer Duffy ◽  
...  

2018 ◽  
Vol 34 (04) ◽  
pp. 373-380
Author(s):  
Ralph Litschel ◽  
Abel-Jan Tasman

AbstractBoth intended and unintended surgical modifications of nasal width and shape of the nasal tip continue to be of interest to the rhinoplasty surgeon. As validated instruments for quantifying width and boxiness are lacking, the objective of this study was to introduce a width index and a boxiness index for the nasal dorsum and the nasal tip. A width index and a boxiness index were defined within the methodological limits of noncontact sonography. The reliability of both indices was studied by comparing the measurements of two examiners on the noses of five volunteers. The validity of the indices was studied by correlating the sonographic width and boxiness with the 5-point Likert scale ratings of photographs of 5 noses by 21 lay persons. Nasal width was defined as the diameter at a distance of 5 mm from the skin surface on a sonographic cross-section perpendicular to the skin surface. Boxiness was defined as the quotient of width at a depth of 1 and 5 mm. Bland–Altmann analysis revealed negligible bias between both examiners and 95% of limits of agreement of 13, 7, and 13% for width at 1 mm, width at 5 mm, and boxiness, respectively. Corresponding Pearson's correlation coefficients were r = 0.93, r = 0.93, and r = 0.71. The correlation between the cumulative lay persons' scores and sonographic width and boxiness were r = 0.97, r = 0.66, and r = 0.81 for nasal tip width, dorsal width, and boxiness, respectively. Both the width at a depth of 5 mm as measured with sonography and the boxiness index that is defined as width at a depth of 1 mm divided by the width at a depth of 5 mm may prove to be acceptable surrogate parameters for width and boxiness of the nose in comparative morphometric studies.


2011 ◽  
Vol 39 (1) ◽  
pp. 37-42
Author(s):  
Yasutomo Fujii ◽  
Masasumi Yoshizawa ◽  
Ryuji Emoto ◽  
Naoto Haruyama ◽  
Takasuke Irie ◽  
...  

2014 ◽  
Vol 35 (3) ◽  
pp. 331-340 ◽  
Author(s):  
A. Campanati ◽  
P. Neri ◽  
K. Giuliodori ◽  
I. Arapi ◽  
G. Carbonari ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Takeshi Katagiri ◽  
Kazuhisa Kondo ◽  
Rei Shibata ◽  
Ryo Hayashida ◽  
Satoshi Shintani ◽  
...  

Abstract Adipose-derived regenerative cell (ADRC) is a promising alternative source of autologous somatic stem cells for the repair of damaged tissue. This study aimed to assess the safety and feasibility of autologous ADRC implantation for therapeutic angiogenesis in patients with critical limb ischaemia (CLI). A clinical pilot study—Therapeutic Angiogenesis by Cell Transplantation using ADRCs (TACT-ADRC) study—was initiated in Japan. Adipose tissue was obtained by ordinary liposuction method. Isolated ADRCs were injected into the ischaemic limb. We performed TACT-ADRC procedure in five patients with CLI. At 6 months, no adverse events related to the TACT-ADRC were observed. No patients required major limb amputation, and ischaemic ulcers were partly or completely healed during the 6-month follow-up. In all cases, significant clinical improvements were seen in terms of rest pain and 6-min walking distance. Numbers of circulating CD34+ and CD133+ cells markers of progenitor cell persistently increased after ADRC implantation. The ratio of VEGF-A165b (an anti-angiogenic isoform of VEGF) to total VEGF-A in plasma significantly decreased after ADRC implantation. In vitro experiments, cultured with ADRC-conditioned media (CM) resulted in increased total VEGF-A and decreased VEGF-A165b in C2C12 cells, but not in macrophages. ADRC-CM also increased CD206+ cells expression and decreased TNF-α in macrophages. Autologous ADRC implantation was safe and effective in patients with CLI and could repair damaged tissue via its ability to promote angiogenesis and suppress tissue inflammation.


2013 ◽  
Vol 31 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Li-Mei Lin ◽  
Shu-Fang Wang ◽  
Ru-Ping Lee ◽  
Bang-Gee Hsu ◽  
Nu-Man Tsai ◽  
...  

Objective This study evaluates the thermographic changes associated with moxa burner moxibustion at the SP6 acupuncture point to establish an appropriate, safe distance of efficacy for moxibustion. Methods Baseline temperature changes using a moxa burner were obtained for a paper substrate at various distances and times, and the tested with volunteers in a pilot study. A single-group trial was then conducted with 36 healthy women to monitor temperature changes on the body surface at the acupuncture point (SP6). Results Based on the temperature changes seen for the paper substrate and in the pilot study, a distance of 3 cm was chosen as the intervention distance. Moxibustion significantly increased the SP6 point skin surface temperature, with a peak increase of 11°C at 4 min (p <0.001). This study also found that during moxibustion the temperature of the moxa burner's rubber layer and moxa cautery were 56.9±0.9°C and 65.8±1.2°C, as compared to baseline values of 35.1°C and 43.8°C (p<0.001). Conclusions We determined 3 cm was a safe distance between the moxa burner and acupuncture point. Moxibustion can increase the skin surface temperature at the SP6 point. This data will aid traditional Chinese medicine (TCM) practitioners in gauging safer treatment distances when using moxibustion treatments.


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