scholarly journals The impact of high dietary zinc oxide on the development of the intestinal microbiota in weaned piglets

2013 ◽  
Vol 87 (2) ◽  
pp. 416-427 ◽  
Author(s):  
Ingo C. Starke ◽  
Robert Pieper ◽  
Konrad Neumann ◽  
Jürgen Zentek ◽  
Wilfried Vahjen
Keyword(s):  
Zinc Oxide ◽  
Intestinal Microbiota ◽  
Weaned Piglets ◽  
Dietary Zinc ◽  
The Impact

scholarly journals 289 Effects of supranutritional levels of dietary zinc oxide on zinc, copper, and iron metabolism in post-weaned pigs

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 106-107
Author(s):  
Danyel Bueno Dalto ◽  
Frédéric Guay ◽  
Yan Martel-Kennes ◽  
Guylaine Talbot ◽  
Martin Lessard ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Serum Concentration ◽  
Treatment Effects ◽  
Experimental Period ◽  
Dietary Zinc ◽  
Weaned Pigs ◽  
Cu Content ◽  
Cu Deficiency ◽  
Fe Homeostasis ◽  
The Impact

Abstract This study evaluated the impact of supranutritional levels of dietary zinc oxide (ZnO) on zinc (Zn), copper (Cu), and iron (Fe) homeostasis in post-weaned pigs. One hundred twenty piglets were selected at d14 of age (5.65 ± 0.68 kg). At weaning (d21), they were fed a basal post-weaning diet (without antibiotics) supplemented (n = 40/treatment) with 100 mg/kg (low; LZn), 1000 mg/kg (medium; MZn) or 3000 mg/kg (high; HZn) of ZnO until d42. Dietary levels of Cu (130 mg/kg) and Fe (260 mg/kg) remained constant throughout the experimental period. Piglets were sacrificed at d21, d23, d35, and d42 of age (n = 10/treatment/d) for samples collection. Serum concentrations and total liver content of Zn and Cu were not different among treatments on d21 and d23 (P ≥ 0.10). For Zn, treatment effects were detected at d35 and d42 (P < 0.01) on both serum concentration and total Zn content in liver. For both parameters, values were greatest for HZn, intermediary for MZn, and lowest for LZn irrespective of ages in the two periods. For Cu, treatment effects were detected at d35 and d42 (P < 0.01) on both serum concentration and total Cu content in liver. For both parameters, values were greatest for LZn and MZn and lowest for HZn irrespective of ages. For Fe, no treatment effect was detected either on whole blood Fe concentrations (P = 0.81) or hemoglobin levels (P = 0.76). However, for total Fe content in liver, treatment effects were detected (P < 0.01). Values were greatest for LZn and lowest for HZn at d35 and d42 whereas for MZn they were intermediary at d35 and similar to LZn at d42 (P ≤ 0.01). In conclusion, supranutritional levels of dietary ZnO fed to piglets during 3 weeks post-weaning significantly impacted Zn, Cu, and Fe homeostasis. These results emphasise the potential risk of Cu deficiency as well as impairment in building body Fe reserves under long-term supranutritional supplementation of ZnO.

scholarly journals 283 Performance and mineral fecal excretion of post weaned piglets are influenced by different sources of zinc oxide

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 108-109
Author(s):  
Vitor Hugo C Moita ◽  
Márvio L Abreu ◽  
Bruno N Silva ◽  
Rhuan Chaves ◽  
Ronaldo Lucas S Tolentino ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Block Design ◽  
Fecal Excretion ◽  
Productive Performance ◽  
Weaned Piglets ◽  
Randomized Block Design ◽  
Dietary Treatments ◽  
Performance Results ◽  
The Impact ◽  
Different Sources

Abstract The study aimed to evaluate the impact of the supplementation on post weaning diets of the conventional source of zinc oxide (ZnO) and/or a potentiated source of zinc oxide (PZnO) and different (P) levels on productive performance, incidence of diarrhea, (Zn) and (Cu) fecal excretion. Eighty-four pigs weaned at 21 days of age were allocated in a randomized block design with four dietary treatments [T1: no inclusion of ZnO and regular P levels (0.440%; 0.420%; 0.400%; 0.380%); T2: inclusion of ZnO and regular P levels (0.440%; 0.420%; 0.400%; 0.380%); T3: ZnO and PZnO and 10% low P levels (0.396%; 0.379%; 0.360%; 0.340%); T4: inclusion of the PZnO and 10% low P levels (0.396%; 0.379%; 0.360%; 0.340%)], with seven replications and three pigs/pen. The nutritional program was: (pre-starter 1: d 21 to 28; pre-starter II: d 28 to 35; starter I: d 35 to 49; and starter II: d 49 to 63). The Tukey test was adopted to compare the means (SAS, 9.3). From d 1 to 14, T2 improved ADG (P < 0.05) and BW (P < 0.05) at d 14. From the period of d1 to d28, pigs fed with T2 diets showed higher ADG (P < 0.05), ADFI (P < 0.05) and, consequently, higher BW (P < 0.05) at d 28. From d 1 to 42, pigs fed with PZnO diet performed the highest ADFI (P < 0.05). Evaluating overall data of diarrhea, T2 reduced the incidence of diarrhea (P < 0.05). T4 reduced Zn and P fecal excretion during the period from d 7 to 28 (P < 0.05). Therefore, the use of ZnO and PZnO provide the same performance results of piglets on the period from d 1 to 42 after weaning. Furthermore, the inclusion of PZnO reduces the Zn and P fecal excretion.

scholarly journals Effect of Dietary Zinc Oxide on Morphological Characteristics, Mucin Composition and Gene Expression in the Colon of Weaned Piglets

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91091 ◽  
Author(s):  
Ping Liu ◽  
Robert Pieper ◽  
Juliane Rieger ◽  
Wilfried Vahjen ◽  
Roger Davin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Zinc Oxide ◽  
Morphological Characteristics ◽  
Weaned Piglets ◽  
Dietary Zinc

scholarly journals Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 886
Author(s):  
Youngbeom Ahn ◽  
Ji Young Jung ◽  
Ohgew Kweon ◽  
Brian T. Veach ◽  
Sangeeta Khare ◽  
...  
Keyword(s):  
Molecular Analysis ◽  
Intestinal Microbiota ◽  
Continuous Flow ◽  
Antimicrobial Drug ◽  
Bioreactor Culture ◽  
Analysis Techniques ◽  
Human Intestinal Microbiota ◽  
Traditional Cultures ◽  
The Impact

Studying potential dietary exposure to antimicrobial drug residues via meat and dairy products is essential to ensure human health and consumer safety. When studying how antimicrobial residues in food impact the development of antimicrobial drug resistance and disrupt normal bacteria community structure in the intestine, there are diverse methodological challenges to overcome. In this study, traditional cultures and molecular analysis techniques were used to determine the effects of tetracycline at chronic subinhibitory exposure levels on human intestinal microbiota using an in vitro continuous flow bioreactor. Six bioreactor culture vessels containing human fecal suspensions were maintained at 37 °C for 7 days. After a steady state was achieved, the suspensions were dosed with 0, 0.015, 0.15, 1.5, 15, or 150 µg/mL tetracycline, respectively. Exposure to 150 µg/mL tetracycline resulted in a decrease of total anaerobic bacteria from 1.9 × 107 ± 0.3 × 107 down to 2 × 106 ± 0.8 × 106 CFU/mL. Dose-dependent effects of tetracycline were noted for perturbations of tetB and tetD gene expression and changes in acetate and propionate concentrations. Although no-observed-adverse-effect concentrations differed, depending on the traditional cultures and the molecular analysis techniques used, this in vitro continuous flow bioreactor study contributes to the knowledge base regarding the impact of chronic exposure of tetracycline on human intestinal microbiota.

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