Full compliance with Respiratory syncytial virus prophylaxis was associated with fewer respiratory‐related hospital admissions in preterm children: A cohort study

2020 ◽  
Author(s):  
Heloise Torchin ◽  
Marie‐Laure Charkaluk ◽  
Jessica Rousseau ◽  
Laetitia Marchand‐Martin ◽  
Ludovic Treluyer ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Hospital Admissions ◽  
Preterm Children ◽  
Full Compliance ◽  
Syncytial Virus

scholarly journals The contribution of child, family and health service factors to respiratory syncytial virus (RSV) hospital admissions in the first 3 years of life: birth cohort study in Scotland, 2009 to 2015

2019 ◽  
Vol 24 (1) ◽  
Author(s):  
Pia Hardelid ◽  
Maximiliane Verfuerden ◽  
Jim McMenamin ◽  
Rosalind L Smyth ◽  
Ruth Gilbert
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Health Service ◽  
Hospital Admission ◽  
Birth Cohort ◽  
Hospital Admissions ◽  
Birth Cohort Study ◽  
Syncytial Virus ◽  
Older Siblings

Introduction Several vaccines for respiratory syncytial virus (RSV) are under development. Designing an effective vaccination programme for RSV requires information about the relative contribution of risk factors for severe RSV symptoms. Aim To inform preventive strategies in Europe by quantifying the contribution of key child, family and health service risk factors to the burden of RSV hospital admissions in young children. Methods We constructed a birth cohort study of all singleton children born in Scotland between October 2009 and September 2012 using linkage between birth registration, maternity, vaccination and hospital admission records, with follow-up until the age of 3 years. RSV-confirmed hospital admissions were defined using linkage to national laboratory surveillance data. We estimated hospital admission rates per 1,000 child years and length of stay according to each risk factor. Cox proportional hazard regression models were used to estimate adjusted hazard ratios. Results There were 5,185 RSV admissions among the 169,726 children in the cohort: 48.6% of admissions occurred before the age of 6 months, and 29.6% after the age of 1 year. Children born prematurely, small for gestational age, between July and December, with chronic conditions, older siblings, mothers < 30 years old or delayed infant vaccination had a significantly increased risk of admission. Minimising the risk posed by older siblings could reduce RSV admissions by up to 34%. Conclusion Future RSV vaccination programmes must protect children throughout early childhood. Vaccination and/or interventions to reduce transmission by older siblings could substantially reduce RSV hospital admissions.

Asthma and Immunoglobulin E Antibodies After Respiratory Syncytial Virus Bronchiolitis: A Prospective Cohort Study With Matched Controls

PEDIATRICS ◽  
1995 ◽  
Vol 95 (4) ◽  
pp. 500-505 ◽  
Author(s):  
N. Sigurs ◽  
R. Bjarnason ◽  
F. Sigurbergsson ◽  
B. Kjellman ◽  
B. Björkstén
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Prospective Cohort ◽  
Egg White ◽  
Control Group ◽  
Igg Antibodies ◽  
Ige Antibodies ◽  
Syncytial Virus

Objective. To study the occurrence of bronchial obstructive symptoms and immunoglobulin (Ig) E antibodies after respiratory syncytial virus (RSV) bronchiolitis in infancy. Previous studies of this subject have mostly been retrospective or without controls, or the controls have not been followed prospectively. Design. This was a prospective cohort study with matched controls. Participants. Forty-seven infants had experienced RSV bronchiolitis severe enough to cause hospitalization at a mean age of 3½ months. For each child with RSV infection, two controls were acquired from the local Child Health Center and matched for date of birth, sex, and residence. Only one control was obtained for one RSV child, and the control group thus contained 93 children. Methods. All the children underwent two follow-up examinations, the first one at a mean age of 1 year and the second at a mean age of 3 years. At the first follow-up, a skin-prick test against egg white was performed, and serum IgG antibodies against RSV were measured. At the second follow-up, serum IgE antibodies were measured using screening tests for common food and inhalant antibodies, and skin-prick tests against egg white, cat, birch, and mite allergen were performed. Hereditary and environmental factors (passive smoking, indoor furred animals) and duration of breast-feeding were recorded. Results. At the first follow-up, 89% in the RSV group and 27% in the control group had IgG antibodies against RSV (P &lt; .001). At the second follow-up, asthma, defined as three episodes of bronchial obstruction verified by a physician, was found in 11 of 47 children (23%) in the RSV group and in 1 of 93 children (1%) in the control group (P &lt; .001). A positive test for IgE antibodies was noted in 14 of 44 (32%) RSV children and in 8 of 92 (9%) children in the control group (P = .002). An analysis of risk factors for the development of asthma and IgE antibodies on the whole group of 140 children showed that RSV bronchiolitis was the most important risk factor, and a family history of atopy or asthma further increased the risk. Conclusions. Respiratory syncytial virus bronchiolitis during the first year of life apparently is an important risk factor for the development of asthma and sensitization to common allergens during the subsequent 2 years, particularly in children with heredity for atopy/asthma.

ASTHMA AND IMMUNOGLOBULIN E (IgE) ANTIBODIES AFTER RESPIRATORY SYNCYTIAL VIRUS (RSV) BRONCHIOLITIS: A PROSPECTIVE COHORT STUDY WITH MATCHED CONTROLS

PEDIATRICS ◽  
1996 ◽  
Vol 98 (2) ◽  
pp. 329-329
Author(s):  
James E. Gern
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Family History ◽  
Prospective Cohort ◽  
Immunoglobulin E ◽  
Specific Ige ◽  
Ige Antibodies ◽  
History Of ◽  
Syncytial Virus

RSV bronchiolitis was the most important risk factor for the development of asthma and allergen-specific IgE, although a family history of atopy or asthma further increased the risk.

scholarly journals Estimating Transmission Parameters for Respiratory Syncytial Virus and Predicting the Impact of Maternal and Pediatric Vaccination

2020 ◽  
Vol 222 (Supplement_7) ◽  
pp. S688-S694
Author(s):  
Michiel van Boven ◽  
Anne C Teirlinck ◽  
Adam Meijer ◽  
Mariëtte Hooiveld ◽  
Christiaan H van Dorp ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Young Children ◽  
Hospital Admissions ◽  
Respiratory Infections ◽  
Parameter Estimates ◽  
Syncytial Virus ◽  
And Shifts ◽  
Pediatric Vaccination ◽  
The Impact ◽  
Transmission Models

Abstract Background Respiratory syncytial virus (RSV) is a leading cause of respiratory tract illness in young children and a major cause of hospital admissions globally. Methods Here we fit age-structured transmission models with immunity propagation to data from the Netherlands (2012–2017). Data included nationwide hospitalizations with confirmed RSV, general practitioner (GP) data on attendance for care from acute respiratory infection, and virological testing of acute respiratory infections at the GP. The transmission models, equipped with key parameter estimates, were used to predict the impact of maternal and pediatric vaccination. Results Estimates of the basic reproduction number were generally high (R0 &gt; 10 in scenarios with high statistical support), while susceptibility was estimated to be low in nonelderly adults (&lt;10% in persons 20–64 years) and was higher in older adults (≥65 years). Scenario analyses predicted that maternal vaccination reduces the incidence of infection in vulnerable infants (&lt;1 year) and shifts the age of first infection from infants to young children. Conclusions Pediatric vaccination is expected to reduce the incidence of infection in infants and young children (0–5 years), slightly increase incidence in 5 to 9-year-old children, and have minor indirect benefits.

scholarly journals 798Hospitalization due to Respiratory Syncytial Virus (RSV) and Influenza Infection in Adult Patients: a Retrospective Cohort Study

2014 ◽  
Vol 1 (suppl_1) ◽  
pp. S227-S227
Author(s):  
Cheryl Volling ◽  
Kazi Hassan ◽  
Ahmed Al-Den ◽  
John Ng ◽  
Lilian Law ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Influenza Infection ◽  
Adult Patients ◽  
Syncytial Virus

Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study

2020 ◽  
pp. 2002688
Author(s):  
Koos Korsten ◽  
Niels Adriaenssens ◽  
Samuel Coenen ◽  
Christopher Butler ◽  
Behnaz Ravanfar ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Severe Disease ◽  
Acute Respiratory Tract Infection ◽  
Community Dwelling ◽  
Symptom Duration ◽  
Care Approach ◽  
Syncytial Virus ◽  
Community Dwelling Older Adults

BackgroundRespiratory syncytial virus (RSV) infection in older adults is recognized as an important health issue. We aimed to assess the community burden of RSV in Europe in older adults aged ≥60 years.MethodsThis international prospective observational cohort study is part of REspiratory Syncytial virus Consortium in EUrope (RESCEU). Participants were recruited before two independent RSV-seasons through general practitioner's offices. Participants reported weekly about symptoms of acute respiratory tract infection (ARTI) during one RSV-season. . ARTI patients were tested for RSV during home visits and completed a daily symptom diary. RSV-illness included PCR-confirmed ARTI and those showing seroconversion over the season. RSV-ARTI was based on PCR alone (ClinicalTrials.gov, NCT03621930).ResultsWe recruited 1040 participants (527 in season 2017–2018, 513 in season 2018–2019) with a median age of 75 years (range 60–100). 1023 (99%) lived independently at home at baseline. RSV-illness incidence was 4.2% (22/527) and 7.2% (37/513) in the respective seasons. RSV-illness did not affect frailty or cardiopulmonary status during the course of the study. No patients were hospitalized or died from RSV-illness. In the 36 patients with PCR confirmed RSV-ARTI, symptom duration averaged 19 days, while a doctor's visit took place in 11/36 (31%) of cases. RSV-ARTI could not clinically be differentiated from all other ARTI based on symptoms.ConclusionThis European study showed that RSV is prevalent in community-dwelling older adults and rarely causes severe disease. This suggests that watchful waiting, using a continuity of care approach to identify those who do need more intensive care is often justified when RSV is suspected in family practice.

scholarly journals Respiratory Syncytial Virus-Associated Hospital Admissions in Children Younger Than 5 Years in 7 European Countries Using Routinely Collected Datasets

2020 ◽  
Vol 222 (Supplement_7) ◽  
pp. S599-S605
Author(s):  
Rachel M Reeves ◽  
Maarten van Wijhe ◽  
Sabine Tong ◽  
Toni Lehtonen ◽  
Luca Stona ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Hospital Admissions ◽  
European Countries ◽  
Hospital Data ◽  
Admission Rates ◽  
Time Series Modelling ◽  
Modelling Methodology ◽  
Syncytial Virus ◽  
Future Work ◽  
The Impact

Abstract Background Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection (RTI) in young children. Registries provide opportunities to explore RSV epidemiology and burden. Methods We explored routinely collected hospital data on RSV in children aged &lt; 5 years in 7 European countries. We compare RSV-associated admission rates, age, seasonality, and time trends between countries. Results We found similar age distributions of RSV-associated hospital admissions in each country, with the highest burden in children &lt; 1 years old and peak at age 1 month. Average annual rates of RTI admission were 41.3–112.0 per 1000 children aged &lt; 1 year and 8.6–22.3 per 1000 children aged &lt; 1 year. In children aged &lt; 5 years, 57%–72% of RTI admissions with specified causal pathogen were coded as RSV, with 62%–87% of pathogen-coded admissions in children &lt; 1 year coded as RSV. Conclusions Our results demonstrate the benefits and limitations of using linked routinely collected data to explore epidemiology and burden of RSV. Our future work will use these data to generate estimates of RSV burden using time-series modelling methodology, to inform policymaking and regulatory decisions regarding RSV immunization strategy and monitor the impact of future vaccines.

Respiratory Syncytial Virus Prophylaxis in Down Syndrome: A Prospective Cohort Study

PEDIATRICS ◽  
2014 ◽  
Vol 133 (6) ◽  
pp. 1031-1037 ◽  
Author(s):  
H. Yi ◽  
K. L. Lanctot ◽  
L. Bont ◽  
B. L. P. Bloemers ◽  
M. Weijerman ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Syncytial Virus
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