The association between serological and dietary vitamin D levels and hepatitis C-related liver disease risk differs in African American and white males

The present study explored the association between dietary vitamin D and non-Hodgkin's lymphoma (NHL) risk. The multiethnic cohort (MEC) includes more than 215 000 Caucasians, African Americans, Native Hawaiians, Japanese Americans and Latinos, aged 45–75. After 10 years of follow-up, 939 incident NHL cases were identified. Risk was estimated using proportional hazards' models adjusted for possible confounders. Vitamin D intake was not associated with NHL risk in the entire cohort (Ptrend = 0·72 for men and Ptrend = 0·83 for women), but significantly lowered disease risk in African American women (hazard ratio (HR) = 0·50, 95 % CI: 0·28, 0·90, Ptrend = 0·03) and was borderline protective in African American men (HR = 0·68; 95 % CI: 0·39, 1·19; Ptrend = 0·31) when the highest to the lowest tertile was compared. In NHL subtype analyses, a 19, 36 and 32 % lowered risk, although not significant, was observed for diffuse large B-cell lymphoma, follicular lymphoma and small lymphocytic lymphoma/chronic lymphocytic leukemia in women, respectively. High dietary intake of vitamin D did not show a protective effect against NHL within the MEC except among African Americans, possibly because vitamin D production due to sun exposure is limited in this population.

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Effects of Vitamin D Supplementation on 1, 25-dihydroxyvitamin D Metabolism and Its Impact on Adipose Tissue Inflammation in Obese Mice (P24-004-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz044.p24-004-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Cited By ~ 1

Author(s):

Chan Yoon Park ◽

Shuang Zhu ◽

Young Sun Jung ◽

Sung Nim Han

Keyword(s):

Vitamin D ◽

Adipose Tissue ◽

Vitamin D Supplementation ◽

Dietary Vitamin ◽

Epididymal Adipose Tissue ◽

Mrna Levels ◽

Obese Mice ◽

Dihydroxyvitamin D ◽

Vitamin D Levels ◽

Dietary Vitamin D

Abstract Objectives Adipose tissue expresses CYP27B1 and VDR, suggesting local metabolism and function of 1,25-dihydroxyvitamin D (1,25(OH)2D) in adipose tissue. Obesity has been associated with dysregulation of 1,25(OH)2D levels. We investigated effects of vitamin D supplementation on 1,25(OH)2D metabolism and its impact in adipose tissue of obese mice. Methods Six-wk-old C57BL/6 mice were divided into 4 groups and fed experimental diets containing 10% or 45% kcal fat (CON or HFD) and differing in vitamin D content (1000 or 25,000 IU/kg of diet, DC or DS) for 13 wks. Serum 1,25(OH)2D and PTH levels were determined with radio- or enzyme-immunoassay. The mRNA levels of Cyp27b1, Cyp24a1, and Lrp2 in the kidney, and Cyp27b1, Vdr, and pro-inflammatory cytokines (Mcp-1, Rantes, Mip-1γ, Tnf-α, Il-6, Il-1β, and Ifn-γ) in the epididymal adipose tissue were determined by real-time PCR. Results Overall, serum 1,25(OH)2D levels were higher in DS groups compared with DC groups. When 1,25(OH)2D levels were compared between CON and HFD groups, differential pattern was observed depending on vitamin D levels in the diet. HFD-DC group showed higher serum 1,25(OH)2D and PTH levels compared with CON-DC group. However, in the DS groups, serum 1,25(OH)2D and PTH levels were not significantly affected by dietary fat amount. Renal Cyp24a1 mRNA levels, which could be up-regulated by dietary vitamin D, was higher in CON-DS group compared with CON-DC group. However, in the HFD groups, renal Cyp24a1 mRNA levels were similar in DC and DS groups. Mcp-1 and Rantes mRNA levels were higher in the HFD groups compared with CON groups, and their overall expression levels were down-regulated by vitamin D supplementation. Overall, mRNA levels of Il-6 and Il-1β were lower in the DS groups compared with DC groups. Conclusions Dietary vitamin D supplementation alleviated inflammatory responses in adipose tissue. Both 1,25(OH)2D in circulation and locally produced 1,25(OH)2D in adipose tissue might have contributed to the effect. Funding Sources Supported by the grant from the National Research Foundation (NRF) of Korea (NRF-2018R1D1A1B070491).

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P0758 : The relationship between hepatitis C related liver disease with diabetes mellitus and vitamin D

Journal of Hepatology ◽

10.1016/s0168-8278(15)30961-2 ◽

2015 ◽

Vol 62 ◽

pp. S613

Author(s):

V. Gupta ◽

A. Kumar ◽

P. Sharma ◽

A. Arora

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Liver Disease ◽

Hepatitis C ◽

Related Liver Disease ◽

The Relationship

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Importance of studying the levels of hepcidin and vitamin D in Egyptian children with chronic hepatitis C

Journal of Translational Internal Medicine ◽

10.2478/jtim-2019-0004 ◽

2019 ◽

Vol 7 (1) ◽

pp. 15-21 ◽

Cited By ~ 3

Author(s):

Amal Ahmed Mohamed ◽

Eman R. Abd Almonaem ◽

Amira I. Mansour ◽

HebatAllah Fadel Algebaly ◽

Rania Abdelmonem Khattab ◽

...

Keyword(s):

Vitamin D ◽

Chronic Hepatitis ◽

Liver Disease ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Iron Metabolism ◽

Hcv Infection ◽

Vitamin D Levels ◽

Egyptian Children ◽

Serum Hepcidin

Abstract Background and Objective Hepcidin is the key regulator of iron metabolism and is a significant biomarker for systemic inflammatory states. Vitamin D is a powerful immunomodulator and plays a significant role in the inflammatory responses and fibrosis occurring due to hepatitis C virus (HCV) infection. This study assessed the level of vitamin D and serum hepcidin and its expression in peripheral blood of children with chronic hepatitis C (CHC) and correlated them with other serum markers to reflect iron metabolism and liver disease severity. Methods A total of 100 children were included in this study: 50 with HCV infection and 50 healthy controls. Biochemical parameters together with vitamin D, hepcidin, and its expression were all measured. Results The level of hepcidin and its expression together with vitamin D and hepcidin-to-ferritin (H/F) ratios were significantly reduced in patients, but the iron and ferritin levels were higher (P<0.001). Serum hepcidin level showed significant positive correlation with hepcidin expression, HCV titer, iron, ferritin, and H/F ratio (r = 0.43, 0.31, 0.34, 0.28, and 0.91, respectively) but significant negative correlation with vitamin D (r = −0.37). Both hepcidin and ferritin were higher in patients with Child Pugh scores B and C than those with score A (P<0.001). Conclusion Measuring serum hepcidin and its expression together with vitamin D levels in patients may have a prognostic value and is promising in the follow-up of the severity of liver disease.

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Effects of Dietary Vitamin D Levels on the in Vitro Mineralization of Chick Metaphyses

Experimental Biology and Medicine ◽

10.3181/00379727-146-38132 ◽

1974 ◽

Vol 146 (2) ◽

pp. 488-493 ◽

Cited By ~ 6

Author(s):

M. A. Crenshaw ◽

W. K. Ramp ◽

W. A. Gonnerman ◽

S. U. Toverud

Keyword(s):

Vitamin D ◽

Dietary Vitamin ◽

Vitamin D Levels ◽

In Vitro Mineralization ◽

Dietary Vitamin D

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Vitamin D modulates cortical transcriptome and behavioral phenotypes in an Mecp2 heterozygous Rett syndrome mouse model

10.1101/2021.06.30.450587 ◽

2021 ◽

Author(s):

Mayara C. Ribeiro ◽

Jessica L. MacDonald

Keyword(s):

Vitamin D ◽

Rett Syndrome ◽

Vitamin D Supplementation ◽

Neuronal Morphology ◽

Dietary Vitamin ◽

Projection Neurons ◽

Behavioral Phenotypes ◽

Vitamin D Levels ◽

Dendritic Complexity ◽

Dietary Vitamin D

Rett syndrome (RTT) is an X-linked neurological disorder caused by mutations in the transcriptional regulator MECP2. Mecp2 loss-of-function leads to the disruption of many cellular pathways, including aberrant activation of the NF-κB pathway. Genetically attenuating the NF-κB pathway in Mecp2-null mice ameliorates hallmark phenotypes of RTT, including reduced dendritic complexity, raising the question of whether NF-κB pathway inhibitors could provide a therapeutic avenue for RTT. Vitamin D is a known inhibitor of NF-κB signaling; further, vitamin D deficiency is prevalent in RTT patients and male Mecp2-null mice. We previously demonstrated that vitamin D rescues the aberrant NF-κB activity and reduced neurite outgrowth of Mecp2-knockdown cortical neurons in vitro, and that dietary vitamin D supplementation rescues decreased dendritic complexity and soma size of neocortical projection neurons in both male hemizygous Mecp2-null and female heterozygous mice in vivo. Here, we have identified over 200 genes whose dysregulated expression in the Mecp2+/- cortex is modulated by dietary vitamin D. Genes normalized with vitamin D supplementation are involved in dendritic complexity, synapses, and neuronal projections, suggesting that the rescue of their expression could underpin the rescue of neuronal morphology. Further, motor and anxiety-like behavioral phenotypes in Mecp2+/- mice correlate with circulating vitamin D levels, and there is a disruption in the homeostasis of the vitamin D synthesis pathway in Mecp2+/- mice. Thus, our data indicate that vitamin D modulates RTT pathology and its supplementation could provide a simple and cost-effective partial therapeutic for RTT.

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Assessment of the Effects of Dietary Vitamin D Levels on Olanzapine-Induced Metabolic Side Effects: Focus on the Endocannabinoidome-Gut Microbiome Axis

International Journal of Molecular Sciences ◽

10.3390/ijms222212361 ◽

2021 ◽

Vol 22 (22) ◽

pp. 12361

Author(s):

Armita Abolghasemi ◽

Claudia Manca ◽

Fabio A. Iannotti ◽

Melissa Shen ◽

Nadine Leblanc ◽

...

Keyword(s):

Mental Health ◽

Insulin Resistance ◽

Vitamin D ◽

Side Effects ◽

Gut Microbiota ◽

Dietary Vitamin ◽

Vitamin D Status ◽

Atypical Antipsychotic Drug ◽

Vitamin D Levels ◽

Dietary Vitamin D

Vitamin D deficiency is associated with poor mental health and dysmetabolism. Several metabolic abnormalities are associated with psychotic diseases, which can be compounded by atypical antipsychotics that induce weight gain and insulin resistance. These side-effects may be affected by vitamin D levels. The gut microbiota and endocannabinoidome (eCBome) are significant regulators of both metabolism and mental health, but their role in the development of atypical antipsychotic drug metabolic side-effects and their interaction with vitamin D status is unknown. We studied the effects of different combinations of vitamin D levels and atypical antipsychotic drug (olanzapine) exposure on whole-body metabolism and the eCBome-gut microbiota axis in female C57BL/6J mice under a high fat/high sucrose (HFHS) diet in an attempt to identify a link between the latter and the different metabolic outputs induced by the treatments. Olanzapine exerted a protective effect against diet-induced obesity and insulin resistance, largely independent of dietary vitamin D status. These changes were concomitant with olanzapine-mediated decreases in Trpv1 expression and increases in the levels of its agonists, including various N-acylethanolamines and 2-monoacylglycerols, which are consistent with the observed improvement in adiposity and metabolic status. Furthermore, while global gut bacteria community architecture was not altered by olanzapine, we identified changes in the relative abundances of various commensal bacterial families. Taken together, changes of eCBome and gut microbiota families under our experimental conditions might contribute to olanzapine and vitamin D-mediated inhibition of weight gain in mice on a HFHS diet.

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Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.3.1490 ◽

2020 ◽

Vol 36 (3) ◽

Cited By ~ 1

Author(s):

Sadia Falak ◽

Lubna Aftab ◽

Muhammad Saeed ◽

Aftab Islam

Keyword(s):

Vitamin D ◽

Liver Disease ◽

Hepatitis C ◽

Vitamin D Deficiency ◽

Liver Damage ◽

Serum Vitamin ◽

Decompensated Cirrhosis ◽

Healthy Controls ◽

Vitamin D Levels ◽

Cirrhotic Patients

Objective: Serum Vitamin-D plays pivotal role in inflammatory and infectious diseases; among them liver infections are more distinct. This study was aimed to determine Vitamin-D status in HCV-infected patients and healthy controls in Faisalabad, Pakistan. Methods: We performed randomized cross-sectional study of 74 individuals from 20th August, 2017 to 20th February 2018 at The University of Faisalabad and Dar us Shifa Clinic, Faisalabad. Fifty-one patients were hepatitis C RNA-PCR positive (22 compensated cirrhotic and 29 decompensated cirrhotic patients). In addition, 23 subjects without liver disease were recruited as healthy control. HCV RNA–PCR was performed by ARTUS ® HCV QS-RGQ V1. Vitamin-D levels were measured by chemiluminescence. SPSS version 20 was used for statistical analysis. Results: The mean level of Vitamin-D was significantly lower in HCV patients in compensated and decompensated cirrhotic patients (26.85 ng/mL & 20.65 ng/mL respectively) as compared to healthy controls (30.41 ng/mL). This study showed sub optimal level of Vitamin-D in 76.5% of HCV patients. Vitamin-D insufficiency (21-29 ng/mL) as prevalent among healthy individuals (47.8%) as well as in HCV patients (39.2%) (P < 0.001). In addition, Vitamin-D levels showed inverse relationship with more severe conditions of liver disease as 55.2% of decompensated cirrhosis patients were sufferer of Vitamin-D deficiency as compared to 13.6% deficiency of Vitamin-D in compensated cirrhotic group (P <0.0001). Conclusion: Suboptimal levels of Vitamin-D (deficiency or insufficiency) are prevalent in patients having hepatitis C infection as compared to healthy controls. Deficiency of Vitamin-D was directly associated with severity of disease. doi: https://doi.org/10.12669/pjms.36.3.1490 How to cite this:Falak S, Aftab L, Saeed M, Islam A. Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.1490 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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