This chapter teaches how to use R to conduct regression analysis to answer the question: Does trade promote economic growth? It demonstrates how to specify a statistical model from a theoretical argument, prepare data, estimate and interpret the statistical model, and use the estimated results to make inferences and answer the question of interest. More specifically, it discusses the logic of regression analysis, the relationship between population and sample regression models, how to estimate a regression model in theory and practice, the estimation of sample regression model using OLS (ordinary least squares), the interpretation of estimation results, the statistical inference in regression analysis using hypothesis testing and confidence interval, the types of sum of squares and overall model fit, and how to report the model results. The validity of regression analysis is contingent upon the assumptions of the Gauss-Markov theorem being met.