Dietary multivalent anti‐ Helicobacter pylori immunoglobulin Y significantly increase the H. pylori eradication and improve the clinical symptoms in patients

Helicobacter ◽  
2021 ◽  
Author(s):  
Rong Guo ◽  
Shan Wu ◽  
Li Guan ◽  
Yongmei Xie ◽  
Xifei Yang ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Symptoms ◽  
Immunoglobulin Y ◽  
H Pylori

scholarly journals Effects of cinnamon extract on complications of treatment and eradication of Helicobacter pylori in infected people

2020 ◽  
Vol 9 (1) ◽  
pp. 55-60
Author(s):  
Ghazal Imani ◽  
Alireza khalilian ◽  
Dara Dastan ◽  
Behzad Imani ◽  
Maryam Mehrpoya
Keyword(s):  
Helicobacter Pylori ◽  
Drug Treatment ◽  
Clinical Symptoms ◽  
Epigastric Pain ◽  
Control Group ◽  
Blurred Vision ◽  
Infected People ◽  
Cinnamon Extract ◽  
H Pylori ◽  
Metallic Flavor

Introduction: Treatment of Helicobacter pylori has various side effects like antibiotic resistance. The purpose of this study was to evaluate the effects of cinnamon extract on complications of treatment and eradication of H. pylori in infected people. Methods: In this randomized clinical trial, a total of 98 eligible healthy and H. pylori-infected patients approved by esophageal endoscopy were selected. The cinnamon group received multi-drug treatment including clarithromycin, amoxicillin and pantoprazole as well as a cinnamon extract capsule. The control group received multi-drug treatment and a 40 mg starch capsule. In order to analyze the cinnamon extract efficacy, the urea breath test (UBT) was performed 3 months after the start of treatment. Clinical symptoms were evaluated by a questionnaire at the beginning (day of 0), 7 days and 14 days after starting treatment. Results: The clinical symptoms such as nausea, vomiting, diarrhea, constipation, blurred vision, headache, metallic flavor, epigastric pain, burp, and appetite were significantly reduced in the cinnamon group (P < 0.05). The odds ratio exhibited a higher eradication rate of H. pylori in the cinnamon group (73.47% in the cinnamon group compared to 53.06% in the control group) (P = 0.036). Conclusion: Cinnamon as assisted therapy is able to alleviate the disease and reduce the complications of H. pylori treatment.

Anti-Helicobacter pylori (H. pylori) urease immunoglobulin Y (IgY)-containing egg yolk prevented H. pylori colonization in mongolian gerbils

2003 ◽  
Vol 124 (4) ◽  
pp. A12
Author(s):  
Sachiko Nomura ◽  
Hidekazu Suzuki ◽  
Tatsuhiro Masaoka ◽  
Kumiko Kurabayashi ◽  
Yuriko Minegishi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Egg Yolk ◽  
Mongolian Gerbils ◽  
Immunoglobulin Y ◽  
H Pylori

scholarly journals Pathogenesis of Helicobacter pylori Infection

2006 ◽  
Vol 19 (3) ◽  
pp. 449-490 ◽  
Author(s):  
Johannes G. Kusters ◽  
Arnoud H. M. van Vliet ◽  
Ernst J. Kuipers
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Clinical Symptoms ◽  
Gastrointestinal Diseases ◽  
Immune Gene ◽  
Human Pathogens ◽  
Vacuolating Cytotoxin ◽  
Chronic Active Gastritis ◽  
Key Factor ◽  
H Pylori

SUMMARY Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world's population is colonized with this gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Disease outcome is the result of the complex interplay between the host and the bacterium. Host immune gene polymorphisms and gastric acid secretion largely determine the bacterium's ability to colonize a specific gastric niche. Bacterial virulence factors such as the cytotoxin-associated gene pathogenicity island-encoded protein CagA and the vacuolating cytotoxin VacA aid in this colonization of the gastric mucosa and subsequently seem to modulate the host's immune system. This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori.

scholarly journals Study of the peculiarities of combined opisthorchosis and helicobacteriosis

2021 ◽  
Vol 15 (1) ◽  
pp. 79-84
Author(s):  
O. I. Bibik ◽  
T. E. Pomytkina ◽  
O. I. Pivovar
Keyword(s):  
Helicobacter Pylori ◽  
Body Weight ◽  
Abdominal Pain ◽  
Visual Analogue Scale ◽  
Blood Test ◽  
Analogue Scale ◽  
Clinical Symptoms ◽  
Enrichment Method ◽  
Opisthorchis Felineus ◽  
H Pylori

The purpose of the research is identifying patients with helicobacteriosis and opisthorchosis, and determining regular features of the course of combined diseases.Materials and methods. The study involved 50 patients in the Gastroenterology Department with helicobacteriosis diagnosed. Helicobacter pylori was confirmed by the HP test during fibrogastroduodenoscopy. Opisthorchis felineus was detected in patients using the study of feces by the Kato technique and enrichment method. The patients were divided into 2 groups of 25 people each. The first group only consisted of patients with H. pylori. The second group consisted of patients in whom H. pуlori and O. felineus were identified. Initially, the levels of aminotransferases and bilirubin were assessed using a biochemical blood test on a MIURA 200 apparatus. The manifestation of such clinical symptoms as abdominal pain was assessed using a visual analogue scale (VAS). Further, the eradication of H. pylori during therapy was assessed based on the Maastricht V recommendations for 14 days, including the use of three drugs: omeprazole at a dose of 20 mg 2 times a day, clarithromycin – 500 mg 2 times a day, amoxicillin – 1000 mg 2 times a day, and the effectivity of treatment of patients of the second group with opisthorchosis with the use of praziquantel at a dose of 60 mg/kg of body weight during the day three times every 4 hours.Results and discussion. In the second group of patients with combined pathology, pain intensity was estimated at 4–5 scores in 20 people (80%), and at 2–3 scores in 25 people (100%) in the first group. The severity of nausea was also higher in 100% of patients in the second group. Values for AST and ALT in blood were higher in patients of the second group – by an average of 50–100% in 18 people (72%); increase in the level of bilirubin by 15% in 23 people (92%). Combined pathology (opisthorchosis and helicobacteriosis) is accompanied by more pronounced clinical symptoms (abdominal pain and nausea). In patients with opisthorchosis and H. pуlori, aminotransferases increased up to three reference values and bilirubin increased by 15% were noted. For helicobacteriosis and opisthorchosis, longer treatment was required. The presence of H. pylori at the same time with opisthorchosis did not affect the efficacy of antiparasitic therapy.

Biofilms in drinking water systems - a possible reservoir for Helicobacter pylori

1998 ◽  
Vol 38 (12) ◽  
pp. 181-185 ◽  
Author(s):  
W. G. Mackay ◽  
L. T. Gribbon ◽  
M. R. Barer ◽  
D. C. Reid
Keyword(s):  
Helicobacter Pylori ◽  
Distribution Systems ◽  
Water Distribution ◽  
Clinical Symptoms ◽  
Economic Status ◽  
Bacterial Pathogen ◽  
Gastrointestinal Diseases ◽  
Waterborne Transmission ◽  
H Pylori ◽  
Diagnosis Of Infection

Helicobacter pylori is a major bacterial pathogen involved in several gastrointestinal diseases. Transmission routes and reservoirs of H pylori are not well understood despite several studies. In contrast to many other infectious diseases, clinical symptoms allowing definitive diagnosis of infection are absent. Person-to-person transmission with faecal-oral and oral-oral routes have been proposed with socio-economic status and density of living as associated factors. Studies have shown that H pylori can survive in water for prolonged periods leading to a waterborne transmission route being proposed but not conclusively identified. This paper describes studies using mature heterotrophic mixed-species biofilms grown under oligotrophic conditions using a continuous-culture chemostat system. The biofilms were challenged with Helicobacter pylori (NCTC 11637). Results indicate the presence of H pylori associated with the biofilm for up to 192h post-challenge, suggesting that biofilms in water distribution systems could be a possible and as yet unrecognised reservoir of H pylori.

CLINICAL, ENDOSCOPIC AND PATHOLOGICAL RESPONSES AFTER ERADICATION WITH RACM REGIMEN IN PATIENTS OF HELICOBACTER PYLORI-RELATED CHRONIC GASTRITIS

2016 ◽  
pp. 12-19
Author(s):  
Thi Hoai Thai ◽  
Van Huy Tran
Keyword(s):  
Helicobacter Pylori ◽  
Intestinal Metaplasia ◽  
Chronic Gastritis ◽  
Clinical Symptoms ◽  
Epigastric Pain ◽  
Bile Reflux ◽  
Helicobacter Pylori Eradication ◽  
Significant Change ◽  
H Pylori ◽  
Active Inflammation

Background: The clinical, endoscopic and histopathological responses after Helicobacter pylori eradication in patients of chronic gastritis were still inconstant. This study is aimed at: (1) evaluating of clinical variations, endoscopic images six months after Helicobacter pylori eradication by Rabeprazole-Amoxicillin—Metronidazole-Clarithromycin therapy for 14 days. (2) assessing histopathological response six months after H. pylori eradication. Method: prospective, consisting of 83 patients examined and treated in Danang hospital from 4/2014 to 6/2015. Results: There were improvements in clinical symptoms 6 months after H. pylori eradication: epigastric pain 85.5% vs. 7.2%); bloating (97.1% vs. 4.3%); indigestion (47.8% vs. 2.9%); weight loss (17.4% vs. 1.4%); anorexia (23.2% vs. 2.9%) (p< 0.01). However, there were no improvement regarding common lesions on endoscopy, edema (33.3% increase to 71%); flat erosion and elevated erosion (15.9% vs. 8.7%); atrophy (7.2%); haemorrhagic (5.8% vs. 0%); hypertrophic (7.2% vs. 0%); bile reflux (14.5% vs. 4.3%). Regarding histopathology: active inflammation accounted for a high proportion (63.8% vs. 27.5%); non-active inflammation (36.2% increase to 72.5%); atrophy (8.7% vs. 5.8%); dysplasia (26.1% vs. 1.4%), no significant change in intestinal metaplasia was found after treatment. Conclusions: There was an improvement in clinical symptoms and histopathological against inflammatory activity grade, dysplasia at the time before and after 6 months treatment H. pylori eradication. However, no significant change in mucosal atrophy and intestinal metaplasia was found. Key words: chronic gastritis; H. pylori; clinical, endoscopic and pathological responses

Effect of Metronidazole Resistance on Bacterial Eradication of Helicobacter pylori in Infected Children

1998 ◽  
Vol 42 (6) ◽  
pp. 1334-1335 ◽  
Author(s):  
J. Raymond ◽  
N. Kalach ◽  
M. Bergeret ◽  
P. H. Benhamou ◽  
J. P. Barbet ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Eradication Rate ◽  
Clinical Symptoms ◽  
Bacterial Eradication ◽  
Biopsy Specimens ◽  
Metronidazole Resistance ◽  
H Pylori ◽  
A Prospective Study ◽  
Positive Results

ABSTRACT A prospective study was performed with 23 Helicobacter pylori-infected children (mean age, 9.5 ± 4.4 years) with clinical symptoms of gastritis and positive results of culture and histologic examination of gastric biopsy specimens to evaluate the influence of antibiotic resistance on eradication. Positive children were treated for 4 weeks with lansoprazole and for 2 weeks with either amoxicillin-metronidazole or spiramycin (a macrolide)-metronidazole. At endoscopy 1 month after the discontinuation of therapy, the eradication rate and improvement of histologically related gastritis were significantly dependent on the susceptibility or the resistance of the infecting organism to metronidazole (83 versus 17% and 88 versus 16.6%, respectively). Pretreatment determination of the susceptibility is appropriate in any anti-H. pylori regimen, including one with metronidazole.

scholarly journals SEROPOSITIVITY OF HELICOBACTER PYLORI AND ASSOCIATED RISK FACTORS AMONG DYSPEPETIC PATIENTS

2020 ◽  
Author(s):  
Huda Mohammed Barajash ◽  
Eidha Ali Bin-Hameed ◽  
Ahmed Mohammed Al-Haddad
Keyword(s):  
Helicobacter Pylori ◽  
Peer Review ◽  
Clinical Symptoms ◽  
Demographic Data ◽  
Age Groups ◽  
Clinical Signs ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
H Pylori ◽  
E Mail

Background and Objectives: The prevalence of Helicobacter pylori infection is most common worldwide, and the seroprevalence of H. pylori infection varies greatly among societies and geographical locations. This study aimed to determine the seroprevalence of H. pylori infection among dyspepsia patients in Al-Mukalla city– Hadhramout/Yemen. Methods: A cross-sectional study was conducted among 100 suspected patients with dyspeptic disorders where the anti- H. pylori antibodies was detected using the H. pylori antibody test cassette rapid immune chromatographic assay. Also, a structured questionnaire was completed for each patient to collect socio-demographic data, personal hygienic status and some clinical signs. Results: The prevalence of serological positivity for H. pylori infection was 37% with a statistically significant value (P=0.000). A high prevalence of H. pylori infection was detected among male more than females. The age group 5–18 years followed by age groups 33–46 years and 47–60 years showed the highest prevalence of H. pylori infection. There was no significant association between H. pylori infection with social, demographic, behavioral, and health variables (P>0.05). Clinical signs of heartburn and regurgitation were found to be significant associated with H. pylori infection (P=0.014). Conclusions: Helicobacter pylori infection was found to be associated with dyspepsia. Heartburn and regurgitation have been found as clinical symptoms associated with H. pylori infection. Peer Review History: Received 18 July 2020; Revised 15 August; Accepted 29 August, Available online 15 September 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Prof. Dr. Hassan A.H. Al-Shamahy Affiliation: Sana'a University, Yemen E-mail: [email protected]   Name: Dr. Tanveer Ahmed Khan Affiliation: Hajvery University, Lahore, Pakistan E-mail: [email protected]   Comments of reviewer(s): Similar Articles: PREVALENCE OF HELICOBACTER PYLORI AMONG ASYMPTOMATIC POPULATIONS IN SANA'A, YEMEN

scholarly journals Correlation Analysis of Helicobacter pylori Infection and Diges-tive Tract Symptoms in Children and Related Factors of Infec-tion

2020 ◽  
Author(s):  
Xiaohong YU ◽  
Dongjin FENG ◽  
Guangmeng WANG ◽  
Zhongmao DONG ◽  
Qi ZHOU ◽  
...  
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Digestive Tract ◽  
Clinical Symptoms ◽  
Helicobacter Pylori Infection ◽  
Related Factors ◽  
Expression Levels ◽  
Independent Risk Factors ◽  
Ifn Γ ◽  
H Pylori

Background: To analyze the correlation between Helicobacter pylori infection and digestive tract symptoms in children and other related factors, and to explore the risk factors of H. pylori infection in children and the expression of inflammatory factors in H. pylori-positive and H. pylori-negative children. Methods: Overall, 234 children with H. pylori test in Xuzhou Children's Hospital, Xuzhou Medical University (Xuzhou, China) were enrolled. Among them, 73 children were H. pylori-positive and 161 were H. pylori-negative. The expression levels of cytokines interleukin-8 (IL-8), interleukin-18 (IL-18) and interferon-γ (IFN-γ) in H. pylori-positive and H. pylori-negative children were determined by ELISA. The correlation between H. pylori-positive and general data, digestive tract symptoms, other clinical symptoms, living habits, eating habits, family history and other related factors was statistically analyzed. Multivariate Logistic regression analysis was used to analyze the independent risk factors of H. pylori infection in children. Results: Family monthly income, inattentive eating, sharing toothbrushes and cups, gnawing fingers, eating fried food, drinking raw water, eating smoked and pickled food, father suffering from gastropathy and mother suffering from gastropathy were independent risk factors for H. pylori infection in children. The most common digestive tract symptoms of children with H. pylori infection were abdominal pain, accompanied by one or more clinical symptoms. The expression levels of IL-8, IL-18 and IFN-γ in H. pylori-positive children were significantly higher than those in H. pylori-negative children. Conclusion: Prevention of H. pylori infection in children is helpful for healthy growth of children, and cytokines IL-8, IL-18, IFN-γ have the potential to be used as biomarkers for diagnosis of H. pylori-positive children.

A Case of Cap Polyposis Remission by Betamethasone Enema aer Antibiotics erapy including Helicobacter pylori Eradication

2014 ◽  
Vol 23 (2) ◽  
pp. 203-206 ◽  
Author(s):  
Hideo Suzuki ◽  
Masashi Sato ◽  
Daisuke Akutsu ◽  
Hiroaki Sugiyama ◽  
Taiki Sato ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Symptoms ◽  
Laboratory Data ◽  
Pathological Examination ◽  
Helicobacter Pylori Eradication ◽  
Endoscopic Findings ◽  
Cap Polyposis ◽  
H Pylori ◽  
Subsequent Administration ◽  
Crypt Cells

We report the case of a 58-year-old woman who was referred to our hospital due to frequent bloody mucus diarrhea. She was diagnosed with cap polyposis based on typical endoscopic and histological findings. Colonoscopy revealed multiple, reddish, mucus-capped polypoid lesions from the rectum to the sigmoid colon. A pathological examination revealed that the polyps were covered by erosive and inflamed granulation tissue with decreased crypt cells. Laboratory data indicated positive values for Helicobacter pylori immunoglobulin G antibody and hypoproteinemia. Metronidazole, H. pylori eradication, and levofloxacin therapies were not effective; however, the subsequent administration of betamethasone enema dramatically improved the clinical symptoms and endoscopic findings. The hypoproteinemia was normalized after the therapy. The dose of the betamethasone enema was tapered gradually, and no recurrence was observed 6 months after discontinuation of the treatment. This case suggests that betamethasone enema may be considered as the second treatment choice for cap polyposis patients after H. pylori eradication, metronidazole or levofloxacin therapy.

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