SEROPOSITIVITY OF HELICOBACTER PYLORI AND ASSOCIATED RISK FACTORS AMONG DYSPEPETIC PATIENTS

Background and Objectives: The prevalence of Helicobacter pylori infection is most common worldwide, and the seroprevalence of H. pylori infection varies greatly among societies and geographical locations. This study aimed to determine the seroprevalence of H. pylori infection among dyspepsia patients in Al-Mukalla city– Hadhramout/Yemen. Methods: A cross-sectional study was conducted among 100 suspected patients with dyspeptic disorders where the anti- H. pylori antibodies was detected using the H. pylori antibody test cassette rapid immune chromatographic assay. Also, a structured questionnaire was completed for each patient to collect socio-demographic data, personal hygienic status and some clinical signs. Results: The prevalence of serological positivity for H. pylori infection was 37% with a statistically significant value (P=0.000). A high prevalence of H. pylori infection was detected among male more than females. The age group 5–18 years followed by age groups 33–46 years and 47–60 years showed the highest prevalence of H. pylori infection. There was no significant association between H. pylori infection with social, demographic, behavioral, and health variables (P>0.05). Clinical signs of heartburn and regurgitation were found to be significant associated with H. pylori infection (P=0.014). Conclusions: Helicobacter pylori infection was found to be associated with dyspepsia. Heartburn and regurgitation have been found as clinical symptoms associated with H. pylori infection. Peer Review History: Received 18 July 2020; Revised 15 August; Accepted 29 August, Available online 15 September 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Prof. Dr. Hassan A.H. Al-Shamahy Affiliation: Sana'a University, Yemen E-mail: [email protected] Name: Dr. Tanveer Ahmed Khan Affiliation: Hajvery University, Lahore, Pakistan E-mail: [email protected] Comments of reviewer(s): Similar Articles: PREVALENCE OF HELICOBACTER PYLORI AMONG ASYMPTOMATIC POPULATIONS IN SANA'A, YEMEN

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Helicobacter pylori infection reduces the risk of gastroesophageal reflux disease

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-193-9-96-101 ◽

2021 ◽

pp. 96-101

Author(s):

R. I. Khlynova ◽

O. M. Khromtsova ◽

R. B. Berdnikov ◽

I. B. Khlynov

Keyword(s):

Helicobacter Pylori ◽

Gastroesophageal Reflux Disease ◽

Gastric Mucosa ◽

Gastroesophageal Reflux ◽

Observational Study ◽

Reflux Disease ◽

Helicobacter Pylori Infection ◽

Cross Sectional ◽

Biopsy Specimens ◽

H Pylori

The aim is to study the effect of Helicobacter pylori infection on risk of developing gastroesophageal reflux disease. Materials and methods - cross-sectional observational study of 1007 patients with dyspepsia syndrome who underwent videoesophagogastroduodenoscopy with biopsy and histological examination of biopsy specimens of the gastric mucosa by OLGA-system. The age, gender, overweight, cigarette smoking, presence of Helicobacter pylori infection and gastritis stage were assessed. Results - the study showed a significant decrease in the incidence of gastroesophageal reflux disease in patients with positive H. Pylori status by 4% (RR 0,68; 95% CI, 0.49-0.94, p=0,041). The risk of developing gastroesophageal reflux disease significantly higher in overweight (RR 2,62; 95% CI 2,0-3,56; р<0,001) men (RR 1,76; 95% CI 1,33-2,32; р=0,0046) who smoked cigarettes (RR 3,23; 95% CI 2,45-4,24; р<0,001) and was not associated with the patient’s age and the stage of gastritis (р>0,05). Conclusion - a significant reduction in the frequency and risk of developing gastroesophageal reflux disease in patients with Helicobacter pylori infection is demonstrated.

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Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

Sao Paulo Medical Journal ◽

10.1590/s1516-31802010000400002 ◽

2010 ◽

Vol 128 (4) ◽

pp. 187-191 ◽

Cited By ~ 13

Author(s):

Aurea Cristina Portorreal Miranda ◽

Rodrigo Strehl Machado ◽

Edina Mariko Koga da Silva ◽

Elisabete Kawakami

Keyword(s):

Helicobacter Pylori ◽

Cross Sectional Study ◽

Sao Paulo ◽

Helicobacter Pylori Infection ◽

Socioeconomic Level ◽

São Paulo ◽

Sectional Study ◽

Cross Sectional ◽

Low Socioeconomic ◽

H Pylori

CONTEXT AND OBJECTIVE: Helicobacter pylori infection is mainly acquired during childhood, and is associated with significant morbidity in adults. The aim here was to evaluate the seroprevalence and risk factors of H. pylori infection among children of low socioeconomic level attended at a public hospital in São Paulo, Brazil. DESIGN AND SETTING: Cross-sectional study, among patients attended at an outpatient clinic. METHODS: 326 children were evaluated (150 boys and 176 girls; mean age 6.82 ± 4.07 years) in a cross-sectional study. Patients with chronic diseases or previous H. pylori treatment, and those whose participation was not permitted by the adult responsible for the child, were excluded. The adults answered a demographic questionnaire and blood samples were collected. The serological test used was Cobas Core II, a second-generation test. Titers > 5 U/ml were considered positive. RESULTS: H. pylori infection was diagnosed in 116 children (35.6%). Infected children were older than uninfected children (7.77 ± 4.08 years versus 5.59 ± 3.86 years; p < 0.0001). The seroprevalence increased from 20.8% among children aged two to four years, to 58.3% among those older than 12 years. There were no significant relationships between seropositivity and gender, color, breastfeeding, number of people in the home, number of rooms, bed sharing, living in a shantytown, maternal educational level, family income or nutritional status. In multivariate analysis, the only variable significantly associated with H. pylori seropositivity was age. CONCLUSION: Infection had intermediate prevalence in the study population, and age was associated with higher prevalence.

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DIAGNOSTIC ACCURACY OF UREA BREATH TEST FOR HELICOBACTER PYLORI INFECTION IN CHILDREN WITH DYSPEPSIA IN COMPARISON TO HISTOPATHOLOGY

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032016000200011 ◽

2016 ◽

Vol 53 (2) ◽

pp. 108-112 ◽

Cited By ~ 4

Author(s):

Naser HONAR ◽

Alireza MINAZADEH ◽

Nader SHAKIBAZAD ◽

Mahmood HAGHIGHAT ◽

Forough SAKI ◽

...

Keyword(s):

Helicobacter Pylori ◽

Carbon Isotope ◽

Sensitivity And Specificity ◽

Breath Test ◽

Close Association ◽

Urea Breath Test ◽

Helicobacter Pylori Infection ◽

Cross Sectional ◽

Predictive Values ◽

H Pylori

ABSTRACT Background - Helicobacter pylori infection is the gram negative bacillus with the close association with chronic antral gastritis. Objective - In this study, we evaluate the accuracy of urea breath test (UBT) with carbon isotope 13 in comparison with histopathology of gastric antrum for detection of H. pylori infection in children with dyspepsia. Methods - This cross-sectional study was performed at specialized laboratory of Shiraz Gastroenterohepatology Research Center and Nemazee Hospital, Iran, during a 12-months period. This study investigated the sensitivity, specificity, and positive and negative predictive values of UBT in comparison with biopsy-based tests. We included a consecutive selection of 60 children who fulfilled Rome III criteria for dyspepsia. All children were referred for performing UBT with carbon isotope 13 (C13) as well as endoscopy. Biopsies were taken from antrum of stomach and duodenum. The pathologic diagnosis was considered as the standard test. Results - The mean age of the participants was 10.1±2.6 (range 7-17 years). From our total 60 patients, 28 (46.7%) had positive UBT results and 32 (53.3%) had negative UBT results. Pathologic report of 16 (57.1%) out of 28 patients who had positive UBT were positive for H. pylori and 12 (42.9%) ones were negative. Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Conclusion - Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Another multicenter study from our country is recommended.

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The Magnitude and associated factors of Helicobacter pylori infection among adult dyspeptic patients attending Bokoji Hospital, Southeast Ethiopia

10.21203/rs.3.rs-25765/v1 ◽

2020 ◽

Author(s):

Dagaga Goboto Kenea ◽

Mesfin Negawo ◽

Firaol Kitila Lemessa ◽

Solomon Tejineh

Keyword(s):

Helicobacter Pylori ◽

Alcohol Drinking ◽

Intestinal Parasites ◽

Helicobacter Pylori Infection ◽

P Value ◽

Cross Sectional ◽

Gastrointestinal Complications ◽

Ulcer Disease ◽

Southeast Ethiopia ◽

H Pylori

Abstract Background: Helicobacter pylori infection is the most common chronic bacterial infection and there were approximately 4.4 billion individuals with H pylori infection worldwide. Among those, hundreds of millions of people develop peptic ulcer disease during their lifetime and still tens of millions might progress to gastric cancer. Hence, early information is very important to prevent upper gastrointestinal complications. Consequently, the current study aimed to assess the magnitude and associated risk factors of Helicobacter pylori infection among adult dyspeptic patients attending Bokoji hospital, Southeast Ethiopia.Methods: A hospital-based cross-sectional study involving 348 adult dyspeptic patients attending Bokoji hospital was carried out from July 16 to October 31, 2019. About 50 mg of fresh stool and 60 µl of capillary blood were collected from each dyspeptic patient and analyzed for detection of Helicobacter pylori antigens, presence of intestinal parasites and ABO blood grouping respectively. Data were entered using Epi Info 7 and Statistical analysis was done using SPSS version 21 and a p-value less than 0.05 was considered as statistically significant.Results: The overall magnitude of Helicobacter pylori infection was 47.7%. The magnitude of H. pylori infection was almost two times higher in patients who do not have a habit of handwashing after toilet visit than those who wash their hand's habit of handwashing after visiting toilet (AOR 2.241, 95% CI (1.410, 3.563) and alcohol drinking habit (AOR 1.796, 95% CI (1.087, 2.968). Conclusions: The magnitude of H. pylori was high in the study area and associated with handwashing habits after toilet use and alcohol drinking habits. Therefore, the community could be educated on the handwashing habit to minimize H. pylori infections.

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HELICOBACTER PYLORI INFECTION;

The Professional Medical Journal ◽

10.29309/tpmj/2017.24.09.884 ◽

2017 ◽

Vol 24 (09) ◽

pp. 1425-1430

Author(s):

Tahira Tabassum ◽

Ayesha Imtiaz ◽

Aamir Sharif ◽

Muhammad Akram

Keyword(s):

Helicobacter Pylori ◽

Age Groups ◽

Helicobacter Pylori Infection ◽

Step Test ◽

Chromatographic Technique ◽

Medical College ◽

Education Levels ◽

One Step ◽

H Pylori

Objectives: To estimate the prevalence of Helicobacter pylori infection inpopulation of Sargodha and determination of possible risk factors. Design: Descriptive study.Place and Duration: University medical complex & Research Center, Sargodha Medical College,Sargodha from 01.01.2017 to 31.03.2017. Material and Methods: The study was conductedamong 486 clinically suspected individuals of Sargodha, Punjab, Pakistan. Data was obtainedby questionnaire and H. pylori antibodies were detected by H. pylori ‘One Step Test Device’based on immune-chromatographic technique. Results: A total of 486 individuals participatedin the study of which 327 (67.28%) were positive for H. pylori infection. The prevalence was66.97% in males and 33.2% in females (p = 0.00) and increased with increasing age (p =0.000). In the study, significant association was found between age groups, education levels,food habits, monthly income with H. pylori infection with p values 0.000, 0.000, 0.001, 0.041respectively while no significant association was seen for source of drinking water (p =0.321).Conclusion: The results of present study showed the prevalence of H. pylori in reported areaand confirmed that it is higher in developing countries. It is concluded that prevalence ofinfection with this bacterium can be minimized by increasing the hygenicity, improving the livingstandards and, of course, by educating the nation.

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Frequency of Helicobacter pylori infection in patients of acne vulgaris

10.53350/pjmhs211561411 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1411-1414

Author(s):

Z. Khalid ◽

H. B. A. Kalhoro ◽

A. Ashraf ◽

H. Mughal ◽

K. Bukhsh ◽

...

Keyword(s):

Helicobacter Pylori ◽

Acne Vulgaris ◽

Serum Levels ◽

Cross Sectional Study ◽

Helicobacter Pylori Infection ◽

Pathology Laboratory ◽

Cross Sectional ◽

Dermatology Department ◽

H Pylori ◽

Very High

Background: Acne vulgaris is a common complaint throughout the world, contributing to both morbidity and healthcare costs. Helicobacter pylori (HP) infection is also a world heath problem, and recent evidence suggests that two conditions may be related. However, there is insignificant evidence to support a casual association of HP infection and acne vulgaris. Aim: To determine the frequency of helicobacter pylori infection in patients of acne vulgaris Study design: Descriptive, cross-sectional study. Settings and duration: Dermatology Department, Liaquat University of medical and health Sciences (LUMHS), Civil Hospital, Hyderabad from 22nd August 2017 to 21st February 2018 Methods: A total of 135 patients, 13 to 30 years of age of both genders with acne vulgaris were included in this study. Patients with H Pylori infection positive without acne vulgaris, family history helicobacter pylori infection, chronic smoker or alcoholics were excluded. Patients were subjected to relevant investigations i.e. HP antibody titer, for that blood sample of each patient was sent to institutional pathology laboratory for measuring of serum levels of anti H. Pylori IgG antibodies where each report was prepared by consultant pathologist. Results: Mean age was 23.33 ± 4.14 years. Out of these 135 patients, 48 (35.56%) were females and 87 (64.44%) were males with female to male ratio of 1:1.8. Frequency of helicobacter pylori infection in patients of acne vulgaris was seen in 107 (79.26%) patients. Conclusion: This study concluded that frequency of helicobacter pylori infection in patients of acne vulgaris is very high and these patients should be screened for helicobacter pylori infection Keywords: Acne, helicobacter pylori, association

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Noninvasive Diagnostic Tests for Helicobacter Pylori Infection in Children

Canadian Journal of Gastroenterology ◽

10.1155/2005/213608 ◽

2005 ◽

Vol 19 (7) ◽

pp. 433-439 ◽

Cited By ~ 28

Author(s):

Sibylle Koletzko

Keyword(s):

Helicobacter Pylori ◽

Breath Test ◽

Clinical Decision Making ◽

Age Groups ◽

Eradication Therapy ◽

High Sensitivity ◽

Urea Breath Test ◽

Helicobacter Pylori Infection ◽

Noninvasive Test ◽

H Pylori

Noninvasive tests can be used for the initial diagnosis of Helicobacter pylori infection and to monitor the success of eradication therapy. In populations with a low prevalence of H pylori infection (children living in North America and Europe), a high sensitivity is required to make the test valuable for clinical practice. The13C-urea breath test has been validated in children of different age groups in a significant number of infected and noninfected children in several countries and, thus far, is the only noninvasive test that fulfills sensitivity and specificity quality standards. In studies to date, enzyme immunoassays using monoclonal antibodies to detect H pylori antigen in stool provide excellent results, but the number of children tested, particularly post-treatment, is not sufficient to recommend the test. All other noninvasive stool tests or methods based on the detection of specific antibodies in serum, whole blood, urine or saliva have limited accuracy in comparison with the13C-urea breath test. Therefore, these tests cannot be recommended for clinical decision making in pediatric patients.

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Helicobacter Pylori Infection in Iran: Demographic, Endoscopic and Pathological Factors

10.21203/rs.3.rs-222253/v1 ◽

2021 ◽

Author(s):

Seyedeh Amineh Hojati ◽

Sara Kokabpeyk ◽

Salma Yaghoubi ◽

Farahnaz Joukar ◽

Mehrnaz Asgharnezhad ◽

...

Keyword(s):

Helicobacter Pylori ◽

Peptic Ulcer ◽

Tap Water ◽

Helicobacter Pylori Infection ◽

Common Symptom ◽

Significant Relation ◽

Cross Sectional ◽

Significant Difference ◽

Pathologic Findings ◽

H Pylori

Abstract Background: Helicobacter pylori infection is the most important risk factor for Gastritis and Peptic Ulcer. But other factors except H. pylori play roles in its pathogenesis. In current study we compare the clinical manifestation and endoscopic and histopathology findings in patients with and without H. pylori infection.Methods: In this cross-sectional study, 233 of patients with dyspepsia who referred for endoscopy were studied about presence of H. pylori infection. During endoscopy 5 biopsies were taken from each individual. The criteria for presence of H. pylori infection was the presence and recognition of bacteria in pathologic specimen which was done for all patient. These two groups of patient were compared with their demographic, background, endoscopic and pathologic findings. Results: From 233 cases, 154 (66.1%) cases were non-smoker, 201 (86.3%) cases were not alcohol user, 153 (65.7%) cases used tap water and the most common symptom was reported in 157 individual (67.4%) was epigastria pain. There was a significant relation between the number of family member, marital status and presence of H. pylori infection. Also there is a significant relation between endoscopic findings and pathologic findings in patients with H. pylori.Conclusions: the results of current studt demonstrated that H. pylori infection was not associated with sex, alcohol and NSAID drugs. According to the role of H. pylori in pathophysiology of peptic ulcer was clarified, also in this study there were a significant difference in endoscopic and pathological findings H. pylori.

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Sero-Prevalence and Risk Factors for Helicobacter pylori Infection Among Individuals with and those Without Dyspepsia in Zaria, Northwestern Nigeria

Annals of Clinical and Experimental Medicine ◽

10.47838/acem.26011977.11162020.asmeda.12.0 ◽

2020 ◽

Vol 1 (1) ◽

pp. 73-76

Author(s):

Okonkwo Lilian Okwubenata ◽

Musa Bolanle Olufunke Priscilla ◽

Hali Bello ◽

Mustapha Shettima Kagu

Keyword(s):

Risk Factors ◽

Helicobacter Pylori ◽

Low Socioeconomic Status ◽

Immunoglobulin G ◽

Rural Areas ◽

Urban Areas ◽

Helicobacter Pylori Infection ◽

Cross Sectional ◽

H Pylori ◽

Study Participants

Background Helicobacter pylori infection is prevalent in African region especially in areas with low socioeconomic status. This study aimed to determine the prevalence and risk factors for Helicobacter pylori Infection among individuals with and those without dyspepsia Materials and Methods The study was cross sectional in which individuals with and those without dyspepsia were enrolled. The prevalence for Helicobacter pylori infection was determined by the screening of Helicobacter pylori immunoglobulin G and this was compared across variables of interest. IBM SPSS was used for the data analysis. Results Overall prevalence of Helicobacter pylori immunoglobulin G was 44 (37.9 %). There was no association between H pylori infection and dyspepsia (0.894). There was statistically significant association between residing in rural areas and acquiring of Helicobacter pylori infection (P= 0.011). Study participants from rural areas had significantly higher and lower pit latrines and water closet toilets respectively than the study participants who reside in urban areas (P= 0.0001). Conclusion Modest prevalence of Helicobacter pylori infection was observed and no association between H pylori infection and dyspepsia was observed. There is a need to take strategic measures towards improving level of socio-economic status of the rural areas so as to reduce the risk of contracting Helicobacter pylori infection in people living in rural areas

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Prevalence and Factors associated with Helicobacter pylori among Adults between 18 and 40 Years at Butembe Health Centre III Kyankwanzi district, Uganda.

10.51168/sjhrafrica.v2i6.37 ◽

2021 ◽

Author(s):

◽

Shubeika Kakooza

Keyword(s):

Helicobacter Pylori ◽

Health Centre ◽

Antibody Test ◽

Population Based ◽

Helicobacter Pylori Infection ◽

Cross Sectional ◽

Face To Face ◽

Factors Associated ◽

Cross Sectional Design ◽

H Pylori

Background: The prevalence of Helicobacter pylori infection varies by geography, ethnicity, and socioeconomic factors. Available data on the prevalence of Helicobacter pylori infection in Uganda are not representative of the general population. We sought to describe the prevalence and factors associated with H.pylori among adults between 18 and 40 years at Butemba Health Centre III. Methodology: Using a cross-sectional design, H. pylori infection was assessed by the H.pylori antibody test among 181respondents attending Butemba Health Centre III in Kyankwanzi. Data were collected by face-to-face interviews using a questionnaire. Associations between H. pylori infection and factors associated were analyzed using logistic regression. Results: The overall prevalence of H. pylori infection was 29.2%. However, H. pylori infection was highest (54.14%) in the age of 18 to 30 years study participants followed by 31 to 40 years (45.8%). H. pylori was associated with smoking of cigarettes (AOR = 0.732; 95% CI: 0.275-1.950), drinking alcohol (AOR = 4.373; 95% CI: 1.359-14.06), Poor sanitation (AOR = 5.33; 95% CI: 2.556-11.11) were also independently associated with H. pylori infection. Conclusion and recommendation: The prevalence of H. pylori infection in Kyakwanzi at 29.2% calls for population-based studies in the region and offers an opportunity to study the transmission dynamics of H. pylori infection. Changes in public health measures need to be instituted in the management of H. pylori infection to include education of the population and health care workers on the non-specific and insidious clinical presentation of the condition.

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